Incidental Mutation 'R8057:Lrrc66'
ID 619442
Institutional Source Beutler Lab
Gene Symbol Lrrc66
Ensembl Gene ENSMUSG00000067206
Gene Name leucine rich repeat containing 66
Synonyms
MMRRC Submission 067494-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R8057 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 73763985-73789771 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 73764875 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 723 (Q723*)
Ref Sequence ENSEMBL: ENSMUSP00000084423 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087177]
AlphaFold Q8K0B3
Predicted Effect probably null
Transcript: ENSMUST00000087177
AA Change: Q723*
SMART Domains Protein: ENSMUSP00000084423
Gene: ENSMUSG00000067206
AA Change: Q723*

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
LRR 140 162 1.81e1 SMART
LRR_TYP 163 186 9.44e-2 SMART
LRR 187 210 1.26e2 SMART
LRR 211 234 4.84e1 SMART
low complexity region 298 309 N/A INTRINSIC
transmembrane domain 369 391 N/A INTRINSIC
low complexity region 434 445 N/A INTRINSIC
low complexity region 842 859 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (81/81)
Allele List at MGI

All alleles(2) : Targeted, other(1) Gene trapped(1)

Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930523C07Rik T C 1: 159,902,826 (GRCm39) L32P probably damaging Het
4930563M21Rik T C 9: 55,916,564 (GRCm39) T38A unknown Het
Abcb6 T C 1: 75,151,002 (GRCm39) N563D probably damaging Het
Ak4 T C 4: 101,317,850 (GRCm39) F140S probably damaging Het
Arhgap27 T A 11: 103,229,519 (GRCm39) R296S probably damaging Het
Atxn7l1 A C 12: 33,376,001 (GRCm39) K98N probably damaging Het
Bex6 G T 16: 32,005,224 (GRCm39) D11Y probably damaging Het
Camta1 T C 4: 151,228,489 (GRCm39) D781G probably damaging Het
Capn7 A G 14: 31,092,936 (GRCm39) D800G probably benign Het
Carmil2 G A 8: 106,419,008 (GRCm39) V716I probably benign Het
Cdk5 C A 5: 24,625,782 (GRCm39) D144Y probably damaging Het
Cep85 T C 4: 133,880,925 (GRCm39) probably benign Het
Chd5 T A 4: 152,450,829 (GRCm39) L651Q probably damaging Het
Cimap1d T A 10: 79,475,835 (GRCm39) H243L probably damaging Het
Clcn7 C T 17: 25,368,233 (GRCm39) Q261* probably null Het
Cntnap2 T A 6: 46,324,079 (GRCm39) F576Y probably damaging Het
Col11a1 G A 3: 113,925,263 (GRCm39) G815D unknown Het
Col4a4 T A 1: 82,501,591 (GRCm39) R387S unknown Het
Cse1l T A 2: 166,781,845 (GRCm39) V663D probably damaging Het
Csf2rb2 G T 15: 78,169,206 (GRCm39) Q650K probably damaging Het
Ctnnd2 A G 15: 30,847,497 (GRCm39) D696G possibly damaging Het
Dnah7c T A 1: 46,728,112 (GRCm39) C2937S possibly damaging Het
Epha10 A T 4: 124,796,476 (GRCm39) Q395L Het
Fam167a T A 14: 63,689,769 (GRCm39) V22E probably benign Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Gabra4 A G 5: 71,781,295 (GRCm39) I372T probably benign Het
Gpt A G 15: 76,580,972 (GRCm39) probably benign Het
H2-K2 C T 17: 34,215,833 (GRCm39) G336D possibly damaging Het
Hapstr1 C T 16: 8,648,232 (GRCm39) probably benign Het
Hoxd8 T C 2: 74,535,070 (GRCm39) probably null Het
Ilrun C T 17: 27,986,863 (GRCm39) A288T unknown Het
Kdm5d T G Y: 927,355 (GRCm39) D658E possibly damaging Het
Krt25 G A 11: 99,208,169 (GRCm39) T353M probably benign Het
Lonp2 T C 8: 87,440,717 (GRCm39) L778P probably damaging Het
Mak T A 13: 41,202,813 (GRCm39) I212F probably damaging Het
Mastl T A 2: 23,023,566 (GRCm39) R386W possibly damaging Het
Mis18bp1 A G 12: 65,195,673 (GRCm39) I697T possibly damaging Het
Nek5 G A 8: 22,578,922 (GRCm39) T415I probably benign Het
Neu3 T A 7: 99,463,435 (GRCm39) N96I probably benign Het
Nxph2 T C 2: 23,290,107 (GRCm39) V153A possibly damaging Het
Or10a3 A T 7: 108,480,571 (GRCm39) F81I probably damaging Het
Or5b102 G A 19: 13,040,638 (GRCm39) probably benign Het
Or8b4 A G 9: 37,830,460 (GRCm39) D169G probably benign Het
Otogl T C 10: 107,644,476 (GRCm39) T1257A probably benign Het
Pcdh10 G A 3: 45,333,694 (GRCm39) V3M probably benign Het
Pitpnm1 G A 19: 4,162,145 (GRCm39) R1017Q probably null Het
Plcb3 A C 19: 6,932,463 (GRCm39) H1065Q probably benign Het
Plcb3 A T 19: 6,936,267 (GRCm39) M752K probably damaging Het
Plch1 T C 3: 63,605,557 (GRCm39) E1449G probably benign Het
Plekha4 T A 7: 45,198,695 (GRCm39) C573S probably benign Het
Plin2 T C 4: 86,575,638 (GRCm39) I304V possibly damaging Het
Pnp2 G A 14: 51,201,838 (GRCm39) V275I probably benign Het
Polr1a G A 6: 71,908,644 (GRCm39) A490T possibly damaging Het
Ppp1r12b A G 1: 134,883,354 (GRCm39) F56S probably damaging Het
Ptk2 GA G 15: 73,170,048 (GRCm39) probably null Het
Rb1cc1 C A 1: 6,315,443 (GRCm39) R473S probably damaging Het
Rcc2 G A 4: 140,429,586 (GRCm39) C40Y probably benign Het
Rdx T C 9: 51,976,946 (GRCm39) V65A probably damaging Het
Rpl27rt T C 18: 34,870,582 (GRCm39) F39L probably damaging Het
Rps6ka5 A G 12: 100,540,055 (GRCm39) probably null Het
Samd5 C T 10: 9,550,641 (GRCm39) V23M probably damaging Het
Scn9a T G 2: 66,345,774 (GRCm39) R1117S probably benign Het
Scrn1 T A 6: 54,497,758 (GRCm39) I278L probably benign Het
Sec31b G T 19: 44,507,804 (GRCm39) P747T probably damaging Het
Sipa1l2 A T 8: 126,195,269 (GRCm39) V823E probably damaging Het
Slc2a13 T C 15: 91,400,619 (GRCm39) N201S probably damaging Het
Slc30a3 C A 5: 31,247,395 (GRCm39) probably benign Het
Snx31 C A 15: 36,523,606 (GRCm39) V359F probably damaging Het
Sstr2 A G 11: 113,515,099 (GRCm39) E6G probably benign Het
Stc2 C A 11: 31,317,806 (GRCm39) E72* probably null Het
Tead1 C T 7: 112,358,721 (GRCm39) P11L probably benign Het
Tmem51 T C 4: 141,759,059 (GRCm39) T230A probably damaging Het
Tmem63c A T 12: 87,118,972 (GRCm39) K301* probably null Het
Tns3 G C 11: 8,442,773 (GRCm39) A530G probably benign Het
Trat1 T C 16: 48,562,600 (GRCm39) D70G probably damaging Het
Trex1 T A 9: 108,887,397 (GRCm39) E198V probably damaging Het
Ttn T G 2: 76,570,072 (GRCm39) R26940S probably damaging Het
Uba2 T C 7: 33,867,835 (GRCm39) K34R possibly damaging Het
Vps13d A C 4: 144,701,753 (GRCm39) M4376R Het
Zfp157 C A 5: 138,454,336 (GRCm39) T178K probably damaging Het
Zfp318 T A 17: 46,710,692 (GRCm39) V805D possibly damaging Het
Other mutations in Lrrc66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00507:Lrrc66 APN 5 73,764,457 (GRCm39) missense probably benign 0.10
IGL00913:Lrrc66 APN 5 73,765,499 (GRCm39) missense possibly damaging 0.76
IGL00954:Lrrc66 APN 5 73,765,741 (GRCm39) missense possibly damaging 0.94
IGL01061:Lrrc66 APN 5 73,772,842 (GRCm39) missense probably benign 0.01
IGL01343:Lrrc66 APN 5 73,765,806 (GRCm39) missense probably damaging 0.98
IGL01714:Lrrc66 APN 5 73,787,320 (GRCm39) missense probably benign 0.10
IGL01822:Lrrc66 APN 5 73,787,311 (GRCm39) missense probably benign 0.17
IGL02005:Lrrc66 APN 5 73,766,077 (GRCm39) missense possibly damaging 0.83
IGL02166:Lrrc66 APN 5 73,764,634 (GRCm39) missense probably damaging 0.99
IGL02380:Lrrc66 APN 5 73,787,009 (GRCm39) missense possibly damaging 0.55
IGL03162:Lrrc66 APN 5 73,764,725 (GRCm39) missense probably benign
BB002:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
BB012:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
D4043:Lrrc66 UTSW 5 73,764,869 (GRCm39) missense probably benign 0.03
R0126:Lrrc66 UTSW 5 73,764,431 (GRCm39) missense probably benign 0.10
R0437:Lrrc66 UTSW 5 73,765,030 (GRCm39) missense probably benign 0.23
R0638:Lrrc66 UTSW 5 73,772,816 (GRCm39) splice site probably benign
R0658:Lrrc66 UTSW 5 73,768,287 (GRCm39) missense probably benign 0.40
R0729:Lrrc66 UTSW 5 73,765,757 (GRCm39) missense probably benign
R1603:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1774:Lrrc66 UTSW 5 73,768,198 (GRCm39) missense probably benign 0.16
R1831:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1832:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1902:Lrrc66 UTSW 5 73,764,965 (GRCm39) missense probably damaging 0.99
R2858:Lrrc66 UTSW 5 73,764,646 (GRCm39) missense probably benign 0.08
R4097:Lrrc66 UTSW 5 73,765,047 (GRCm39) missense possibly damaging 0.94
R4164:Lrrc66 UTSW 5 73,787,119 (GRCm39) splice site probably null
R4582:Lrrc66 UTSW 5 73,765,580 (GRCm39) missense possibly damaging 0.94
R4708:Lrrc66 UTSW 5 73,787,005 (GRCm39) missense probably benign 0.06
R4856:Lrrc66 UTSW 5 73,765,910 (GRCm39) missense probably benign 0.10
R4886:Lrrc66 UTSW 5 73,765,910 (GRCm39) missense probably benign 0.10
R5074:Lrrc66 UTSW 5 73,765,354 (GRCm39) missense probably damaging 1.00
R5464:Lrrc66 UTSW 5 73,765,622 (GRCm39) missense probably benign 0.05
R5640:Lrrc66 UTSW 5 73,765,977 (GRCm39) missense probably benign 0.00
R5709:Lrrc66 UTSW 5 73,766,206 (GRCm39) missense probably benign
R5811:Lrrc66 UTSW 5 73,772,860 (GRCm39) missense possibly damaging 0.82
R6146:Lrrc66 UTSW 5 73,765,432 (GRCm39) missense probably benign 0.10
R7037:Lrrc66 UTSW 5 73,764,504 (GRCm39) missense probably benign 0.10
R7041:Lrrc66 UTSW 5 73,765,899 (GRCm39) missense possibly damaging 0.81
R7141:Lrrc66 UTSW 5 73,787,320 (GRCm39) missense probably benign 0.10
R7201:Lrrc66 UTSW 5 73,787,240 (GRCm39) missense probably benign 0.11
R7250:Lrrc66 UTSW 5 73,768,224 (GRCm39) missense probably benign 0.03
R7367:Lrrc66 UTSW 5 73,765,724 (GRCm39) missense probably benign 0.13
R7773:Lrrc66 UTSW 5 73,764,664 (GRCm39) missense probably damaging 0.98
R7925:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
R8167:Lrrc66 UTSW 5 73,786,952 (GRCm39) nonsense probably null
R8552:Lrrc66 UTSW 5 73,768,228 (GRCm39) missense probably benign 0.16
R8834:Lrrc66 UTSW 5 73,765,928 (GRCm39) missense possibly damaging 0.56
R8992:Lrrc66 UTSW 5 73,787,227 (GRCm39) missense probably benign 0.04
R9017:Lrrc66 UTSW 5 73,765,244 (GRCm39) missense possibly damaging 0.94
R9051:Lrrc66 UTSW 5 73,765,268 (GRCm39) missense probably benign 0.00
R9051:Lrrc66 UTSW 5 73,765,267 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- CACACAAGAGTCTGGACCAG -3'
(R):5'- CAGCGAGGTCCTACACAATGAC -3'

Sequencing Primer
(F):5'- GTCTGGACCAGAAATAAGAGTGTTTC -3'
(R):5'- ACCCTCTCTTAGGCCAAGATGG -3'
Posted On 2020-01-23