Incidental Mutation 'R8070:Olfm3'
ID 620212
Institutional Source Beutler Lab
Gene Symbol Olfm3
Ensembl Gene ENSMUSG00000027965
Gene Name olfactomedin 3
Synonyms B230206G02Rik, optimedin
MMRRC Submission 067505-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R8070 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 114697727-114919371 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 114895604 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 195 (D195G)
Ref Sequence ENSEMBL: ENSMUSP00000060985 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051309] [ENSMUST00000081752] [ENSMUST00000149158]
AlphaFold P63056
Predicted Effect probably damaging
Transcript: ENSMUST00000051309
AA Change: D195G

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000060985
Gene: ENSMUSG00000027965
AA Change: D195G

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:Noelin-1 46 145 3.9e-52 PFAM
Blast:OLF 162 207 3e-8 BLAST
OLF 220 470 4.33e-114 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000081752
AA Change: D175G

PolyPhen 2 Score 0.083 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000080448
Gene: ENSMUSG00000027965
AA Change: D175G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:Noelin-1 25 125 7.6e-54 PFAM
Blast:OLF 142 187 3e-8 BLAST
OLF 200 450 4.33e-114 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000149158
AA Change: D162G

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000121097
Gene: ENSMUSG00000027965
AA Change: D162G

DomainStartEndE-ValueType
Pfam:Noelin-1 12 112 2.5e-51 PFAM
Blast:OLF 129 174 1e-8 BLAST
Blast:OLF 187 210 1e-7 BLAST
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik A G 5: 64,055,510 (GRCm39) E82G probably benign Het
9830107B12Rik A G 17: 48,452,681 (GRCm39) F86S probably damaging Het
Aamdc A T 7: 97,224,855 (GRCm39) Y2* probably null Het
Acta1 T A 8: 124,620,360 (GRCm39) D26V possibly damaging Het
Adra1d A C 2: 131,403,502 (GRCm39) L196R probably damaging Het
Agbl2 G A 2: 90,621,909 (GRCm39) C132Y probably benign Het
Amd1 A G 10: 40,170,226 (GRCm39) V92A probably benign Het
Arid4b T A 13: 14,310,844 (GRCm39) I149K probably benign Het
Atg7 A G 6: 114,674,041 (GRCm39) M312V probably benign Het
Bap1 T A 14: 30,978,643 (GRCm39) V381E probably damaging Het
Cbfa2t3 C T 8: 123,369,720 (GRCm39) V207I possibly damaging Het
Cdh24 T C 14: 54,870,030 (GRCm39) Q629R probably benign Het
Cdhr2 G T 13: 54,867,606 (GRCm39) V479L probably benign Het
Chd2 A G 7: 73,101,506 (GRCm39) S1407P probably benign Het
Clstn2 A G 9: 97,681,523 (GRCm39) V39A possibly damaging Het
Cwh43 T A 5: 73,578,806 (GRCm39) M357K possibly damaging Het
Dcdc2a T A 13: 25,386,180 (GRCm39) D351E probably benign Het
Dennd6b T C 15: 89,069,576 (GRCm39) I517V probably benign Het
Dnah17 T C 11: 117,915,497 (GRCm39) E4374G probably damaging Het
Emsy A G 7: 98,275,922 (GRCm39) S336P possibly damaging Het
Enoph1 A T 5: 100,208,841 (GRCm39) E65D probably benign Het
Fam83f T A 15: 80,556,281 (GRCm39) L55Q probably damaging Het
Fry T C 5: 150,401,472 (GRCm39) F379L Het
Fscb A T 12: 64,521,382 (GRCm39) M28K probably benign Het
Gas7 G A 11: 67,574,260 (GRCm39) V412M probably damaging Het
Gatad1 T C 5: 3,693,540 (GRCm39) R210G probably benign Het
Gcn1 T A 5: 115,727,057 (GRCm39) V638E probably benign Het
Ggt1 A T 10: 75,414,733 (GRCm39) I184F probably damaging Het
Gigyf2 A G 1: 87,368,629 (GRCm39) N1103S probably benign Het
Gm5592 G A 7: 40,935,887 (GRCm39) A130T possibly damaging Het
Gys2 T C 6: 142,394,230 (GRCm39) probably null Het
Hmcn1 C A 1: 150,525,743 (GRCm39) E3327* probably null Het
Ighv1-36 C T 12: 114,843,656 (GRCm39) G68E probably damaging Het
Igkv6-32 G A 6: 70,051,089 (GRCm39) T89M probably damaging Het
Ipo7 A G 7: 109,652,014 (GRCm39) D931G probably benign Het
Jakmip1 A G 5: 37,330,631 (GRCm39) E437G probably benign Het
Lingo3 C T 10: 80,671,955 (GRCm39) probably benign Het
Lnpep A G 17: 17,758,900 (GRCm39) S815P probably damaging Het
Ly6a T C 15: 74,869,449 (GRCm39) D2G probably damaging Het
Madd C A 2: 90,988,359 (GRCm39) E1223* probably null Het
Mapk8ip3 A T 17: 25,120,078 (GRCm39) probably null Het
Mecom T C 3: 30,033,987 (GRCm39) E239G probably damaging Het
Mug1 T C 6: 121,852,838 (GRCm39) V889A probably benign Het
Myo18b T A 5: 112,938,986 (GRCm39) N1675I probably benign Het
Ndrg4 T C 8: 96,426,756 (GRCm39) F50L possibly damaging Het
Ndst4 A G 3: 125,508,293 (GRCm39) Y286C probably damaging Het
Nrp2 C T 1: 62,784,567 (GRCm39) R239C probably damaging Het
Or2y14 A T 11: 49,404,941 (GRCm39) T159S probably damaging Het
Or4p21 G T 2: 88,277,003 (GRCm39) T93K probably benign Het
Pds5a A G 5: 65,809,741 (GRCm39) L407P possibly damaging Het
Pgm2 A G 5: 64,269,425 (GRCm39) N504S probably benign Het
Plce1 A G 19: 38,690,283 (GRCm39) M656V probably damaging Het
Pou6f2 T C 13: 18,414,209 (GRCm39) T189A unknown Het
Ppp1r12b T C 1: 134,803,807 (GRCm39) S451G probably benign Het
Prox1 T G 1: 189,893,107 (GRCm39) N446T probably damaging Het
Ralgapa2 T A 2: 146,195,199 (GRCm39) R1195S probably damaging Het
Rere A G 4: 150,701,832 (GRCm39) D37G probably damaging Het
Tfip11 T A 5: 112,482,796 (GRCm39) M560K possibly damaging Het
Thop1 T C 10: 80,915,320 (GRCm39) V260A probably damaging Het
Tle6 A G 10: 81,434,476 (GRCm39) M41T possibly damaging Het
Trav13d-4 T C 14: 53,995,249 (GRCm39) S68P possibly damaging Het
Trim24 A G 6: 37,934,661 (GRCm39) N826S probably damaging Het
Tuba3a T C 6: 125,255,433 (GRCm39) E414G probably damaging Het
Vmn2r78 A G 7: 86,571,695 (GRCm39) I502V probably benign Het
Vmn2r79 A T 7: 86,651,336 (GRCm39) Y245F probably benign Het
Other mutations in Olfm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01656:Olfm3 APN 3 114,916,282 (GRCm39) missense probably damaging 1.00
IGL01686:Olfm3 APN 3 114,916,497 (GRCm39) missense probably benign 0.00
IGL01732:Olfm3 APN 3 114,890,649 (GRCm39) missense possibly damaging 0.82
IGL02539:Olfm3 APN 3 114,895,579 (GRCm39) missense possibly damaging 0.93
IGL02580:Olfm3 APN 3 114,916,157 (GRCm39) missense probably damaging 1.00
IGL02999:Olfm3 APN 3 114,916,397 (GRCm39) missense probably damaging 1.00
IGL03142:Olfm3 APN 3 114,890,679 (GRCm39) missense probably damaging 0.97
IGL03239:Olfm3 APN 3 114,916,243 (GRCm39) missense probably damaging 0.99
R0361:Olfm3 UTSW 3 114,914,622 (GRCm39) missense probably damaging 1.00
R0373:Olfm3 UTSW 3 114,916,454 (GRCm39) missense probably damaging 0.99
R0505:Olfm3 UTSW 3 114,916,330 (GRCm39) missense possibly damaging 0.46
R0689:Olfm3 UTSW 3 114,916,194 (GRCm39) missense probably benign 0.28
R0973:Olfm3 UTSW 3 114,895,635 (GRCm39) missense probably benign 0.00
R0973:Olfm3 UTSW 3 114,895,635 (GRCm39) missense probably benign 0.00
R0974:Olfm3 UTSW 3 114,895,635 (GRCm39) missense probably benign 0.00
R1253:Olfm3 UTSW 3 114,916,418 (GRCm39) missense probably damaging 0.98
R1293:Olfm3 UTSW 3 114,895,579 (GRCm39) missense possibly damaging 0.93
R1952:Olfm3 UTSW 3 114,895,589 (GRCm39) missense probably null 1.00
R2255:Olfm3 UTSW 3 114,915,842 (GRCm39) splice site probably null
R2334:Olfm3 UTSW 3 114,895,608 (GRCm39) nonsense probably null
R2510:Olfm3 UTSW 3 114,915,959 (GRCm39) missense probably damaging 1.00
R4222:Olfm3 UTSW 3 114,883,820 (GRCm39) nonsense probably null
R4716:Olfm3 UTSW 3 114,874,755 (GRCm39) missense probably benign 0.00
R4912:Olfm3 UTSW 3 114,895,589 (GRCm39) missense probably damaging 1.00
R5084:Olfm3 UTSW 3 114,698,202 (GRCm39) critical splice donor site probably null
R5649:Olfm3 UTSW 3 114,890,573 (GRCm39) missense probably damaging 0.99
R5681:Olfm3 UTSW 3 114,915,924 (GRCm39) missense probably benign 0.28
R5861:Olfm3 UTSW 3 114,916,052 (GRCm39) missense probably damaging 1.00
R5924:Olfm3 UTSW 3 114,916,187 (GRCm39) missense probably benign 0.44
R5929:Olfm3 UTSW 3 114,895,529 (GRCm39) missense probably damaging 0.97
R5958:Olfm3 UTSW 3 114,915,955 (GRCm39) missense probably damaging 0.99
R6166:Olfm3 UTSW 3 114,916,074 (GRCm39) missense probably damaging 1.00
R6299:Olfm3 UTSW 3 114,914,632 (GRCm39) missense probably damaging 1.00
R6804:Olfm3 UTSW 3 114,916,328 (GRCm39) missense probably benign 0.10
R7032:Olfm3 UTSW 3 114,883,805 (GRCm39) missense probably damaging 1.00
R7565:Olfm3 UTSW 3 114,916,393 (GRCm39) missense probably damaging 0.98
R7600:Olfm3 UTSW 3 114,890,589 (GRCm39) missense possibly damaging 0.65
R7976:Olfm3 UTSW 3 114,874,794 (GRCm39) missense probably benign 0.00
R8334:Olfm3 UTSW 3 114,916,206 (GRCm39) missense probably damaging 0.96
R8527:Olfm3 UTSW 3 114,916,196 (GRCm39) missense probably benign 0.10
R8542:Olfm3 UTSW 3 114,916,196 (GRCm39) missense probably benign 0.10
R8835:Olfm3 UTSW 3 114,916,061 (GRCm39) missense probably damaging 1.00
R9063:Olfm3 UTSW 3 114,914,582 (GRCm39) missense probably benign 0.36
R9594:Olfm3 UTSW 3 114,883,785 (GRCm39) missense probably damaging 1.00
R9690:Olfm3 UTSW 3 114,890,594 (GRCm39) nonsense probably null
R9690:Olfm3 UTSW 3 114,890,593 (GRCm39) missense probably benign 0.39
R9719:Olfm3 UTSW 3 114,916,091 (GRCm39) nonsense probably null
Z1088:Olfm3 UTSW 3 114,698,317 (GRCm39) start gained probably benign
Z1177:Olfm3 UTSW 3 114,874,750 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GACTCTTGGAAACACTCTATTGC -3'
(R):5'- TGCTCACGTGACTAAGAGAC -3'

Sequencing Primer
(F):5'- GCTTTCTCCAGGAGTTGAAAGAG -3'
(R):5'- GAGACACTTGGCCCTGTAATTCAG -3'
Posted On 2020-01-23