Incidental Mutation 'R8067:Cd209c'
ID 620062
Institutional Source Beutler Lab
Gene Symbol Cd209c
Ensembl Gene ENSMUSG00000040165
Gene Name CD209c antigen
Synonyms mSIGNR2, SIGNR2
MMRRC Submission 067502-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # R8067 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 3990222-4004746 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 3995700 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 34 (M34R)
Ref Sequence ENSEMBL: ENSMUSP00000039861 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044060] [ENSMUST00000208622]
AlphaFold Q91ZW9
Predicted Effect probably benign
Transcript: ENSMUST00000044060
AA Change: M34R

PolyPhen 2 Score 0.124 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000039861
Gene: ENSMUSG00000040165
AA Change: M34R

DomainStartEndE-ValueType
CLECT 48 169 7.66e-30 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000208622
AA Change: M34R

PolyPhen 2 Score 0.517 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (45/45)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700029H14Rik A T 8: 13,608,643 (GRCm39) D145E possibly damaging Het
Adcy7 T C 8: 89,037,697 (GRCm39) L255P probably damaging Het
Cbx7 A T 15: 79,818,099 (GRCm39) V1D unknown Het
Chodl A T 16: 78,743,601 (GRCm39) L229F probably damaging Het
Depdc5 C A 5: 33,053,252 (GRCm39) N197K possibly damaging Het
Dnai1 T A 4: 41,614,258 (GRCm39) D311E probably damaging Het
Dop1a A G 9: 86,400,392 (GRCm39) Y1017C probably benign Het
Dop1b T A 16: 93,562,336 (GRCm39) L927* probably null Het
Dpp10 A G 1: 123,280,389 (GRCm39) S646P probably benign Het
Ebf1 G A 11: 44,511,374 (GRCm39) V90M probably benign Het
Efhd1 C T 1: 87,192,313 (GRCm39) P48S probably benign Het
Fam83b T C 9: 76,398,380 (GRCm39) T908A probably benign Het
Fbxl16 G A 17: 26,036,957 (GRCm39) V313I probably damaging Het
Git2 C T 5: 114,904,579 (GRCm39) M113I probably damaging Het
Gpr87 T A 3: 59,087,308 (GRCm39) I66F probably damaging Het
H60c A C 10: 3,209,338 (GRCm39) L217V unknown Het
Iba57 T C 11: 59,054,086 (GRCm39) probably benign Het
Igkv11-125 C A 6: 67,890,814 (GRCm39) T44N probably benign Het
Itih2 T A 2: 10,128,294 (GRCm39) I136F probably damaging Het
Itpr3 T A 17: 27,329,836 (GRCm39) D1543E probably benign Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Mylk A T 16: 34,792,389 (GRCm39) E1570V probably benign Het
N4bp2 T A 5: 65,964,639 (GRCm39) L896H probably damaging Het
Ndc1 T A 4: 107,247,595 (GRCm39) S468T probably benign Het
Ndst3 T C 3: 123,395,094 (GRCm39) N512S probably damaging Het
Or51b6 A G 7: 103,555,610 (GRCm39) probably benign Het
Or5w15 T A 2: 87,568,147 (GRCm39) I174F probably damaging Het
Plekhn1 T C 4: 156,312,697 (GRCm39) I54V possibly damaging Het
Polr3c T C 3: 96,622,968 (GRCm39) E350G probably null Het
Prpf8 T C 11: 75,390,976 (GRCm39) W1342R probably damaging Het
Pum1 T C 4: 130,478,836 (GRCm39) V486A possibly damaging Het
Rin2 T G 2: 145,702,977 (GRCm39) S558A probably damaging Het
Ripk4 A T 16: 97,564,737 (GRCm39) V58D probably damaging Het
Smyd3 A G 1: 179,238,028 (GRCm39) M113T possibly damaging Het
Spock1 A T 13: 57,843,984 (GRCm39) probably null Het
Srgap3 C T 6: 112,716,325 (GRCm39) R625H probably benign Het
Tasor2 C T 13: 3,619,602 (GRCm39) V2210I probably benign Het
Tmed2 T C 5: 124,684,986 (GRCm39) I134T possibly damaging Het
Washc2 T A 6: 116,201,464 (GRCm39) S353R probably damaging Het
Xdh T A 17: 74,207,652 (GRCm39) R902W probably benign Het
Zbtb5 A T 4: 44,994,972 (GRCm39) S137R probably benign Het
Zfp286 A T 11: 62,644,345 (GRCm39) I192K unknown Het
Zfp942 T C 17: 22,149,391 (GRCm39) Y38C probably damaging Het
Zfpm1 T C 8: 123,062,323 (GRCm39) S461P probably benign Het
Other mutations in Cd209c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Cd209c APN 8 3,990,339 (GRCm39) missense probably damaging 1.00
IGL01340:Cd209c APN 8 3,995,892 (GRCm39) missense probably benign 0.00
IGL02682:Cd209c APN 8 3,990,324 (GRCm39) missense probably damaging 0.99
R1311:Cd209c UTSW 8 3,995,908 (GRCm39) start codon destroyed probably benign
R1859:Cd209c UTSW 8 3,994,953 (GRCm39) missense probably benign
R4374:Cd209c UTSW 8 4,004,635 (GRCm39) exon noncoding transcript
R4375:Cd209c UTSW 8 4,004,635 (GRCm39) exon noncoding transcript
R4377:Cd209c UTSW 8 4,004,635 (GRCm39) exon noncoding transcript
R4769:Cd209c UTSW 8 3,994,953 (GRCm39) missense probably benign
R4786:Cd209c UTSW 8 3,995,698 (GRCm39) missense possibly damaging 0.77
R4841:Cd209c UTSW 8 3,995,905 (GRCm39) missense probably benign 0.00
R4842:Cd209c UTSW 8 3,995,905 (GRCm39) missense probably benign 0.00
R4869:Cd209c UTSW 8 3,994,077 (GRCm39) missense probably benign 0.00
R5333:Cd209c UTSW 8 3,994,976 (GRCm39) missense probably damaging 1.00
R5835:Cd209c UTSW 8 3,995,699 (GRCm39) missense probably benign 0.01
R6369:Cd209c UTSW 8 3,994,984 (GRCm39) missense probably damaging 1.00
R6497:Cd209c UTSW 8 3,994,122 (GRCm39) missense possibly damaging 0.72
R6591:Cd209c UTSW 8 3,995,680 (GRCm39) missense probably benign 0.14
R6691:Cd209c UTSW 8 3,995,680 (GRCm39) missense probably benign 0.14
R7181:Cd209c UTSW 8 3,995,712 (GRCm39) missense probably benign 0.01
R8701:Cd209c UTSW 8 3,995,892 (GRCm39) missense probably benign 0.00
R9722:Cd209c UTSW 8 3,995,905 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CAACTTCTGGTGGCTCAACC -3'
(R):5'- TGTGACACTTTGTCCACAGC -3'

Sequencing Primer
(F):5'- GTTGTAACTGCTGAGCCATCCAG -3'
(R):5'- CCCGCCTACAGTTTTTAAAAAGAGG -3'
Posted On 2020-01-23