Incidental Mutation 'R8066:Vmn1r8'
ID619993
Institutional Source Beutler Lab
Gene Symbol Vmn1r8
Ensembl Gene ENSMUSG00000061208
Gene Namevomeronasal 1 receptor 8
SynonymsV1rc32
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock #R8066 (G1)
Quality Score225.009
Status Not validated
Chromosome6
Chromosomal Location57032284-57037391 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 57036434 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Valine at position 157 (M157V)
Ref Sequence ENSEMBL: ENSMUSP00000093561 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078186] [ENSMUST00000227706] [ENSMUST00000228690]
Predicted Effect probably benign
Transcript: ENSMUST00000078186
AA Change: M157V

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000093561
Gene: ENSMUSG00000061208
AA Change: M157V

DomainStartEndE-ValueType
Pfam:V1R 28 293 1.2e-58 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000227706
AA Change: M157V

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000228690
AA Change: M157V

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700022I11Rik C A 4: 42,971,929 Q421K possibly damaging Het
3632451O06Rik T C 14: 49,768,523 T572A possibly damaging Het
Acap1 A G 11: 69,889,863 V177A probably benign Het
Acsm2 C A 7: 119,591,325 T517K probably damaging Het
Adam29 T G 8: 55,872,668 L250F probably benign Het
Ankrd37 T C 8: 45,997,689 D135G probably benign Het
Aspa T C 11: 73,313,546 K199E possibly damaging Het
Aurka A T 2: 172,370,418 I13K probably benign Het
Bag6 A G 17: 35,142,307 D446G unknown Het
Bcar3 A T 3: 122,524,924 I654F probably damaging Het
Ccdc188 A T 16: 18,219,194 N210Y probably damaging Het
Ccdc25 A T 14: 65,846,302 D28V possibly damaging Het
Cdc37 C T 9: 21,143,141 E63K probably benign Het
Chrm4 T A 2: 91,927,697 L150H probably damaging Het
Col5a2 A T 1: 45,413,468 probably null Het
Ctr9 T A 7: 111,033,897 Y117* probably null Het
Cyp4f37 C A 17: 32,635,073 R499S probably benign Het
Egr4 T C 6: 85,512,295 Y261C probably damaging Het
Fanca A T 8: 123,303,940 C468S unknown Het
Gart T C 16: 91,639,447 N141D probably benign Het
Get4 G A 5: 139,263,538 V126M probably damaging Het
Gja3 T C 14: 57,035,806 S370G probably benign Het
Gopc T C 10: 52,354,716 K162R probably benign Het
Grpel1 A G 5: 36,469,545 D57G probably benign Het
Hmmr G A 11: 40,721,672 S206F probably damaging Het
Kcnma1 A G 14: 23,311,676 L1149P probably benign Het
Lmbrd2 G A 15: 9,172,085 R322Q probably benign Het
Lrrc59 T C 11: 94,634,600 L74P possibly damaging Het
Mcam G T 9: 44,140,960 K589N probably damaging Het
Mgea5 T C 19: 45,771,852 K289R probably damaging Het
Myl10 G C 5: 136,697,971 V70L probably benign Het
Nadk G T 4: 155,577,067 D17Y probably benign Het
Nrap A T 19: 56,354,130 L813Q possibly damaging Het
Olfr239 T C 17: 33,199,152 F35L probably benign Het
Olfr307 A T 7: 86,335,806 C197S probably benign Het
Olfr690 C T 7: 105,329,554 V213I possibly damaging Het
Pcdhga8 A T 18: 37,726,382 I164L probably benign Het
Pck2 C A 14: 55,544,401 P251H probably benign Het
Phip A T 9: 82,875,298 I1607K probably benign Het
Piwil2 T C 14: 70,420,719 T220A probably benign Het
Plch1 G A 3: 63,711,057 Q686* probably null Het
Pnpla2 A G 7: 141,459,668 *487W probably null Het
Prdm14 C A 1: 13,114,316 G544C probably benign Het
Psg22 A G 7: 18,718,293 E45G possibly damaging Het
Psmb5 T C 14: 54,614,241 D249G probably benign Het
Pstpip1 A G 9: 56,126,629 I296V probably benign Het
S1pr3 T A 13: 51,419,919 *379R probably null Het
Smc3 G A 19: 53,615,145 R57H probably damaging Het
Srcap C T 7: 127,521,632 R155C probably damaging Het
Srcap T A 7: 127,540,312 H1268Q possibly damaging Het
Srgap3 A G 6: 112,771,378 F438L probably damaging Het
Svep1 A G 4: 58,113,650 V999A probably benign Het
Tchp T A 5: 114,709,411 L97Q probably benign Het
Tex46 G A 4: 136,612,954 V117M probably benign Het
Tnnc2 T A 2: 164,777,741 I102F possibly damaging Het
Trbv5 T A 6: 41,062,392 C12S probably damaging Het
Trub2 T A 2: 29,777,855 T258S possibly damaging Het
Uba3 T A 6: 97,201,921 N87I probably damaging Het
Vmn1r160 A T 7: 22,871,890 I223F probably damaging Het
Vmn1r192 G T 13: 22,187,395 Y218* probably null Het
Vps53 T C 11: 76,136,307 E127G probably damaging Het
Vsig10 G T 5: 117,351,784 E538D probably benign Het
Wisp2 G T 2: 163,828,942 C123F probably damaging Het
Zfp647 A T 15: 76,911,895 H188Q probably damaging Het
Other mutations in Vmn1r8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01569:Vmn1r8 APN 6 57036287 missense possibly damaging 0.70
IGL01820:Vmn1r8 APN 6 57036668 missense possibly damaging 0.94
IGL02416:Vmn1r8 APN 6 57036620 missense probably damaging 0.97
IGL02496:Vmn1r8 APN 6 57036571 missense probably damaging 1.00
IGL02930:Vmn1r8 APN 6 57036594 missense probably benign 0.03
IGL02954:Vmn1r8 APN 6 57036330 missense probably benign 0.03
IGL03235:Vmn1r8 APN 6 57036761 nonsense probably null
IGL03353:Vmn1r8 APN 6 57036791 missense probably benign 0.03
PIT4494001:Vmn1r8 UTSW 6 57036727 missense probably benign 0.01
R0656:Vmn1r8 UTSW 6 57036588 missense probably benign 0.35
R1328:Vmn1r8 UTSW 6 57036293 missense possibly damaging 0.94
R1846:Vmn1r8 UTSW 6 57036428 missense probably benign 0.06
R2083:Vmn1r8 UTSW 6 57036340 missense probably benign 0.21
R3683:Vmn1r8 UTSW 6 57036275 missense probably damaging 1.00
R4134:Vmn1r8 UTSW 6 57036720 missense probably benign
R4754:Vmn1r8 UTSW 6 57035967 start codon destroyed probably null 1.00
R4857:Vmn1r8 UTSW 6 57036353 missense probably benign 0.00
R5787:Vmn1r8 UTSW 6 57036259 missense probably damaging 1.00
R6158:Vmn1r8 UTSW 6 57036289 missense probably benign 0.00
R6711:Vmn1r8 UTSW 6 57036459 missense probably damaging 1.00
R6971:Vmn1r8 UTSW 6 57036415 missense probably damaging 1.00
R8261:Vmn1r8 UTSW 6 57036173 missense probably benign 0.00
R8526:Vmn1r8 UTSW 6 57036377 missense probably benign 0.05
R8552:Vmn1r8 UTSW 6 57036153 missense possibly damaging 0.76
R8692:Vmn1r8 UTSW 6 57036572 missense probably benign 0.01
R8712:Vmn1r8 UTSW 6 57036680 missense probably benign 0.07
Predicted Primers PCR Primer
(F):5'- TCAGAGTGATGAGAGGCCTC -3'
(R):5'- TGGCTGAAGCTATGAAGATGC -3'

Sequencing Primer
(F):5'- CTCCTGAGTGTGTTCCAGGC -3'
(R):5'- AGCTATGAAGATGCTTGCATTGCC -3'
Posted On2020-01-23