Incidental Mutation 'R8072:Vmn2r90'
| ID |
620305 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r90
|
| Ensembl Gene |
ENSMUSG00000092120 |
| Gene Name |
vomeronasal 2, receptor 90 |
| Synonyms |
EG626942 |
| MMRRC Submission |
067507-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.139)
|
| Stock # |
R8072 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
17924203-17954429 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 17947142 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Isoleucine
at position 473
(N473I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126650
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169805]
[ENSMUST00000231659]
[ENSMUST00000232078]
[ENSMUST00000232113]
|
| AlphaFold |
E9PXJ8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169805
AA Change: N473I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000126650
Gene: ENSMUSG00000092120
AA Change: N473I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
1.8e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
3e-22 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
9.8e-54 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231659
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232078
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232113
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.3%
- 20x: 97.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 47 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
C |
11: 9,244,574 (GRCm39) |
S2146P |
probably benign |
Het |
| Acad9 |
G |
A |
3: 36,129,404 (GRCm39) |
V160I |
probably benign |
Het |
| Ace |
T |
C |
11: 105,863,785 (GRCm39) |
V411A |
probably damaging |
Het |
| Ankrd66 |
T |
C |
17: 43,854,526 (GRCm39) |
E2G |
possibly damaging |
Het |
| Apol6 |
A |
T |
15: 76,935,303 (GRCm39) |
T191S |
probably benign |
Het |
| Arhgef17 |
T |
A |
7: 100,531,004 (GRCm39) |
T352S |
probably benign |
Het |
| Atad2 |
C |
T |
15: 57,963,374 (GRCm39) |
R1081Q |
possibly damaging |
Het |
| Atg3 |
G |
T |
16: 45,008,048 (GRCm39) |
V297F |
probably damaging |
Het |
| Atp9b |
A |
C |
18: 80,808,276 (GRCm39) |
S663A |
|
Het |
| Col10a1 |
G |
T |
10: 34,266,663 (GRCm39) |
V16F |
unknown |
Het |
| Col3a1 |
G |
A |
1: 45,360,734 (GRCm39) |
V55I |
unknown |
Het |
| Ctns |
T |
C |
11: 73,082,572 (GRCm39) |
T53A |
probably benign |
Het |
| Cyp2b23 |
A |
T |
7: 26,365,431 (GRCm39) |
I468N |
probably damaging |
Het |
| Dcbld2 |
G |
A |
16: 58,283,460 (GRCm39) |
W565* |
probably null |
Het |
| Esco2 |
A |
T |
14: 66,070,130 (GRCm39) |
N16K |
probably benign |
Het |
| Fggy |
A |
G |
4: 95,732,394 (GRCm39) |
N462D |
possibly damaging |
Het |
| Fhod3 |
TGAGGAGGAGGAGGAGGA |
TGAGGAGGAGGAGGA |
18: 25,153,722 (GRCm39) |
|
probably benign |
Het |
| Gm4846 |
T |
C |
1: 166,322,241 (GRCm39) |
T109A |
probably benign |
Het |
| H2-M11 |
G |
T |
17: 36,859,026 (GRCm39) |
V189L |
probably benign |
Het |
| Hmcn1 |
T |
A |
1: 150,532,256 (GRCm39) |
T3175S |
possibly damaging |
Het |
| Hook2 |
G |
A |
8: 85,721,120 (GRCm39) |
V184M |
probably benign |
Het |
| Hspa4l |
A |
T |
3: 40,741,178 (GRCm39) |
D730V |
probably damaging |
Het |
| Igkv4-68 |
C |
T |
6: 69,282,113 (GRCm39) |
M19I |
probably benign |
Het |
| Igsf9b |
C |
A |
9: 27,228,660 (GRCm39) |
T140N |
possibly damaging |
Het |
| Kcnj1 |
G |
A |
9: 32,308,593 (GRCm39) |
R339Q |
probably damaging |
Het |
| Lcn8 |
T |
G |
2: 25,545,184 (GRCm39) |
L118W |
probably damaging |
Het |
| Lin28a |
A |
G |
4: 133,745,453 (GRCm39) |
F47L |
possibly damaging |
Het |
| Loxl4 |
T |
C |
19: 42,596,021 (GRCm39) |
E144G |
probably damaging |
Het |
| Mmp1a |
TG |
TGG |
9: 7,465,083 (GRCm38) |
|
probably null |
Het |
| Mrgprb1 |
C |
A |
7: 48,097,895 (GRCm39) |
E6* |
probably null |
Het |
| Mthfsd |
A |
C |
8: 121,825,555 (GRCm39) |
Y339D |
probably damaging |
Het |
| Mup11 |
A |
T |
4: 60,615,777 (GRCm39) |
F153L |
probably damaging |
Het |
| Pcdhac2 |
G |
A |
18: 37,278,717 (GRCm39) |
V566M |
probably benign |
Het |
| Plpp7 |
G |
T |
2: 31,986,121 (GRCm39) |
A100S |
probably benign |
Het |
| Prg4 |
T |
C |
1: 150,331,774 (GRCm39) |
T300A |
possibly damaging |
Het |
| Ptprd |
A |
G |
4: 76,004,273 (GRCm39) |
F161L |
probably benign |
Het |
| Pwp2 |
G |
A |
10: 78,007,930 (GRCm39) |
A875V |
possibly damaging |
Het |
| Rhd |
A |
G |
4: 134,611,460 (GRCm39) |
T207A |
possibly damaging |
Het |
| Sh2d3c |
C |
T |
2: 32,643,150 (GRCm39) |
R778C |
probably damaging |
Het |
| Slc34a3 |
A |
C |
2: 25,119,289 (GRCm39) |
V527G |
probably benign |
Het |
| Smad2 |
T |
C |
18: 76,420,022 (GRCm39) |
|
probably null |
Het |
| Sp110 |
GTACT |
GTACTACT |
1: 85,515,207 (GRCm39) |
|
probably benign |
Het |
| Spata21 |
C |
T |
4: 140,839,317 (GRCm39) |
Q611* |
probably null |
Het |
| Taf4b |
A |
G |
18: 14,954,585 (GRCm39) |
T554A |
probably benign |
Het |
| Tial1 |
T |
C |
7: 128,044,194 (GRCm39) |
T107A |
unknown |
Het |
| Ubxn6 |
C |
A |
17: 56,380,195 (GRCm39) |
R42L |
probably benign |
Het |
| Ythdc1 |
T |
A |
5: 86,969,133 (GRCm39) |
Y351* |
probably null |
Het |
|
| Other mutations in Vmn2r90 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Vmn2r90
|
APN |
17 |
17,953,758 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01330:Vmn2r90
|
APN |
17 |
17,953,542 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01989:Vmn2r90
|
APN |
17 |
17,933,494 (GRCm39) |
nonsense |
probably null |
|
|
IGL02080:Vmn2r90
|
APN |
17 |
17,933,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02112:Vmn2r90
|
APN |
17 |
17,932,465 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02123:Vmn2r90
|
APN |
17 |
17,953,744 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02749:Vmn2r90
|
APN |
17 |
17,947,122 (GRCm39) |
makesense |
probably null |
|
|
IGL03114:Vmn2r90
|
APN |
17 |
17,953,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Vmn2r90
|
UTSW |
17 |
17,932,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0131:Vmn2r90
|
UTSW |
17 |
17,932,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0132:Vmn2r90
|
UTSW |
17 |
17,932,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0184:Vmn2r90
|
UTSW |
17 |
17,947,139 (GRCm39) |
nonsense |
probably null |
|
|
R0379:Vmn2r90
|
UTSW |
17 |
17,948,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1022:Vmn2r90
|
UTSW |
17 |
17,948,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1024:Vmn2r90
|
UTSW |
17 |
17,948,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1897:Vmn2r90
|
UTSW |
17 |
17,953,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1993:Vmn2r90
|
UTSW |
17 |
17,933,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2472:Vmn2r90
|
UTSW |
17 |
17,948,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2508:Vmn2r90
|
UTSW |
17 |
17,954,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2679:Vmn2r90
|
UTSW |
17 |
17,933,131 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3409:Vmn2r90
|
UTSW |
17 |
17,953,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4693:Vmn2r90
|
UTSW |
17 |
17,953,956 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4797:Vmn2r90
|
UTSW |
17 |
17,932,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5258:Vmn2r90
|
UTSW |
17 |
17,933,114 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5358:Vmn2r90
|
UTSW |
17 |
17,924,412 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5445:Vmn2r90
|
UTSW |
17 |
17,954,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5446:Vmn2r90
|
UTSW |
17 |
17,932,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5567:Vmn2r90
|
UTSW |
17 |
17,932,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5680:Vmn2r90
|
UTSW |
17 |
17,947,034 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5686:Vmn2r90
|
UTSW |
17 |
17,933,712 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5751:Vmn2r90
|
UTSW |
17 |
17,954,128 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6156:Vmn2r90
|
UTSW |
17 |
17,953,606 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6185:Vmn2r90
|
UTSW |
17 |
17,953,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6450:Vmn2r90
|
UTSW |
17 |
17,953,498 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6707:Vmn2r90
|
UTSW |
17 |
17,948,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6802:Vmn2r90
|
UTSW |
17 |
17,932,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6913:Vmn2r90
|
UTSW |
17 |
17,924,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7070:Vmn2r90
|
UTSW |
17 |
17,924,313 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7237:Vmn2r90
|
UTSW |
17 |
17,924,249 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7503:Vmn2r90
|
UTSW |
17 |
17,933,510 (GRCm39) |
missense |
not run |
|
|
R7698:Vmn2r90
|
UTSW |
17 |
17,953,596 (GRCm39) |
missense |
probably benign |
|
|
R7943:Vmn2r90
|
UTSW |
17 |
17,932,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8128:Vmn2r90
|
UTSW |
17 |
17,954,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8295:Vmn2r90
|
UTSW |
17 |
17,948,358 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8345:Vmn2r90
|
UTSW |
17 |
17,933,127 (GRCm39) |
nonsense |
probably null |
|
|
R8682:Vmn2r90
|
UTSW |
17 |
17,932,344 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8716:Vmn2r90
|
UTSW |
17 |
17,924,343 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9041:Vmn2r90
|
UTSW |
17 |
17,954,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9412:Vmn2r90
|
UTSW |
17 |
17,954,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9607:Vmn2r90
|
UTSW |
17 |
17,953,638 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9705:Vmn2r90
|
UTSW |
17 |
17,933,039 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Z1088:Vmn2r90
|
UTSW |
17 |
17,953,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r90
|
UTSW |
17 |
17,933,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCACTGCTATTGTTTGTCTTACT -3'
(R):5'- GATTGGTACCAAATAACTATCCATGTA -3'
Sequencing Primer
(F):5'- TGAGAGGCCCCTCGGTATTAAAAAC -3'
(R):5'- GAGGCCATTGTATCCTCT -3'
|
| Posted On |
2020-01-23 |
Incidental Mutation