Incidental Mutation 'R8053:Lrrc37'
ID 619201
Institutional Source Beutler Lab
Gene Symbol Lrrc37
Ensembl Gene ENSMUSG00000034239
Gene Name leucine rich repeat containing 37
Synonyms LOC380730, Gm884
MMRRC Submission 067490-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.257) question?
Stock # R8053 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 103425403-103511966 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 103495392 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Isoleucine at position 2809 (K2809I)
Ref Sequence ENSEMBL: ENSMUSP00000058511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059279] [ENSMUST00000167262]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000059279
AA Change: K2809I
SMART Domains Protein: ENSMUSP00000058511
Gene: ENSMUSG00000034239
AA Change: K2809I

DomainStartEndE-ValueType
Pfam:LRRC37 149 223 5.4e-10 PFAM
low complexity region 244 264 N/A INTRINSIC
low complexity region 298 308 N/A INTRINSIC
Pfam:LRRC37 335 403 1.9e-14 PFAM
Pfam:LRRC37 419 514 1.2e-8 PFAM
Pfam:LRRC37 565 620 2e-10 PFAM
Pfam:LRRC37 669 739 7.6e-18 PFAM
Pfam:LRRC37 741 792 1.6e-9 PFAM
Pfam:LRRC37 789 860 1.4e-23 PFAM
Pfam:LRRC37 861 914 2.8e-9 PFAM
Pfam:LRRC37 911 983 1.9e-23 PFAM
Pfam:LRRC37 979 1038 1e-8 PFAM
Pfam:LRRC37 1034 1105 2.7e-24 PFAM
Pfam:LRRC37 1105 1158 2.3e-9 PFAM
Pfam:LRRC37 1155 1219 2.4e-17 PFAM
Pfam:LRRC37 1222 1265 9.2e-7 PFAM
Pfam:LRRC37 1263 1330 4.9e-24 PFAM
Pfam:LRRC37 1331 1384 1.4e-10 PFAM
Pfam:LRRC37 1380 1451 4.3e-15 PFAM
Pfam:LRRC37 1487 1558 1.9e-15 PFAM
Pfam:LRRC37 1594 1665 2.9e-18 PFAM
Pfam:LRRC37 1701 1772 5.6e-23 PFAM
Pfam:LRRC37 1808 1910 2.8e-18 PFAM
Pfam:LRRC37 1915 1986 7.2e-17 PFAM
Pfam:LRRC37 2022 2093 4.9e-22 PFAM
Pfam:LRRC37 2129 2200 4.4e-22 PFAM
Pfam:LRRC37 2236 2307 2.1e-21 PFAM
Pfam:LRRC37 2343 2414 3.8e-17 PFAM
Pfam:LRRC37 2449 2519 1.6e-19 PFAM
LRR 2777 2796 3.09e1 SMART
LRR_TYP 2797 2820 2.09e-3 SMART
LRR 2821 2844 4.44e0 SMART
LRR 2848 2872 8.26e1 SMART
low complexity region 2991 3002 N/A INTRINSIC
low complexity region 3220 3230 N/A INTRINSIC
low complexity region 3382 3393 N/A INTRINSIC
Pfam:LRRC37AB_C 3424 3570 7.7e-76 PFAM
low complexity region 3571 3589 N/A INTRINSIC
low complexity region 3622 3640 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000167262
AA Change: K633I
SMART Domains Protein: ENSMUSP00000129662
Gene: ENSMUSG00000034239
AA Change: K633I

DomainStartEndE-ValueType
internal_repeat_1 1 70 1.46e-11 PROSPERO
internal_repeat_1 108 290 1.46e-11 PROSPERO
LRR 601 620 3.09e1 SMART
LRR_TYP 621 644 2.09e-3 SMART
LRR 645 668 4.44e0 SMART
LRR 672 696 8.26e1 SMART
low complexity region 815 826 N/A INTRINSIC
low complexity region 1044 1054 N/A INTRINSIC
low complexity region 1206 1217 N/A INTRINSIC
Pfam:LRRC37AB_C 1243 1396 1.2e-92 PFAM
low complexity region 1446 1464 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730507C01Rik C T 12: 18,583,728 (GRCm39) R263* probably null Het
Abca12 G A 1: 71,388,328 (GRCm39) R181* probably null Het
Adar T C 3: 89,654,592 (GRCm39) L908P probably damaging Het
Ankrd55 C T 13: 112,459,687 (GRCm39) R94C probably damaging Het
Aopep A T 13: 63,338,345 (GRCm39) K574* probably null Het
Carf A T 1: 60,167,197 (GRCm39) T177S probably benign Het
Ccdc162 C A 10: 41,520,577 (GRCm39) G693V probably benign Het
Ccng2 C G 5: 93,421,202 (GRCm39) S237R probably benign Het
Chd4 G T 6: 125,105,779 (GRCm39) E1799* probably null Het
Chrna3 T A 9: 54,922,674 (GRCm39) N378I probably benign Het
Clec4a2 T C 6: 123,104,998 (GRCm39) V96A probably benign Het
Cntnap5b T A 1: 100,318,402 (GRCm39) L683Q probably damaging Het
Crisp4 T A 1: 18,194,498 (GRCm39) Q208L probably benign Het
Crocc A G 4: 140,770,230 (GRCm39) probably null Het
Cyp2ab1 T C 16: 20,133,018 (GRCm39) E192G probably benign Het
Cyrib T C 15: 63,813,832 (GRCm39) D155G probably damaging Het
Daglb A G 5: 143,489,024 (GRCm39) K627R probably benign Het
Desi2 G A 1: 178,065,482 (GRCm39) W16* probably null Het
Dtx3l T C 16: 35,759,322 (GRCm39) probably benign Het
Elf2 A G 3: 51,215,551 (GRCm39) V53A possibly damaging Het
Eomes A G 9: 118,309,621 (GRCm39) D325G probably damaging Het
Etl4 A T 2: 20,666,774 (GRCm39) L60F probably damaging Het
Exoc4 A G 6: 33,309,191 (GRCm39) D271G probably benign Het
F5 A G 1: 164,020,338 (GRCm39) I938V probably benign Het
Fdxr T A 11: 115,160,665 (GRCm39) K290M probably benign Het
Fgd5 G A 6: 91,966,425 (GRCm39) S886N probably benign Het
Gm11595 G A 11: 99,662,954 (GRCm39) S242F unknown Het
Gm14322 A T 2: 177,411,424 (GRCm39) Q78L probably damaging Het
Gm8267 A T 14: 44,962,307 (GRCm39) S38T possibly damaging Het
Gpr75 A T 11: 30,841,559 (GRCm39) T155S probably benign Het
Hectd3 T C 4: 116,858,055 (GRCm39) S628P possibly damaging Het
Hrh2 A G 13: 54,368,104 (GRCm39) T27A probably benign Het
Kif16b G A 2: 142,695,634 (GRCm39) R157C probably damaging Het
Krt16 T C 11: 100,137,613 (GRCm39) Y364C probably damaging Het
Map2k5 T A 9: 63,250,707 (GRCm39) N95I probably benign Het
Melk A G 4: 44,318,109 (GRCm39) Y170C probably damaging Het
Mthfd1 T A 12: 76,327,282 (GRCm39) D123E probably damaging Het
Muc2 A T 7: 141,284,575 (GRCm39) Y827F probably benign Het
Myh15 T A 16: 48,963,302 (GRCm39) M1081K possibly damaging Het
Nbeal1 A G 1: 60,318,954 (GRCm39) T1998A probably damaging Het
Neb T A 2: 52,176,029 (GRCm39) T1477S possibly damaging Het
Nox4 C A 7: 87,019,255 (GRCm39) P416Q probably damaging Het
Or10ak7 A G 4: 118,791,308 (GRCm39) S246P probably damaging Het
Or1e31 T C 11: 73,689,822 (GRCm39) T254A probably benign Het
Or2j3 A T 17: 38,616,101 (GRCm39) F84I probably benign Het
Or4c123 A T 2: 89,127,540 (GRCm39) F25I possibly damaging Het
Or5g23 T C 2: 85,439,234 (GRCm39) T7A probably damaging Het
Pcdhga4 A G 18: 37,819,308 (GRCm39) K286E probably benign Het
Pde10a A G 17: 9,193,604 (GRCm39) T679A probably benign Het
Phc2 C T 4: 128,603,433 (GRCm39) Q188* probably null Het
Pramel12 C A 4: 143,144,208 (GRCm39) Q185K probably benign Het
Prdm15 A G 16: 97,636,807 (GRCm39) M170T probably benign Het
Rab20 G T 8: 11,504,443 (GRCm39) Q86K probably damaging Het
Rev1 T C 1: 38,102,222 (GRCm39) I714V possibly damaging Het
Rexo2 A G 9: 48,386,418 (GRCm39) probably null Het
Rnf213 A G 11: 119,293,473 (GRCm39) K75E Het
Sdk2 C T 11: 113,745,177 (GRCm39) R706Q probably damaging Het
Sema3c C T 5: 17,860,020 (GRCm39) T95I probably benign Het
Sh3rf2 T A 18: 42,286,087 (GRCm39) S527T probably damaging Het
Sis A T 3: 72,856,901 (GRCm39) Y434* probably null Het
Slc16a6 G A 11: 109,349,395 (GRCm39) T222I probably damaging Het
Smad6 A G 9: 63,927,789 (GRCm39) L173P probably damaging Het
Sugct T A 13: 17,476,554 (GRCm39) N310I probably damaging Het
Syne1 T A 10: 5,002,658 (GRCm39) K259* probably null Het
Taar6 A G 10: 23,861,144 (GRCm39) V134A possibly damaging Het
Tmem199 A G 11: 78,398,612 (GRCm39) I184T possibly damaging Het
Tnrc18 G T 5: 142,736,385 (GRCm39) D1530E unknown Het
Tnxb G A 17: 34,923,153 (GRCm39) V2579M probably damaging Het
Vangl2 A G 1: 171,832,303 (GRCm39) F518L probably damaging Het
Vmn2r40 T C 7: 8,911,245 (GRCm39) T683A Het
Wapl C T 14: 34,414,278 (GRCm39) T380I probably damaging Het
Zfp874b A T 13: 67,622,217 (GRCm39) H360Q probably damaging Het
Other mutations in Lrrc37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00572:Lrrc37 APN 11 103,506,236 (GRCm39) missense probably benign 0.01
IGL00576:Lrrc37 APN 11 103,508,212 (GRCm39) unclassified probably benign
IGL00813:Lrrc37 APN 11 103,505,324 (GRCm39) missense probably benign 0.05
IGL01311:Lrrc37 APN 11 103,425,502 (GRCm39) missense unknown
IGL01946:Lrrc37 APN 11 103,503,759 (GRCm39) missense probably benign 0.28
IGL02217:Lrrc37 APN 11 103,503,697 (GRCm39) splice site probably benign
IGL02556:Lrrc37 APN 11 103,504,109 (GRCm39) missense probably benign 0.01
IGL02825:Lrrc37 APN 11 103,507,894 (GRCm39) unclassified probably benign
IGL02868:Lrrc37 APN 11 103,505,965 (GRCm39) missense probably benign 0.10
IGL02904:Lrrc37 APN 11 103,507,187 (GRCm39) unclassified probably benign
IGL03008:Lrrc37 APN 11 103,511,293 (GRCm39) missense unknown
IGL03120:Lrrc37 APN 11 103,507,801 (GRCm39) unclassified probably benign
IGL03159:Lrrc37 APN 11 103,495,328 (GRCm39) splice site probably benign
IGL03181:Lrrc37 APN 11 103,507,242 (GRCm39) unclassified probably benign
IGL03202:Lrrc37 APN 11 103,506,199 (GRCm39) missense probably benign 0.03
IGL03263:Lrrc37 APN 11 103,504,525 (GRCm39) missense possibly damaging 0.86
esteemed UTSW 11 103,509,656 (GRCm39) missense unknown
lauded UTSW 11 103,503,929 (GRCm39) missense possibly damaging 0.62
PIT4486001:Lrrc37 UTSW 11 103,509,027 (GRCm39) missense unknown
R0040:Lrrc37 UTSW 11 103,433,816 (GRCm39) missense probably damaging 0.99
R0135:Lrrc37 UTSW 11 103,508,873 (GRCm39) unclassified probably benign
R0141:Lrrc37 UTSW 11 103,504,512 (GRCm39) missense probably damaging 1.00
R0226:Lrrc37 UTSW 11 103,494,067 (GRCm39) missense probably benign 0.08
R0547:Lrrc37 UTSW 11 103,510,990 (GRCm39) missense unknown
R0646:Lrrc37 UTSW 11 103,503,986 (GRCm39) nonsense probably null
R0685:Lrrc37 UTSW 11 103,507,714 (GRCm39) unclassified probably benign
R0732:Lrrc37 UTSW 11 103,510,664 (GRCm39) missense unknown
R1015:Lrrc37 UTSW 11 103,436,622 (GRCm39) missense probably benign 0.01
R1166:Lrrc37 UTSW 11 103,506,209 (GRCm39) missense probably benign 0.21
R1168:Lrrc37 UTSW 11 103,509,776 (GRCm39) unclassified probably benign
R1257:Lrrc37 UTSW 11 103,425,467 (GRCm39) missense unknown
R1545:Lrrc37 UTSW 11 103,499,745 (GRCm39) missense probably benign 0.16
R1570:Lrrc37 UTSW 11 103,500,764 (GRCm39) missense possibly damaging 0.76
R1677:Lrrc37 UTSW 11 103,505,768 (GRCm39) missense probably benign 0.19
R1703:Lrrc37 UTSW 11 103,431,700 (GRCm39) missense probably benign 0.39
R1719:Lrrc37 UTSW 11 103,507,897 (GRCm39) unclassified probably benign
R1752:Lrrc37 UTSW 11 103,505,381 (GRCm39) missense possibly damaging 0.67
R1870:Lrrc37 UTSW 11 103,511,431 (GRCm39) missense unknown
R2155:Lrrc37 UTSW 11 103,511,285 (GRCm39) missense unknown
R2191:Lrrc37 UTSW 11 103,509,793 (GRCm39) unclassified probably benign
R2271:Lrrc37 UTSW 11 103,505,033 (GRCm39) missense possibly damaging 0.53
R2378:Lrrc37 UTSW 11 103,510,537 (GRCm39) unclassified probably benign
R2405:Lrrc37 UTSW 11 103,511,810 (GRCm39) missense unknown
R2864:Lrrc37 UTSW 11 103,431,744 (GRCm39) missense probably benign 0.34
R3011:Lrrc37 UTSW 11 103,503,929 (GRCm39) missense possibly damaging 0.62
R3415:Lrrc37 UTSW 11 103,505,435 (GRCm39) missense possibly damaging 0.82
R3417:Lrrc37 UTSW 11 103,505,435 (GRCm39) missense possibly damaging 0.82
R3835:Lrrc37 UTSW 11 103,510,836 (GRCm39) missense unknown
R3974:Lrrc37 UTSW 11 103,509,927 (GRCm39) unclassified probably benign
R4019:Lrrc37 UTSW 11 103,506,119 (GRCm39) missense probably benign 0.19
R4020:Lrrc37 UTSW 11 103,506,119 (GRCm39) missense probably benign 0.19
R4176:Lrrc37 UTSW 11 103,427,426 (GRCm39) missense unknown
R4361:Lrrc37 UTSW 11 103,508,327 (GRCm39) frame shift probably null
R4418:Lrrc37 UTSW 11 103,509,140 (GRCm39) unclassified probably benign
R4633:Lrrc37 UTSW 11 103,509,957 (GRCm39) unclassified probably benign
R4693:Lrrc37 UTSW 11 103,510,686 (GRCm39) missense unknown
R4758:Lrrc37 UTSW 11 103,505,290 (GRCm39) missense possibly damaging 0.48
R4878:Lrrc37 UTSW 11 103,508,717 (GRCm39) unclassified probably benign
R4887:Lrrc37 UTSW 11 103,505,698 (GRCm39) missense probably benign 0.03
R4944:Lrrc37 UTSW 11 103,504,286 (GRCm39) missense possibly damaging 0.68
R4952:Lrrc37 UTSW 11 103,505,033 (GRCm39) missense possibly damaging 0.53
R5030:Lrrc37 UTSW 11 103,425,675 (GRCm39) missense unknown
R5183:Lrrc37 UTSW 11 103,433,947 (GRCm39) missense probably damaging 0.99
R5294:Lrrc37 UTSW 11 103,507,057 (GRCm39) unclassified probably benign
R5317:Lrrc37 UTSW 11 103,504,971 (GRCm39) missense possibly damaging 0.73
R5334:Lrrc37 UTSW 11 103,504,699 (GRCm39) missense probably benign 0.18
R5426:Lrrc37 UTSW 11 103,511,586 (GRCm39) missense unknown
R5467:Lrrc37 UTSW 11 103,494,091 (GRCm39) nonsense probably null
R5518:Lrrc37 UTSW 11 103,506,079 (GRCm39) missense probably benign 0.03
R5634:Lrrc37 UTSW 11 103,432,840 (GRCm39) missense possibly damaging 0.95
R5647:Lrrc37 UTSW 11 103,508,300 (GRCm39) unclassified probably benign
R5663:Lrrc37 UTSW 11 103,503,949 (GRCm39) missense probably benign 0.01
R5668:Lrrc37 UTSW 11 103,507,880 (GRCm39) unclassified probably benign
R5763:Lrrc37 UTSW 11 103,504,469 (GRCm39) missense probably damaging 0.97
R5829:Lrrc37 UTSW 11 103,432,712 (GRCm39) missense possibly damaging 0.95
R5871:Lrrc37 UTSW 11 103,507,280 (GRCm39) unclassified probably benign
R5905:Lrrc37 UTSW 11 103,505,081 (GRCm39) missense probably damaging 0.98
R5940:Lrrc37 UTSW 11 103,504,712 (GRCm39) missense probably benign 0.18
R5964:Lrrc37 UTSW 11 103,432,946 (GRCm39) missense possibly damaging 0.92
R5988:Lrrc37 UTSW 11 103,506,722 (GRCm39) unclassified probably benign
R5992:Lrrc37 UTSW 11 103,504,618 (GRCm39) missense possibly damaging 0.81
R6114:Lrrc37 UTSW 11 103,508,617 (GRCm39) unclassified probably benign
R6154:Lrrc37 UTSW 11 103,504,969 (GRCm39) missense probably benign 0.33
R6233:Lrrc37 UTSW 11 103,504,214 (GRCm39) missense probably damaging 0.98
R6301:Lrrc37 UTSW 11 103,509,756 (GRCm39) unclassified probably benign
R6362:Lrrc37 UTSW 11 103,511,478 (GRCm39) missense unknown
R6471:Lrrc37 UTSW 11 103,510,448 (GRCm39) unclassified probably benign
R6806:Lrrc37 UTSW 11 103,511,950 (GRCm39) missense unknown
R6962:Lrrc37 UTSW 11 103,505,126 (GRCm39) missense possibly damaging 0.67
R6996:Lrrc37 UTSW 11 103,509,583 (GRCm39) nonsense probably null
R7028:Lrrc37 UTSW 11 103,505,363 (GRCm39) missense probably benign 0.28
R7034:Lrrc37 UTSW 11 103,506,638 (GRCm39) unclassified probably benign
R7036:Lrrc37 UTSW 11 103,506,638 (GRCm39) unclassified probably benign
R7113:Lrrc37 UTSW 11 103,509,625 (GRCm39) missense unknown
R7405:Lrrc37 UTSW 11 103,505,987 (GRCm39) missense probably benign 0.02
R7420:Lrrc37 UTSW 11 103,504,451 (GRCm39) missense probably benign 0.11
R7461:Lrrc37 UTSW 11 103,507,116 (GRCm39) missense unknown
R7544:Lrrc37 UTSW 11 103,506,274 (GRCm39) missense probably benign 0.01
R7613:Lrrc37 UTSW 11 103,507,116 (GRCm39) missense unknown
R7711:Lrrc37 UTSW 11 103,505,738 (GRCm39) missense probably benign 0.02
R7714:Lrrc37 UTSW 11 103,507,719 (GRCm39) missense unknown
R7747:Lrrc37 UTSW 11 103,505,081 (GRCm39) missense probably damaging 0.98
R7814:Lrrc37 UTSW 11 103,504,999 (GRCm39) missense possibly damaging 0.53
R8063:Lrrc37 UTSW 11 103,433,087 (GRCm39) missense unknown
R8116:Lrrc37 UTSW 11 103,434,115 (GRCm39) missense unknown
R8124:Lrrc37 UTSW 11 103,511,257 (GRCm39) missense unknown
R8141:Lrrc37 UTSW 11 103,511,855 (GRCm39) missense unknown
R8163:Lrrc37 UTSW 11 103,506,688 (GRCm39) missense unknown
R8270:Lrrc37 UTSW 11 103,434,141 (GRCm39) missense unknown
R8348:Lrrc37 UTSW 11 103,511,726 (GRCm39) missense unknown
R8362:Lrrc37 UTSW 11 103,506,163 (GRCm39) missense probably benign 0.34
R8448:Lrrc37 UTSW 11 103,511,726 (GRCm39) missense unknown
R8465:Lrrc37 UTSW 11 103,506,947 (GRCm39) unclassified probably benign
R8473:Lrrc37 UTSW 11 103,434,266 (GRCm39) missense unknown
R8781:Lrrc37 UTSW 11 103,508,958 (GRCm39) missense unknown
R8821:Lrrc37 UTSW 11 103,510,470 (GRCm39) missense unknown
R8859:Lrrc37 UTSW 11 103,506,370 (GRCm39) missense unknown
R8888:Lrrc37 UTSW 11 103,509,656 (GRCm39) missense unknown
R8895:Lrrc37 UTSW 11 103,509,656 (GRCm39) missense unknown
R9083:Lrrc37 UTSW 11 103,509,830 (GRCm39) missense unknown
R9085:Lrrc37 UTSW 11 103,507,565 (GRCm39) missense unknown
R9088:Lrrc37 UTSW 11 103,511,762 (GRCm39) missense unknown
R9124:Lrrc37 UTSW 11 103,509,721 (GRCm39) missense unknown
R9177:Lrrc37 UTSW 11 103,508,263 (GRCm39) missense unknown
R9238:Lrrc37 UTSW 11 103,509,859 (GRCm39) missense unknown
R9267:Lrrc37 UTSW 11 103,495,406 (GRCm39) missense unknown
R9444:Lrrc37 UTSW 11 103,508,846 (GRCm39) nonsense probably null
R9517:Lrrc37 UTSW 11 103,433,416 (GRCm39) missense unknown
R9564:Lrrc37 UTSW 11 103,503,822 (GRCm39) missense unknown
R9632:Lrrc37 UTSW 11 103,433,252 (GRCm39) missense unknown
R9741:Lrrc37 UTSW 11 103,504,255 (GRCm39) missense possibly damaging 0.68
Z1176:Lrrc37 UTSW 11 103,504,507 (GRCm39) missense probably benign 0.45
Predicted Primers PCR Primer
(F):5'- TAAGTCTGCCTTCTCCATATGAG -3'
(R):5'- AAGACAGCCTCTGAAATTTATCAGG -3'

Sequencing Primer
(F):5'- TCAGAATAAGTAGCATGGGG -3'
(R):5'- GGAGCATAAAGGTTGAGATACTTAG -3'
Posted On 2020-01-23