Incidental Mutation 'R8048:Or5m3'
ID 618850
Institutional Source Beutler Lab
Gene Symbol Or5m3
Ensembl Gene ENSMUSG00000042796
Gene Name olfactory receptor family 5 subfamily M member 3
Synonyms Olfr1032, MOR199-1, GA_x6K02T2Q125-47485813-47486745
MMRRC Submission 067485-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R8048 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 85838122-85839054 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 85838524 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 135 (S135A)
Ref Sequence ENSEMBL: ENSMUSP00000107216 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062166] [ENSMUST00000079298] [ENSMUST00000111589]
AlphaFold A2ATE5
Predicted Effect probably damaging
Transcript: ENSMUST00000062166
AA Change: S135A

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000054494
Gene: ENSMUSG00000042796
AA Change: S135A

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 5.6e-50 PFAM
Pfam:7tm_1 39 288 1.1e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000079298
AA Change: S135A

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000078279
Gene: ENSMUSG00000042796
AA Change: S135A

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.3e-50 PFAM
Pfam:7tm_1 39 288 9.9e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111589
AA Change: S135A

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000107216
Gene: ENSMUSG00000042796
AA Change: S135A

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.4e-50 PFAM
Pfam:7tm_1 39 288 3.5e-21 PFAM
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 A T 16: 14,228,708 (GRCm39) L318F probably damaging Het
Alms1 T A 6: 85,618,316 (GRCm39) S2318R probably benign Het
Arhgap12 G A 18: 6,052,883 (GRCm39) T443I probably benign Het
Arhgap29 C T 3: 121,786,550 (GRCm39) R372W probably damaging Het
Astn1 T C 1: 158,516,208 (GRCm39) I1266T probably benign Het
Bsg T C 10: 79,545,580 (GRCm39) V164A probably benign Het
C1qa G T 4: 136,623,921 (GRCm39) S94R probably benign Het
Cadps2 A G 6: 23,838,862 (GRCm39) V92A probably benign Het
Ccdc187 T A 2: 26,183,526 (GRCm39) D158V possibly damaging Het
Cngb1 T A 8: 95,989,838 (GRCm39) Y758F possibly damaging Het
Ddx4 G A 13: 112,758,706 (GRCm39) A285V probably null Het
Dsg1c A T 18: 20,407,824 (GRCm39) K390M probably damaging Het
Dst T C 1: 34,229,717 (GRCm39) F2437L probably benign Het
Eln CTCCAGCTCCGAT C 5: 134,758,003 (GRCm39) probably benign Het
Fam227a CATTGTCTTGA CA 15: 79,533,959 (GRCm39) probably null Het
Fez2 T C 17: 78,694,482 (GRCm39) I303V probably benign Het
Ffar1 A T 7: 30,560,003 (GRCm39) I298N probably benign Het
Hpx C T 7: 105,244,685 (GRCm39) V228I probably benign Het
Igkv1-117 T G 6: 68,098,786 (GRCm39) C112G probably damaging Het
Il3ra A G 14: 14,348,903 (GRCm38) D99G probably benign Het
Ivl T A 3: 92,479,231 (GRCm39) K278M probably damaging Het
Lyst A G 13: 13,862,230 (GRCm39) T2589A probably benign Het
Madd A T 2: 90,984,793 (GRCm39) M1359K probably damaging Het
Nav3 T C 10: 109,600,779 (GRCm39) T1283A probably benign Het
Ncapd2 G T 6: 125,156,661 (GRCm39) C439* probably null Het
Nebl T C 2: 17,429,333 (GRCm39) D266G probably benign Het
Oas1f G T 5: 120,985,602 (GRCm39) G49V probably damaging Het
Oas1f A T 5: 120,986,479 (GRCm39) Q144L possibly damaging Het
Or11g7 T C 14: 50,691,373 (GRCm39) L288P possibly damaging Het
Or2ab1 A G 11: 58,488,233 (GRCm39) I6V unknown Het
Or2n1 T C 17: 38,486,419 (GRCm39) V148A probably benign Het
Or5an6 A G 19: 12,371,719 (GRCm39) I31V not run Het
Or5j3 C T 2: 86,128,672 (GRCm39) P171S probably benign Het
Or5t18 T A 2: 86,636,515 (GRCm39) Y276F probably damaging Het
Or6b6 C T 7: 106,571,671 (GRCm39) probably benign Het
Or8b52 C T 9: 38,577,108 (GRCm39) E11K probably benign Het
Or8j3c T A 2: 86,253,651 (GRCm39) Y123F probably damaging Het
Pard3b T A 1: 62,193,148 (GRCm39) V217E probably damaging Het
Pcdha2 T A 18: 37,072,513 (GRCm39) I48N probably damaging Het
Pi4ka A G 16: 17,120,991 (GRCm39) F1248L Het
Plekha2 A T 8: 25,554,005 (GRCm39) probably benign Het
Plpp4 C T 7: 128,981,201 (GRCm39) R151C unknown Het
Pramel14 T A 4: 143,718,177 (GRCm39) Y422F probably benign Het
Prdm16 A G 4: 154,405,339 (GRCm39) L1245P probably damaging Het
Prob1 G A 18: 35,786,604 (GRCm39) A550V probably benign Het
Prok1 T C 3: 107,144,408 (GRCm39) H65R probably benign Het
Ptcd1 A G 5: 145,091,887 (GRCm39) V404A probably benign Het
Sbf2 T C 7: 109,914,289 (GRCm39) E1631G probably benign Het
Sdad1 C A 5: 92,447,948 (GRCm39) K262N probably benign Het
Sh3bp1 G T 15: 78,794,272 (GRCm39) A547S probably benign Het
Sptb T C 12: 76,675,333 (GRCm39) D227G probably benign Het
Tbx1 A G 16: 18,406,769 (GRCm39) M1T probably null Het
Tespa1 T A 10: 130,183,208 (GRCm39) V51D probably damaging Het
Tmc7 T C 7: 118,165,468 (GRCm39) N82S probably benign Het
Tmem8b A G 4: 43,689,476 (GRCm39) D290G possibly damaging Het
Trbv13-2 A T 6: 41,098,493 (GRCm39) T23S probably damaging Het
Trib3 A T 2: 152,180,553 (GRCm39) D213E probably damaging Het
Tubgcp4 T C 2: 121,013,981 (GRCm39) V178A probably benign Het
Virma T A 4: 11,539,918 (GRCm39) C1412* probably null Het
Vmn2r108 T C 17: 20,691,762 (GRCm39) T254A probably benign Het
Vps13d A G 4: 144,882,137 (GRCm39) V1152A Het
Wdr47 T C 3: 108,526,284 (GRCm39) V269A probably damaging Het
Zc3h13 T A 14: 75,561,977 (GRCm39) D676E unknown Het
Zc3h6 T A 2: 128,858,934 (GRCm39) S988R probably benign Het
Other mutations in Or5m3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01069:Or5m3 APN 2 85,838,891 (GRCm39) missense probably damaging 1.00
IGL03110:Or5m3 APN 2 85,838,942 (GRCm39) missense probably damaging 0.99
IGL03167:Or5m3 APN 2 85,838,511 (GRCm39) nonsense probably null
R0206:Or5m3 UTSW 2 85,838,636 (GRCm39) missense probably damaging 1.00
R0206:Or5m3 UTSW 2 85,838,636 (GRCm39) missense probably damaging 1.00
R0919:Or5m3 UTSW 2 85,838,984 (GRCm39) missense possibly damaging 0.52
R2018:Or5m3 UTSW 2 85,838,567 (GRCm39) missense probably damaging 1.00
R2019:Or5m3 UTSW 2 85,838,567 (GRCm39) missense probably damaging 1.00
R2938:Or5m3 UTSW 2 85,838,357 (GRCm39) missense probably damaging 0.97
R3843:Or5m3 UTSW 2 85,838,548 (GRCm39) missense probably benign 0.09
R4295:Or5m3 UTSW 2 85,838,614 (GRCm39) missense probably benign 0.01
R5813:Or5m3 UTSW 2 85,838,636 (GRCm39) missense probably damaging 1.00
R6283:Or5m3 UTSW 2 85,838,443 (GRCm39) missense possibly damaging 0.73
R7031:Or5m3 UTSW 2 85,838,939 (GRCm39) missense probably benign 0.26
R7427:Or5m3 UTSW 2 85,838,563 (GRCm39) missense probably benign 0.00
R7428:Or5m3 UTSW 2 85,838,563 (GRCm39) missense probably benign 0.00
R7856:Or5m3 UTSW 2 85,838,640 (GRCm39) missense probably damaging 0.99
R8504:Or5m3 UTSW 2 85,838,149 (GRCm39) missense probably damaging 0.99
R9129:Or5m3 UTSW 2 85,838,356 (GRCm39) missense
R9150:Or5m3 UTSW 2 85,838,626 (GRCm39) nonsense probably null
R9180:Or5m3 UTSW 2 85,838,325 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCAGTCCACAGCTCAGCAG -3'
(R):5'- TCTTTCACAAAGGTCCCTGC -3'

Sequencing Primer
(F):5'- TCCAATGTCACTCCTAAAATGCTAG -3'
(R):5'- CTGCACAGGCCATCTTGATAAGG -3'
Posted On 2020-01-23