Mutagenetix > Incidental Mutation

Incidental Mutation 'R8045:Or56a41'

618711

Institutional Source

Beutler Lab

Gene Symbol

Or56a41

Ensembl Gene

ENSMUSG00000041885

Gene Name

olfactory receptor family 56 subfamily A member 41, pseudogene 1

Synonyms

MOR40-10P, GA_x6K02T2PBJ9-7720330-7719479, Olfr680

MMRRC Submission

067482-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

R8045 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

104739909-104740601 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 104740190 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 219 (S219T)

Ref Sequence

ENSEMBL: ENSMUSP00000154703 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042676] [ENSMUST00000098158] [ENSMUST00000214328] [ENSMUST00000215704]

AlphaFold

A0A2I3BS13

Predicted Effect

probably benign
Transcript: ENSMUST00000042676
AA Change: S219T

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)

Predicted Effect

probably benign
Transcript: ENSMUST00000098158

SMART Domains

Protein: ENSMUSP00000095761
Gene: ENSMUSG00000096029

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	314	1.2e-73	PFAM
Pfam:7TM_GPCR_Srsx	39	311	6.2e-10	PFAM
Pfam:7tm_1	45	296	1.8e-14	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214328

Predicted Effect

probably benign
Transcript: ENSMUST00000215704

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (37/37)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Amotl2	C	T	9: 102,600,968 (GRCm39)	T345I	probably benign	Het
Anks1b	A	G	10: 90,516,722 (GRCm39)	I906V	probably benign	Het
Arhgap29	C	A	3: 121,801,211 (GRCm39)		silent	Het
Casz1	A	G	4: 149,017,236 (GRCm39)	D175G	probably damaging	Het
Ccdc142	T	C	6: 83,080,407 (GRCm39)	L406P	probably damaging	Het
Ccdc148	A	G	2: 58,892,083 (GRCm39)		probably null	Het
Ccdc175	C	T	12: 72,202,676 (GRCm39)		probably benign	Het
Ccdc192	A	T	18: 57,863,991 (GRCm39)	D265V	probably damaging	Het
Cebpz	A	G	17: 79,239,585 (GRCm39)	I612T	probably damaging	Het
Cfhr4	T	A	1: 139,661,243 (GRCm39)	K535N	probably damaging	Het
Clcn1	T	C	6: 42,267,628 (GRCm39)	Y137H	probably damaging	Het
Clint1	T	A	11: 45,781,566 (GRCm39)	I212N	possibly damaging	Het
Clpsl2	G	A	17: 28,769,702 (GRCm39)	G55R	probably damaging	Het
Crnkl1	G	A	2: 145,774,851 (GRCm39)	T29M	probably damaging	Het
Dao	AGG	AG	5: 114,153,270 (GRCm39)		probably benign	Het
Disp1	T	C	1: 182,870,794 (GRCm39)	Y542C	probably damaging	Het
Gm15446	A	G	5: 110,088,394 (GRCm39)	T36A	probably damaging	Het
Herc2	T	C	7: 55,834,648 (GRCm39)	C3209R	probably damaging	Het
Igf2bp2	T	A	16: 21,902,728 (GRCm39)	D117V	possibly damaging	Het
Lta4h	A	G	10: 93,304,968 (GRCm39)	Y257C	probably damaging	Het
Mamstr	T	A	7: 45,293,827 (GRCm39)	L301Q	probably damaging	Het
Mllt3	A	G	4: 87,759,350 (GRCm39)	S233P	probably damaging	Het
Myh7b	A	T	2: 155,455,101 (GRCm39)	D42V	probably benign	Het
Ncam1	T	C	9: 49,418,736 (GRCm39)	T855A		Het
Ogfr	AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG	AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG	2: 180,236,850 (GRCm39)		probably benign	Het
Or5h25	A	T	16: 58,930,402 (GRCm39)	N190K	probably benign	Het
Pde11a	G	A	2: 75,853,072 (GRCm39)	L849F	probably damaging	Het
Prpf38b	T	C	3: 108,811,350 (GRCm39)	K505R	unknown	Het
Rbbp4	A	G	4: 129,211,693 (GRCm39)	S355P	probably benign	Het
Rbm20	C	A	19: 53,806,402 (GRCm39)	A494D	probably benign	Het
Sema6c	C	T	3: 95,080,535 (GRCm39)	S943L	probably benign	Het
Slc27a3	A	G	3: 90,294,449 (GRCm39)	F441L	probably damaging	Het
Taar2	T	C	10: 23,817,386 (GRCm39)	W309R	probably damaging	Het
Topors	A	G	4: 40,261,988 (GRCm39)	V432A	probably benign	Het
Vmn1r121	T	G	7: 20,831,829 (GRCm39)	S204R	probably damaging	Het
Wdr20	T	A	12: 110,759,753 (GRCm39)	L213H	probably damaging	Het
Zfp512b	A	G	2: 181,226,617 (GRCm39)	*880R	probably null	Het
Zfp652	T	C	11: 95,640,483 (GRCm39)	V136A	possibly damaging	Het

Other mutations in Or56a41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R6961:Or56a41	UTSW	7	104,741,978 (GRCm39)	missense	probably benign	0.31
R6969:Or56a41	UTSW	7	104,740,463 (GRCm39)	missense	probably benign	0.00
R7139:Or56a41	UTSW	7	104,742,005 (GRCm39)	missense	probably benign	0.20
R7169:Or56a41	UTSW	7	104,740,397 (GRCm39)	missense	possibly damaging	0.71
R7316:Or56a41	UTSW	7	104,740,107 (GRCm39)	missense	probably damaging	0.97
R7537:Or56a41	UTSW	7	104,741,978 (GRCm39)	missense	probably benign	0.31
R7970:Or56a41	UTSW	7	104,740,556 (GRCm39)	missense	probably benign	0.00
R8444:Or56a41	UTSW	7	104,740,165 (GRCm39)	missense	probably damaging	0.96
R8712:Or56a41	UTSW	7	104,741,808 (GRCm39)	missense	possibly damaging	0.79
R8922:Or56a41	UTSW	7	104,740,469 (GRCm39)	missense	probably benign	0.03
R9038:Or56a41	UTSW	7	104,740,433 (GRCm39)	missense	probably benign	0.00
R9437:Or56a41	UTSW	7	104,739,963 (GRCm39)	nonsense	probably null
R9643:Or56a41	UTSW	7	104,740,445 (GRCm39)	missense	probably benign
Z1177:Or56a41	UTSW	7	104,740,145 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CATACACAATGGGATTGAGGGC -3'
(R):5'- TCCAGTTCTGGCTGCTAGACTC -3'

Sequencing Primer
(F):5'- TTAAGAAGAATTGGTACCTCTGACGG -3'
(R):5'- CTCAATTACTGTGCCAGCAATGTGG -3'

Posted On

2020-01-23