Mutagenetix > Incidental Mutation

Incidental Mutation 'R8041:Tex15'

618528

Institutional Source

Beutler Lab

Gene Symbol

Tex15

Ensembl Gene

ENSMUSG00000009628

Gene Name

testis expressed gene 15

Synonyms

2210014E14Rik

MMRRC Submission

067478-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.291) question?

Stock #

R8041 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

34006766-34075610 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 34065874 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Leucine at position 1768 (R1768L)

Ref Sequence

ENSEMBL: ENSMUSP00000009772 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000009772] [ENSMUST00000124496] [ENSMUST00000124501]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000009772
AA Change: R1768L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000009772
Gene: ENSMUSG00000009628
AA Change: R1768L

Domain	Start	End	E-Value	Type
low complexity region	262	274	N/A	INTRINSIC
low complexity region	302	313	N/A	INTRINSIC
low complexity region	524	536	N/A	INTRINSIC
low complexity region	665	674	N/A	INTRINSIC
low complexity region	713	725	N/A	INTRINSIC
low complexity region	946	961	N/A	INTRINSIC
low complexity region	1497	1508	N/A	INTRINSIC
Pfam:TEX15	1572	1788	1.3e-109	PFAM
Pfam:TEX15	1901	2119	1.1e-16	PFAM
low complexity region	2758	2770	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124496

SMART Domains

Protein: ENSMUSP00000120744
Gene: ENSMUSG00000009628

Domain	Start	End	E-Value	Type
Pfam:DUF3715	89	251	1.6e-58	PFAM
low complexity region	536	548	N/A	INTRINSIC
low complexity region	576	587	N/A	INTRINSIC
low complexity region	798	810	N/A	INTRINSIC
low complexity region	939	948	N/A	INTRINSIC
low complexity region	987	999	N/A	INTRINSIC
low complexity region	1220	1235	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124501

SMART Domains

Protein: ENSMUSP00000138070
Gene: ENSMUSG00000009628

Domain	Start	End	E-Value	Type
Pfam:DUF3715	96	251	2.4e-52	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks. However, female mice are fertile. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afap1l1	A	T	18: 61,891,754 (GRCm39)	L21Q	probably damaging	Het
Ago1	G	A	4: 126,335,729 (GRCm39)	R661C	probably damaging	Het
Albfm1	T	A	5: 90,740,864 (GRCm39)		probably null	Het
Aoc3	T	C	11: 101,223,132 (GRCm39)	V456A	probably benign	Het
Aopep	G	C	13: 63,180,921 (GRCm39)	W294C	probably damaging	Het
Cacna1b	A	T	2: 24,547,311 (GRCm39)	F1223L	probably damaging	Het
Ccdc40	T	C	11: 119,122,507 (GRCm39)	F33S	possibly damaging	Het
Ccnjl	T	C	11: 43,470,538 (GRCm39)	V102A	probably damaging	Het
Cd48	T	C	1: 171,526,958 (GRCm39)	V128A	probably damaging	Het
Cmah	A	G	13: 24,652,601 (GRCm39)	D577G	probably benign	Het
Cnnm4	A	G	1: 36,511,174 (GRCm39)	K134R	probably benign	Het
Cntnap5a	T	A	1: 116,187,209 (GRCm39)	Y594N	probably damaging	Het
Col14a1	A	G	15: 55,318,626 (GRCm39)	E1375G	unknown	Het
Comtd1	T	A	14: 21,897,985 (GRCm39)	E153V	probably benign	Het
Dchs1	T	A	7: 105,404,395 (GRCm39)	T2716S	probably benign	Het
Ddx4	A	T	13: 112,762,928 (GRCm39)	S143T	probably benign	Het
Dlg1	A	G	16: 31,656,885 (GRCm39)	D593G	possibly damaging	Het
Dok6	A	G	18: 89,578,213 (GRCm39)	I68T	possibly damaging	Het
Dpysl5	A	G	5: 30,953,658 (GRCm39)	I563V	probably benign	Het
Eapp	A	G	12: 54,739,650 (GRCm39)	S56P	probably damaging	Het
Efcab3	T	G	11: 104,810,305 (GRCm39)	D3147E	unknown	Het
Fgd5	A	T	6: 92,038,837 (GRCm39)	D1157V	probably damaging	Het
Fmn1	T	A	2: 113,194,939 (GRCm39)	L213Q	unknown	Het
Foxo1	T	A	3: 52,253,044 (GRCm39)	Y402*	probably null	Het
Fyb2	C	A	4: 104,857,681 (GRCm39)	F619L	possibly damaging	Het
Gtf2i	A	T	5: 134,322,599 (GRCm39)		probably null	Het
Hrh1	G	A	6: 114,456,878 (GRCm39)	R53H	not run	Het
Hydin	A	T	8: 111,301,626 (GRCm39)	M3786L	probably benign	Het
Ifi207	T	C	1: 173,555,268 (GRCm39)	R805G	possibly damaging	Het
Igfn1	C	A	1: 135,895,797 (GRCm39)	G1590*	probably null	Het
Jph3	A	C	8: 122,516,201 (GRCm39)	I740L	probably benign	Het
Kbtbd7	T	A	14: 79,666,144 (GRCm39)	F659I	probably benign	Het
Kcns2	A	T	15: 34,839,291 (GRCm39)	Q218L	probably benign	Het
Kcnt2	A	G	1: 140,537,398 (GRCm39)	N1119S	probably benign	Het
Krit1	A	T	5: 3,857,309 (GRCm39)	H38L	probably benign	Het
Krt20	T	A	11: 99,328,663 (GRCm39)	R87S	probably damaging	Het
Ly6g5c	A	G	17: 35,330,808 (GRCm39)	E110G	probably damaging	Het
Mamdc4	A	G	2: 25,454,707 (GRCm39)	F1035S	probably damaging	Het
Mmp13	A	T	9: 7,280,865 (GRCm39)	D416V	probably benign	Het
Nadk	G	T	4: 155,661,524 (GRCm39)	D17Y	probably benign	Het
Nrap	A	T	19: 56,352,768 (GRCm39)	L566*	probably null	Het
Or12d17	T	C	17: 37,777,540 (GRCm39)	F148L	probably benign	Het
Or4b12	A	T	2: 90,096,488 (GRCm39)	C95*	probably null	Het
Or51ai2	T	C	7: 103,586,788 (GRCm39)	L67P	probably damaging	Het
Or5p69	T	C	7: 107,966,741 (GRCm39)	F15L	probably damaging	Het
Pcdhb19	T	C	18: 37,630,367 (GRCm39)	L54P	possibly damaging	Het
Pitpnm2	A	G	5: 124,259,519 (GRCm39)	F1272S	probably damaging	Het
Pml	C	A	9: 58,141,968 (GRCm39)	R288L	probably benign	Het
Reep4	T	C	14: 70,785,627 (GRCm39)	Y186H	probably benign	Het
Rpgrip1	A	G	14: 52,356,702 (GRCm39)	T89A	possibly damaging	Het
Shc1	T	C	3: 89,330,260 (GRCm39)	S175P	probably damaging	Het
Sipa1l3	A	G	7: 29,063,645 (GRCm39)	S1156P	probably damaging	Het
Slc1a3	G	A	15: 8,665,683 (GRCm39)	P522L	probably benign	Het
Slc6a17	T	A	3: 107,381,744 (GRCm39)	T446S	probably damaging	Het
Tas1r2	A	T	4: 139,387,290 (GRCm39)	N250Y	possibly damaging	Het
Ttll9	G	C	2: 152,844,956 (GRCm39)	Q441H	possibly damaging	Het
Unc5c	T	A	3: 141,171,545 (GRCm39)	V24E	possibly damaging	Het
Unc79	A	G	12: 103,054,726 (GRCm39)	E888G	probably benign	Het
Vmn2r19	T	C	6: 123,312,750 (GRCm39)	S607P	possibly damaging	Het
Vsig1	C	T	X: 139,833,875 (GRCm39)	H232Y	probably benign	Het
Wdfy4	A	G	14: 32,875,965 (GRCm39)		probably null	Het
Zbtb49	T	C	5: 38,358,198 (GRCm39)	D685G	possibly damaging	Het

Other mutations in Tex15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00639:Tex15	APN	8	34,065,339 (GRCm39)	missense	probably benign	0.18
IGL00705:Tex15	APN	8	34,071,620 (GRCm39)	missense	probably damaging	1.00
IGL00820:Tex15	APN	8	34,069,034 (GRCm39)	splice site	probably benign
IGL01288:Tex15	APN	8	34,061,412 (GRCm39)	missense	probably benign	0.02
IGL01328:Tex15	APN	8	34,061,424 (GRCm39)	nonsense	probably null
IGL01359:Tex15	APN	8	34,071,926 (GRCm39)	missense	probably damaging	0.99
IGL01603:Tex15	APN	8	34,063,575 (GRCm39)	missense	possibly damaging	0.93
IGL01861:Tex15	APN	8	34,060,717 (GRCm39)	missense	probably damaging	1.00
IGL02052:Tex15	APN	8	34,072,493 (GRCm39)	missense	probably benign	0.28
IGL02560:Tex15	APN	8	34,071,779 (GRCm39)	missense	probably benign	0.00
IGL02677:Tex15	APN	8	34,061,108 (GRCm39)	missense	probably benign	0.03
IGL02739:Tex15	APN	8	34,071,721 (GRCm39)	missense	possibly damaging	0.68
Big_gulp	UTSW	8	34,071,762 (GRCm39)	missense	probably damaging	1.00
P0005:Tex15	UTSW	8	34,060,896 (GRCm39)	missense	probably benign	0.00
P0037:Tex15	UTSW	8	34,071,608 (GRCm39)	missense	probably benign	0.00
PIT4377001:Tex15	UTSW	8	34,061,129 (GRCm39)	missense	probably damaging	1.00
R0056:Tex15	UTSW	8	34,072,055 (GRCm39)	missense	probably benign	0.00
R0056:Tex15	UTSW	8	34,072,055 (GRCm39)	missense	probably benign	0.00
R0058:Tex15	UTSW	8	34,071,530 (GRCm39)	splice site	probably benign
R0058:Tex15	UTSW	8	34,071,530 (GRCm39)	splice site	probably benign
R0595:Tex15	UTSW	8	34,062,645 (GRCm39)	missense	probably damaging	1.00
R0646:Tex15	UTSW	8	34,072,354 (GRCm39)	missense	possibly damaging	0.83
R0688:Tex15	UTSW	8	34,063,528 (GRCm39)	missense	probably damaging	1.00
R0842:Tex15	UTSW	8	34,061,575 (GRCm39)	missense	possibly damaging	0.95
R0987:Tex15	UTSW	8	34,066,875 (GRCm39)	missense	probably damaging	1.00
R1084:Tex15	UTSW	8	34,067,032 (GRCm39)	missense	probably benign	0.28
R1183:Tex15	UTSW	8	34,064,893 (GRCm39)	missense	probably benign	0.35
R1186:Tex15	UTSW	8	34,061,661 (GRCm39)	missense	probably benign	0.19
R1378:Tex15	UTSW	8	34,065,244 (GRCm39)	missense	probably damaging	0.99
R1500:Tex15	UTSW	8	34,065,120 (GRCm39)	missense	probably damaging	0.96
R1508:Tex15	UTSW	8	34,066,880 (GRCm39)	missense	probably damaging	1.00
R1597:Tex15	UTSW	8	34,061,511 (GRCm39)	missense	probably damaging	0.96
R1636:Tex15	UTSW	8	34,066,415 (GRCm39)	nonsense	probably null
R1639:Tex15	UTSW	8	34,060,845 (GRCm39)	missense	possibly damaging	0.94
R1809:Tex15	UTSW	8	34,064,262 (GRCm39)	missense	probably benign
R1843:Tex15	UTSW	8	34,066,682 (GRCm39)	missense	probably benign	0.27
R2029:Tex15	UTSW	8	34,061,302 (GRCm39)	missense	probably damaging	0.99
R2228:Tex15	UTSW	8	34,061,265 (GRCm39)	missense	probably benign	0.05
R2229:Tex15	UTSW	8	34,061,265 (GRCm39)	missense	probably benign	0.05
R2245:Tex15	UTSW	8	34,061,524 (GRCm39)	missense	possibly damaging	0.77
R2246:Tex15	UTSW	8	34,072,540 (GRCm39)	missense	possibly damaging	0.49
R2880:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R2881:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R2882:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R3001:Tex15	UTSW	8	34,064,556 (GRCm39)	missense	probably benign	0.15
R3002:Tex15	UTSW	8	34,064,556 (GRCm39)	missense	probably benign	0.15
R3020:Tex15	UTSW	8	34,066,698 (GRCm39)	missense	probably damaging	1.00
R3084:Tex15	UTSW	8	34,064,913 (GRCm39)	missense	probably benign	0.11
R3085:Tex15	UTSW	8	34,064,913 (GRCm39)	missense	probably benign	0.11
R3701:Tex15	UTSW	8	34,064,194 (GRCm39)	missense	probably benign	0.00
R3702:Tex15	UTSW	8	34,064,194 (GRCm39)	missense	probably benign	0.00
R3752:Tex15	UTSW	8	34,061,443 (GRCm39)	missense	probably benign
R4162:Tex15	UTSW	8	34,071,586 (GRCm39)	missense	probably damaging	1.00
R4231:Tex15	UTSW	8	34,062,165 (GRCm39)	missense	probably damaging	0.99
R4589:Tex15	UTSW	8	34,047,401 (GRCm39)	missense	probably damaging	1.00
R4707:Tex15	UTSW	8	34,072,525 (GRCm39)	missense	probably benign	0.00
R4773:Tex15	UTSW	8	34,072,760 (GRCm39)	missense	probably benign	0.42
R4967:Tex15	UTSW	8	34,064,498 (GRCm39)	missense	probably benign	0.34
R5063:Tex15	UTSW	8	34,072,638 (GRCm39)	missense	possibly damaging	0.59
R5121:Tex15	UTSW	8	34,061,794 (GRCm39)	missense	probably damaging	1.00
R5147:Tex15	UTSW	8	34,062,340 (GRCm39)	nonsense	probably null
R5166:Tex15	UTSW	8	34,066,420 (GRCm39)	missense	probably benign	0.07
R5173:Tex15	UTSW	8	34,061,768 (GRCm39)	missense	possibly damaging	0.73
R5439:Tex15	UTSW	8	34,064,199 (GRCm39)	missense	possibly damaging	0.93
R5537:Tex15	UTSW	8	34,061,641 (GRCm39)	missense	probably damaging	1.00
R5580:Tex15	UTSW	8	34,062,457 (GRCm39)	missense	probably damaging	1.00
R5588:Tex15	UTSW	8	34,067,215 (GRCm39)	missense	probably damaging	1.00
R5696:Tex15	UTSW	8	34,063,220 (GRCm39)	missense	probably benign	0.01
R5734:Tex15	UTSW	8	34,036,364 (GRCm39)	missense	probably benign	0.01
R5756:Tex15	UTSW	8	34,065,861 (GRCm39)	missense	probably benign	0.17
R5823:Tex15	UTSW	8	34,060,962 (GRCm39)	missense	possibly damaging	0.67
R6126:Tex15	UTSW	8	34,063,591 (GRCm39)	missense	probably benign	0.19
R6129:Tex15	UTSW	8	34,064,158 (GRCm39)	missense	possibly damaging	0.90
R6276:Tex15	UTSW	8	34,067,217 (GRCm39)	missense	possibly damaging	0.93
R6374:Tex15	UTSW	8	34,065,940 (GRCm39)	missense	probably damaging	1.00
R6430:Tex15	UTSW	8	34,061,329 (GRCm39)	missense	probably benign	0.01
R6452:Tex15	UTSW	8	34,062,844 (GRCm39)	missense	probably damaging	1.00
R6471:Tex15	UTSW	8	34,071,762 (GRCm39)	missense	probably damaging	1.00
R6700:Tex15	UTSW	8	34,064,917 (GRCm39)	missense	possibly damaging	0.93
R6918:Tex15	UTSW	8	34,063,212 (GRCm39)	missense	probably benign	0.27
R6958:Tex15	UTSW	8	34,060,899 (GRCm39)	missense	probably benign	0.01
R6970:Tex15	UTSW	8	34,047,456 (GRCm39)	missense	probably benign	0.03
R7059:Tex15	UTSW	8	34,064,758 (GRCm39)	missense	possibly damaging	0.57
R7069:Tex15	UTSW	8	34,060,748 (GRCm39)	missense	probably benign
R7072:Tex15	UTSW	8	34,065,459 (GRCm39)	missense	possibly damaging	0.85
R7212:Tex15	UTSW	8	34,063,023 (GRCm39)	missense	probably damaging	1.00
R7212:Tex15	UTSW	8	34,060,854 (GRCm39)	nonsense	probably null
R7216:Tex15	UTSW	8	34,063,014 (GRCm39)	missense	possibly damaging	0.93
R7219:Tex15	UTSW	8	34,036,268 (GRCm39)	missense	probably benign	0.40
R7313:Tex15	UTSW	8	34,064,845 (GRCm39)	missense	possibly damaging	0.82
R7315:Tex15	UTSW	8	34,071,544 (GRCm39)	missense	probably benign	0.01
R7444:Tex15	UTSW	8	34,066,590 (GRCm39)	missense	possibly damaging	0.92
R7455:Tex15	UTSW	8	34,067,025 (GRCm39)	missense	possibly damaging	0.91
R7643:Tex15	UTSW	8	34,065,148 (GRCm39)	missense	probably damaging	1.00
R7644:Tex15	UTSW	8	34,064,445 (GRCm39)	missense	probably benign	0.01
R7724:Tex15	UTSW	8	34,036,291 (GRCm39)	missense	possibly damaging	0.60
R7779:Tex15	UTSW	8	34,065,309 (GRCm39)	missense	probably damaging	1.00
R7798:Tex15	UTSW	8	34,071,875 (GRCm39)	missense	possibly damaging	0.69
R7816:Tex15	UTSW	8	34,071,683 (GRCm39)	missense	probably benign	0.14
R7820:Tex15	UTSW	8	34,065,090 (GRCm39)	missense	probably damaging	0.98
R8150:Tex15	UTSW	8	34,063,534 (GRCm39)	missense	probably benign	0.06
R8152:Tex15	UTSW	8	34,062,921 (GRCm39)	missense	possibly damaging	0.82
R8237:Tex15	UTSW	8	34,067,427 (GRCm39)	missense	possibly damaging	0.72
R8250:Tex15	UTSW	8	34,055,233 (GRCm39)	missense	probably null	0.27
R8264:Tex15	UTSW	8	34,072,390 (GRCm39)	missense	probably benign	0.18
R8279:Tex15	UTSW	8	34,061,765 (GRCm39)	missense	probably damaging	0.96
R8353:Tex15	UTSW	8	34,066,899 (GRCm39)	nonsense	probably null
R8388:Tex15	UTSW	8	34,065,237 (GRCm39)	missense	probably benign	0.00
R8432:Tex15	UTSW	8	34,066,572 (GRCm39)	missense	probably damaging	0.99
R8453:Tex15	UTSW	8	34,066,899 (GRCm39)	nonsense	probably null
R8489:Tex15	UTSW	8	34,067,574 (GRCm39)	missense	probably benign	0.02
R8670:Tex15	UTSW	8	34,064,746 (GRCm39)	missense	probably benign	0.19
R8703:Tex15	UTSW	8	34,062,724 (GRCm39)	missense	probably benign	0.00
R8871:Tex15	UTSW	8	34,066,992 (GRCm39)	missense	possibly damaging	0.62
R8945:Tex15	UTSW	8	34,064,724 (GRCm39)	missense	probably benign	0.00
R9104:Tex15	UTSW	8	34,060,950 (GRCm39)	missense	possibly damaging	0.86
R9132:Tex15	UTSW	8	34,067,554 (GRCm39)	missense	possibly damaging	0.84
R9207:Tex15	UTSW	8	34,065,784 (GRCm39)	missense	probably damaging	1.00
R9210:Tex15	UTSW	8	34,064,319 (GRCm39)	missense	possibly damaging	0.91
R9330:Tex15	UTSW	8	34,065,143 (GRCm39)	missense	probably benign	0.01
R9354:Tex15	UTSW	8	34,063,344 (GRCm39)	missense	possibly damaging	0.86
R9365:Tex15	UTSW	8	34,064,564 (GRCm39)	missense	possibly damaging	0.56
R9440:Tex15	UTSW	8	34,072,273 (GRCm39)	missense	possibly damaging	0.90
R9534:Tex15	UTSW	8	34,060,999 (GRCm39)	missense	probably benign	0.45
R9570:Tex15	UTSW	8	34,067,309 (GRCm39)	missense	probably damaging	0.96
R9574:Tex15	UTSW	8	34,064,509 (GRCm39)	missense	probably benign	0.09
R9618:Tex15	UTSW	8	34,062,397 (GRCm39)	missense	probably benign	0.35
R9655:Tex15	UTSW	8	34,066,784 (GRCm39)	nonsense	probably null
R9786:Tex15	UTSW	8	34,062,457 (GRCm39)	missense	probably damaging	1.00
R9798:Tex15	UTSW	8	34,062,721 (GRCm39)	missense	probably damaging	0.98
RF005:Tex15	UTSW	8	34,066,705 (GRCm39)	missense	probably benign	0.05
X0020:Tex15	UTSW	8	34,066,607 (GRCm39)	missense	probably benign	0.03
X0065:Tex15	UTSW	8	34,065,545 (GRCm39)	nonsense	probably null
Z1088:Tex15	UTSW	8	34,061,343 (GRCm39)	missense	possibly damaging	0.89
Z1088:Tex15	UTSW	8	34,064,898 (GRCm39)	missense	probably benign
Z1088:Tex15	UTSW	8	34,061,838 (GRCm39)	missense	possibly damaging	0.68
Z1176:Tex15	UTSW	8	34,064,754 (GRCm39)	missense	possibly damaging	0.84

Predicted Primers

PCR Primer
(F):5'- AAACCATGTGCTGTTGATACTTGG -3'
(R):5'- GTTAACTCCACAGGCAAATGGAAC -3'

Sequencing Primer
(F):5'- ATACTTGGGTAGAACTTCAGATGGC -3'
(R):5'- CAGAAAGACAAAAGTCAAAGCAATC -3'

Posted On

2020-01-23