Incidental Mutation 'R8046:Or8b8'
ID 618758
Institutional Source Beutler Lab
Gene Symbol Or8b8
Ensembl Gene ENSMUSG00000066748
Gene Name olfactory receptor family 8 subfamily B member 8
Synonyms GA_x6K02T2PVTD-31578734-31579666, Olfr145, K21, MOR161-6
MMRRC Submission 067483-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # R8046 (G1)
Quality Score 222.009
Status Validated
Chromosome 9
Chromosomal Location 37808020-37814815 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 37808685 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150284 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086062] [ENSMUST00000213688]
AlphaFold Q60882
Predicted Effect probably benign
Transcript: ENSMUST00000086062
SMART Domains Protein: ENSMUSP00000083229
Gene: ENSMUSG00000066748

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 4e-51 PFAM
Pfam:7tm_1 40 289 1.4e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213688
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh G T 5: 77,044,325 (GRCm39) D188E probably benign Het
Ahcyl2 T C 6: 29,878,619 (GRCm39) L273P probably damaging Het
Amotl2 C T 9: 102,600,968 (GRCm39) T345I probably benign Het
Angpt1 T C 15: 42,359,752 (GRCm39) T227A probably benign Het
Ankle1 C T 8: 71,860,665 (GRCm39) T374M probably damaging Het
Arhgap18 T C 10: 26,763,853 (GRCm39) V481A probably damaging Het
Astn2 A T 4: 66,184,587 (GRCm39) L170* probably null Het
Bms1 T C 6: 118,385,105 (GRCm39) T368A probably benign Het
Boll A G 1: 55,385,562 (GRCm39) I121T probably damaging Het
Brca1 A C 11: 101,416,296 (GRCm39) C613G probably benign Het
Cdk14 T A 5: 5,299,159 (GRCm39) I65F possibly damaging Het
Chn1 T C 2: 73,448,363 (GRCm39) D335G probably damaging Het
Clpsl2 G A 17: 28,769,702 (GRCm39) G55R probably damaging Het
Col12a1 A G 9: 79,613,508 (GRCm39) probably null Het
Cplane2 A C 4: 140,947,348 (GRCm39) Q243P probably damaging Het
Crtac1 T C 19: 42,297,492 (GRCm39) probably benign Het
Dhx40 A T 11: 86,675,766 (GRCm39) C507* probably null Het
Dok2 A G 14: 71,015,482 (GRCm39) D403G probably damaging Het
Eif1ad14 T C 12: 87,886,335 (GRCm39) D98G probably benign Het
Eif2b5 A G 16: 20,325,154 (GRCm39) T556A possibly damaging Het
Eml6 A T 11: 29,708,981 (GRCm39) V1480E probably damaging Het
Evl C T 12: 108,647,783 (GRCm39) R295* probably null Het
Glra1 A G 11: 55,427,225 (GRCm39) S120P probably damaging Het
Habp4 T C 13: 64,322,656 (GRCm39) S242P probably benign Het
Igkv12-46 A G 6: 69,741,570 (GRCm39) I95T probably damaging Het
Itch G T 2: 155,052,422 (GRCm39) G674V probably damaging Het
Itpr2 A G 6: 146,327,957 (GRCm39) L92P probably damaging Het
Kcnk2 A G 1: 188,990,933 (GRCm39) probably null Het
Krt75 T C 15: 101,481,199 (GRCm39) T192A probably benign Het
Lrp1b T A 2: 41,159,199 (GRCm39) K1694N Het
Lrrc14 A G 15: 76,598,731 (GRCm39) K456E possibly damaging Het
Map1lc3a G T 2: 155,119,129 (GRCm39) probably benign Het
Naip5 T A 13: 100,358,741 (GRCm39) M832L probably benign Het
Nectin1 A G 9: 43,703,798 (GRCm39) T263A probably benign Het
Nnt A T 13: 119,511,286 (GRCm39) M330K probably damaging Het
Nrap T C 19: 56,308,683 (GRCm39) N1711D possibly damaging Het
Olfm1 A G 2: 28,119,135 (GRCm39) N285D possibly damaging Het
Or4b1d T A 2: 89,969,159 (GRCm39) E108V probably damaging Het
Or51ab3 T A 7: 103,201,584 (GRCm39) S197R possibly damaging Het
Pag1 A G 3: 9,764,482 (GRCm39) Y224H probably damaging Het
Pde8a T C 7: 80,958,587 (GRCm39) C322R possibly damaging Het
Pde8a A T 7: 80,967,118 (GRCm39) T420S probably benign Het
Per2 A C 1: 91,363,425 (GRCm39) L365R possibly damaging Het
Pml A G 9: 58,154,256 (GRCm39) probably null Het
Ppp1r1a T A 15: 103,446,305 (GRCm39) M1L possibly damaging Het
Ppp3r2 G T 4: 49,681,913 (GRCm39) C12* probably null Het
Rbm20 C A 19: 53,806,402 (GRCm39) A494D probably benign Het
Scyl1 C T 19: 5,810,620 (GRCm39) R531Q possibly damaging Het
Skp2 C A 15: 9,139,687 (GRCm39) V38F probably damaging Het
Slc27a3 A G 3: 90,296,974 (GRCm39) C42R probably damaging Het
Tekt5 A G 16: 10,213,277 (GRCm39) F3L probably benign Het
Tmem200c A G 17: 69,147,513 (GRCm39) K32R probably benign Het
Tmprss11f T A 5: 86,676,132 (GRCm39) R350W probably damaging Het
Tph2 A T 10: 115,015,499 (GRCm39) I121N possibly damaging Het
Trim37 A G 11: 87,037,794 (GRCm39) D176G possibly damaging Het
Trpc4 A T 3: 54,102,335 (GRCm39) I78F probably damaging Het
Ttn T C 2: 76,609,829 (GRCm39) K17526E probably damaging Het
Tuba8 A C 6: 121,199,832 (GRCm39) Y172S probably damaging Het
Tubg1 G T 11: 101,014,854 (GRCm39) A199S probably benign Het
Urb2 A T 8: 124,754,771 (GRCm39) R159S possibly damaging Het
Usp25 T A 16: 76,906,063 (GRCm39) C840S probably damaging Het
Vmn1r36 T A 6: 66,692,964 (GRCm39) K304* probably null Het
Vmn1r37 C A 6: 66,708,656 (GRCm39) T94N probably damaging Het
Vmn2r7 T C 3: 64,614,479 (GRCm39) N445S probably damaging Het
Wnk4 G A 11: 101,164,918 (GRCm39) G749D probably benign Het
Wscd2 G A 5: 113,689,176 (GRCm39) V61I probably benign Het
Zfp85 T A 13: 67,897,098 (GRCm39) R325* probably null Het
Other mutations in Or8b8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01362:Or8b8 APN 9 37,809,359 (GRCm39) missense probably benign 0.13
IGL01586:Or8b8 APN 9 37,809,272 (GRCm39) missense possibly damaging 0.73
IGL02185:Or8b8 APN 9 37,809,531 (GRCm39) missense probably damaging 1.00
IGL02895:Or8b8 APN 9 37,809,278 (GRCm39) missense probably benign 0.01
IGL02956:Or8b8 APN 9 37,809,404 (GRCm39) missense probably damaging 1.00
R0391:Or8b8 UTSW 9 37,809,138 (GRCm39) missense probably benign 0.31
R0513:Or8b8 UTSW 9 37,809,351 (GRCm39) missense probably damaging 1.00
R4600:Or8b8 UTSW 9 37,809,622 (GRCm39) missense probably benign
R4610:Or8b8 UTSW 9 37,809,622 (GRCm39) missense probably benign
R4611:Or8b8 UTSW 9 37,809,622 (GRCm39) missense probably benign
R4982:Or8b8 UTSW 9 37,808,811 (GRCm39) missense probably damaging 1.00
R5574:Or8b8 UTSW 9 37,808,877 (GRCm39) missense probably damaging 1.00
R5608:Or8b8 UTSW 9 37,809,078 (GRCm39) missense probably damaging 0.98
R5688:Or8b8 UTSW 9 37,809,359 (GRCm39) missense possibly damaging 0.91
R5906:Or8b8 UTSW 9 37,809,174 (GRCm39) missense probably damaging 1.00
R6286:Or8b8 UTSW 9 37,809,074 (GRCm39) missense probably damaging 0.99
R7138:Or8b8 UTSW 9 37,809,360 (GRCm39) missense probably damaging 0.99
R7145:Or8b8 UTSW 9 37,808,859 (GRCm39) missense probably benign 0.01
R7993:Or8b8 UTSW 9 37,808,633 (GRCm39) intron probably benign
R8185:Or8b8 UTSW 9 37,809,531 (GRCm39) missense probably damaging 1.00
R9276:Or8b8 UTSW 9 37,809,415 (GRCm39) missense probably benign 0.04
R9352:Or8b8 UTSW 9 37,808,712 (GRCm39) missense probably benign 0.00
X0012:Or8b8 UTSW 9 37,809,624 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACTTGAGAGTCCCCTCACTG -3'
(R):5'- AGTTCAGTCCAATCAGGGTG -3'

Sequencing Primer
(F):5'- TAACCTAAAGGACCCTTGTGTC -3'
(R):5'- TTCAGTCCAATCAGGGTGATCAAG -3'
Posted On 2020-01-23