Incidental Mutation 'R8059:Or6d14'
ID 619595
Institutional Source Beutler Lab
Gene Symbol Or6d14
Ensembl Gene ENSMUSG00000051046
Gene Name olfactory receptor family 6 subfamily D member 14
Synonyms Olfr214, GA_x54KRFPKN04-58190962-58191900, MOR119-1
MMRRC Submission 067894-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.212) question?
Stock # R8059 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 116533388-116534350 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 116533434 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 16 (T16I)
Ref Sequence ENSEMBL: ENSMUSP00000145465 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060204] [ENSMUST00000122096] [ENSMUST00000203867] [ENSMUST00000214699] [ENSMUST00000215846] [ENSMUST00000217313]
AlphaFold Q8VG27
Predicted Effect possibly damaging
Transcript: ENSMUST00000060204
AA Change: T16I

PolyPhen 2 Score 0.468 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000052730
Gene: ENSMUSG00000051046
AA Change: T16I

DomainStartEndE-ValueType
Pfam:7tm_4 39 316 4.7e-47 PFAM
Pfam:7tm_1 49 298 5.9e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000122096
SMART Domains Protein: ENSMUSP00000145194
Gene: ENSMUSG00000107906

DomainStartEndE-ValueType
DEXDc 57 254 2.4e-59 SMART
HELICc 291 372 6.6e-38 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000203867
AA Change: T16I

PolyPhen 2 Score 0.468 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000145465
Gene: ENSMUSG00000051046
AA Change: T16I

DomainStartEndE-ValueType
Pfam:7tm_4 39 316 4.7e-47 PFAM
Pfam:7tm_1 49 298 5.9e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214699
AA Change: T16I

PolyPhen 2 Score 0.468 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215846
AA Change: T16I

PolyPhen 2 Score 0.468 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217313
AA Change: T16I

PolyPhen 2 Score 0.468 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,323,279 (GRCm39) M3372K probably benign Het
Abcg3 A T 5: 105,100,948 (GRCm39) probably null Het
Adam19 G A 11: 46,027,293 (GRCm39) probably benign Het
Adgrg6 G T 10: 14,344,794 (GRCm39) T53K probably damaging Het
Ccdc141 A C 2: 76,875,095 (GRCm39) L705R probably damaging Het
Cep78 A T 19: 15,958,876 (GRCm39) V156E probably benign Het
Cers2 A G 3: 95,229,982 (GRCm39) D342G probably damaging Het
Chl1 T A 6: 103,651,948 (GRCm39) I272N probably damaging Het
Defb30 A G 14: 63,273,383 (GRCm39) *77Q probably null Het
Dnai3 C G 3: 145,752,428 (GRCm39) R749S possibly damaging Het
Dnm3 A G 1: 161,911,708 (GRCm39) V63A probably damaging Het
Dsc2 C T 18: 20,165,331 (GRCm39) G881R possibly damaging Het
Entpd2 G T 2: 25,288,096 (GRCm39) V107L probably damaging Het
Hectd1 T A 12: 51,837,161 (GRCm39) H799L possibly damaging Het
Hira T C 16: 18,730,901 (GRCm39) V200A probably damaging Het
Hspd1 T C 1: 55,120,883 (GRCm39) K269E possibly damaging Het
Kcnj4 T C 15: 79,369,003 (GRCm39) S326G probably benign Het
Kctd19 T G 8: 106,122,983 (GRCm39) I144L probably benign Het
Lama4 T C 10: 38,842,057 (GRCm39) I36T probably benign Het
Lrrn3 T C 12: 41,504,216 (GRCm39) T34A probably benign Het
Maco1 A T 4: 134,555,359 (GRCm39) C371* probably null Het
Maml3 A G 3: 51,764,110 (GRCm39) S285P probably damaging Het
Man2b2 A G 5: 36,973,504 (GRCm39) Y492H probably damaging Het
Mapk10 G T 5: 103,114,478 (GRCm39) N303K probably damaging Het
Matn2 C T 15: 34,345,481 (GRCm39) R163C probably damaging Het
Mtmr7 C T 8: 41,034,564 (GRCm39) A253T probably damaging Het
Naca C T 10: 127,876,372 (GRCm39) P468L unknown Het
Nckap1l T C 15: 103,401,714 (GRCm39) S1084P possibly damaging Het
Nek11 T C 9: 105,040,173 (GRCm39) *629W probably null Het
Nfkb1 C T 3: 135,299,613 (GRCm39) A731T possibly damaging Het
Nop2 T C 6: 125,117,775 (GRCm39) V442A probably damaging Het
Oaz2 C T 9: 65,596,425 (GRCm39) P163L probably damaging Het
Or5p57 T C 7: 107,665,223 (GRCm39) T231A probably benign Het
Or8k23 A G 2: 86,186,306 (GRCm39) V140A probably benign Het
Pabpc2 A T 18: 39,907,875 (GRCm39) N380I probably benign Het
Pax3 T C 1: 78,080,003 (GRCm39) D461G probably benign Het
Pds5b G T 5: 150,731,300 (GRCm39) R1443L unknown Het
Per1 G A 11: 68,997,309 (GRCm39) R828H probably damaging Het
Phlpp2 T A 8: 110,622,189 (GRCm39) S144T probably benign Het
Plod1 A T 4: 148,012,941 (GRCm39) I207N probably damaging Het
Psmc6 A T 14: 45,578,260 (GRCm39) I208F probably damaging Het
Rev3l T C 10: 39,719,491 (GRCm39) S2494P probably damaging Het
Rgs3 T C 4: 62,521,214 (GRCm39) probably benign Het
Rtraf T C 14: 19,872,631 (GRCm39) probably benign Het
Slc17a6 T A 7: 51,294,792 (GRCm39) N166K probably damaging Het
Slc18a2 A T 19: 59,272,572 (GRCm39) T348S probably benign Het
Slc39a8 G T 3: 135,532,347 (GRCm39) A39S probably benign Het
Slc8a3 C T 12: 81,249,032 (GRCm39) G799S probably damaging Het
Sp1 T G 15: 102,316,337 (GRCm39) S46R possibly damaging Het
Spta1 A G 1: 174,045,936 (GRCm39) probably benign Het
Stab1 G A 14: 30,882,198 (GRCm39) P499L probably benign Het
Trav21-dv12 C A 14: 54,114,178 (GRCm39) D99E probably damaging Het
Trpv6 T G 6: 41,601,520 (GRCm39) I467L probably benign Het
Ttc41 A G 10: 86,548,842 (GRCm39) Y12C probably benign Het
Vmn1r233 T C 17: 21,214,698 (GRCm39) N84S probably benign Het
Vrtn T C 12: 84,696,690 (GRCm39) F480S probably benign Het
Zc3h13 C G 14: 75,565,250 (GRCm39) R788G unknown Het
Other mutations in Or6d14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00951:Or6d14 APN 6 116,534,027 (GRCm39) missense probably benign
IGL01837:Or6d14 APN 6 116,533,807 (GRCm39) nonsense probably null
IGL02523:Or6d14 APN 6 116,534,054 (GRCm39) missense probably benign 0.03
R0027:Or6d14 UTSW 6 116,533,910 (GRCm39) missense probably damaging 0.99
R0616:Or6d14 UTSW 6 116,533,889 (GRCm39) missense probably benign 0.00
R1121:Or6d14 UTSW 6 116,534,190 (GRCm39) missense probably damaging 0.99
R1555:Or6d14 UTSW 6 116,533,787 (GRCm39) missense probably damaging 1.00
R1691:Or6d14 UTSW 6 116,533,538 (GRCm39) missense probably benign 0.00
R2196:Or6d14 UTSW 6 116,533,578 (GRCm39) missense probably damaging 0.99
R3080:Or6d14 UTSW 6 116,534,178 (GRCm39) missense probably damaging 0.98
R5416:Or6d14 UTSW 6 116,534,166 (GRCm39) missense probably damaging 1.00
R5706:Or6d14 UTSW 6 116,534,074 (GRCm39) missense probably damaging 1.00
R6848:Or6d14 UTSW 6 116,533,736 (GRCm39) missense probably damaging 0.98
R7425:Or6d14 UTSW 6 116,533,398 (GRCm39) missense possibly damaging 0.95
R8349:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8449:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8551:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8552:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8553:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8555:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8988:Or6d14 UTSW 6 116,534,255 (GRCm39) missense possibly damaging 0.89
R9720:Or6d14 UTSW 6 116,534,016 (GRCm39) missense possibly damaging 0.61
Predicted Primers PCR Primer
(F):5'- ATTTGTATTTCAGAAATGAGAGAAGGG -3'
(R):5'- CTCCTGAGGAAGAAGTACATCG -3'

Sequencing Primer
(F):5'- CTCCTAGTGAGGCTGAACAAG -3'
(R):5'- AGTACATCGGGGTCTGCAG -3'
Posted On 2020-01-23