Incidental Mutation 'R8073:Vmn2r79'
| ID |
620345 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r79
|
| Ensembl Gene |
ENSMUSG00000090362 |
| Gene Name |
vomeronasal 2, receptor 79 |
| Synonyms |
EG621430 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.092)
|
| Stock # |
R8073 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
86645673-86687176 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 86651462 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Leucine
at position 287
(Q287L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132478
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164462]
|
| AlphaFold |
E9Q067 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164462
AA Change: Q287L
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: Q287L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
1.9e-31 |
PFAM |
|
Pfam:NCD3G
|
506 |
559 |
3.1e-21 |
PFAM |
|
Pfam:7tm_3
|
592 |
827 |
2.8e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ago1 |
C |
T |
4: 126,337,019 (GRCm39) |
V533I |
probably benign |
Het |
| Akap3 |
A |
T |
6: 126,842,736 (GRCm39) |
T452S |
probably damaging |
Het |
| Angpt1 |
C |
T |
15: 42,301,699 (GRCm39) |
M436I |
probably benign |
Het |
| B3galt4 |
T |
C |
17: 34,169,797 (GRCm39) |
K147R |
probably damaging |
Het |
| Birc6 |
C |
A |
17: 74,910,080 (GRCm39) |
T1491K |
probably damaging |
Het |
| Boll |
T |
C |
1: 55,394,881 (GRCm39) |
|
probably benign |
Het |
| C6 |
T |
C |
15: 4,764,675 (GRCm39) |
F124L |
probably benign |
Het |
| Camta1 |
T |
C |
4: 151,163,281 (GRCm39) |
Y436C |
probably damaging |
Het |
| Celsr1 |
T |
C |
15: 85,823,356 (GRCm39) |
N1684S |
probably benign |
Het |
| Cflar |
T |
C |
1: 58,791,981 (GRCm39) |
L428P |
|
Het |
| Clk4 |
T |
C |
11: 51,168,716 (GRCm39) |
I363T |
probably benign |
Het |
| Cnst |
A |
G |
1: 179,434,002 (GRCm39) |
T273A |
probably benign |
Het |
| Col5a1 |
C |
T |
2: 27,852,141 (GRCm39) |
A546V |
possibly damaging |
Het |
| Col6a6 |
T |
A |
9: 105,659,146 (GRCm39) |
N600Y |
probably benign |
Het |
| Cxadr |
A |
G |
16: 78,130,301 (GRCm39) |
N156S |
probably benign |
Het |
| Diaph1 |
C |
T |
18: 38,024,850 (GRCm39) |
G537E |
unknown |
Het |
| Dmxl1 |
T |
A |
18: 50,011,500 (GRCm39) |
V1219D |
probably damaging |
Het |
| Dnajb12 |
T |
A |
10: 59,726,001 (GRCm39) |
Y95* |
probably null |
Het |
| Dnajc5g |
A |
G |
5: 31,269,029 (GRCm39) |
T137A |
probably benign |
Het |
| Dpy19l3 |
G |
A |
7: 35,429,173 (GRCm39) |
T89M |
probably damaging |
Het |
| Dusp19 |
C |
A |
2: 80,447,828 (GRCm39) |
T34N |
probably benign |
Het |
| Eln |
CTCCAGCTCCGAT |
C |
5: 134,758,003 (GRCm39) |
|
probably benign |
Het |
| Enpp1 |
A |
G |
10: 24,555,142 (GRCm39) |
V68A |
possibly damaging |
Het |
| Epha7 |
T |
A |
4: 28,821,022 (GRCm39) |
D62E |
probably damaging |
Het |
| Frmd4b |
A |
T |
6: 97,283,674 (GRCm39) |
V445E |
probably benign |
Het |
| Gp9 |
A |
C |
6: 87,756,336 (GRCm39) |
D117A |
probably benign |
Het |
| Haao |
T |
C |
17: 84,142,649 (GRCm39) |
E152G |
possibly damaging |
Het |
| Ift70a2 |
A |
G |
2: 75,806,997 (GRCm39) |
V505A |
probably damaging |
Het |
| Ighd |
A |
G |
12: 113,379,789 (GRCm39) |
S52P |
probably benign |
Het |
| Ikzf3 |
T |
C |
11: 98,358,255 (GRCm39) |
K361E |
probably benign |
Het |
| Lgi2 |
T |
A |
5: 52,704,013 (GRCm39) |
E206V |
probably benign |
Het |
| Mfsd11 |
T |
A |
11: 116,754,749 (GRCm39) |
V220E |
probably benign |
Het |
| Moxd1 |
G |
T |
10: 24,128,848 (GRCm39) |
G200C |
probably damaging |
Het |
| Mthfd1l |
C |
A |
10: 3,923,417 (GRCm39) |
Q55K |
probably benign |
Het |
| Nlrp9a |
T |
A |
7: 26,260,260 (GRCm39) |
L672M |
probably damaging |
Het |
| Npvf |
A |
C |
6: 50,631,349 (GRCm39) |
F9V |
probably damaging |
Het |
| Nup205 |
G |
T |
6: 35,179,104 (GRCm39) |
|
probably null |
Het |
| Nup43 |
T |
C |
10: 7,546,713 (GRCm39) |
V111A |
probably benign |
Het |
| Obscn |
C |
T |
11: 59,026,516 (GRCm39) |
R229H |
probably benign |
Het |
| Olfml2a |
C |
A |
2: 38,847,766 (GRCm39) |
R442S |
probably damaging |
Het |
| Or10j2 |
A |
G |
1: 173,098,552 (GRCm39) |
D270G |
probably benign |
Het |
| Or2ag16 |
C |
A |
7: 106,352,008 (GRCm39) |
E196* |
probably null |
Het |
| Or4c120 |
T |
A |
2: 89,001,284 (GRCm39) |
I91F |
probably damaging |
Het |
| Or5b12b |
T |
A |
19: 12,861,980 (GRCm39) |
V245E |
probably benign |
Het |
| Or9s13 |
T |
A |
1: 92,547,806 (GRCm39) |
D59E |
probably damaging |
Het |
| Pcdhga7 |
T |
C |
18: 37,848,398 (GRCm39) |
F135S |
probably damaging |
Het |
| Pde4a |
A |
T |
9: 21,122,065 (GRCm39) |
I654F |
probably damaging |
Het |
| Pip5kl1 |
G |
A |
2: 32,473,440 (GRCm39) |
R359Q |
possibly damaging |
Het |
| Ppp2ca |
T |
C |
11: 52,010,124 (GRCm39) |
V244A |
possibly damaging |
Het |
| Qrich1 |
T |
A |
9: 108,411,627 (GRCm39) |
L384H |
possibly damaging |
Het |
| Rab4a |
T |
C |
8: 124,554,135 (GRCm39) |
V62A |
possibly damaging |
Het |
| Ranbp10 |
A |
G |
8: 106,513,261 (GRCm39) |
L217P |
probably damaging |
Het |
| Rhebl1 |
C |
T |
15: 98,776,405 (GRCm39) |
A131T |
probably benign |
Het |
| Rnf150 |
A |
T |
8: 83,590,546 (GRCm39) |
|
probably benign |
Het |
| Slc32a1 |
G |
A |
2: 158,456,685 (GRCm39) |
A447T |
probably damaging |
Het |
| Spag5 |
T |
A |
11: 78,192,803 (GRCm39) |
M45K |
probably benign |
Het |
| Spata13 |
A |
G |
14: 60,928,705 (GRCm39) |
N88D |
probably damaging |
Het |
| Spred2 |
C |
A |
11: 19,958,422 (GRCm39) |
T128N |
probably benign |
Het |
| Tenm2 |
T |
C |
11: 36,030,471 (GRCm39) |
E776G |
possibly damaging |
Het |
| Tet1 |
C |
G |
10: 62,649,132 (GRCm39) |
E156Q |
probably damaging |
Het |
| Tmc1 |
T |
C |
19: 20,845,725 (GRCm39) |
N166S |
probably benign |
Het |
| Trim43a |
C |
A |
9: 88,464,490 (GRCm39) |
Q134K |
possibly damaging |
Het |
| Tsks |
A |
T |
7: 44,607,305 (GRCm39) |
M543L |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,574,181 (GRCm39) |
K25571E |
probably damaging |
Het |
| Vamp5 |
C |
A |
6: 72,357,436 (GRCm39) |
|
probably benign |
Het |
| Zfp326 |
T |
A |
5: 106,062,682 (GRCm39) |
V517E |
unknown |
Het |
| Zfp467 |
A |
T |
6: 48,414,959 (GRCm39) |
H564Q |
probably damaging |
Het |
| Zfp51 |
G |
A |
17: 21,684,294 (GRCm39) |
C303Y |
probably damaging |
Het |
|
| Other mutations in Vmn2r79 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01401:Vmn2r79
|
APN |
7 |
86,686,481 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01675:Vmn2r79
|
APN |
7 |
86,645,856 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01760:Vmn2r79
|
APN |
7 |
86,651,366 (GRCm39) |
missense |
probably benign |
|
|
IGL01834:Vmn2r79
|
APN |
7 |
86,686,354 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01843:Vmn2r79
|
APN |
7 |
86,686,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01914:Vmn2r79
|
APN |
7 |
86,686,571 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01980:Vmn2r79
|
APN |
7 |
86,686,290 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02438:Vmn2r79
|
APN |
7 |
86,651,744 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02740:Vmn2r79
|
APN |
7 |
86,653,366 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03052:Vmn2r79
|
UTSW |
7 |
86,652,799 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4445001:Vmn2r79
|
UTSW |
7 |
86,651,408 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0096:Vmn2r79
|
UTSW |
7 |
86,686,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Vmn2r79
|
UTSW |
7 |
86,686,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0270:Vmn2r79
|
UTSW |
7 |
86,652,594 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0336:Vmn2r79
|
UTSW |
7 |
86,651,287 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0418:Vmn2r79
|
UTSW |
7 |
86,651,611 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1070:Vmn2r79
|
UTSW |
7 |
86,652,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1234:Vmn2r79
|
UTSW |
7 |
86,653,307 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1459:Vmn2r79
|
UTSW |
7 |
86,687,002 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1513:Vmn2r79
|
UTSW |
7 |
86,686,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1624:Vmn2r79
|
UTSW |
7 |
86,653,247 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1633:Vmn2r79
|
UTSW |
7 |
86,687,042 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1676:Vmn2r79
|
UTSW |
7 |
86,651,839 (GRCm39) |
missense |
probably benign |
|
|
R1781:Vmn2r79
|
UTSW |
7 |
86,651,555 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1794:Vmn2r79
|
UTSW |
7 |
86,650,621 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1823:Vmn2r79
|
UTSW |
7 |
86,687,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2013:Vmn2r79
|
UTSW |
7 |
86,653,289 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2018:Vmn2r79
|
UTSW |
7 |
86,651,634 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2019:Vmn2r79
|
UTSW |
7 |
86,651,634 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2177:Vmn2r79
|
UTSW |
7 |
86,645,839 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2984:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3719:Vmn2r79
|
UTSW |
7 |
86,651,245 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3798:Vmn2r79
|
UTSW |
7 |
86,651,402 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3969:Vmn2r79
|
UTSW |
7 |
86,652,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4183:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4245:Vmn2r79
|
UTSW |
7 |
86,651,624 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4301:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4391:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4393:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4394:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4396:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4397:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4592:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4697:Vmn2r79
|
UTSW |
7 |
86,687,168 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4897:Vmn2r79
|
UTSW |
7 |
86,650,675 (GRCm39) |
missense |
probably benign |
|
|
R5016:Vmn2r79
|
UTSW |
7 |
86,686,548 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5058:Vmn2r79
|
UTSW |
7 |
86,651,423 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5177:Vmn2r79
|
UTSW |
7 |
86,651,177 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6078:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6079:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6138:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6257:Vmn2r79
|
UTSW |
7 |
86,651,778 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6260:Vmn2r79
|
UTSW |
7 |
86,686,365 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6307:Vmn2r79
|
UTSW |
7 |
86,686,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6323:Vmn2r79
|
UTSW |
7 |
86,650,522 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6374:Vmn2r79
|
UTSW |
7 |
86,651,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6530:Vmn2r79
|
UTSW |
7 |
86,651,252 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6546:Vmn2r79
|
UTSW |
7 |
86,652,741 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6682:Vmn2r79
|
UTSW |
7 |
86,653,370 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6858:Vmn2r79
|
UTSW |
7 |
86,686,580 (GRCm39) |
missense |
probably benign |
|
|
R6965:Vmn2r79
|
UTSW |
7 |
86,651,100 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7130:Vmn2r79
|
UTSW |
7 |
86,651,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7156:Vmn2r79
|
UTSW |
7 |
86,686,851 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7604:Vmn2r79
|
UTSW |
7 |
86,652,592 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7691:Vmn2r79
|
UTSW |
7 |
86,687,111 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8055:Vmn2r79
|
UTSW |
7 |
86,686,541 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8070:Vmn2r79
|
UTSW |
7 |
86,651,336 (GRCm39) |
missense |
probably benign |
|
|
R8145:Vmn2r79
|
UTSW |
7 |
86,686,862 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8263:Vmn2r79
|
UTSW |
7 |
86,686,726 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8350:Vmn2r79
|
UTSW |
7 |
86,686,741 (GRCm39) |
nonsense |
probably null |
|
|
R8400:Vmn2r79
|
UTSW |
7 |
86,651,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8814:Vmn2r79
|
UTSW |
7 |
86,651,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8862:Vmn2r79
|
UTSW |
7 |
86,645,712 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9146:Vmn2r79
|
UTSW |
7 |
86,650,681 (GRCm39) |
nonsense |
probably null |
|
|
R9276:Vmn2r79
|
UTSW |
7 |
86,687,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9361:Vmn2r79
|
UTSW |
7 |
86,652,822 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9676:Vmn2r79
|
UTSW |
7 |
86,686,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
U15987:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0054:Vmn2r79
|
UTSW |
7 |
86,653,270 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1088:Vmn2r79
|
UTSW |
7 |
86,651,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r79
|
UTSW |
7 |
86,686,377 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r79
|
UTSW |
7 |
86,651,526 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTTCTGAATTGAGAGCAGGAATGG -3'
(R):5'- TAAGTCCACCACAGTTTAGCC -3'
Sequencing Primer
(F):5'- GGAAAGTAACACTGTCTGCTTAGC -3'
(R):5'- CCACAGTTTAGCCAATGAAATGTC -3'
|
| Posted On |
2020-01-23 |
Incidental Mutation