Incidental Mutation 'R8045:Taar2'
| ID |
618714 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Taar2
|
| Ensembl Gene |
ENSMUSG00000059763 |
| Gene Name |
trace amine-associated receptor 2 |
| Synonyms |
Gpr58 |
| MMRRC Submission |
067482-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8045 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
23814470-23817481 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23817386 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Arginine
at position 309
(W309R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078137
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079134]
|
| AlphaFold |
Q5QD17 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000079134
AA Change: W309R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000078137
Gene: ENSMUSG00000059763
AA Change: W309R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srsx
|
42 |
318 |
2.4e-10 |
PFAM |
|
Pfam:7tm_1
|
48 |
303 |
2.9e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (37/37) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Amotl2 |
C |
T |
9: 102,600,968 (GRCm39) |
T345I |
probably benign |
Het |
| Anks1b |
A |
G |
10: 90,516,722 (GRCm39) |
I906V |
probably benign |
Het |
| Arhgap29 |
C |
A |
3: 121,801,211 (GRCm39) |
|
silent |
Het |
| Casz1 |
A |
G |
4: 149,017,236 (GRCm39) |
D175G |
probably damaging |
Het |
| Ccdc142 |
T |
C |
6: 83,080,407 (GRCm39) |
L406P |
probably damaging |
Het |
| Ccdc148 |
A |
G |
2: 58,892,083 (GRCm39) |
|
probably null |
Het |
| Ccdc175 |
C |
T |
12: 72,202,676 (GRCm39) |
|
probably benign |
Het |
| Ccdc192 |
A |
T |
18: 57,863,991 (GRCm39) |
D265V |
probably damaging |
Het |
| Cebpz |
A |
G |
17: 79,239,585 (GRCm39) |
I612T |
probably damaging |
Het |
| Cfhr4 |
T |
A |
1: 139,661,243 (GRCm39) |
K535N |
probably damaging |
Het |
| Clcn1 |
T |
C |
6: 42,267,628 (GRCm39) |
Y137H |
probably damaging |
Het |
| Clint1 |
T |
A |
11: 45,781,566 (GRCm39) |
I212N |
possibly damaging |
Het |
| Clpsl2 |
G |
A |
17: 28,769,702 (GRCm39) |
G55R |
probably damaging |
Het |
| Crnkl1 |
G |
A |
2: 145,774,851 (GRCm39) |
T29M |
probably damaging |
Het |
| Dao |
AGG |
AG |
5: 114,153,270 (GRCm39) |
|
probably benign |
Het |
| Disp1 |
T |
C |
1: 182,870,794 (GRCm39) |
Y542C |
probably damaging |
Het |
| Gm15446 |
A |
G |
5: 110,088,394 (GRCm39) |
T36A |
probably damaging |
Het |
| Herc2 |
T |
C |
7: 55,834,648 (GRCm39) |
C3209R |
probably damaging |
Het |
| Igf2bp2 |
T |
A |
16: 21,902,728 (GRCm39) |
D117V |
possibly damaging |
Het |
| Lta4h |
A |
G |
10: 93,304,968 (GRCm39) |
Y257C |
probably damaging |
Het |
| Mamstr |
T |
A |
7: 45,293,827 (GRCm39) |
L301Q |
probably damaging |
Het |
| Mllt3 |
A |
G |
4: 87,759,350 (GRCm39) |
S233P |
probably damaging |
Het |
| Myh7b |
A |
T |
2: 155,455,101 (GRCm39) |
D42V |
probably benign |
Het |
| Ncam1 |
T |
C |
9: 49,418,736 (GRCm39) |
T855A |
|
Het |
| Ogfr |
AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG |
AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG |
2: 180,236,850 (GRCm39) |
|
probably benign |
Het |
| Or56a41 |
A |
T |
7: 104,740,190 (GRCm39) |
S219T |
probably benign |
Het |
| Or5h25 |
A |
T |
16: 58,930,402 (GRCm39) |
N190K |
probably benign |
Het |
| Pde11a |
G |
A |
2: 75,853,072 (GRCm39) |
L849F |
probably damaging |
Het |
| Prpf38b |
T |
C |
3: 108,811,350 (GRCm39) |
K505R |
unknown |
Het |
| Rbbp4 |
A |
G |
4: 129,211,693 (GRCm39) |
S355P |
probably benign |
Het |
| Rbm20 |
C |
A |
19: 53,806,402 (GRCm39) |
A494D |
probably benign |
Het |
| Sema6c |
C |
T |
3: 95,080,535 (GRCm39) |
S943L |
probably benign |
Het |
| Slc27a3 |
A |
G |
3: 90,294,449 (GRCm39) |
F441L |
probably damaging |
Het |
| Topors |
A |
G |
4: 40,261,988 (GRCm39) |
V432A |
probably benign |
Het |
| Vmn1r121 |
T |
G |
7: 20,831,829 (GRCm39) |
S204R |
probably damaging |
Het |
| Wdr20 |
T |
A |
12: 110,759,753 (GRCm39) |
L213H |
probably damaging |
Het |
| Zfp512b |
A |
G |
2: 181,226,617 (GRCm39) |
*880R |
probably null |
Het |
| Zfp652 |
T |
C |
11: 95,640,483 (GRCm39) |
V136A |
possibly damaging |
Het |
|
| Other mutations in Taar2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00229:Taar2
|
APN |
10 |
23,817,266 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL00807:Taar2
|
APN |
10 |
23,816,573 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01346:Taar2
|
APN |
10 |
23,816,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01433:Taar2
|
APN |
10 |
23,816,657 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01782:Taar2
|
APN |
10 |
23,817,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03106:Taar2
|
APN |
10 |
23,817,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03372:Taar2
|
APN |
10 |
23,817,069 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0046:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0046:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0090:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0101:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0101:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0103:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0157:Taar2
|
UTSW |
10 |
23,817,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0189:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0190:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0226:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0226:Taar2
|
UTSW |
10 |
23,816,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0265:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0267:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0349:Taar2
|
UTSW |
10 |
23,817,407 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0349:Taar2
|
UTSW |
10 |
23,817,327 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0426:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0556:Taar2
|
UTSW |
10 |
23,816,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0698:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1191:Taar2
|
UTSW |
10 |
23,816,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2919:Taar2
|
UTSW |
10 |
23,817,454 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4615:Taar2
|
UTSW |
10 |
23,817,263 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4658:Taar2
|
UTSW |
10 |
23,817,401 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4766:Taar2
|
UTSW |
10 |
23,816,669 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4872:Taar2
|
UTSW |
10 |
23,816,591 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5205:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5271:Taar2
|
UTSW |
10 |
23,816,930 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5517:Taar2
|
UTSW |
10 |
23,816,627 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6033:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
|
|
R6033:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
|
|
R6325:Taar2
|
UTSW |
10 |
23,816,615 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6398:Taar2
|
UTSW |
10 |
23,817,177 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6762:Taar2
|
UTSW |
10 |
23,817,300 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7121:Taar2
|
UTSW |
10 |
23,816,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7209:Taar2
|
UTSW |
10 |
23,816,597 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R7709:Taar2
|
UTSW |
10 |
23,816,621 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8223:Taar2
|
UTSW |
10 |
23,817,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8743:Taar2
|
UTSW |
10 |
23,817,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9307:Taar2
|
UTSW |
10 |
23,817,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9350:Taar2
|
UTSW |
10 |
23,817,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9351:Taar2
|
UTSW |
10 |
23,816,900 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9755:Taar2
|
UTSW |
10 |
23,817,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Taar2
|
UTSW |
10 |
23,817,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGCGTAATTGACAACTTGCC -3'
(R):5'- GGCATGTCAACCCTTATTTGCC -3'
Sequencing Primer
(F):5'- CAGCCAAAACTTTAGGGATAGTG -3'
(R):5'- ATGTCAACCCTTATTTGCCGATCC -3'
|
| Posted On |
2020-01-23 |
Incidental Mutation