Mutagenetix > Incidental Mutation

Incidental Mutation 'R8045:Vmn1r121'

618708

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r121

Ensembl Gene

ENSMUSG00000094680

Gene Name

vomeronasal 1 receptor 121

Synonyms

Gm8533

MMRRC Submission

067482-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R8045 (G1)

Quality Score

129.008

Status

Not validated

Chromosome

Chromosomal Location

20831494-20832438 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 20831829 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 204 (S204R)

Ref Sequence

ENSEMBL: ENSMUSP00000100832 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105197]

AlphaFold

K7N6J4

Predicted Effect

probably damaging
Transcript: ENSMUST00000105197
AA Change: S204R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000100832
Gene: ENSMUSG00000094680
AA Change: S204R

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	302	4.9e-18	PFAM
Pfam:7tm_1	31	278	1.6e-7	PFAM
Pfam:V1R	41	297	1.4e-17	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (37/37)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Amotl2	C	T	9: 102,600,968 (GRCm39)	T345I	probably benign	Het
Anks1b	A	G	10: 90,516,722 (GRCm39)	I906V	probably benign	Het
Arhgap29	C	A	3: 121,801,211 (GRCm39)		silent	Het
Casz1	A	G	4: 149,017,236 (GRCm39)	D175G	probably damaging	Het
Ccdc142	T	C	6: 83,080,407 (GRCm39)	L406P	probably damaging	Het
Ccdc148	A	G	2: 58,892,083 (GRCm39)		probably null	Het
Ccdc175	C	T	12: 72,202,676 (GRCm39)		probably benign	Het
Ccdc192	A	T	18: 57,863,991 (GRCm39)	D265V	probably damaging	Het
Cebpz	A	G	17: 79,239,585 (GRCm39)	I612T	probably damaging	Het
Cfhr4	T	A	1: 139,661,243 (GRCm39)	K535N	probably damaging	Het
Clcn1	T	C	6: 42,267,628 (GRCm39)	Y137H	probably damaging	Het
Clint1	T	A	11: 45,781,566 (GRCm39)	I212N	possibly damaging	Het
Clpsl2	G	A	17: 28,769,702 (GRCm39)	G55R	probably damaging	Het
Crnkl1	G	A	2: 145,774,851 (GRCm39)	T29M	probably damaging	Het
Dao	AGG	AG	5: 114,153,270 (GRCm39)		probably benign	Het
Disp1	T	C	1: 182,870,794 (GRCm39)	Y542C	probably damaging	Het
Gm15446	A	G	5: 110,088,394 (GRCm39)	T36A	probably damaging	Het
Herc2	T	C	7: 55,834,648 (GRCm39)	C3209R	probably damaging	Het
Igf2bp2	T	A	16: 21,902,728 (GRCm39)	D117V	possibly damaging	Het
Lta4h	A	G	10: 93,304,968 (GRCm39)	Y257C	probably damaging	Het
Mamstr	T	A	7: 45,293,827 (GRCm39)	L301Q	probably damaging	Het
Mllt3	A	G	4: 87,759,350 (GRCm39)	S233P	probably damaging	Het
Myh7b	A	T	2: 155,455,101 (GRCm39)	D42V	probably benign	Het
Ncam1	T	C	9: 49,418,736 (GRCm39)	T855A		Het
Ogfr	AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG	AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG	2: 180,236,850 (GRCm39)		probably benign	Het
Or56a41	A	T	7: 104,740,190 (GRCm39)	S219T	probably benign	Het
Or5h25	A	T	16: 58,930,402 (GRCm39)	N190K	probably benign	Het
Pde11a	G	A	2: 75,853,072 (GRCm39)	L849F	probably damaging	Het
Prpf38b	T	C	3: 108,811,350 (GRCm39)	K505R	unknown	Het
Rbbp4	A	G	4: 129,211,693 (GRCm39)	S355P	probably benign	Het
Rbm20	C	A	19: 53,806,402 (GRCm39)	A494D	probably benign	Het
Sema6c	C	T	3: 95,080,535 (GRCm39)	S943L	probably benign	Het
Slc27a3	A	G	3: 90,294,449 (GRCm39)	F441L	probably damaging	Het
Taar2	T	C	10: 23,817,386 (GRCm39)	W309R	probably damaging	Het
Topors	A	G	4: 40,261,988 (GRCm39)	V432A	probably benign	Het
Wdr20	T	A	12: 110,759,753 (GRCm39)	L213H	probably damaging	Het
Zfp512b	A	G	2: 181,226,617 (GRCm39)	*880R	probably null	Het
Zfp652	T	C	11: 95,640,483 (GRCm39)	V136A	possibly damaging	Het

Other mutations in Vmn1r121

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01636:Vmn1r121	APN	7	20,832,282 (GRCm39)	missense	probably benign	0.43
IGL02270:Vmn1r121	APN	7	20,832,401 (GRCm39)	missense	probably damaging	1.00
IGL02456:Vmn1r121	APN	7	20,832,438 (GRCm39)	start codon destroyed	possibly damaging	0.92
R0304:Vmn1r121	UTSW	7	20,832,332 (GRCm39)	missense	possibly damaging	0.91
R0336:Vmn1r121	UTSW	7	20,832,387 (GRCm39)	missense	possibly damaging	0.69
R3055:Vmn1r121	UTSW	7	20,832,390 (GRCm39)	nonsense	probably null
R4944:Vmn1r121	UTSW	7	20,831,538 (GRCm39)	missense	probably benign	0.00
R7443:Vmn1r121	UTSW	7	20,831,945 (GRCm39)	missense	probably damaging	1.00
R7492:Vmn1r121	UTSW	7	20,832,095 (GRCm39)	missense	probably damaging	1.00
R7575:Vmn1r121	UTSW	7	20,832,198 (GRCm39)	nonsense	probably null
R7723:Vmn1r121	UTSW	7	20,832,119 (GRCm39)	missense	probably damaging	1.00
R7914:Vmn1r121	UTSW	7	20,831,589 (GRCm39)	missense	probably benign	0.03
R8195:Vmn1r121	UTSW	7	20,832,228 (GRCm39)	missense	probably damaging	1.00
R8255:Vmn1r121	UTSW	7	20,831,679 (GRCm39)	missense	probably benign	0.19
R8256:Vmn1r121	UTSW	7	20,831,679 (GRCm39)	missense	probably benign	0.19
R9298:Vmn1r121	UTSW	7	20,832,344 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCTCACCAAGAAGCCGTATG -3'
(R):5'- CAGAGCAAGTGTCCCAAATTTG -3'

Sequencing Primer
(F):5'- TTGCTCTGGACTCAGCTT -3'
(R):5'- GTTGGTTTTTCAGTGTCTTAAGTAAC -3'

Posted On

2020-01-23