Incidental Mutation 'R8048:Vmn2r108'
| ID |
618902 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r108
|
| Ensembl Gene |
ENSMUSG00000091805 |
| Gene Name |
vomeronasal 2, receptor 108 |
| Synonyms |
EG627805 |
| MMRRC Submission |
067485-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R8048 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20682635-20701498 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 20691762 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 254
(T254A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130373
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167314]
|
| AlphaFold |
E9PYS0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167314
AA Change: T254A
PolyPhen 2
Score 0.288 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: T254A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
6e-33 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
9.2e-22 |
PFAM |
|
Pfam:7tm_3
|
593 |
831 |
2.2e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
100% (65/65) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc1 |
A |
T |
16: 14,228,708 (GRCm39) |
L318F |
probably damaging |
Het |
| Alms1 |
T |
A |
6: 85,618,316 (GRCm39) |
S2318R |
probably benign |
Het |
| Arhgap12 |
G |
A |
18: 6,052,883 (GRCm39) |
T443I |
probably benign |
Het |
| Arhgap29 |
C |
T |
3: 121,786,550 (GRCm39) |
R372W |
probably damaging |
Het |
| Astn1 |
T |
C |
1: 158,516,208 (GRCm39) |
I1266T |
probably benign |
Het |
| Bsg |
T |
C |
10: 79,545,580 (GRCm39) |
V164A |
probably benign |
Het |
| C1qa |
G |
T |
4: 136,623,921 (GRCm39) |
S94R |
probably benign |
Het |
| Cadps2 |
A |
G |
6: 23,838,862 (GRCm39) |
V92A |
probably benign |
Het |
| Ccdc187 |
T |
A |
2: 26,183,526 (GRCm39) |
D158V |
possibly damaging |
Het |
| Cngb1 |
T |
A |
8: 95,989,838 (GRCm39) |
Y758F |
possibly damaging |
Het |
| Ddx4 |
G |
A |
13: 112,758,706 (GRCm39) |
A285V |
probably null |
Het |
| Dsg1c |
A |
T |
18: 20,407,824 (GRCm39) |
K390M |
probably damaging |
Het |
| Dst |
T |
C |
1: 34,229,717 (GRCm39) |
F2437L |
probably benign |
Het |
| Eln |
CTCCAGCTCCGAT |
C |
5: 134,758,003 (GRCm39) |
|
probably benign |
Het |
| Fam227a |
CATTGTCTTGA |
CA |
15: 79,533,959 (GRCm39) |
|
probably null |
Het |
| Fez2 |
T |
C |
17: 78,694,482 (GRCm39) |
I303V |
probably benign |
Het |
| Ffar1 |
A |
T |
7: 30,560,003 (GRCm39) |
I298N |
probably benign |
Het |
| Hpx |
C |
T |
7: 105,244,685 (GRCm39) |
V228I |
probably benign |
Het |
| Igkv1-117 |
T |
G |
6: 68,098,786 (GRCm39) |
C112G |
probably damaging |
Het |
| Il3ra |
A |
G |
14: 14,348,903 (GRCm38) |
D99G |
probably benign |
Het |
| Ivl |
T |
A |
3: 92,479,231 (GRCm39) |
K278M |
probably damaging |
Het |
| Lyst |
A |
G |
13: 13,862,230 (GRCm39) |
T2589A |
probably benign |
Het |
| Madd |
A |
T |
2: 90,984,793 (GRCm39) |
M1359K |
probably damaging |
Het |
| Nav3 |
T |
C |
10: 109,600,779 (GRCm39) |
T1283A |
probably benign |
Het |
| Ncapd2 |
G |
T |
6: 125,156,661 (GRCm39) |
C439* |
probably null |
Het |
| Nebl |
T |
C |
2: 17,429,333 (GRCm39) |
D266G |
probably benign |
Het |
| Oas1f |
G |
T |
5: 120,985,602 (GRCm39) |
G49V |
probably damaging |
Het |
| Oas1f |
A |
T |
5: 120,986,479 (GRCm39) |
Q144L |
possibly damaging |
Het |
| Or11g7 |
T |
C |
14: 50,691,373 (GRCm39) |
L288P |
possibly damaging |
Het |
| Or2ab1 |
A |
G |
11: 58,488,233 (GRCm39) |
I6V |
unknown |
Het |
| Or2n1 |
T |
C |
17: 38,486,419 (GRCm39) |
V148A |
probably benign |
Het |
| Or5an6 |
A |
G |
19: 12,371,719 (GRCm39) |
I31V |
not run |
Het |
| Or5j3 |
C |
T |
2: 86,128,672 (GRCm39) |
P171S |
probably benign |
Het |
| Or5m3 |
T |
G |
2: 85,838,524 (GRCm39) |
S135A |
probably damaging |
Het |
| Or5t18 |
T |
A |
2: 86,636,515 (GRCm39) |
Y276F |
probably damaging |
Het |
| Or6b6 |
C |
T |
7: 106,571,671 (GRCm39) |
|
probably benign |
Het |
| Or8b52 |
C |
T |
9: 38,577,108 (GRCm39) |
E11K |
probably benign |
Het |
| Or8j3c |
T |
A |
2: 86,253,651 (GRCm39) |
Y123F |
probably damaging |
Het |
| Pard3b |
T |
A |
1: 62,193,148 (GRCm39) |
V217E |
probably damaging |
Het |
| Pcdha2 |
T |
A |
18: 37,072,513 (GRCm39) |
I48N |
probably damaging |
Het |
| Pi4ka |
A |
G |
16: 17,120,991 (GRCm39) |
F1248L |
|
Het |
| Plekha2 |
A |
T |
8: 25,554,005 (GRCm39) |
|
probably benign |
Het |
| Plpp4 |
C |
T |
7: 128,981,201 (GRCm39) |
R151C |
unknown |
Het |
| Pramel14 |
T |
A |
4: 143,718,177 (GRCm39) |
Y422F |
probably benign |
Het |
| Prdm16 |
A |
G |
4: 154,405,339 (GRCm39) |
L1245P |
probably damaging |
Het |
| Prob1 |
G |
A |
18: 35,786,604 (GRCm39) |
A550V |
probably benign |
Het |
| Prok1 |
T |
C |
3: 107,144,408 (GRCm39) |
H65R |
probably benign |
Het |
| Ptcd1 |
A |
G |
5: 145,091,887 (GRCm39) |
V404A |
probably benign |
Het |
| Sbf2 |
T |
C |
7: 109,914,289 (GRCm39) |
E1631G |
probably benign |
Het |
| Sdad1 |
C |
A |
5: 92,447,948 (GRCm39) |
K262N |
probably benign |
Het |
| Sh3bp1 |
G |
T |
15: 78,794,272 (GRCm39) |
A547S |
probably benign |
Het |
| Sptb |
T |
C |
12: 76,675,333 (GRCm39) |
D227G |
probably benign |
Het |
| Tbx1 |
A |
G |
16: 18,406,769 (GRCm39) |
M1T |
probably null |
Het |
| Tespa1 |
T |
A |
10: 130,183,208 (GRCm39) |
V51D |
probably damaging |
Het |
| Tmc7 |
T |
C |
7: 118,165,468 (GRCm39) |
N82S |
probably benign |
Het |
| Tmem8b |
A |
G |
4: 43,689,476 (GRCm39) |
D290G |
possibly damaging |
Het |
| Trbv13-2 |
A |
T |
6: 41,098,493 (GRCm39) |
T23S |
probably damaging |
Het |
| Trib3 |
A |
T |
2: 152,180,553 (GRCm39) |
D213E |
probably damaging |
Het |
| Tubgcp4 |
T |
C |
2: 121,013,981 (GRCm39) |
V178A |
probably benign |
Het |
| Virma |
T |
A |
4: 11,539,918 (GRCm39) |
C1412* |
probably null |
Het |
| Vps13d |
A |
G |
4: 144,882,137 (GRCm39) |
V1152A |
|
Het |
| Wdr47 |
T |
C |
3: 108,526,284 (GRCm39) |
V269A |
probably damaging |
Het |
| Zc3h13 |
T |
A |
14: 75,561,977 (GRCm39) |
D676E |
unknown |
Het |
| Zc3h6 |
T |
A |
2: 128,858,934 (GRCm39) |
S988R |
probably benign |
Het |
|
| Other mutations in Vmn2r108 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00903:Vmn2r108
|
APN |
17 |
20,682,774 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01143:Vmn2r108
|
APN |
17 |
20,682,727 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01311:Vmn2r108
|
APN |
17 |
20,682,939 (GRCm39) |
nonsense |
probably null |
|
|
IGL01411:Vmn2r108
|
APN |
17 |
20,691,282 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01414:Vmn2r108
|
APN |
17 |
20,691,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01536:Vmn2r108
|
APN |
17 |
20,683,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01748:Vmn2r108
|
APN |
17 |
20,683,476 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01769:Vmn2r108
|
APN |
17 |
20,691,280 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02022:Vmn2r108
|
APN |
17 |
20,691,987 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02041:Vmn2r108
|
APN |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02049:Vmn2r108
|
APN |
17 |
20,691,608 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02344:Vmn2r108
|
APN |
17 |
20,689,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02939:Vmn2r108
|
APN |
17 |
20,691,545 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03202:Vmn2r108
|
APN |
17 |
20,691,319 (GRCm39) |
nonsense |
probably null |
|
|
PIT4498001:Vmn2r108
|
UTSW |
17 |
20,683,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0112:Vmn2r108
|
UTSW |
17 |
20,691,897 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0505:Vmn2r108
|
UTSW |
17 |
20,683,096 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0833:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
|
R0836:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
|
R0943:Vmn2r108
|
UTSW |
17 |
20,691,397 (GRCm39) |
nonsense |
probably null |
|
|
R1411:Vmn2r108
|
UTSW |
17 |
20,683,107 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1442:Vmn2r108
|
UTSW |
17 |
20,692,623 (GRCm39) |
nonsense |
probably null |
|
|
R1587:Vmn2r108
|
UTSW |
17 |
20,692,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Vmn2r108
|
UTSW |
17 |
20,682,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1773:Vmn2r108
|
UTSW |
17 |
20,689,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2021:Vmn2r108
|
UTSW |
17 |
20,691,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2159:Vmn2r108
|
UTSW |
17 |
20,689,363 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2224:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
|
R2226:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
|
R2517:Vmn2r108
|
UTSW |
17 |
20,692,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3710:Vmn2r108
|
UTSW |
17 |
20,682,932 (GRCm39) |
missense |
probably benign |
|
|
R4470:Vmn2r108
|
UTSW |
17 |
20,682,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4686:Vmn2r108
|
UTSW |
17 |
20,691,636 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4729:Vmn2r108
|
UTSW |
17 |
20,692,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4799:Vmn2r108
|
UTSW |
17 |
20,682,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Vmn2r108
|
UTSW |
17 |
20,701,449 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5088:Vmn2r108
|
UTSW |
17 |
20,690,454 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5213:Vmn2r108
|
UTSW |
17 |
20,691,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5289:Vmn2r108
|
UTSW |
17 |
20,691,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5290:Vmn2r108
|
UTSW |
17 |
20,691,665 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5713:Vmn2r108
|
UTSW |
17 |
20,691,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5753:Vmn2r108
|
UTSW |
17 |
20,683,179 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5792:Vmn2r108
|
UTSW |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5798:Vmn2r108
|
UTSW |
17 |
20,692,545 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5897:Vmn2r108
|
UTSW |
17 |
20,691,580 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6018:Vmn2r108
|
UTSW |
17 |
20,683,268 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6093:Vmn2r108
|
UTSW |
17 |
20,701,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6156:Vmn2r108
|
UTSW |
17 |
20,692,447 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6199:Vmn2r108
|
UTSW |
17 |
20,682,644 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6259:Vmn2r108
|
UTSW |
17 |
20,683,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6309:Vmn2r108
|
UTSW |
17 |
20,691,660 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6324:Vmn2r108
|
UTSW |
17 |
20,691,977 (GRCm39) |
nonsense |
probably null |
|
|
R6364:Vmn2r108
|
UTSW |
17 |
20,691,260 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6446:Vmn2r108
|
UTSW |
17 |
20,692,609 (GRCm39) |
nonsense |
probably null |
|
|
R6541:Vmn2r108
|
UTSW |
17 |
20,701,480 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7025:Vmn2r108
|
UTSW |
17 |
20,691,345 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7063:Vmn2r108
|
UTSW |
17 |
20,701,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Vmn2r108
|
UTSW |
17 |
20,701,338 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7096:Vmn2r108
|
UTSW |
17 |
20,682,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7203:Vmn2r108
|
UTSW |
17 |
20,683,038 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7458:Vmn2r108
|
UTSW |
17 |
20,692,532 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7619:Vmn2r108
|
UTSW |
17 |
20,692,457 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7841:Vmn2r108
|
UTSW |
17 |
20,690,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7944:Vmn2r108
|
UTSW |
17 |
20,691,890 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8213:Vmn2r108
|
UTSW |
17 |
20,690,350 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8218:Vmn2r108
|
UTSW |
17 |
20,683,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8507:Vmn2r108
|
UTSW |
17 |
20,683,195 (GRCm39) |
nonsense |
probably null |
|
|
R8708:Vmn2r108
|
UTSW |
17 |
20,682,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8845:Vmn2r108
|
UTSW |
17 |
20,691,361 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9030:Vmn2r108
|
UTSW |
17 |
20,690,312 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9226:Vmn2r108
|
UTSW |
17 |
20,691,330 (GRCm39) |
missense |
probably benign |
|
|
R9278:Vmn2r108
|
UTSW |
17 |
20,692,561 (GRCm39) |
missense |
probably benign |
0.11 |
|
X0022:Vmn2r108
|
UTSW |
17 |
20,691,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r108
|
UTSW |
17 |
20,691,375 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Vmn2r108
|
UTSW |
17 |
20,691,219 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGAGTCAAGCATGAAATAGTCAGC -3'
(R):5'- TGACCGTGGACAATATTCTTCTC -3'
Sequencing Primer
(F):5'- CAAGCATGAAATAGTCAGCATAGTC -3'
(R):5'- TCTATCAGATGGCCTCCAAGTAC -3'
|
| Posted On |
2020-01-23 |
Incidental Mutation