Incidental Mutation 'R8069:Dido1'
ID 620149
Institutional Source Beutler Lab
Gene Symbol Dido1
Ensembl Gene ENSMUSG00000038914
Gene Name death inducer-obliterator 1
Synonyms D130048F08Rik, Datf1, 6720461J16Rik, dido, DIO-1, C130092D22Rik
MMRRC Submission 067504-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.960) question?
Stock # R8069 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 180299757-180351792 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 180302705 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 1733 (D1733G)
Ref Sequence ENSEMBL: ENSMUSP00000084794 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087517]
AlphaFold Q8C9B9
Predicted Effect probably benign
Transcript: ENSMUST00000087517
AA Change: D1733G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000084794
Gene: ENSMUSG00000038914
AA Change: D1733G

DomainStartEndE-ValueType
low complexity region 134 155 N/A INTRINSIC
PHD 267 317 1.19e-11 SMART
low complexity region 430 446 N/A INTRINSIC
TFS2M 669 770 1.16e-45 SMART
low complexity region 937 962 N/A INTRINSIC
low complexity region 1023 1037 N/A INTRINSIC
Pfam:SPOC 1052 1158 1e-22 PFAM
low complexity region 1253 1267 N/A INTRINSIC
low complexity region 1279 1308 N/A INTRINSIC
low complexity region 1372 1391 N/A INTRINSIC
coiled coil region 1458 1502 N/A INTRINSIC
low complexity region 1649 1680 N/A INTRINSIC
low complexity region 1748 1766 N/A INTRINSIC
low complexity region 1780 1792 N/A INTRINSIC
low complexity region 1804 1815 N/A INTRINSIC
internal_repeat_2 1816 1852 3.9e-5 PROSPERO
internal_repeat_1 1819 1859 6.92e-7 PROSPERO
internal_repeat_2 1926 1964 3.9e-5 PROSPERO
internal_repeat_1 1940 1982 6.92e-7 PROSPERO
low complexity region 2025 2045 N/A INTRINSIC
low complexity region 2123 2160 N/A INTRINSIC
low complexity region 2163 2177 N/A INTRINSIC
low complexity region 2182 2239 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation. [provided by MGI curators]
Allele List at MGI

All alleles(245) : Targeted, knock-out(1) Gene trapped(244)

Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdhppt T A 9: 4,296,823 (GRCm39) D261V probably benign Het
Abca8a T C 11: 109,980,876 (GRCm39) Y54C probably damaging Het
Adad2 T C 8: 120,342,746 (GRCm39) S431P probably benign Het
Adam18 A G 8: 25,118,246 (GRCm39) Y557H possibly damaging Het
Adam5 C T 8: 25,303,541 (GRCm39) E129K probably damaging Het
Adgra2 T C 8: 27,609,251 (GRCm39) V824A probably benign Het
Armc12 A T 17: 28,751,410 (GRCm39) K135* probably null Het
Aup1 C T 6: 83,032,910 (GRCm39) Q215* probably null Het
AW146154 G A 7: 41,129,935 (GRCm39) R394C probably benign Het
Canx T G 11: 50,202,531 (GRCm39) D25A possibly damaging Het
Ccnf A G 17: 24,443,989 (GRCm39) L593P probably damaging Het
Cd40 A T 2: 164,898,695 (GRCm39) I41F unknown Het
Cdh1 C T 8: 107,384,405 (GRCm39) A291V probably benign Het
Cdhr2 A T 13: 54,878,883 (GRCm39) I963F probably damaging Het
Cenpe G A 3: 134,949,479 (GRCm39) G88D probably damaging Het
Cep295 T A 9: 15,233,882 (GRCm39) T2305S possibly damaging Het
Cimap1a A T 7: 140,430,215 (GRCm39) T201S probably benign Het
Clcn4 T C 7: 7,299,758 (GRCm39) R24G probably damaging Het
Cnot7 T C 8: 40,960,514 (GRCm39) N98S possibly damaging Het
Defa3 T G 8: 21,778,288 (GRCm39) C91G probably damaging Het
Dennd2c T C 3: 103,072,446 (GRCm39) F844L probably damaging Het
Dnah7b G A 1: 46,263,866 (GRCm39) W2116* probably null Het
Dnaja3 T C 16: 4,502,131 (GRCm39) V45A probably benign Het
Efcab7 T A 4: 99,717,615 (GRCm39) S11T unknown Het
Enpp2 T A 15: 54,710,697 (GRCm39) K744N probably damaging Het
Fam171b CCAGCAGCAGCAGCAGCAGCAGC CCAGCAGCAGCAGCAGCAGC 2: 83,643,218 (GRCm39) probably benign Het
Fdxacb1 T G 9: 50,680,135 (GRCm39) F107C probably damaging Het
Fnbp1 A T 2: 30,926,606 (GRCm39) Y433N probably damaging Het
Gatad1 T C 5: 3,693,540 (GRCm39) R210G probably benign Het
Gm15446 T A 5: 110,088,306 (GRCm39) Y6* probably null Het
Gm45140 T C 6: 87,796,551 (GRCm39) H66R Het
Grin3b G A 10: 79,812,868 (GRCm39) R981Q unknown Het
Ipp T G 4: 116,368,053 (GRCm39) I95M probably benign Het
Iqca1 A G 1: 89,973,466 (GRCm39) F769L probably damaging Het
Jkamp C T 12: 72,136,832 (GRCm39) L67F probably damaging Het
Llgl2 T A 11: 115,744,112 (GRCm39) M773K probably damaging Het
Man2b1 A G 8: 85,823,674 (GRCm39) T973A probably benign Het
Mcm2 T C 6: 88,869,039 (GRCm39) Y271C probably damaging Het
Msl2 T C 9: 100,978,159 (GRCm39) S178P probably benign Het
Myo7a G T 7: 97,732,833 (GRCm39) S648* probably null Het
Neurl1b G T 17: 26,651,201 (GRCm39) V158F probably damaging Het
Nkain2 A G 10: 32,766,034 (GRCm39) V142A unknown Het
Nrp2 C T 1: 62,784,567 (GRCm39) R239C probably damaging Het
Oma1 A T 4: 103,176,232 (GRCm39) probably benign Het
Or10ag58 A T 2: 87,265,364 (GRCm39) N178Y possibly damaging Het
Or5aq7 A G 2: 86,938,411 (GRCm39) Y107H probably damaging Het
Plekhg6 T C 6: 125,340,009 (GRCm39) T784A probably benign Het
Prtg T C 9: 72,752,265 (GRCm39) I217T probably benign Het
Ptx4 T C 17: 25,341,753 (GRCm39) F76S probably damaging Het
Rap1b A C 10: 117,657,514 (GRCm39) I55S probably damaging Het
Sftpd T C 14: 40,894,538 (GRCm39) T294A probably benign Het
Spg11 C T 2: 121,943,637 (GRCm39) V172I probably benign Het
Srms T A 2: 180,848,751 (GRCm39) H363L probably damaging Het
Tbc1d13 A T 2: 30,037,415 (GRCm39) M266L probably damaging Het
Tbc1d2 A C 4: 46,649,737 (GRCm39) C100G possibly damaging Het
Tdg A T 10: 82,474,627 (GRCm39) Q39L probably benign Het
Tiam1 G A 16: 89,586,146 (GRCm39) A1547V probably benign Het
Trpm1 A G 7: 63,858,718 (GRCm39) E380G possibly damaging Het
Unc13b T G 4: 43,177,597 (GRCm39) D2808E unknown Het
Usp25 A T 16: 76,865,943 (GRCm39) D287V possibly damaging Het
Zfp648 A T 1: 154,079,862 (GRCm39) Q7L probably benign Het
Zfp931 T C 2: 177,709,709 (GRCm39) R226G probably benign Het
Zfyve9 T A 4: 108,542,215 (GRCm39) E201D probably benign Het
Other mutations in Dido1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00425:Dido1 APN 2 180,325,782 (GRCm39) missense probably benign
IGL00834:Dido1 APN 2 180,331,319 (GRCm39) missense possibly damaging 0.87
IGL01317:Dido1 APN 2 180,313,550 (GRCm39) missense probably benign 0.17
IGL01588:Dido1 APN 2 180,330,668 (GRCm39) missense probably benign 0.00
IGL01834:Dido1 APN 2 180,325,824 (GRCm39) splice site probably benign
IGL02102:Dido1 APN 2 180,304,040 (GRCm39) missense possibly damaging 0.58
IGL02556:Dido1 APN 2 180,331,128 (GRCm39) missense possibly damaging 0.69
IGL02756:Dido1 APN 2 180,303,716 (GRCm39) missense probably benign 0.00
IGL02826:Dido1 APN 2 180,325,751 (GRCm39) missense probably benign
IGL02970:Dido1 APN 2 180,331,208 (GRCm39) missense probably damaging 0.99
IGL03110:Dido1 APN 2 180,331,135 (GRCm39) missense probably damaging 1.00
IGL03116:Dido1 APN 2 180,312,772 (GRCm39) missense probably damaging 1.00
3370:Dido1 UTSW 2 180,313,335 (GRCm39) missense probably benign
A4554:Dido1 UTSW 2 180,317,164 (GRCm39) missense probably damaging 1.00
H8441:Dido1 UTSW 2 180,330,807 (GRCm39) missense probably benign 0.12
R0044:Dido1 UTSW 2 180,303,612 (GRCm39) missense probably damaging 1.00
R0044:Dido1 UTSW 2 180,303,612 (GRCm39) missense probably damaging 1.00
R0054:Dido1 UTSW 2 180,303,267 (GRCm39) missense probably benign 0.00
R0054:Dido1 UTSW 2 180,303,267 (GRCm39) missense probably benign 0.00
R0127:Dido1 UTSW 2 180,313,617 (GRCm39) missense probably benign 0.01
R0620:Dido1 UTSW 2 180,301,644 (GRCm39) missense probably benign 0.26
R0734:Dido1 UTSW 2 180,301,835 (GRCm39) missense probably benign 0.01
R1390:Dido1 UTSW 2 180,326,917 (GRCm39) missense possibly damaging 0.70
R1445:Dido1 UTSW 2 180,313,263 (GRCm39) missense possibly damaging 0.62
R1466:Dido1 UTSW 2 180,304,121 (GRCm39) missense probably damaging 1.00
R1466:Dido1 UTSW 2 180,304,121 (GRCm39) missense probably damaging 1.00
R1472:Dido1 UTSW 2 180,302,513 (GRCm39) missense probably benign 0.02
R1538:Dido1 UTSW 2 180,326,763 (GRCm39) missense possibly damaging 0.49
R1584:Dido1 UTSW 2 180,304,121 (GRCm39) missense probably damaging 1.00
R2020:Dido1 UTSW 2 180,301,378 (GRCm39) missense unknown
R2025:Dido1 UTSW 2 180,330,974 (GRCm39) nonsense probably null
R2026:Dido1 UTSW 2 180,330,974 (GRCm39) nonsense probably null
R2027:Dido1 UTSW 2 180,330,974 (GRCm39) nonsense probably null
R2089:Dido1 UTSW 2 180,303,677 (GRCm39) missense probably benign 0.29
R2091:Dido1 UTSW 2 180,303,677 (GRCm39) missense probably benign 0.29
R2091:Dido1 UTSW 2 180,303,677 (GRCm39) missense probably benign 0.29
R2495:Dido1 UTSW 2 180,331,181 (GRCm39) missense probably benign 0.00
R2931:Dido1 UTSW 2 180,303,446 (GRCm39) missense probably damaging 1.00
R3418:Dido1 UTSW 2 180,302,728 (GRCm39) missense possibly damaging 0.84
R3735:Dido1 UTSW 2 180,325,829 (GRCm39) splice site probably benign
R4523:Dido1 UTSW 2 180,314,085 (GRCm39) missense probably damaging 1.00
R4674:Dido1 UTSW 2 180,329,352 (GRCm39) missense probably damaging 0.97
R4729:Dido1 UTSW 2 180,329,443 (GRCm39) missense probably benign 0.00
R4762:Dido1 UTSW 2 180,331,368 (GRCm39) missense probably damaging 1.00
R4786:Dido1 UTSW 2 180,312,664 (GRCm39) missense possibly damaging 0.85
R4817:Dido1 UTSW 2 180,303,209 (GRCm39) missense probably benign 0.02
R4892:Dido1 UTSW 2 180,316,822 (GRCm39) nonsense probably null
R4979:Dido1 UTSW 2 180,302,606 (GRCm39) missense probably damaging 0.98
R5510:Dido1 UTSW 2 180,326,966 (GRCm39) missense probably benign 0.00
R5586:Dido1 UTSW 2 180,301,445 (GRCm39) nonsense probably null
R5672:Dido1 UTSW 2 180,313,696 (GRCm39) missense probably damaging 0.99
R5863:Dido1 UTSW 2 180,303,566 (GRCm39) missense probably benign 0.02
R5943:Dido1 UTSW 2 180,303,675 (GRCm39) missense probably benign 0.00
R5974:Dido1 UTSW 2 180,313,290 (GRCm39) missense probably benign 0.02
R6123:Dido1 UTSW 2 180,325,760 (GRCm39) missense probably benign 0.07
R6214:Dido1 UTSW 2 180,303,945 (GRCm39) missense probably damaging 1.00
R6215:Dido1 UTSW 2 180,303,945 (GRCm39) missense probably damaging 1.00
R6248:Dido1 UTSW 2 180,302,048 (GRCm39) missense probably damaging 1.00
R6285:Dido1 UTSW 2 180,302,940 (GRCm39) missense probably benign 0.00
R6349:Dido1 UTSW 2 180,302,494 (GRCm39) missense probably benign 0.03
R6437:Dido1 UTSW 2 180,316,806 (GRCm39) missense probably damaging 1.00
R6477:Dido1 UTSW 2 180,302,274 (GRCm39) missense probably benign 0.00
R6836:Dido1 UTSW 2 180,304,100 (GRCm39) missense probably benign 0.16
R7055:Dido1 UTSW 2 180,303,002 (GRCm39) missense probably benign 0.09
R7289:Dido1 UTSW 2 180,301,424 (GRCm39) missense unknown
R7304:Dido1 UTSW 2 180,329,286 (GRCm39) missense probably damaging 1.00
R7343:Dido1 UTSW 2 180,316,914 (GRCm39) missense possibly damaging 0.49
R7363:Dido1 UTSW 2 180,304,310 (GRCm39) nonsense probably null
R7429:Dido1 UTSW 2 180,331,319 (GRCm39) missense possibly damaging 0.87
R7594:Dido1 UTSW 2 180,316,905 (GRCm39) missense probably benign
R7629:Dido1 UTSW 2 180,303,266 (GRCm39) missense probably benign
R7899:Dido1 UTSW 2 180,313,390 (GRCm39) missense possibly damaging 0.82
R7946:Dido1 UTSW 2 180,303,501 (GRCm39) missense possibly damaging 0.81
R7951:Dido1 UTSW 2 180,312,674 (GRCm39) missense probably benign 0.01
R8033:Dido1 UTSW 2 180,316,635 (GRCm39) missense probably damaging 1.00
R8331:Dido1 UTSW 2 180,302,242 (GRCm39) missense probably benign 0.00
R8479:Dido1 UTSW 2 180,315,022 (GRCm39) critical splice donor site probably null
R8936:Dido1 UTSW 2 180,303,195 (GRCm39) missense probably benign
R9089:Dido1 UTSW 2 180,303,293 (GRCm39) missense probably benign 0.00
R9647:Dido1 UTSW 2 180,315,068 (GRCm39) missense probably benign 0.00
R9648:Dido1 UTSW 2 180,302,468 (GRCm39) missense probably damaging 1.00
R9784:Dido1 UTSW 2 180,325,354 (GRCm39) missense probably benign 0.27
V1024:Dido1 UTSW 2 180,330,807 (GRCm39) missense probably benign 0.12
X0011:Dido1 UTSW 2 180,302,627 (GRCm39) missense probably benign 0.00
X0019:Dido1 UTSW 2 180,313,365 (GRCm39) missense possibly damaging 0.62
Predicted Primers PCR Primer
(F):5'- TTCTGTGCCCCAAATCTGG -3'
(R):5'- GCTTCCCTTTGCAACCTAAGG -3'

Sequencing Primer
(F):5'- TGGTCCATCACTATTAGGAACAAGG -3'
(R):5'- GGCCCAAAATTTTAGTTCTGGAAGC -3'
Posted On 2020-01-23