Mutagenetix > Incidental Mutation

Incidental Mutation 'R8040:Vmn2r107'

618492

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

MMRRC Submission

Accession Numbers

Genbank: NM_001104569; MGI: 1316664

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R8040 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20345425-20375772 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20375546 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 787 (C787Y)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably damaging
Transcript: ENSMUST00000042090
AA Change: C787Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: C787Y

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

100% (47/47)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1a	A	T	5: 8,715,035	D675V	probably benign	Het
Adam21	T	C	12: 81,560,437	R184G	probably benign	Het
Adcy10	A	G	1: 165,552,024	K952E	probably damaging	Het
Allc	A	T	12: 28,555,352	I316N	probably damaging	Het
Ano8	T	C	8: 71,482,168	T432A	probably benign	Het
Cadps2	C	A	6: 23,412,943		probably benign	Het
Camsap2	T	C	1: 136,281,247	S168G		Het
Ccl19	T	C	4: 42,756,297	S12G	probably damaging	Het
Cltc	A	G	11: 86,725,205	S412P	probably damaging	Het
Cwc25	A	G	11: 97,750,870		probably null	Het
Cxcr4	A	G	1: 128,589,798	F42S	probably damaging	Het
Cyp4a12a	A	G	4: 115,326,215	Q177R	probably benign	Het
Dnal4	T	C	15: 79,761,968	T112A	probably benign	Het
Dock9	C	A	14: 121,651,794	G304C	probably benign	Het
Evpl	T	C	11: 116,222,932	T1311A	probably damaging	Het
Fat4	T	C	3: 38,981,666	Y3156H	probably damaging	Het
Golgb1	A	G	16: 36,913,479	I1070M	possibly damaging	Het
Hcls1	A	G	16: 36,951,149	D139G	probably damaging	Het
Ighv1-7	A	G	12: 114,538,770	S26P	probably benign	Het
Il1r1	A	T	1: 40,313,349	T563S	probably benign	Het
Kcna1	C	T	6: 126,642,740	D206N	probably benign	Het
Kcnk4	A	G	19: 6,927,627	Y219H	probably damaging	Het
Kcnt2	G	A	1: 140,450,217	A403T	probably damaging	Het
Maats1	A	G	16: 38,320,371	S407P	possibly damaging	Het
Mdp1	T	A	14: 55,660,066	N44I	probably benign	Het
Nceh1	A	G	3: 27,241,225	N212D	probably benign	Het
Nynrin	G	A	14: 55,871,525	G1363D	probably benign	Het
Olfr1165-ps	T	A	2: 88,101,359	R209S	unknown	Het
Olfr26	T	A	9: 38,855,164	I34N	probably damaging	Het
Olfr429	T	C	1: 174,089,157	I39T	possibly damaging	Het
Olfr986	A	G	9: 40,187,421	H102R	probably damaging	Het
Papd7	A	G	13: 69,500,481	Y719H	probably damaging	Het
Parp2	T	A	14: 50,810,173	M47K	probably benign	Het
Pfdn6	T	C	17: 33,939,977		probably benign	Het
Plat	G	T	8: 22,772,232	G91W	probably damaging	Het
Plb1	T	A	5: 32,273,069	H123Q	possibly damaging	Het
Pml	C	A	9: 58,234,685	R288L	probably benign	Het
Prodh2	A	G	7: 30,506,411	D238G	probably damaging	Het
Rad51ap2	T	A	12: 11,458,791	S905T	probably benign	Het
Sclt1	C	T	3: 41,657,376	R487H	probably damaging	Het
Serpina3b	A	G	12: 104,131,076	I205M	probably benign	Het
Sowahb	A	G	5: 93,043,433	S476P	possibly damaging	Het
Srgap3	C	T	6: 112,739,364	R625H	probably benign	Het
Tnxb	T	C	17: 34,716,558	Y2611H	probably damaging	Het
Uggt1	T	C	1: 36,211,473	E237G	possibly damaging	Het
Vmn1r87	T	A	7: 13,132,159	Y67F	possibly damaging	Het
Zscan4-ps3	T	A	7: 11,612,673	I212N	probably damaging	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20375747	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20345606	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20357800	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20374906	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20356777	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20375561	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20356744	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20357755	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20375712	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20356911	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20356776	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20357958	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20345504	missense	probably benign
BB006:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20345611	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20374823	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20375132	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20357759	missense	probably benign
R0621:Vmn2r107	UTSW	17	20374990	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20355654	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20356598	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20357769	missense	probably benign
R1237:Vmn2r107	UTSW	17	20356685	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20374847	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20356513	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20345578	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20355617	splice site	probably null
R2009:Vmn2r107	UTSW	17	20375467	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20375287	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20375642	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20375555	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20360345	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20374889	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20375455	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20375221	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20355779	missense	probably benign
R4963:Vmn2r107	UTSW	17	20375141	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20355753	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20375164	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20375054	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20345587	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20355782	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20375677	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20375375	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20356879	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20355876	missense	probably benign
R7448:Vmn2r107	UTSW	17	20375732	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20375009	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20375372	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20360373	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20356639	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20357008	missense	probably benign	0.00
R8263:Vmn2r107	UTSW	17	20360352	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20356977	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20356789	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20374887	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20360399	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20357000	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20356968	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- AGATGCTCATATTGAACATGGTCAC -3'
(R):5'- TGACCCCTTTTATGAAGTCGTTAAC -3'

Sequencing Primer
(F):5'- CATCATCATTTTGTGCAACAAGGGC -3'
(R):5'- AATCTTCCTTCTAGAATGTGTTGTTC -3'

Posted On

2020-01-23