Mutagenetix > Incidental Mutation

Incidental Mutation 'R8052:Celsr2'

619092

Institutional Source

Beutler Lab

Gene Symbol

Celsr2

Ensembl Gene

ENSMUSG00000068740

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 2

Synonyms

mfmi1, EGFL2, flamingo

MMRRC Submission

067489-MU

Accession Numbers

Genbank: NM_017392.3, NM_001004177.2 ; Ensembl: ENSMUST00000090558

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8052 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

108390851-108415552 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 108412655 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Alanine at position 947 (D947A)

Ref Sequence

ENSEMBL: ENSMUSP00000088046 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090558]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000090558
AA Change: D947A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000088046
Gene: ENSMUSG00000068740
AA Change: D947A

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
low complexity region	35	53	N/A	INTRINSIC
CA	203	287	1.36e-26	SMART
CA	311	397	1.33e-29	SMART
CA	421	503	2.59e-27	SMART
CA	527	608	3.33e-30	SMART
CA	632	710	5.18e-18	SMART
CA	734	813	1.08e-29	SMART
CA	837	919	8.08e-29	SMART
low complexity region	920	932	N/A	INTRINSIC
CA	943	1021	4.3e-24	SMART
CA	1049	1125	1.87e-1	SMART
low complexity region	1188	1198	N/A	INTRINSIC
EGF	1231	1286	1.81e-3	SMART
EGF_CA	1288	1324	2.24e-8	SMART
EGF	1331	1366	6.65e-2	SMART
LamG	1387	1554	8.4e-30	SMART
EGF	1577	1610	8e-5	SMART
LamG	1636	1770	1.56e-24	SMART
EGF	1796	1829	2.35e-2	SMART
EGF	1831	1867	3.88e-3	SMART
TNFR	1908	1943	1.35e-1	SMART
EGF_Lam	1924	1969	9.54e-12	SMART
HormR	1972	2034	1.57e-20	SMART
Pfam:GAIN	2046	2289	3e-62	PFAM
GPS	2315	2368	1.86e-25	SMART
Pfam:7tm_2	2373	2605	1.1e-48	PFAM
low complexity region	2715	2733	N/A	INTRINSIC
low complexity region	2857	2873	N/A	INTRINSIC
low complexity region	2874	2881	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.5%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this allele have mild to moderately dilated lateral ventricles in the brain but are otherwise normal. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted, knock-out(1) Targeted, other(3)

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700123L14Rik	TCC	TCCGCC	6: 96,165,097 (GRCm38)		probably benign	Het
1700123L14Rik	TCC	TCCCCC	6: 96,165,103 (GRCm38)		probably benign	Het
2010111I01Rik	G	A	13: 63,068,251 (GRCm38)	V446I	probably damaging	Het
Abi1	T	C	2: 22,953,543 (GRCm38)	T297A	probably benign	Het
Acadl	G	T	1: 66,853,178 (GRCm38)	T162K	probably benign	Het
Aldoart2	A	T	12: 55,565,751 (GRCm38)	I154F	probably damaging	Het
Alkbh8	G	A	9: 3,385,478 (GRCm38)	R625H	probably damaging	Het
Ankrd31	T	A	13: 96,832,528 (GRCm38)	V891E	probably benign	Het
Atp8b5	C	T	4: 43,356,982 (GRCm38)	R577*	probably null	Het
Capn3	G	T	2: 120,486,386 (GRCm38)	E285D	probably benign	Het
Cd79b	G	T	11: 106,313,700 (GRCm38)	P87T	probably damaging	Het
Csmd3	A	C	15: 47,706,387 (GRCm38)	S1213R		Het
Cyp2j5	T	C	4: 96,664,004 (GRCm38)	M3V	probably benign	Het
Ddi1	C	T	9: 6,265,787 (GRCm38)	R194K	probably benign	Het
Decr1	T	C	4: 15,933,019 (GRCm38)	K49R	probably benign	Het
Dnah10	A	C	5: 124,828,511 (GRCm38)	E4130A	probably benign	Het
Dst	A	G	1: 34,284,363 (GRCm38)	D4648G	probably damaging	Het
Ecd	A	G	14: 20,329,952 (GRCm38)		probably null	Het
Erbin	A	T	13: 103,834,356 (GRCm38)	Y917*	probably null	Het
Evpl	T	C	11: 116,223,163 (GRCm38)	K1234E	probably benign	Het
F11r	T	A	1: 171,461,623 (GRCm38)	Y218N	possibly damaging	Het
Fam43a	C	G	16: 30,601,804 (GRCm38)	T402S	probably benign	Het
Frem2	T	C	3: 53,549,643 (GRCm38)	N2096S	probably benign	Het
Gm7697	A	T	8: 69,522,752 (GRCm38)	Y21N	possibly damaging	Het
Gpd2	T	A	2: 57,306,950 (GRCm38)	Y172*	probably null	Het
Hscb	A	G	5: 110,835,978 (GRCm38)	V90A	probably benign	Het
Iqgap2	T	C	13: 95,657,879 (GRCm38)	D1195G	probably damaging	Het
Map2k2	T	C	10: 81,115,066 (GRCm38)	I115T	probably damaging	Het
Mast2	C	T	4: 116,312,975 (GRCm38)	R707H	probably damaging	Het
Mindy4	A	G	6: 55,300,992 (GRCm38)	N607S	probably damaging	Het
Mrpl9	T	A	3: 94,443,743 (GRCm38)	Y77N	probably damaging	Het
Muc16	G	A	9: 18,659,051 (GRCm38)	T724I	unknown	Het
Nat3	A	T	8: 67,547,826 (GRCm38)	Y119F	possibly damaging	Het
Nol7	T	C	13: 43,401,514 (GRCm38)	S208P	probably damaging	Het
Notch3	A	T	17: 32,146,571 (GRCm38)	C1056S	probably damaging	Het
Olfr1039	A	T	2: 86,131,377 (GRCm38)	Y95*	probably null	Het
Olfr146	G	T	9: 39,019,487 (GRCm38)	T18K	probably damaging	Het
Olfr399	T	A	11: 74,054,475 (GRCm38)	I95F	probably benign	Het
Olfr71	A	T	4: 43,705,884 (GRCm38)	V228E	probably damaging	Het
Osbpl3	A	C	6: 50,346,015 (GRCm38)	L288R	probably damaging	Het
Oscp1	A	C	4: 126,088,323 (GRCm38)	D352A	possibly damaging	Het
Pcdh9	G	A	14: 93,885,786 (GRCm38)	R983C	probably benign	Het
Pcdhgb8	T	C	18: 37,763,502 (GRCm38)	S542P	probably benign	Het
Pi4ka	T	C	16: 17,356,166 (GRCm38)	T490A		Het
Pkd1l1	A	T	11: 8,947,315 (GRCm38)	D531E		Het
Prr3	G	T	17: 35,979,161 (GRCm38)	D26E	possibly damaging	Het
Psmd8	T	C	7: 29,180,576 (GRCm38)	K24E	probably benign	Het
Rasgrp4	G	A	7: 29,149,937 (GRCm38)	C583Y	probably damaging	Het
Rest	A	G	5: 77,268,324 (GRCm38)	I128M	probably benign	Het
Rftn1	A	T	17: 50,086,579 (GRCm38)	F144I	probably damaging	Het
Rusc2	T	C	4: 43,421,851 (GRCm38)	F757S	probably benign	Het
Ryr1	A	G	7: 29,083,385 (GRCm38)	S1942P	probably benign	Het
Sdk2	C	T	11: 113,854,351 (GRCm38)	R706Q	probably damaging	Het
Sergef	G	T	7: 46,614,638 (GRCm38)	T275K	probably damaging	Het
Serpina10	T	C	12: 103,628,310 (GRCm38)	T217A	probably damaging	Het
Shd	G	C	17: 55,976,235 (GRCm38)	S288T	probably damaging	Het
Siglec15	C	A	18: 78,048,588 (GRCm38)	A133S	possibly damaging	Het
Stat4	C	T	1: 52,079,773 (GRCm38)	P325L	probably damaging	Het
Syt8	G	A	7: 142,440,144 (GRCm38)	G344D	probably damaging	Het
Tes	A	G	6: 17,097,292 (GRCm38)	E133G	probably benign	Het
Tmprss2	T	C	16: 97,568,416 (GRCm38)	Y386C	probably damaging	Het
Tnfrsf11b	A	T	15: 54,252,106 (GRCm38)	L365Q	probably damaging	Het
Tns1	T	A	1: 73,953,437 (GRCm38)	D67V	probably damaging	Het
Tns2	T	C	15: 102,112,845 (GRCm38)	S982P	probably damaging	Het
Tpcn2	A	T	7: 145,260,946 (GRCm38)	F473I	probably benign	Het
Tsg101	A	T	7: 46,892,509 (GRCm38)	I232N	probably damaging	Het
Ttc3	T	C	16: 94,467,989 (GRCm38)	S1977P	probably benign	Het
Ttll11	T	A	2: 35,979,515 (GRCm38)	E37V	unknown	Het
Ttn	A	T	2: 76,818,816 (GRCm38)	V12716E	possibly damaging	Het
Vmn2r70	A	C	7: 85,563,715 (GRCm38)	S495A	probably benign	Het
Zfp974	A	G	7: 27,911,272 (GRCm38)	C343R	probably damaging	Het
Zfy1	A	T	Y: 726,004 (GRCm38)	I587N	possibly damaging	Het

Other mutations in Celsr2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00898:Celsr2	APN	3	108,413,879 (GRCm38)	missense	possibly damaging	0.49
IGL01020:Celsr2	APN	3	108,403,270 (GRCm38)	missense	probably damaging	0.99
IGL01420:Celsr2	APN	3	108,393,763 (GRCm38)	missense	probably benign	0.13
IGL01448:Celsr2	APN	3	108,393,239 (GRCm38)	missense	probably damaging	0.99
IGL01559:Celsr2	APN	3	108,406,867 (GRCm38)	missense	possibly damaging	0.75
IGL01674:Celsr2	APN	3	108,414,843 (GRCm38)	missense	probably damaging	1.00
IGL01863:Celsr2	APN	3	108,394,022 (GRCm38)	missense	probably benign	0.00
IGL02309:Celsr2	APN	3	108,396,011 (GRCm38)	missense	probably damaging	1.00
IGL02325:Celsr2	APN	3	108,412,871 (GRCm38)	missense	probably damaging	1.00
IGL02409:Celsr2	APN	3	108,413,955 (GRCm38)	missense	probably damaging	1.00
IGL02514:Celsr2	APN	3	108,397,510 (GRCm38)	missense	probably benign	0.01
IGL02812:Celsr2	APN	3	108,414,113 (GRCm38)	missense	probably benign	0.25
IGL02894:Celsr2	APN	3	108,395,210 (GRCm38)	missense	probably damaging	1.00
IGL03281:Celsr2	APN	3	108,412,940 (GRCm38)	missense	probably damaging	1.00
barrow	UTSW	3	108,394,965 (GRCm38)	missense	possibly damaging	0.92
goldeneye	UTSW	3	108,394,919 (GRCm38)	missense	probably damaging	1.00
1mM(1):Celsr2	UTSW	3	108,400,838 (GRCm38)	missense	probably benign	0.01
ANU74:Celsr2	UTSW	3	108,412,499 (GRCm38)	missense	probably damaging	1.00
IGL02799:Celsr2	UTSW	3	108,414,062 (GRCm38)	missense	probably damaging	1.00
R0011:Celsr2	UTSW	3	108,413,402 (GRCm38)	missense	probably benign	0.19
R0031:Celsr2	UTSW	3	108,413,063 (GRCm38)	missense	probably damaging	1.00
R0049:Celsr2	UTSW	3	108,397,254 (GRCm38)	missense	probably benign	0.12
R0049:Celsr2	UTSW	3	108,397,254 (GRCm38)	missense	probably benign	0.12
R0090:Celsr2	UTSW	3	108,393,327 (GRCm38)	splice site	probably benign
R0140:Celsr2	UTSW	3	108,397,933 (GRCm38)	missense	probably benign	0.00
R0524:Celsr2	UTSW	3	108,401,587 (GRCm38)	missense	probably damaging	1.00
R0607:Celsr2	UTSW	3	108,403,895 (GRCm38)	critical splice donor site	probably null
R0662:Celsr2	UTSW	3	108,398,520 (GRCm38)	missense	probably damaging	0.99
R0690:Celsr2	UTSW	3	108,414,977 (GRCm38)	missense	probably damaging	1.00
R0691:Celsr2	UTSW	3	108,412,623 (GRCm38)	missense	probably damaging	1.00
R0710:Celsr2	UTSW	3	108,412,712 (GRCm38)	missense	probably benign	0.42
R0730:Celsr2	UTSW	3	108,398,606 (GRCm38)	missense	probably damaging	1.00
R0815:Celsr2	UTSW	3	108,401,301 (GRCm38)	missense	possibly damaging	0.56
R0848:Celsr2	UTSW	3	108,414,338 (GRCm38)	missense	probably benign
R0989:Celsr2	UTSW	3	108,403,272 (GRCm38)	missense	probably benign	0.00
R1185:Celsr2	UTSW	3	108,399,709 (GRCm38)	missense	possibly damaging	0.95
R1185:Celsr2	UTSW	3	108,399,709 (GRCm38)	missense	possibly damaging	0.95
R1185:Celsr2	UTSW	3	108,399,709 (GRCm38)	missense	possibly damaging	0.95
R1469:Celsr2	UTSW	3	108,414,108 (GRCm38)	missense	probably damaging	1.00
R1469:Celsr2	UTSW	3	108,414,108 (GRCm38)	missense	probably damaging	1.00
R1474:Celsr2	UTSW	3	108,393,739 (GRCm38)	missense	possibly damaging	0.91
R1608:Celsr2	UTSW	3	108,402,483 (GRCm38)	missense	probably damaging	1.00
R1653:Celsr2	UTSW	3	108,413,520 (GRCm38)	missense	possibly damaging	0.52
R1659:Celsr2	UTSW	3	108,414,095 (GRCm38)	missense	probably benign
R1689:Celsr2	UTSW	3	108,407,304 (GRCm38)	missense	possibly damaging	0.63
R1848:Celsr2	UTSW	3	108,401,310 (GRCm38)	missense	probably benign	0.35
R1859:Celsr2	UTSW	3	108,396,630 (GRCm38)	missense	probably damaging	1.00
R1918:Celsr2	UTSW	3	108,398,650 (GRCm38)	missense	probably benign	0.05
R1974:Celsr2	UTSW	3	108,414,214 (GRCm38)	missense	probably damaging	1.00
R2042:Celsr2	UTSW	3	108,402,495 (GRCm38)	missense	probably damaging	0.98
R2167:Celsr2	UTSW	3	108,413,193 (GRCm38)	missense	probably damaging	0.96
R2333:Celsr2	UTSW	3	108,398,605 (GRCm38)	missense	probably benign	0.16
R2434:Celsr2	UTSW	3	108,404,479 (GRCm38)	missense	probably damaging	1.00
R2504:Celsr2	UTSW	3	108,413,591 (GRCm38)	missense	probably benign	0.11
R3420:Celsr2	UTSW	3	108,414,416 (GRCm38)	missense	probably benign	0.03
R3712:Celsr2	UTSW	3	108,400,839 (GRCm38)	missense	probably benign
R3723:Celsr2	UTSW	3	108,397,415 (GRCm38)	splice site	probably benign
R3809:Celsr2	UTSW	3	108,403,239 (GRCm38)	missense	possibly damaging	0.67
R4018:Celsr2	UTSW	3	108,394,965 (GRCm38)	missense	possibly damaging	0.92
R4126:Celsr2	UTSW	3	108,402,097 (GRCm38)	missense	possibly damaging	0.71
R4177:Celsr2	UTSW	3	108,413,978 (GRCm38)	missense	probably damaging	0.96
R4232:Celsr2	UTSW	3	108,413,772 (GRCm38)	missense	probably benign	0.02
R4293:Celsr2	UTSW	3	108,393,677 (GRCm38)	missense	probably benign	0.01
R4458:Celsr2	UTSW	3	108,394,997 (GRCm38)	missense	probably damaging	0.98
R4621:Celsr2	UTSW	3	108,395,216 (GRCm38)	missense	possibly damaging	0.86
R4645:Celsr2	UTSW	3	108,395,969 (GRCm38)	missense	probably damaging	1.00
R4700:Celsr2	UTSW	3	108,397,231 (GRCm38)	missense	probably benign	0.24
R4732:Celsr2	UTSW	3	108,398,952 (GRCm38)	missense	probably damaging	0.99
R4733:Celsr2	UTSW	3	108,398,952 (GRCm38)	missense	probably damaging	0.99
R4901:Celsr2	UTSW	3	108,406,987 (GRCm38)	missense	possibly damaging	0.81
R4932:Celsr2	UTSW	3	108,402,758 (GRCm38)	missense	probably damaging	1.00
R4989:Celsr2	UTSW	3	108,412,629 (GRCm38)	missense	possibly damaging	0.62
R5052:Celsr2	UTSW	3	108,412,358 (GRCm38)	missense	probably damaging	1.00
R5093:Celsr2	UTSW	3	108,413,373 (GRCm38)	missense	possibly damaging	0.66
R5114:Celsr2	UTSW	3	108,393,996 (GRCm38)	missense	probably benign	0.05
R5120:Celsr2	UTSW	3	108,393,120 (GRCm38)	missense	probably benign	0.02
R5135:Celsr2	UTSW	3	108,398,659 (GRCm38)	missense	probably damaging	1.00
R5247:Celsr2	UTSW	3	108,397,630 (GRCm38)	missense	probably benign	0.34
R5381:Celsr2	UTSW	3	108,402,757 (GRCm38)	missense	probably damaging	1.00
R5412:Celsr2	UTSW	3	108,399,995 (GRCm38)	missense	probably damaging	1.00
R5445:Celsr2	UTSW	3	108,392,658 (GRCm38)	missense	probably benign	0.01
R5528:Celsr2	UTSW	3	108,413,294 (GRCm38)	missense	probably damaging	1.00
R5598:Celsr2	UTSW	3	108,402,803 (GRCm38)	missense	possibly damaging	0.82
R5652:Celsr2	UTSW	3	108,396,735 (GRCm38)	missense	probably null	0.49
R5697:Celsr2	UTSW	3	108,403,921 (GRCm38)	nonsense	probably null
R5718:Celsr2	UTSW	3	108,393,358 (GRCm38)	missense	probably benign
R5869:Celsr2	UTSW	3	108,413,909 (GRCm38)	missense	probably damaging	1.00
R5876:Celsr2	UTSW	3	108,413,943 (GRCm38)	missense	probably damaging	0.96
R6021:Celsr2	UTSW	3	108,401,245 (GRCm38)	missense	probably benign
R6054:Celsr2	UTSW	3	108,406,963 (GRCm38)	missense	possibly damaging	0.95
R6244:Celsr2	UTSW	3	108,393,128 (GRCm38)	missense	probably damaging	0.96
R6313:Celsr2	UTSW	3	108,401,214 (GRCm38)	missense	probably damaging	0.99
R6322:Celsr2	UTSW	3	108,412,574 (GRCm38)	missense	probably damaging	1.00
R6555:Celsr2	UTSW	3	108,394,919 (GRCm38)	missense	probably damaging	1.00
R6682:Celsr2	UTSW	3	108,400,501 (GRCm38)	critical splice donor site	probably null
R7062:Celsr2	UTSW	3	108,402,510 (GRCm38)	missense	possibly damaging	0.95
R7110:Celsr2	UTSW	3	108,397,865 (GRCm38)	missense	probably damaging	1.00
R7139:Celsr2	UTSW	3	108,415,359 (GRCm38)	missense	unknown
R7326:Celsr2	UTSW	3	108,394,995 (GRCm38)	missense	possibly damaging	0.85
R7425:Celsr2	UTSW	3	108,402,457 (GRCm38)	missense	probably damaging	1.00
R7452:Celsr2	UTSW	3	108,413,090 (GRCm38)	missense	possibly damaging	0.95
R7461:Celsr2	UTSW	3	108,395,640 (GRCm38)	missense	probably damaging	1.00
R7502:Celsr2	UTSW	3	108,398,902 (GRCm38)	missense	probably benign	0.00
R7613:Celsr2	UTSW	3	108,395,640 (GRCm38)	missense	probably damaging	1.00
R7644:Celsr2	UTSW	3	108,413,490 (GRCm38)	missense	probably damaging	0.99
R7666:Celsr2	UTSW	3	108,398,588 (GRCm38)	missense	probably benign
R7687:Celsr2	UTSW	3	108,397,769 (GRCm38)	missense	probably benign	0.27
R7695:Celsr2	UTSW	3	108,402,753 (GRCm38)	missense	probably damaging	1.00
R8002:Celsr2	UTSW	3	108,403,969 (GRCm38)	missense	probably damaging	1.00
R8283:Celsr2	UTSW	3	108,396,455 (GRCm38)	missense	probably damaging	1.00
R8356:Celsr2	UTSW	3	108,413,531 (GRCm38)	missense	possibly damaging	0.90
R8381:Celsr2	UTSW	3	108,395,636 (GRCm38)	missense	probably damaging	1.00
R8427:Celsr2	UTSW	3	108,392,633 (GRCm38)	makesense	probably null
R8435:Celsr2	UTSW	3	108,414,399 (GRCm38)	missense	probably benign
R8438:Celsr2	UTSW	3	108,393,823 (GRCm38)	missense	probably damaging	1.00
R8458:Celsr2	UTSW	3	108,398,902 (GRCm38)	missense	probably benign	0.00
R8460:Celsr2	UTSW	3	108,396,777 (GRCm38)	missense	possibly damaging	0.84
R8462:Celsr2	UTSW	3	108,412,851 (GRCm38)	nonsense	probably null
R8479:Celsr2	UTSW	3	108,398,902 (GRCm38)	missense	probably benign	0.00
R8480:Celsr2	UTSW	3	108,398,902 (GRCm38)	missense	probably benign	0.00
R8512:Celsr2	UTSW	3	108,413,838 (GRCm38)	missense	probably damaging	1.00
R8694:Celsr2	UTSW	3	108,406,860 (GRCm38)	missense	probably damaging	1.00
R8772:Celsr2	UTSW	3	108,397,073 (GRCm38)	missense	possibly damaging	0.84
R8843:Celsr2	UTSW	3	108,396,127 (GRCm38)	splice site	probably benign
R8888:Celsr2	UTSW	3	108,413,564 (GRCm38)	missense	possibly damaging	0.95
R8895:Celsr2	UTSW	3	108,413,564 (GRCm38)	missense	possibly damaging	0.95
R8917:Celsr2	UTSW	3	108,396,566 (GRCm38)	missense	probably benign	0.00
R9119:Celsr2	UTSW	3	108,401,972 (GRCm38)	missense	possibly damaging	0.90
R9169:Celsr2	UTSW	3	108,402,546 (GRCm38)	missense	probably benign	0.04
R9209:Celsr2	UTSW	3	108,414,033 (GRCm38)	missense	probably benign	0.02
R9342:Celsr2	UTSW	3	108,413,126 (GRCm38)	missense	probably damaging	1.00
R9416:Celsr2	UTSW	3	108,414,768 (GRCm38)	missense	probably damaging	0.96
R9493:Celsr2	UTSW	3	108,393,758 (GRCm38)	missense	probably damaging	1.00
R9564:Celsr2	UTSW	3	108,414,518 (GRCm38)	missense	probably damaging	1.00
R9598:Celsr2	UTSW	3	108,415,262 (GRCm38)	missense	possibly damaging	0.72
R9629:Celsr2	UTSW	3	108,401,599 (GRCm38)	missense	probably damaging	1.00
R9691:Celsr2	UTSW	3	108,394,235 (GRCm38)	missense	probably damaging	1.00
X0020:Celsr2	UTSW	3	108,396,110 (GRCm38)	missense	probably damaging	1.00
X0050:Celsr2	UTSW	3	108,401,272 (GRCm38)	missense	probably benign	0.09
Z1088:Celsr2	UTSW	3	108,414,117 (GRCm38)	missense	probably damaging	1.00
Z1176:Celsr2	UTSW	3	108,412,341 (GRCm38)	missense	probably benign	0.07
Z1176:Celsr2	UTSW	3	108,393,131 (GRCm38)	missense	probably benign	0.10
Z1177:Celsr2	UTSW	3	108,413,571 (GRCm38)	missense	probably benign	0.32
Z1177:Celsr2	UTSW	3	108,412,220 (GRCm38)	missense	probably damaging	1.00
Z1191:Celsr2	UTSW	3	108,414,549 (GRCm38)	missense	possibly damaging	0.68

Predicted Primers

PCR Primer
(F):5'- ATCATTGCGGTCAAGGAGG -3'
(R):5'- AGTCGACATCGGGCATTGTG -3'

Sequencing Primer
(F):5'- ATGGACAGTAGCCCTGCTCAC -3'
(R):5'- TGAGAACGTGGCCCAGTAC -3'

Posted On

2020-01-23