Incidental Mutation 'R8063:Or10d4b'
ID 619853
Institutional Source Beutler Lab
Gene Symbol Or10d4b
Ensembl Gene ENSMUSG00000059867
Gene Name olfactory receptor family 10 subfamily D member 4B
Synonyms GA_x6K02T2PVTD-33320043-33320987, Olfr960, MOR224-12
MMRRC Submission 067499-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R8063 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 39534421-39535461 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 39534823 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 133 (I133F)
Ref Sequence ENSEMBL: ENSMUSP00000148949 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077060] [ENSMUST00000216584]
AlphaFold Q8VET5
Predicted Effect probably damaging
Transcript: ENSMUST00000077060
AA Change: I135F

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000076315
Gene: ENSMUSG00000059867
AA Change: I135F

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1.3e-48 PFAM
Pfam:7tm_1 41 288 1e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216584
AA Change: I133F

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 98% (53/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ace T A 11: 105,862,190 (GRCm39) I248N possibly damaging Het
Agk T A 6: 40,306,490 (GRCm39) C20S possibly damaging Het
Alpk2 G A 18: 65,483,417 (GRCm39) S197L probably benign Het
Armc10 T C 5: 21,853,768 (GRCm39) probably null Het
Asxl2 A G 12: 3,550,768 (GRCm39) T837A probably benign Het
Atp12a A G 14: 56,603,545 (GRCm39) E50G probably damaging Het
Bend5 G T 4: 111,317,031 (GRCm39) C398F probably damaging Het
Bicra A G 7: 15,712,969 (GRCm39) V1026A probably benign Het
Canx A T 11: 50,199,173 (GRCm39) Y165* probably null Het
Casp14 A G 10: 78,549,865 (GRCm39) F210L probably damaging Het
Cep70 T A 9: 99,178,175 (GRCm39) D458E probably benign Het
Cisd3 T C 11: 97,576,710 (GRCm39) V12A probably benign Het
Cnot4 A T 6: 35,045,578 (GRCm39) M211K probably damaging Het
Cyp4f18 A G 8: 72,752,075 (GRCm39) L197P probably damaging Het
Dnah5 T A 15: 28,230,729 (GRCm39) I209N probably benign Het
Dsc2 C T 18: 20,165,331 (GRCm39) G881R possibly damaging Het
Edem2 A T 2: 155,544,376 (GRCm39) M458K probably benign Het
Eif2ak4 G A 2: 118,241,382 (GRCm39) E178K possibly damaging Het
Fars2 G A 13: 36,388,880 (GRCm39) W123* probably null Het
Ighv1-20 T C 12: 114,687,405 (GRCm39) Y113C probably damaging Het
Il18r1 T A 1: 40,526,198 (GRCm39) I248N probably benign Het
Impg2 T A 16: 56,081,819 (GRCm39) probably benign Het
Kcnh2 T C 5: 24,526,670 (GRCm39) E1042G probably benign Het
Krt42 G C 11: 100,155,865 (GRCm39) R294G possibly damaging Het
Lasp1 T C 11: 97,724,957 (GRCm39) Y188H probably benign Het
Lrrc37 T C 11: 103,433,087 (GRCm39) T3361A unknown Het
Lrrc52 A G 1: 167,294,090 (GRCm39) I65T probably damaging Het
Megf9 A G 4: 70,406,495 (GRCm39) C224R probably damaging Het
Ms4a10 T C 19: 10,942,136 (GRCm39) T162A probably benign Het
Mstn T A 1: 53,105,607 (GRCm39) F316L probably benign Het
Ndufs8 T C 19: 3,961,019 (GRCm39) Y86C probably damaging Het
Pappa2 C T 1: 158,764,126 (GRCm39) D462N possibly damaging Het
Rad51d A G 11: 82,780,597 (GRCm39) S62P probably benign Het
Ralgapa2 A G 2: 146,285,775 (GRCm39) Y388H probably damaging Het
Rdm1 C A 11: 101,521,694 (GRCm39) Q150K probably benign Het
Rictor C T 15: 6,801,635 (GRCm39) S441L probably benign Het
Sctr T C 1: 119,991,005 (GRCm39) V446A probably benign Het
Sin3b G A 8: 73,452,169 (GRCm39) D71N probably damaging Het
Sirt5 A T 13: 43,524,323 (GRCm39) T32S probably benign Het
Slc17a1 T C 13: 24,059,524 (GRCm39) V85A probably benign Het
Snx1 C T 9: 66,004,676 (GRCm39) probably benign Het
Sorcs1 T A 19: 50,132,415 (GRCm39) D1181V unknown Het
Tcof1 A G 18: 60,971,834 (GRCm39) S158P probably damaging Het
Tet3 T C 6: 83,379,723 (GRCm39) D815G probably damaging Het
Tnfsf11 A T 14: 78,516,098 (GRCm39) I290N probably damaging Het
Uba6 A T 5: 86,300,544 (GRCm39) N225K probably benign Het
Usp30 A G 5: 114,238,524 (GRCm39) T11A probably benign Het
Vmn1r5 T G 6: 56,962,583 (GRCm39) M86R probably damaging Het
Vmn2r26 T A 6: 124,001,914 (GRCm39) H66Q probably benign Het
Vps13d T C 4: 144,841,327 (GRCm39) E2647G Het
Wdr5b T A 16: 35,862,158 (GRCm39) D92E possibly damaging Het
Zfp960 C A 17: 17,308,623 (GRCm39) R446S probably benign Het
Zscan20 C T 4: 128,480,028 (GRCm39) S821N probably benign Het
Other mutations in Or10d4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01012:Or10d4b APN 9 39,534,661 (GRCm39) missense probably benign 0.37
IGL03031:Or10d4b APN 9 39,534,694 (GRCm39) missense probably damaging 1.00
IGL03199:Or10d4b APN 9 39,535,240 (GRCm39) missense probably benign 0.02
R2510:Or10d4b UTSW 9 39,534,727 (GRCm39) missense probably damaging 1.00
R4829:Or10d4b UTSW 9 39,534,734 (GRCm39) missense probably damaging 1.00
R5039:Or10d4b UTSW 9 39,534,856 (GRCm39) missense possibly damaging 0.68
R5394:Or10d4b UTSW 9 39,534,430 (GRCm39) missense probably benign 0.20
R5934:Or10d4b UTSW 9 39,534,479 (GRCm39) missense probably damaging 1.00
R6030:Or10d4b UTSW 9 39,534,637 (GRCm39) missense probably damaging 1.00
R6030:Or10d4b UTSW 9 39,534,637 (GRCm39) missense probably damaging 1.00
R7491:Or10d4b UTSW 9 39,535,268 (GRCm39) missense possibly damaging 0.65
R7509:Or10d4b UTSW 9 39,534,623 (GRCm39) missense probably damaging 0.96
R9133:Or10d4b UTSW 9 39,534,809 (GRCm39) nonsense probably null
R9653:Or10d4b UTSW 9 39,535,154 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGACATGGGCTTCTGTTCCAC -3'
(R):5'- ATTTGTGAAACCTACCCTCTGTGC -3'

Sequencing Primer
(F):5'- TGTTCCACTACAGCTCCCAAGATG -3'
(R):5'- CTGTGCTAGAGAGGAATCTTCAC -3'
Posted On 2020-01-23