Mutagenetix > Incidental Mutation

Incidental Mutation 'R8070:Dnah17'

620250

Institutional Source

Beutler Lab

Gene Symbol

Dnah17

Ensembl Gene

ENSMUSG00000033987

Gene Name

dynein, axonemal, heavy chain 17

Synonyms

LOC382552, Dnahcl1, 2810003K23Rik, Dnahc17

MMRRC Submission

067505-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8070 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

118021723-118130634 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 118024671 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 4374 (E4374G)

Ref Sequence

ENSEMBL: ENSMUSP00000101915 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084803] [ENSMUST00000100185] [ENSMUST00000106308] [ENSMUST00000132676] [ENSMUST00000132685]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000017859

SMART Domains

Protein: ENSMUSP00000017859
Gene: ENSMUSG00000017715

Domain	Start	End	E-Value	Type
low complexity region	11	56	N/A	INTRINSIC
SCOP:d1f0ia1	70	287	4e-25	SMART
PDB:3HSI\|C	81	464	7e-8	PDB
Blast:PLDc	211	237	2e-8	BLAST

Predicted Effect

possibly damaging
Transcript: ENSMUST00000084803
AA Change: E4346G

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000081864
Gene: ENSMUSG00000033987
AA Change: E4346G

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	183	766	8.5e-142	PFAM
low complexity region	1015	1028	N/A	INTRINSIC
Pfam:DHC_N2	1260	1673	5.8e-135	PFAM
Pfam:AAA_6	1793	2023	6e-161	PFAM
low complexity region	2092	2104	N/A	INTRINSIC
Pfam:AAA_5	2107	2243	7.8e-13	PFAM
Pfam:AAA_7	2400	2671	1.1e-171	PFAM
Pfam:AAA_8	2748	3015	4.9e-166	PFAM
Pfam:MT	3027	3370	3.4e-214	PFAM
Pfam:AAA_9	3388	3615	2.4e-144	PFAM
Pfam:Dynein_heavy	3742	4452	N/A	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000100185

SMART Domains

Protein: ENSMUSP00000097760
Gene: ENSMUSG00000017715

Domain	Start	End	E-Value	Type
SCOP:d1f0ia1	18	158	7e-13	SMART
Blast:PLDc	82	108	1e-8	BLAST
low complexity region	202	215	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000106308
AA Change: E4374G

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000101915
Gene: ENSMUSG00000033987
AA Change: E4374G

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	184	764	1.7e-152	PFAM
low complexity region	1015	1028	N/A	INTRINSIC
Pfam:DHC_N2	1262	1671	4.1e-132	PFAM
Pfam:AAA_6	1793	2023	7e-149	PFAM
low complexity region	2092	2104	N/A	INTRINSIC
Pfam:AAA_5	2107	2243	2.5e-11	PFAM
Pfam:AAA_7	2400	2671	4.4e-169	PFAM
Pfam:AAA_8	2748	3015	7.1e-163	PFAM
Pfam:MT	3027	3370	1.1e-210	PFAM
Pfam:AAA_9	3392	3614	1e-84	PFAM
Pfam:Dynein_heavy	3748	4479	3.5e-230	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000132676

SMART Domains

Protein: ENSMUSP00000121973
Gene: ENSMUSG00000017715

Domain	Start	End	E-Value	Type
low complexity region	12	57	N/A	INTRINSIC
SCOP:d1f0ia1	71	288	3e-25	SMART
PDB:3HSI\|C	82	475	3e-9	PDB
Blast:PLDc	212	238	2e-8	BLAST
Blast:PLDc	459	490	1e-13	BLAST
low complexity region	508	521	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000132685
AA Change: E4352G

SMART Domains

Protein: ENSMUSP00000120542
Gene: ENSMUSG00000033987
AA Change: E4352G

Domain	Start	End	E-Value	Type
Pfam:DHC_N2	279	688	3.1e-132	PFAM
Pfam:AAA_6	811	1041	5.3e-149	PFAM
low complexity region	1110	1122	N/A	INTRINSIC
Blast:AAA	1123	1354	1e-104	BLAST
Pfam:AAA_7	1452	1671	8.9e-134	PFAM
Pfam:AAA_8	1763	2030	5.4e-163	PFAM
Pfam:MT	2042	2168	6.8e-52	PFAM
Pfam:MT	2163	2412	8.2e-149	PFAM
Pfam:AAA_9	2434	2656	7.9e-85	PFAM
Pfam:Dynein_heavy	2790	3457	2.6e-209	PFAM
Pfam:Dynein_heavy	3460	3569	4.6e-17	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. DNAH17 is a heavy chain associated with axonemal dynein (Milisav and Affara, 1998 [PubMed 9545504]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610040J01Rik	A	G	5: 63,898,167 (GRCm38)	E82G	probably benign	Het
9830107B12Rik	A	G	17: 48,145,510 (GRCm38)	F86S	probably damaging	Het
Aamdc	A	T	7: 97,575,648 (GRCm38)	Y2*	probably null	Het
Acta1	T	A	8: 123,893,621 (GRCm38)	D26V	possibly damaging	Het
Adra1d	A	C	2: 131,561,582 (GRCm38)	L196R	probably damaging	Het
Agbl2	G	A	2: 90,791,565 (GRCm38)	C132Y	probably benign	Het
Amd1	A	G	10: 40,294,230 (GRCm38)	V92A	probably benign	Het
Arid4b	T	A	13: 14,136,259 (GRCm38)	I149K	probably benign	Het
Atg7	A	G	6: 114,697,080 (GRCm38)	M312V	probably benign	Het
Bap1	T	A	14: 31,256,686 (GRCm38)	V381E	probably damaging	Het
Cbfa2t3	C	T	8: 122,642,981 (GRCm38)	V207I	possibly damaging	Het
Cdh24	T	C	14: 54,632,573 (GRCm38)	Q629R	probably benign	Het
Cdhr2	G	T	13: 54,719,793 (GRCm38)	V479L	probably benign	Het
Chd2	A	G	7: 73,451,758 (GRCm38)	S1407P	probably benign	Het
Clstn2	A	G	9: 97,799,470 (GRCm38)	V39A	possibly damaging	Het
Cwh43	T	A	5: 73,421,463 (GRCm38)	M357K	possibly damaging	Het
Dcdc2a	T	A	13: 25,202,197 (GRCm38)	D351E	probably benign	Het
Dennd6b	T	C	15: 89,185,373 (GRCm38)	I517V	probably benign	Het
Emsy	A	G	7: 98,626,715 (GRCm38)	S336P	possibly damaging	Het
Enoph1	A	T	5: 100,060,982 (GRCm38)	E65D	probably benign	Het
Fam83f	T	A	15: 80,672,080 (GRCm38)	L55Q	probably damaging	Het
Fry	T	C	5: 150,478,007 (GRCm38)	F379L		Het
Fscb	A	T	12: 64,474,608 (GRCm38)	M28K	probably benign	Het
Gas7	G	A	11: 67,683,434 (GRCm38)	V412M	probably damaging	Het
Gatad1	T	C	5: 3,643,540 (GRCm38)	R210G	probably benign	Het
Gcn1l1	T	A	5: 115,588,998 (GRCm38)	V638E	probably benign	Het
Ggt1	A	T	10: 75,578,899 (GRCm38)	I184F	probably damaging	Het
Gigyf2	A	G	1: 87,440,907 (GRCm38)	N1103S	probably benign	Het
Gm13757	G	T	2: 88,446,659 (GRCm38)	T93K	probably benign	Het
Gm5592	G	A	7: 41,286,463 (GRCm38)	A130T	possibly damaging	Het
Gys2	T	C	6: 142,448,504 (GRCm38)		probably null	Het
Hmcn1	C	A	1: 150,649,992 (GRCm38)	E3327*	probably null	Het
Ighv1-36	C	T	12: 114,880,036 (GRCm38)	G68E	probably damaging	Het
Igkv6-32	G	A	6: 70,074,105 (GRCm38)	T89M	probably damaging	Het
Ipo7	A	G	7: 110,052,807 (GRCm38)	D931G	probably benign	Het
Jakmip1	A	G	5: 37,173,287 (GRCm38)	E437G	probably benign	Het
Lingo3	C	T	10: 80,836,121 (GRCm38)		probably benign	Het
Lnpep	A	G	17: 17,538,638 (GRCm38)	S815P	probably damaging	Het
Ly6a	T	C	15: 74,997,600 (GRCm38)	D2G	probably damaging	Het
Madd	C	A	2: 91,158,014 (GRCm38)	E1223*	probably null	Het
Mapk8ip3	A	T	17: 24,901,104 (GRCm38)		probably null	Het
Mecom	T	C	3: 29,979,838 (GRCm38)	E239G	probably damaging	Het
Mug1	T	C	6: 121,875,879 (GRCm38)	V889A	probably benign	Het
Myo18b	T	A	5: 112,791,120 (GRCm38)	N1675I	probably benign	Het
Ndrg4	T	C	8: 95,700,128 (GRCm38)	F50L	possibly damaging	Het
Ndst4	A	G	3: 125,714,644 (GRCm38)	Y286C	probably damaging	Het
Nrp2	C	T	1: 62,745,408 (GRCm38)	R239C	probably damaging	Het
Olfm3	A	G	3: 115,101,955 (GRCm38)	D195G	probably damaging	Het
Olfr1384	A	T	11: 49,514,114 (GRCm38)	T159S	probably damaging	Het
Pds5a	A	G	5: 65,652,398 (GRCm38)	L407P	possibly damaging	Het
Pgm1	A	G	5: 64,112,082 (GRCm38)	N504S	probably benign	Het
Plce1	A	G	19: 38,701,839 (GRCm38)	M656V	probably damaging	Het
Pou6f2	T	C	13: 18,239,624 (GRCm38)	T189A	unknown	Het
Ppp1r12b	T	C	1: 134,876,069 (GRCm38)	S451G	probably benign	Het
Prox1	T	G	1: 190,160,910 (GRCm38)	N446T	probably damaging	Het
Ralgapa2	T	A	2: 146,353,279 (GRCm38)	R1195S	probably damaging	Het
Rere	A	G	4: 150,617,375 (GRCm38)	D37G	probably damaging	Het
Tfip11	T	A	5: 112,334,930 (GRCm38)	M560K	possibly damaging	Het
Thop1	T	C	10: 81,079,486 (GRCm38)	V260A	probably damaging	Het
Tle6	A	G	10: 81,598,642 (GRCm38)	M41T	possibly damaging	Het
Trav13-4-dv7	T	C	14: 53,757,792 (GRCm38)	S68P	possibly damaging	Het
Trim24	A	G	6: 37,957,726 (GRCm38)	N826S	probably damaging	Het
Tuba3a	T	C	6: 125,278,470 (GRCm38)	E414G	probably damaging	Het
Vmn2r78	A	G	7: 86,922,487 (GRCm38)	I502V	probably benign	Het
Vmn2r79	A	T	7: 87,002,128 (GRCm38)	Y245F	probably benign	Het

Other mutations in Dnah17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00231:Dnah17	APN	11	118,088,214 (GRCm38)	missense	possibly damaging	0.81
IGL00531:Dnah17	APN	11	118,043,173 (GRCm38)	missense	probably damaging	0.97
IGL00764:Dnah17	APN	11	118,096,485 (GRCm38)	missense	probably damaging	0.99
IGL00795:Dnah17	APN	11	118,093,634 (GRCm38)	missense	probably benign	0.35
IGL00823:Dnah17	APN	11	118,047,161 (GRCm38)	missense	probably benign	0.22
IGL01145:Dnah17	APN	11	118,047,173 (GRCm38)	missense	possibly damaging	0.63
IGL01433:Dnah17	APN	11	118,049,934 (GRCm38)	missense	probably damaging	1.00
IGL01454:Dnah17	APN	11	118,058,397 (GRCm38)	missense	probably damaging	1.00
IGL01545:Dnah17	APN	11	118,119,568 (GRCm38)	missense	probably damaging	1.00
IGL01548:Dnah17	APN	11	118,098,612 (GRCm38)	missense	probably benign	0.21
IGL01557:Dnah17	APN	11	118,073,686 (GRCm38)	missense	probably damaging	0.98
IGL01632:Dnah17	APN	11	118,033,881 (GRCm38)	missense	probably damaging	1.00
IGL01636:Dnah17	APN	11	118,041,056 (GRCm38)	missense	probably benign	0.03
IGL01672:Dnah17	APN	11	118,042,160 (GRCm38)	missense	probably damaging	0.97
IGL01822:Dnah17	APN	11	118,081,993 (GRCm38)	missense	probably damaging	1.00
IGL01869:Dnah17	APN	11	118,052,676 (GRCm38)	missense	probably benign	0.09
IGL01916:Dnah17	APN	11	118,125,288 (GRCm38)	missense	probably benign	0.00
IGL02131:Dnah17	APN	11	118,072,908 (GRCm38)	missense	probably damaging	1.00
IGL02154:Dnah17	APN	11	118,124,261 (GRCm38)	missense	probably benign	0.01
IGL02220:Dnah17	APN	11	118,072,967 (GRCm38)	nonsense	probably null
IGL02454:Dnah17	APN	11	118,080,767 (GRCm38)	missense	probably damaging	0.98
IGL02458:Dnah17	APN	11	118,036,350 (GRCm38)	missense	probably damaging	1.00
IGL02588:Dnah17	APN	11	118,025,653 (GRCm38)	missense	possibly damaging	0.95
IGL02865:Dnah17	APN	11	118,073,548 (GRCm38)	missense	probably damaging	1.00
IGL02881:Dnah17	APN	11	118,042,118 (GRCm38)	missense	probably damaging	1.00
IGL02952:Dnah17	APN	11	118,088,268 (GRCm38)	missense	probably benign	0.03
IGL03382:Dnah17	APN	11	118,081,943 (GRCm38)	missense	probably damaging	1.00
IGL03389:Dnah17	APN	11	118,094,979 (GRCm38)	missense	probably damaging	1.00
ergos	UTSW	11	118,041,158 (GRCm38)	splice site	probably benign
watt	UTSW	11	118,080,766 (GRCm38)	missense	probably damaging	0.96
PIT4280001:Dnah17	UTSW	11	118,098,582 (GRCm38)	missense	possibly damaging	0.85
R0004:Dnah17	UTSW	11	118,060,092 (GRCm38)	missense	possibly damaging	0.90
R0112:Dnah17	UTSW	11	118,074,434 (GRCm38)	missense	possibly damaging	0.82
R0116:Dnah17	UTSW	11	118,058,306 (GRCm38)	missense	probably benign	0.01
R0157:Dnah17	UTSW	11	118,127,171 (GRCm38)	missense	probably benign
R0320:Dnah17	UTSW	11	118,052,674 (GRCm38)	missense	possibly damaging	0.56
R0362:Dnah17	UTSW	11	118,098,539 (GRCm38)	missense	probably benign	0.10
R0382:Dnah17	UTSW	11	118,128,996 (GRCm38)	missense	probably damaging	1.00
R0383:Dnah17	UTSW	11	118,067,547 (GRCm38)	missense	probably benign
R0400:Dnah17	UTSW	11	118,082,078 (GRCm38)	missense	probably damaging	1.00
R0420:Dnah17	UTSW	11	118,039,939 (GRCm38)	missense	probably damaging	1.00
R0483:Dnah17	UTSW	11	118,047,124 (GRCm38)	missense	probably benign
R0533:Dnah17	UTSW	11	118,110,537 (GRCm38)	missense	possibly damaging	0.50
R0562:Dnah17	UTSW	11	118,072,900 (GRCm38)	missense	probably damaging	1.00
R0564:Dnah17	UTSW	11	118,082,981 (GRCm38)	missense	probably damaging	1.00
R0604:Dnah17	UTSW	11	118,121,471 (GRCm38)	missense	probably benign	0.00
R0608:Dnah17	UTSW	11	118,090,749 (GRCm38)	nonsense	probably null
R0614:Dnah17	UTSW	11	118,070,568 (GRCm38)	splice site	probably benign
R0632:Dnah17	UTSW	11	118,067,682 (GRCm38)	splice site	probably benign
R0831:Dnah17	UTSW	11	118,060,271 (GRCm38)	missense	probably damaging	0.99
R0838:Dnah17	UTSW	11	118,060,104 (GRCm38)	missense	probably damaging	1.00
R0879:Dnah17	UTSW	11	118,056,835 (GRCm38)	splice site	probably benign
R1061:Dnah17	UTSW	11	118,052,688 (GRCm38)	missense	possibly damaging	0.51
R1190:Dnah17	UTSW	11	118,042,175 (GRCm38)	missense	probably damaging	1.00
R1293:Dnah17	UTSW	11	118,127,137 (GRCm38)	critical splice donor site	probably null
R1297:Dnah17	UTSW	11	118,121,366 (GRCm38)	splice site	probably benign
R1332:Dnah17	UTSW	11	118,043,215 (GRCm38)	missense	possibly damaging	0.70
R1336:Dnah17	UTSW	11	118,043,215 (GRCm38)	missense	possibly damaging	0.70
R1364:Dnah17	UTSW	11	118,125,606 (GRCm38)	splice site	probably benign
R1418:Dnah17	UTSW	11	118,074,023 (GRCm38)	missense	probably damaging	0.98
R1432:Dnah17	UTSW	11	118,023,327 (GRCm38)	missense	probably damaging	1.00
R1497:Dnah17	UTSW	11	118,114,233 (GRCm38)	missense	probably damaging	1.00
R1500:Dnah17	UTSW	11	118,101,053 (GRCm38)	missense	probably benign
R1506:Dnah17	UTSW	11	118,125,387 (GRCm38)	missense	possibly damaging	0.53
R1512:Dnah17	UTSW	11	118,095,015 (GRCm38)	missense	probably benign
R1567:Dnah17	UTSW	11	118,125,985 (GRCm38)	missense	probably damaging	1.00
R1597:Dnah17	UTSW	11	118,103,498 (GRCm38)	splice site	probably benign
R1665:Dnah17	UTSW	11	118,121,495 (GRCm38)	splice site	probably benign
R1703:Dnah17	UTSW	11	118,026,749 (GRCm38)	missense	probably damaging	1.00
R1716:Dnah17	UTSW	11	118,032,598 (GRCm38)	missense	probably benign	0.00
R1727:Dnah17	UTSW	11	118,096,536 (GRCm38)	nonsense	probably null
R1727:Dnah17	UTSW	11	118,070,489 (GRCm38)	missense	probably damaging	0.98
R1728:Dnah17	UTSW	11	118,069,519 (GRCm38)	missense	possibly damaging	0.76
R1784:Dnah17	UTSW	11	118,069,519 (GRCm38)	missense	possibly damaging	0.76
R1852:Dnah17	UTSW	11	118,121,916 (GRCm38)	missense	probably damaging	0.97
R1869:Dnah17	UTSW	11	118,047,189 (GRCm38)	nonsense	probably null
R1886:Dnah17	UTSW	11	118,108,161 (GRCm38)	missense	possibly damaging	0.62
R1893:Dnah17	UTSW	11	118,066,968 (GRCm38)	missense	probably benign	0.00
R1954:Dnah17	UTSW	11	118,024,731 (GRCm38)	missense	probably damaging	1.00
R1969:Dnah17	UTSW	11	118,104,535 (GRCm38)	missense	probably benign	0.00
R1971:Dnah17	UTSW	11	118,104,535 (GRCm38)	missense	probably benign	0.00
R1975:Dnah17	UTSW	11	118,096,536 (GRCm38)	nonsense	probably null
R1977:Dnah17	UTSW	11	118,112,591 (GRCm38)	missense	possibly damaging	0.52
R2055:Dnah17	UTSW	11	118,067,531 (GRCm38)	missense	probably benign	0.00
R2115:Dnah17	UTSW	11	118,119,802 (GRCm38)	missense	probably benign	0.00
R2132:Dnah17	UTSW	11	118,033,747 (GRCm38)	missense	probably damaging	0.98
R2200:Dnah17	UTSW	11	118,102,409 (GRCm38)	splice site	probably benign
R2277:Dnah17	UTSW	11	118,096,561 (GRCm38)	missense	possibly damaging	0.81
R2279:Dnah17	UTSW	11	118,096,561 (GRCm38)	missense	possibly damaging	0.81
R2400:Dnah17	UTSW	11	118,126,384 (GRCm38)	critical splice acceptor site	probably null
R2402:Dnah17	UTSW	11	118,125,974 (GRCm38)	missense	probably benign	0.10
R2497:Dnah17	UTSW	11	118,087,024 (GRCm38)	splice site	probably null
R2923:Dnah17	UTSW	11	118,093,547 (GRCm38)	missense	probably damaging	1.00
R3121:Dnah17	UTSW	11	118,041,086 (GRCm38)	missense	probably damaging	1.00
R3236:Dnah17	UTSW	11	118,094,854 (GRCm38)	missense	probably benign	0.08
R3237:Dnah17	UTSW	11	118,094,854 (GRCm38)	missense	probably benign	0.08
R3498:Dnah17	UTSW	11	118,080,849 (GRCm38)	splice site	probably benign
R3499:Dnah17	UTSW	11	118,080,849 (GRCm38)	splice site	probably benign
R3746:Dnah17	UTSW	11	118,082,916 (GRCm38)	missense	probably benign	0.00
R3749:Dnah17	UTSW	11	118,082,916 (GRCm38)	missense	probably benign	0.00
R3762:Dnah17	UTSW	11	118,104,526 (GRCm38)	missense	probably benign	0.00
R3826:Dnah17	UTSW	11	118,041,158 (GRCm38)	splice site	probably benign
R3828:Dnah17	UTSW	11	118,041,158 (GRCm38)	splice site	probably benign
R3829:Dnah17	UTSW	11	118,041,158 (GRCm38)	splice site	probably benign
R3877:Dnah17	UTSW	11	118,024,707 (GRCm38)	missense	probably damaging	1.00
R3899:Dnah17	UTSW	11	118,094,808 (GRCm38)	missense	possibly damaging	0.78
R3900:Dnah17	UTSW	11	118,094,808 (GRCm38)	missense	possibly damaging	0.78
R3911:Dnah17	UTSW	11	118,080,849 (GRCm38)	splice site	probably benign
R3913:Dnah17	UTSW	11	118,080,849 (GRCm38)	splice site	probably benign
R3930:Dnah17	UTSW	11	118,080,849 (GRCm38)	splice site	probably benign
R3931:Dnah17	UTSW	11	118,080,849 (GRCm38)	splice site	probably benign
R3969:Dnah17	UTSW	11	118,041,158 (GRCm38)	splice site	probably benign
R3970:Dnah17	UTSW	11	118,041,158 (GRCm38)	splice site	probably benign
R4056:Dnah17	UTSW	11	118,070,538 (GRCm38)	missense	probably benign	0.05
R4113:Dnah17	UTSW	11	118,112,594 (GRCm38)	missense	possibly damaging	0.50
R4295:Dnah17	UTSW	11	118,118,772 (GRCm38)	missense	probably damaging	1.00
R4324:Dnah17	UTSW	11	118,094,213 (GRCm38)	missense	probably benign	0.01
R4412:Dnah17	UTSW	11	118,073,683 (GRCm38)	missense	probably damaging	1.00
R4413:Dnah17	UTSW	11	118,025,168 (GRCm38)	missense	probably benign	0.00
R4422:Dnah17	UTSW	11	118,081,973 (GRCm38)	missense	possibly damaging	0.91
R4552:Dnah17	UTSW	11	118,052,943 (GRCm38)	missense	possibly damaging	0.79
R4669:Dnah17	UTSW	11	118,074,293 (GRCm38)	missense	probably benign	0.02
R4677:Dnah17	UTSW	11	118,119,814 (GRCm38)	missense	probably damaging	1.00
R4716:Dnah17	UTSW	11	118,073,648 (GRCm38)	missense	probably benign	0.02
R4832:Dnah17	UTSW	11	118,026,780 (GRCm38)	missense	probably damaging	1.00
R4868:Dnah17	UTSW	11	118,108,212 (GRCm38)	missense	probably benign	0.03
R4897:Dnah17	UTSW	11	118,078,593 (GRCm38)	missense	probably damaging	1.00
R4928:Dnah17	UTSW	11	118,027,433 (GRCm38)	missense	probably damaging	1.00
R4937:Dnah17	UTSW	11	118,042,154 (GRCm38)	missense	probably damaging	1.00
R4957:Dnah17	UTSW	11	118,074,298 (GRCm38)	missense	probably benign	0.44
R5008:Dnah17	UTSW	11	118,110,577 (GRCm38)	missense	probably benign	0.01
R5016:Dnah17	UTSW	11	118,080,766 (GRCm38)	missense	probably damaging	0.96
R5027:Dnah17	UTSW	11	118,102,539 (GRCm38)	missense	probably benign	0.01
R5133:Dnah17	UTSW	11	118,117,113 (GRCm38)	missense	probably benign	0.00
R5140:Dnah17	UTSW	11	118,086,945 (GRCm38)	missense	probably damaging	1.00
R5146:Dnah17	UTSW	11	118,114,179 (GRCm38)	missense	probably damaging	0.99
R5151:Dnah17	UTSW	11	118,027,467 (GRCm38)	missense	probably damaging	1.00
R5153:Dnah17	UTSW	11	118,082,974 (GRCm38)	nonsense	probably null
R5192:Dnah17	UTSW	11	118,034,359 (GRCm38)	missense	possibly damaging	0.96
R5315:Dnah17	UTSW	11	118,127,283 (GRCm38)	missense	possibly damaging	0.79
R5317:Dnah17	UTSW	11	118,127,283 (GRCm38)	missense	possibly damaging	0.79
R5335:Dnah17	UTSW	11	118,112,514 (GRCm38)	missense	probably damaging	1.00
R5379:Dnah17	UTSW	11	118,117,203 (GRCm38)	intron	probably benign
R5396:Dnah17	UTSW	11	118,127,282 (GRCm38)	missense	probably benign
R5418:Dnah17	UTSW	11	118,094,984 (GRCm38)	missense	probably benign	0.04
R5534:Dnah17	UTSW	11	118,052,770 (GRCm38)	missense	possibly damaging	0.83
R5539:Dnah17	UTSW	11	118,073,660 (GRCm38)	missense	probably benign	0.03
R5594:Dnah17	UTSW	11	118,043,229 (GRCm38)	splice site	probably null
R5634:Dnah17	UTSW	11	118,052,926 (GRCm38)	splice site	probably null
R5696:Dnah17	UTSW	11	118,101,056 (GRCm38)	missense	probably benign	0.44
R5802:Dnah17	UTSW	11	118,036,446 (GRCm38)	missense	possibly damaging	0.79
R5826:Dnah17	UTSW	11	118,034,367 (GRCm38)	missense	probably damaging	1.00
R5873:Dnah17	UTSW	11	118,056,897 (GRCm38)	missense	probably benign	0.01
R5898:Dnah17	UTSW	11	118,114,213 (GRCm38)	missense	probably benign	0.00
R5934:Dnah17	UTSW	11	118,041,102 (GRCm38)	missense	probably benign
R6030:Dnah17	UTSW	11	118,025,549 (GRCm38)	missense	probably benign	0.32
R6030:Dnah17	UTSW	11	118,025,549 (GRCm38)	missense	probably benign	0.32
R6038:Dnah17	UTSW	11	118,055,889 (GRCm38)	missense	probably benign	0.00
R6038:Dnah17	UTSW	11	118,055,889 (GRCm38)	missense	probably benign	0.00
R6113:Dnah17	UTSW	11	118,126,275 (GRCm38)	missense	probably damaging	1.00
R6117:Dnah17	UTSW	11	118,119,571 (GRCm38)	missense	probably benign	0.00
R6137:Dnah17	UTSW	11	118,025,654 (GRCm38)	missense	probably damaging	1.00
R6173:Dnah17	UTSW	11	118,039,946 (GRCm38)	missense	probably damaging	1.00
R6258:Dnah17	UTSW	11	118,126,324 (GRCm38)	missense	probably damaging	1.00
R6258:Dnah17	UTSW	11	118,126,322 (GRCm38)	missense	probably damaging	1.00
R6258:Dnah17	UTSW	11	118,126,323 (GRCm38)	nonsense	probably null
R6260:Dnah17	UTSW	11	118,126,323 (GRCm38)	nonsense	probably null
R6260:Dnah17	UTSW	11	118,126,324 (GRCm38)	missense	probably damaging	1.00
R6260:Dnah17	UTSW	11	118,126,322 (GRCm38)	missense	probably damaging	1.00
R6278:Dnah17	UTSW	11	118,126,290 (GRCm38)	missense	probably damaging	0.99
R6298:Dnah17	UTSW	11	118,108,161 (GRCm38)	missense	probably benign	0.00
R6300:Dnah17	UTSW	11	118,034,310 (GRCm38)	missense	probably damaging	1.00
R6302:Dnah17	UTSW	11	118,129,155 (GRCm38)	missense	probably benign	0.09
R6363:Dnah17	UTSW	11	118,110,505 (GRCm38)	missense	probably benign
R6381:Dnah17	UTSW	11	118,129,185 (GRCm38)	missense	probably benign	0.08
R6418:Dnah17	UTSW	11	118,129,197 (GRCm38)	missense	probably damaging	0.99
R6660:Dnah17	UTSW	11	118,100,188 (GRCm38)	missense	probably benign
R6803:Dnah17	UTSW	11	118,125,372 (GRCm38)	missense	probably benign	0.00
R6820:Dnah17	UTSW	11	118,069,000 (GRCm38)	missense	probably damaging	0.99
R6885:Dnah17	UTSW	11	118,090,772 (GRCm38)	missense	possibly damaging	0.47
R6921:Dnah17	UTSW	11	118,041,484 (GRCm38)	missense	probably damaging	0.98
R6932:Dnah17	UTSW	11	118,060,079 (GRCm38)	missense	possibly damaging	0.95
R6954:Dnah17	UTSW	11	118,066,432 (GRCm38)	missense	probably damaging	1.00
R7000:Dnah17	UTSW	11	118,025,702 (GRCm38)	critical splice acceptor site	probably null
R7007:Dnah17	UTSW	11	118,118,871 (GRCm38)	missense	possibly damaging	0.92
R7048:Dnah17	UTSW	11	118,046,118 (GRCm38)	missense	possibly damaging	0.80
R7056:Dnah17	UTSW	11	118,125,386 (GRCm38)	missense	probably benign
R7131:Dnah17	UTSW	11	118,079,658 (GRCm38)	missense	probably benign	0.14
R7143:Dnah17	UTSW	11	118,086,130 (GRCm38)	missense	probably damaging	1.00
R7146:Dnah17	UTSW	11	118,082,110 (GRCm38)	missense	probably damaging	0.98
R7147:Dnah17	UTSW	11	118,094,929 (GRCm38)	missense	probably benign	0.31
R7172:Dnah17	UTSW	11	118,041,131 (GRCm38)	nonsense	probably null
R7183:Dnah17	UTSW	11	118,129,188 (GRCm38)	missense	probably benign
R7297:Dnah17	UTSW	11	118,103,356 (GRCm38)	missense	probably damaging	0.98
R7297:Dnah17	UTSW	11	118,055,730 (GRCm38)	critical splice donor site	probably null
R7367:Dnah17	UTSW	11	118,115,196 (GRCm38)	missense	probably benign
R7398:Dnah17	UTSW	11	118,080,724 (GRCm38)	missense	probably damaging	0.96
R7426:Dnah17	UTSW	11	118,090,717 (GRCm38)	missense	probably null	0.79
R7524:Dnah17	UTSW	11	118,121,481 (GRCm38)	missense	probably benign	0.03
R7529:Dnah17	UTSW	11	118,049,866 (GRCm38)	critical splice donor site	probably null
R7615:Dnah17	UTSW	11	118,110,547 (GRCm38)	nonsense	probably null
R7681:Dnah17	UTSW	11	118,025,186 (GRCm38)	missense	probably damaging	1.00
R7702:Dnah17	UTSW	11	118,121,478 (GRCm38)	missense	possibly damaging	0.64
R7702:Dnah17	UTSW	11	118,025,640 (GRCm38)	missense	probably benign	0.00
R7713:Dnah17	UTSW	11	118,025,171 (GRCm38)	missense	probably benign	0.02
R7809:Dnah17	UTSW	11	118,104,636 (GRCm38)	missense	probably benign	0.09
R7842:Dnah17	UTSW	11	118,079,682 (GRCm38)	critical splice acceptor site	probably null
R7935:Dnah17	UTSW	11	118,127,222 (GRCm38)	missense	probably benign	0.20
R7951:Dnah17	UTSW	11	118,118,766 (GRCm38)	missense	possibly damaging	0.64
R8098:Dnah17	UTSW	11	118,050,367 (GRCm38)	missense	probably damaging	1.00
R8101:Dnah17	UTSW	11	118,125,918 (GRCm38)	missense	probably benign
R8177:Dnah17	UTSW	11	118,128,927 (GRCm38)	missense	possibly damaging	0.60
R8343:Dnah17	UTSW	11	118,114,195 (GRCm38)	missense	probably benign
R8350:Dnah17	UTSW	11	118,087,047 (GRCm38)	missense	probably damaging	0.98
R8393:Dnah17	UTSW	11	118,057,029 (GRCm38)	missense	probably damaging	1.00
R8401:Dnah17	UTSW	11	118,024,659 (GRCm38)	missense	probably damaging	0.96
R8418:Dnah17	UTSW	11	118,103,458 (GRCm38)	missense	probably benign	0.01
R8450:Dnah17	UTSW	11	118,087,047 (GRCm38)	missense	probably damaging	0.98
R8546:Dnah17	UTSW	11	118,124,275 (GRCm38)	missense	probably benign	0.00
R8697:Dnah17	UTSW	11	118,086,159 (GRCm38)	missense	possibly damaging	0.96
R8710:Dnah17	UTSW	11	118,042,147 (GRCm38)	missense	probably damaging	1.00
R8713:Dnah17	UTSW	11	118,088,202 (GRCm38)	missense	probably damaging	1.00
R8722:Dnah17	UTSW	11	118,070,457 (GRCm38)	nonsense	probably null
R8797:Dnah17	UTSW	11	118,101,375 (GRCm38)	missense	probably benign	0.00
R8953:Dnah17	UTSW	11	118,125,412 (GRCm38)	splice site	probably benign
R8965:Dnah17	UTSW	11	118,024,666 (GRCm38)	missense	probably damaging	1.00
R8976:Dnah17	UTSW	11	118,026,840 (GRCm38)	missense	probably damaging	1.00
R9090:Dnah17	UTSW	11	118,041,044 (GRCm38)	missense	probably damaging	1.00
R9128:Dnah17	UTSW	11	118,046,178 (GRCm38)	missense	possibly damaging	0.76
R9134:Dnah17	UTSW	11	118,088,146 (GRCm38)	missense	probably damaging	1.00
R9245:Dnah17	UTSW	11	118,125,677 (GRCm38)	missense	probably benign	0.02
R9251:Dnah17	UTSW	11	118,121,792 (GRCm38)	missense	probably benign	0.03
R9271:Dnah17	UTSW	11	118,041,044 (GRCm38)	missense	probably damaging	1.00
R9367:Dnah17	UTSW	11	118,121,386 (GRCm38)	missense	possibly damaging	0.93
R9367:Dnah17	UTSW	11	118,096,638 (GRCm38)	missense	possibly damaging	0.95
R9381:Dnah17	UTSW	11	118,023,393 (GRCm38)	missense	probably benign
R9405:Dnah17	UTSW	11	118,118,911 (GRCm38)	missense	probably benign
R9449:Dnah17	UTSW	11	118,096,626 (GRCm38)	missense	probably benign	0.07
R9517:Dnah17	UTSW	11	118,024,614 (GRCm38)	missense	possibly damaging	0.76
R9588:Dnah17	UTSW	11	118,121,957 (GRCm38)	missense	probably benign	0.00
R9629:Dnah17	UTSW	11	118,088,978 (GRCm38)	missense	probably damaging	1.00
R9654:Dnah17	UTSW	11	118,036,330 (GRCm38)	critical splice donor site	probably null
R9655:Dnah17	UTSW	11	118,080,823 (GRCm38)	missense	possibly damaging	0.94
R9662:Dnah17	UTSW	11	118,034,340 (GRCm38)	missense	probably damaging	0.97
R9686:Dnah17	UTSW	11	118,088,222 (GRCm38)	missense	possibly damaging	0.46
R9689:Dnah17	UTSW	11	118,072,905 (GRCm38)	missense	probably damaging	1.00
R9706:Dnah17	UTSW	11	118,126,200 (GRCm38)	missense	probably damaging	1.00
X0058:Dnah17	UTSW	11	118,082,925 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah17	UTSW	11	118,127,166 (GRCm38)	missense	probably benign	0.01
Z1177:Dnah17	UTSW	11	118,086,960 (GRCm38)	missense	probably damaging	1.00
Z1177:Dnah17	UTSW	11	118,078,563 (GRCm38)	missense	possibly damaging	0.91
Z1177:Dnah17	UTSW	11	118,127,142 (GRCm38)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGAAATCCTAGCAATCCTCCAGG -3'
(R):5'- AGCAGCTCACGTTTTCTTCCAG -3'

Sequencing Primer
(F):5'- CTCAGTGTGGCTCCAAGC -3'
(R):5'- AGGAGCTTGAATCCTGGACCAC -3'

Posted On

2020-01-23