Incidental Mutation 'R8062:Dab2'
| ID |
619816 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dab2
|
| Ensembl Gene |
ENSMUSG00000022150 |
| Gene Name |
disabled 2, mitogen-responsive phosphoprotein |
| Synonyms |
5730435J12Rik, D15Wsu122e, D630005B22Rik, p96 |
| MMRRC Submission |
067498-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.914)
|
| Stock # |
R8062 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
6329269-6470193 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 6456822 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Aspartic acid
at position 233
(G233D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125021
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000078019]
[ENSMUST00000080880]
[ENSMUST00000110663]
[ENSMUST00000110664]
[ENSMUST00000160134]
[ENSMUST00000161040]
[ENSMUST00000161812]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000078019
|
| SMART Domains |
Protein: ENSMUSP00000077166
Gene: ENSMUSG00000022150
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
low complexity region
|
270 |
288 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
306 |
N/A |
INTRINSIC |
|
low complexity region
|
335 |
355 |
N/A |
INTRINSIC |
|
low complexity region
|
378 |
394 |
N/A |
INTRINSIC |
|
PDB:3H8D|H
|
465 |
493 |
2e-12 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000080880
|
| SMART Domains |
Protein: ENSMUSP00000079689
Gene: ENSMUSG00000022150
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
low complexity region
|
488 |
506 |
N/A |
INTRINSIC |
|
low complexity region
|
510 |
524 |
N/A |
INTRINSIC |
|
low complexity region
|
553 |
573 |
N/A |
INTRINSIC |
|
low complexity region
|
596 |
612 |
N/A |
INTRINSIC |
|
PDB:3H8D|H
|
683 |
711 |
3e-12 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110663
|
| SMART Domains |
Protein: ENSMUSP00000106291
Gene: ENSMUSG00000022150
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
low complexity region
|
270 |
288 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
306 |
N/A |
INTRINSIC |
|
low complexity region
|
335 |
355 |
N/A |
INTRINSIC |
|
low complexity region
|
378 |
394 |
N/A |
INTRINSIC |
|
PDB:3H8D|H
|
465 |
493 |
2e-12 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110664
|
| SMART Domains |
Protein: ENSMUSP00000106292
Gene: ENSMUSG00000022150
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
low complexity region
|
467 |
485 |
N/A |
INTRINSIC |
|
low complexity region
|
489 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
532 |
552 |
N/A |
INTRINSIC |
|
low complexity region
|
575 |
591 |
N/A |
INTRINSIC |
|
PDB:3H8D|H
|
662 |
690 |
3e-12 |
PDB |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160134
AA Change: G233D
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000125021
Gene: ENSMUSG00000022150
AA Change: G233D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161040
|
| SMART Domains |
Protein: ENSMUSP00000124478
Gene: ENSMUSG00000022150
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161812
|
| SMART Domains |
Protein: ENSMUSP00000124589
Gene: ENSMUSG00000022150
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
low complexity region
|
249 |
267 |
N/A |
INTRINSIC |
|
low complexity region
|
271 |
285 |
N/A |
INTRINSIC |
|
low complexity region
|
314 |
334 |
N/A |
INTRINSIC |
|
low complexity region
|
357 |
373 |
N/A |
INTRINSIC |
|
PDB:3H8D|H
|
444 |
472 |
2e-12 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163082
|
| SMART Domains |
Protein: ENSMUSP00000124996
Gene: ENSMUSG00000022150
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PTB
|
2 |
59 |
1e-33 |
BLAST |
|
PDB:1P3R|C
|
2 |
59 |
2e-34 |
PDB |
|
SCOP:d1ddma_
|
3 |
59 |
9e-12 |
SMART |
|
low complexity region
|
60 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
356 |
374 |
N/A |
INTRINSIC |
|
low complexity region
|
378 |
392 |
N/A |
INTRINSIC |
|
low complexity region
|
421 |
441 |
N/A |
INTRINSIC |
|
low complexity region
|
464 |
480 |
N/A |
INTRINSIC |
|
PDB:3H8D|H
|
551 |
579 |
3e-12 |
PDB |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous null mutants exhibit abnormal primitive endoderm structure and/or function, lack a proamniotic cavity and die prior to embryonic day 9.5. A conditional mutant survives, but shows kidney proximal tubule abnormality. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(1) |
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abce1 |
A |
T |
8: 80,427,773 (GRCm39) |
Y172N |
possibly damaging |
Het |
| Abhd2 |
T |
A |
7: 78,975,338 (GRCm39) |
M176K |
possibly damaging |
Het |
| Adamts14 |
A |
G |
10: 61,036,140 (GRCm39) |
|
probably null |
Het |
| Atg2a |
T |
C |
19: 6,302,609 (GRCm39) |
|
probably null |
Het |
| Bach2 |
G |
A |
4: 32,562,937 (GRCm39) |
G468E |
probably damaging |
Het |
| Bap1 |
T |
A |
14: 30,979,465 (GRCm39) |
N489K |
probably benign |
Het |
| Btaf1 |
G |
A |
19: 36,969,865 (GRCm39) |
V1180I |
probably benign |
Het |
| Calm5 |
A |
G |
13: 3,904,405 (GRCm39) |
H33R |
probably benign |
Het |
| Cby2 |
A |
T |
14: 75,830,046 (GRCm39) |
I49N |
probably benign |
Het |
| Cnr1 |
T |
A |
4: 33,944,707 (GRCm39) |
V365E |
possibly damaging |
Het |
| Crym |
A |
C |
7: 119,800,391 (GRCm39) |
V77G |
probably damaging |
Het |
| Cyp2j7 |
T |
A |
4: 96,103,587 (GRCm39) |
E316V |
probably null |
Het |
| Ddx19b |
A |
T |
8: 111,747,611 (GRCm39) |
S108T |
probably benign |
Het |
| Dsc2 |
C |
T |
18: 20,165,331 (GRCm39) |
G881R |
possibly damaging |
Het |
| Duxf1 |
G |
A |
10: 58,059,632 (GRCm39) |
A374V |
unknown |
Het |
| Duxf3 |
A |
C |
10: 58,066,750 (GRCm39) |
M93R |
probably benign |
Het |
| Duxf3 |
G |
A |
10: 58,066,889 (GRCm39) |
L537F |
probably damaging |
Het |
| Eif2s2 |
A |
G |
2: 154,719,724 (GRCm39) |
F182L |
possibly damaging |
Het |
| Erlin1 |
T |
A |
19: 44,044,598 (GRCm39) |
K156I |
probably benign |
Het |
| Gapvd1 |
A |
G |
2: 34,568,126 (GRCm39) |
S1413P |
probably benign |
Het |
| Gm1110 |
G |
A |
9: 26,793,117 (GRCm39) |
A553V |
probably damaging |
Het |
| Gm3250 |
C |
A |
10: 77,618,234 (GRCm39) |
C48F |
unknown |
Het |
| Gm3604 |
T |
C |
13: 62,518,155 (GRCm39) |
S68G |
probably damaging |
Het |
| Golga5 |
T |
A |
12: 102,450,739 (GRCm39) |
M464K |
probably benign |
Het |
| Gpr142 |
G |
A |
11: 114,697,357 (GRCm39) |
R301Q |
probably benign |
Het |
| Gria4 |
C |
T |
9: 4,480,273 (GRCm39) |
D392N |
possibly damaging |
Het |
| Grik2 |
T |
A |
10: 49,116,863 (GRCm39) |
T633S |
probably damaging |
Het |
| Gsap |
T |
A |
5: 21,399,461 (GRCm39) |
I54N |
probably damaging |
Het |
| Hdlbp |
A |
G |
1: 93,366,064 (GRCm39) |
Y40H |
probably benign |
Het |
| Hyal5 |
C |
A |
6: 24,876,196 (GRCm39) |
T23K |
possibly damaging |
Het |
| Iqank1 |
G |
A |
15: 75,918,603 (GRCm39) |
R508H |
probably benign |
Het |
| Itga6 |
T |
A |
2: 71,672,087 (GRCm39) |
F834L |
probably benign |
Het |
| Klf1 |
T |
A |
8: 85,629,928 (GRCm39) |
L251Q |
probably benign |
Het |
| Kndc1 |
A |
G |
7: 139,498,760 (GRCm39) |
D558G |
probably benign |
Het |
| Ktn1 |
T |
A |
14: 47,962,429 (GRCm39) |
|
probably null |
Het |
| Lcmt2 |
A |
G |
2: 120,970,753 (GRCm39) |
V110A |
possibly damaging |
Het |
| Lgr4 |
C |
T |
2: 109,831,282 (GRCm39) |
R304C |
probably damaging |
Het |
| Lnpk |
T |
A |
2: 74,381,407 (GRCm39) |
I119L |
possibly damaging |
Het |
| Med13 |
A |
G |
11: 86,210,264 (GRCm39) |
V626A |
probably benign |
Het |
| Mroh9 |
A |
T |
1: 162,866,544 (GRCm39) |
L700M |
probably damaging |
Het |
| Muc4 |
T |
A |
16: 32,577,123 (GRCm39) |
W138R |
|
Het |
| Myh2 |
G |
T |
11: 67,084,209 (GRCm39) |
E1611* |
probably null |
Het |
| Myo9b |
T |
G |
8: 71,774,457 (GRCm39) |
S323A |
probably damaging |
Het |
| Or2n1c |
A |
T |
17: 38,520,065 (GRCm39) |
I310F |
probably benign |
Het |
| Or4c52 |
T |
A |
2: 89,846,080 (GRCm39) |
F269I |
possibly damaging |
Het |
| Or5t7 |
A |
C |
2: 86,507,410 (GRCm39) |
V89G |
probably benign |
Het |
| Or8b101 |
G |
T |
9: 38,020,213 (GRCm39) |
C72F |
probably damaging |
Het |
| P2ry13 |
A |
T |
3: 59,117,703 (GRCm39) |
M25K |
probably benign |
Het |
| Pan3 |
T |
A |
5: 147,463,960 (GRCm39) |
F571Y |
probably benign |
Het |
| Pdcd11 |
A |
G |
19: 47,119,152 (GRCm39) |
D1831G |
possibly damaging |
Het |
| Peg10 |
CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG |
CCACATCAGGATCCACATCAGGATGCACATCAG |
6: 4,756,398 (GRCm39) |
|
probably benign |
Het |
| Pex1 |
T |
G |
5: 3,655,656 (GRCm39) |
M161R |
probably benign |
Het |
| Piezo2 |
T |
A |
18: 63,163,537 (GRCm39) |
D2127V |
possibly damaging |
Het |
| Plod3 |
A |
T |
5: 137,019,123 (GRCm39) |
H336L |
possibly damaging |
Het |
| Pp2d1 |
A |
T |
17: 53,822,798 (GRCm39) |
N89K |
probably benign |
Het |
| Ppp4r3a |
A |
G |
12: 101,008,230 (GRCm39) |
S736P |
probably damaging |
Het |
| Prp2 |
C |
A |
6: 132,577,651 (GRCm39) |
Q313K |
unknown |
Het |
| Psma5 |
T |
G |
3: 108,173,795 (GRCm39) |
D90E |
probably benign |
Het |
| Reln |
G |
A |
5: 22,176,990 (GRCm39) |
T1892I |
probably benign |
Het |
| Rictor |
C |
T |
15: 6,801,635 (GRCm39) |
S441L |
probably benign |
Het |
| Rsf1 |
T |
G |
7: 97,326,594 (GRCm39) |
D1039E |
|
Het |
| Rtel1 |
A |
G |
2: 180,982,360 (GRCm39) |
D370G |
probably benign |
Het |
| Scyl2 |
T |
A |
10: 89,490,022 (GRCm39) |
N447Y |
probably damaging |
Het |
| Sis |
A |
T |
3: 72,828,321 (GRCm39) |
Y1222* |
probably null |
Het |
| Slc37a3 |
A |
T |
6: 39,341,530 (GRCm39) |
H35Q |
probably damaging |
Het |
| Sltm |
A |
T |
9: 70,480,779 (GRCm39) |
K210N |
unknown |
Het |
| Spata3 |
T |
C |
1: 85,952,148 (GRCm39) |
I134T |
unknown |
Het |
| Speer4d |
A |
T |
5: 15,825,437 (GRCm39) |
N54I |
possibly damaging |
Het |
| Syne1 |
A |
G |
10: 5,135,394 (GRCm39) |
|
probably null |
Het |
| Tars1 |
A |
T |
15: 11,388,400 (GRCm39) |
F465Y |
possibly damaging |
Het |
| Tlr4 |
T |
G |
4: 66,758,087 (GRCm39) |
N293K |
probably benign |
Het |
| Tmprss13 |
C |
A |
9: 45,239,986 (GRCm39) |
T98K |
unknown |
Het |
| Tnfsf8 |
G |
A |
4: 63,779,432 (GRCm39) |
|
probably benign |
Het |
| Trim30b |
T |
A |
7: 104,015,393 (GRCm39) |
|
probably benign |
Het |
| Trpm1 |
A |
G |
7: 63,851,689 (GRCm39) |
K136E |
probably benign |
Het |
| Ttc6 |
A |
G |
12: 57,783,764 (GRCm39) |
Y1741C |
possibly damaging |
Het |
| Usp38 |
T |
C |
8: 81,711,218 (GRCm39) |
D939G |
probably damaging |
Het |
| Vmn1r196 |
T |
A |
13: 22,477,440 (GRCm39) |
N26K |
probably damaging |
Het |
| Vmn2r50 |
C |
A |
7: 9,774,240 (GRCm39) |
|
probably null |
Het |
| Wdr3 |
T |
A |
3: 100,049,810 (GRCm39) |
M773L |
probably benign |
Het |
| Zfp993 |
T |
G |
4: 146,739,415 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Dab2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00586:Dab2
|
APN |
15 |
6,459,306 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00731:Dab2
|
APN |
15 |
6,465,191 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02382:Dab2
|
APN |
15 |
6,466,468 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL02598:Dab2
|
APN |
15 |
6,458,847 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03054:Dab2
|
APN |
15 |
6,447,707 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03093:Dab2
|
APN |
15 |
6,465,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03369:Dab2
|
APN |
15 |
6,464,790 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL03372:Dab2
|
APN |
15 |
6,459,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0157:Dab2
|
UTSW |
15 |
6,459,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0326:Dab2
|
UTSW |
15 |
6,447,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0488:Dab2
|
UTSW |
15 |
6,454,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0552:Dab2
|
UTSW |
15 |
6,464,895 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0938:Dab2
|
UTSW |
15 |
6,464,865 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1433:Dab2
|
UTSW |
15 |
6,459,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1635:Dab2
|
UTSW |
15 |
6,459,351 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1713:Dab2
|
UTSW |
15 |
6,459,182 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1757:Dab2
|
UTSW |
15 |
6,359,933 (GRCm39) |
intron |
probably benign |
|
|
R1800:Dab2
|
UTSW |
15 |
6,464,948 (GRCm39) |
missense |
probably benign |
|
|
R1837:Dab2
|
UTSW |
15 |
6,365,957 (GRCm39) |
intron |
probably benign |
|
|
R1999:Dab2
|
UTSW |
15 |
6,446,398 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2050:Dab2
|
UTSW |
15 |
6,464,696 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R2117:Dab2
|
UTSW |
15 |
6,465,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2129:Dab2
|
UTSW |
15 |
6,365,864 (GRCm39) |
nonsense |
probably null |
|
|
R2150:Dab2
|
UTSW |
15 |
6,446,398 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2329:Dab2
|
UTSW |
15 |
6,459,044 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2338:Dab2
|
UTSW |
15 |
6,464,733 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R2680:Dab2
|
UTSW |
15 |
6,466,474 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3978:Dab2
|
UTSW |
15 |
6,464,644 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3979:Dab2
|
UTSW |
15 |
6,464,644 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3980:Dab2
|
UTSW |
15 |
6,464,644 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4551:Dab2
|
UTSW |
15 |
6,464,775 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4795:Dab2
|
UTSW |
15 |
6,459,092 (GRCm39) |
missense |
probably benign |
0.16 |
|
R4829:Dab2
|
UTSW |
15 |
6,454,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4830:Dab2
|
UTSW |
15 |
6,457,008 (GRCm39) |
missense |
probably benign |
|
|
R4832:Dab2
|
UTSW |
15 |
6,366,080 (GRCm39) |
splice site |
probably null |
|
|
R5168:Dab2
|
UTSW |
15 |
6,365,924 (GRCm39) |
intron |
probably benign |
|
|
R5620:Dab2
|
UTSW |
15 |
6,447,796 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5996:Dab2
|
UTSW |
15 |
6,464,792 (GRCm39) |
nonsense |
probably null |
|
|
R6159:Dab2
|
UTSW |
15 |
6,465,941 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6998:Dab2
|
UTSW |
15 |
6,454,130 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7002:Dab2
|
UTSW |
15 |
6,464,846 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Dab2
|
UTSW |
15 |
6,451,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7138:Dab2
|
UTSW |
15 |
6,458,780 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7448:Dab2
|
UTSW |
15 |
6,451,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7548:Dab2
|
UTSW |
15 |
6,459,399 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8124:Dab2
|
UTSW |
15 |
6,458,878 (GRCm39) |
nonsense |
probably null |
|
|
R8164:Dab2
|
UTSW |
15 |
6,460,449 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8171:Dab2
|
UTSW |
15 |
6,453,407 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8230:Dab2
|
UTSW |
15 |
6,451,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8372:Dab2
|
UTSW |
15 |
6,446,406 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8427:Dab2
|
UTSW |
15 |
6,458,840 (GRCm39) |
nonsense |
probably null |
|
|
R8919:Dab2
|
UTSW |
15 |
6,465,271 (GRCm39) |
missense |
|
|
|
R9363:Dab2
|
UTSW |
15 |
6,460,481 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9461:Dab2
|
UTSW |
15 |
6,460,435 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9532:Dab2
|
UTSW |
15 |
6,451,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9779:Dab2
|
UTSW |
15 |
6,460,525 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGGTCCTACCATGTAAGCAGTC -3'
(R):5'- ACCAAACAGGAGTCACAATGTTAG -3'
Sequencing Primer
(F):5'- TGTAAGCAGTCTGAAAACCGATC -3'
(R):5'- ATGTTAGACTTCTGAACAGTCACCC -3'
|
| Posted On |
2020-01-23 |
Incidental Mutation