Mutagenetix > Incidental Mutation

Incidental Mutation 'R8073:Dmxl1'

620381

Institutional Source

Beutler Lab

Gene Symbol

Dmxl1

Ensembl Gene

ENSMUSG00000037416

Gene Name

Dmx-like 1

Synonyms

C630007L23Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.953) question?

Stock #

R8073 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

49832670-49965473 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 49878433 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 1219 (V1219D)

Ref Sequence

ENSEMBL: ENSMUSP00000137871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041772] [ENSMUST00000180611]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000041772
AA Change: V1219D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000045559
Gene: ENSMUSG00000037416
AA Change: V1219D

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
Pfam:Rav1p_C	1102	1877	4.3e-84	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2371	2385	N/A	INTRINSIC
low complexity region	2397	2410	N/A	INTRINSIC
low complexity region	2449	2466	N/A	INTRINSIC
WD40	2735	2770	1.07e1	SMART
WD40	2773	2813	3.7e0	SMART
WD40	2825	2867	1.07e0	SMART
WD40	2873	2912	1.05e-2	SMART
WD40	2915	2954	4.51e-7	SMART
Blast:WD40	2957	3005	9e-26	BLAST

Predicted Effect

probably damaging
Transcript: ENSMUST00000180611
AA Change: V1219D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000137871
Gene: ENSMUSG00000037416
AA Change: V1219D

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
low complexity region	1195	1206	N/A	INTRINSIC
low complexity region	1258	1271	N/A	INTRINSIC
Pfam:Rav1p_C	1287	1876	9.4e-72	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2385	2398	N/A	INTRINSIC
low complexity region	2437	2454	N/A	INTRINSIC
WD40	2723	2758	1.07e1	SMART
WD40	2761	2801	3.7e0	SMART
WD40	2813	2855	1.07e0	SMART
WD40	2861	2900	1.05e-2	SMART
WD40	2903	2942	4.51e-7	SMART
Blast:WD40	2945	2993	9e-26	BLAST

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ago1	C	T	4: 126,443,226	V533I	probably benign	Het
Akap3	A	T	6: 126,865,773	T452S	probably damaging	Het
Angpt1	C	T	15: 42,438,303	M436I	probably benign	Het
B3galt4	T	C	17: 33,950,823	K147R	probably damaging	Het
Birc6	C	A	17: 74,603,085	T1491K	probably damaging	Het
Boll	T	C	1: 55,355,722		probably benign	Het
C6	T	C	15: 4,735,193	F124L	probably benign	Het
Camta1	T	C	4: 151,078,824	Y436C	probably damaging	Het
Celsr1	T	C	15: 85,939,155	N1684S	probably benign	Het
Cflar	T	C	1: 58,752,822	L428P		Het
Clk4	T	C	11: 51,277,889	I363T	probably benign	Het
Cnst	A	G	1: 179,606,437	T273A	probably benign	Het
Col5a1	C	T	2: 27,962,129	A546V	possibly damaging	Het
Col6a6	T	A	9: 105,781,947	N600Y	probably benign	Het
Cxadr	A	G	16: 78,333,413	N156S	probably benign	Het
Diaph1	C	T	18: 37,891,797	G537E	unknown	Het
Dnajb12	T	A	10: 59,890,179	Y95*	probably null	Het
Dnajc5g	A	G	5: 31,111,685	T137A	probably benign	Het
Dpy19l3	G	A	7: 35,729,748	T89M	probably damaging	Het
Dusp19	C	A	2: 80,617,484	T34N	probably benign	Het
Eln	CTCCAGCTCCGAT	C	5: 134,729,149		probably benign	Het
Enpp1	A	G	10: 24,679,244	V68A	possibly damaging	Het
Epha7	T	A	4: 28,821,022	D62E	probably damaging	Het
Frmd4b	A	T	6: 97,306,713	V445E	probably benign	Het
Gp9	A	C	6: 87,779,354	D117A	probably benign	Het
Haao	T	C	17: 83,835,220	E152G	possibly damaging	Het
Ighd	A	G	12: 113,416,169	S52P	probably benign	Het
Ikzf3	T	C	11: 98,467,429	K361E	probably benign	Het
Lgi2	T	A	5: 52,546,671	E206V	probably benign	Het
Mfsd11	T	A	11: 116,863,923	V220E	probably benign	Het
Moxd1	G	T	10: 24,252,950	G200C	probably damaging	Het
Mthfd1l	C	A	10: 3,973,417	Q55K	probably benign	Het
Nlrp9a	T	A	7: 26,560,835	L672M	probably damaging	Het
Npvf	A	C	6: 50,654,369	F9V	probably damaging	Het
Nup205	G	T	6: 35,202,169		probably null	Het
Nup43	T	C	10: 7,670,949	V111A	probably benign	Het
Obscn	C	T	11: 59,135,690	R229H	probably benign	Het
Olfml2a	C	A	2: 38,957,754	R442S	probably damaging	Het
Olfr12	T	A	1: 92,620,084	D59E	probably damaging	Het
Olfr1225	T	A	2: 89,170,940	I91F	probably damaging	Het
Olfr1445	T	A	19: 12,884,616	V245E	probably benign	Het
Olfr418	A	G	1: 173,270,985	D270G	probably benign	Het
Olfr698	C	A	7: 106,752,801	E196*	probably null	Het
Pcdhga7	T	C	18: 37,715,345	F135S	probably damaging	Het
Pde4a	A	T	9: 21,210,769	I654F	probably damaging	Het
Pip5kl1	G	A	2: 32,583,428	R359Q	possibly damaging	Het
Ppp2ca	T	C	11: 52,119,297	V244A	possibly damaging	Het
Qrich1	T	A	9: 108,534,428	L384H	possibly damaging	Het
Rab4a	T	C	8: 123,827,396	V62A	possibly damaging	Het
Ranbp10	A	G	8: 105,786,629	L217P	probably damaging	Het
Rhebl1	C	T	15: 98,878,524	A131T	probably benign	Het
Rnf150	A	T	8: 82,863,917		probably benign	Het
Slc32a1	G	A	2: 158,614,765	A447T	probably damaging	Het
Spag5	T	A	11: 78,301,977	M45K	probably benign	Het
Spata13	A	G	14: 60,691,256	N88D	probably damaging	Het
Spred2	C	A	11: 20,008,422	T128N	probably benign	Het
Tenm2	T	C	11: 36,139,644	E776G	possibly damaging	Het
Tet1	C	G	10: 62,813,353	E156Q	probably damaging	Het
Tmc1	T	C	19: 20,868,361	N166S	probably benign	Het
Trim43a	C	A	9: 88,582,437	Q134K	possibly damaging	Het
Tsks	A	T	7: 44,957,881	M543L	probably benign	Het
Ttc30a2	A	G	2: 75,976,653	V505A	probably damaging	Het
Ttn	T	C	2: 76,743,837	K25571E	probably damaging	Het
Vamp5	C	A	6: 72,380,453		probably benign	Het
Vmn2r79	A	T	7: 87,002,254	Q287L	probably benign	Het
Zfp326	T	A	5: 105,914,816	V517E	unknown	Het
Zfp467	A	T	6: 48,438,025	H564Q	probably damaging	Het
Zfp51	G	A	17: 21,464,032	C303Y	probably damaging	Het

Other mutations in Dmxl1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Dmxl1	APN	18	49,851,467 (GRCm38)	missense	probably damaging	1.00
IGL00668:Dmxl1	APN	18	49,939,553 (GRCm38)	missense	possibly damaging	0.64
IGL00740:Dmxl1	APN	18	49,917,668 (GRCm38)	missense	probably benign	0.00
IGL00969:Dmxl1	APN	18	49,912,725 (GRCm38)	missense	probably benign	0.02
IGL01113:Dmxl1	APN	18	49,912,751 (GRCm38)	missense	probably benign	0.01
IGL01384:Dmxl1	APN	18	49,857,334 (GRCm38)	missense	probably benign
IGL01475:Dmxl1	APN	18	49,871,714 (GRCm38)	missense	probably damaging	1.00
IGL01559:Dmxl1	APN	18	49,920,938 (GRCm38)	missense	probably damaging	0.99
IGL01578:Dmxl1	APN	18	49,962,205 (GRCm38)	missense	probably damaging	1.00
IGL01632:Dmxl1	APN	18	49,863,025 (GRCm38)	missense	probably damaging	0.99
IGL01814:Dmxl1	APN	18	49,864,868 (GRCm38)	missense	probably damaging	1.00
IGL01843:Dmxl1	APN	18	49,878,382 (GRCm38)	nonsense	probably null
IGL01933:Dmxl1	APN	18	49,877,785 (GRCm38)	missense	probably benign	0.17
IGL01952:Dmxl1	APN	18	49,890,654 (GRCm38)	missense	probably benign	0.11
IGL02120:Dmxl1	APN	18	49,894,178 (GRCm38)	missense	possibly damaging	0.83
IGL02162:Dmxl1	APN	18	49,961,163 (GRCm38)	missense	probably benign	0.00
IGL02213:Dmxl1	APN	18	49,877,674 (GRCm38)	splice site	probably benign
IGL02261:Dmxl1	APN	18	49,840,499 (GRCm38)	missense	possibly damaging	0.85
IGL02689:Dmxl1	APN	18	49,864,895 (GRCm38)	missense	probably damaging	1.00
IGL02892:Dmxl1	APN	18	49,859,120 (GRCm38)	missense	probably damaging	0.96
IGL03232:Dmxl1	APN	18	49,878,180 (GRCm38)	missense	probably benign	0.01
IGL03258:Dmxl1	APN	18	49,920,893 (GRCm38)	missense	probably damaging	1.00
IGL03298:Dmxl1	APN	18	49,864,818 (GRCm38)	missense	probably benign
capture	UTSW	18	49,962,261 (GRCm38)	missense	probably damaging	1.00
carnivora	UTSW	18	49,864,383 (GRCm38)	missense	probably damaging	0.99
digestion	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
drowning	UTSW	18	49,878,225 (GRCm38)	missense	possibly damaging	0.55
hibiscus	UTSW	18	49,889,467 (GRCm38)	missense	probably damaging	1.00
impound	UTSW	18	49,893,249 (GRCm38)	missense	probably benign
pitcher	UTSW	18	49,864,148 (GRCm38)	missense	probably damaging	1.00
PIT4810001:Dmxl1	UTSW	18	49,931,963 (GRCm38)	missense	probably damaging	1.00
R0001:Dmxl1	UTSW	18	49,888,897 (GRCm38)	splice site	probably benign
R0027:Dmxl1	UTSW	18	49,957,295 (GRCm38)	splice site	probably benign
R0042:Dmxl1	UTSW	18	49,864,035 (GRCm38)	missense	probably benign	0.03
R0042:Dmxl1	UTSW	18	49,864,035 (GRCm38)	missense	probably benign	0.03
R0046:Dmxl1	UTSW	18	49,878,082 (GRCm38)	missense	probably benign	0.22
R0046:Dmxl1	UTSW	18	49,878,082 (GRCm38)	missense	probably benign	0.22
R0257:Dmxl1	UTSW	18	49,955,803 (GRCm38)	splice site	probably benign
R0349:Dmxl1	UTSW	18	49,879,282 (GRCm38)	missense	probably damaging	0.99
R0390:Dmxl1	UTSW	18	49,879,362 (GRCm38)	missense	probably benign	0.14
R0511:Dmxl1	UTSW	18	49,891,467 (GRCm38)	nonsense	probably null
R0539:Dmxl1	UTSW	18	49,857,430 (GRCm38)	splice site	probably benign
R0542:Dmxl1	UTSW	18	49,893,694 (GRCm38)	missense	probably benign	0.05
R0587:Dmxl1	UTSW	18	49,935,307 (GRCm38)	missense	probably benign	0.39
R0635:Dmxl1	UTSW	18	49,851,423 (GRCm38)	splice site	probably benign
R0744:Dmxl1	UTSW	18	49,833,148 (GRCm38)	missense	probably damaging	1.00
R0836:Dmxl1	UTSW	18	49,833,148 (GRCm38)	missense	probably damaging	1.00
R0845:Dmxl1	UTSW	18	49,893,402 (GRCm38)	missense	probably damaging	1.00
R1218:Dmxl1	UTSW	18	49,893,611 (GRCm38)	missense	probably damaging	1.00
R1278:Dmxl1	UTSW	18	49,893,225 (GRCm38)	missense	probably benign
R1313:Dmxl1	UTSW	18	49,878,483 (GRCm38)	missense	probably damaging	1.00
R1313:Dmxl1	UTSW	18	49,878,483 (GRCm38)	missense	probably damaging	1.00
R1349:Dmxl1	UTSW	18	49,888,853 (GRCm38)	missense	probably damaging	1.00
R1453:Dmxl1	UTSW	18	49,857,249 (GRCm38)	missense	probably benign	0.05
R1522:Dmxl1	UTSW	18	49,852,367 (GRCm38)	missense	probably benign	0.05
R1629:Dmxl1	UTSW	18	49,859,286 (GRCm38)	critical splice donor site	probably null
R1638:Dmxl1	UTSW	18	49,890,767 (GRCm38)	nonsense	probably null
R1646:Dmxl1	UTSW	18	49,962,261 (GRCm38)	missense	probably damaging	1.00
R1719:Dmxl1	UTSW	18	49,934,637 (GRCm38)	missense	probably damaging	1.00
R1732:Dmxl1	UTSW	18	49,902,988 (GRCm38)	missense	probably benign
R1732:Dmxl1	UTSW	18	49,893,444 (GRCm38)	nonsense	probably null
R1886:Dmxl1	UTSW	18	49,859,135 (GRCm38)	missense	probably benign	0.09
R1887:Dmxl1	UTSW	18	49,859,135 (GRCm38)	missense	probably benign	0.09
R1895:Dmxl1	UTSW	18	49,955,914 (GRCm38)	splice site	probably null
R1911:Dmxl1	UTSW	18	49,878,163 (GRCm38)	missense	probably benign	0.00
R2020:Dmxl1	UTSW	18	49,889,558 (GRCm38)	nonsense	probably null
R2116:Dmxl1	UTSW	18	49,878,817 (GRCm38)	missense	probably damaging	1.00
R2196:Dmxl1	UTSW	18	49,917,631 (GRCm38)	missense	probably benign	0.00
R2206:Dmxl1	UTSW	18	49,894,094 (GRCm38)	missense	probably benign	0.12
R2216:Dmxl1	UTSW	18	49,893,923 (GRCm38)	missense	probably benign	0.00
R2255:Dmxl1	UTSW	18	49,846,639 (GRCm38)	missense	probably benign	0.34
R2333:Dmxl1	UTSW	18	49,919,976 (GRCm38)	splice site	probably null
R2343:Dmxl1	UTSW	18	49,890,678 (GRCm38)	missense	probably damaging	1.00
R2496:Dmxl1	UTSW	18	49,880,791 (GRCm38)	missense	possibly damaging	0.51
R3757:Dmxl1	UTSW	18	49,935,317 (GRCm38)	missense	probably damaging	0.98
R3758:Dmxl1	UTSW	18	49,935,317 (GRCm38)	missense	probably damaging	0.98
R3783:Dmxl1	UTSW	18	49,865,122 (GRCm38)	missense	probably damaging	1.00
R3786:Dmxl1	UTSW	18	49,865,122 (GRCm38)	missense	probably damaging	1.00
R3787:Dmxl1	UTSW	18	49,865,122 (GRCm38)	missense	probably damaging	1.00
R3885:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3886:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3887:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3888:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3889:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R4014:Dmxl1	UTSW	18	49,863,962 (GRCm38)	missense	probably benign
R4033:Dmxl1	UTSW	18	49,851,431 (GRCm38)	missense	possibly damaging	0.95
R4096:Dmxl1	UTSW	18	49,961,197 (GRCm38)	missense	probably damaging	1.00
R4366:Dmxl1	UTSW	18	49,878,017 (GRCm38)	nonsense	probably null
R4406:Dmxl1	UTSW	18	49,889,553 (GRCm38)	missense	probably damaging	1.00
R4412:Dmxl1	UTSW	18	49,848,761 (GRCm38)	missense	probably benign
R4454:Dmxl1	UTSW	18	49,893,332 (GRCm38)	missense	probably benign	0.01
R4459:Dmxl1	UTSW	18	49,961,216 (GRCm38)	missense	possibly damaging	0.80
R4569:Dmxl1	UTSW	18	49,852,360 (GRCm38)	missense	probably damaging	1.00
R4570:Dmxl1	UTSW	18	49,852,360 (GRCm38)	missense	probably damaging	1.00
R4606:Dmxl1	UTSW	18	49,962,181 (GRCm38)	missense	probably damaging	0.98
R4649:Dmxl1	UTSW	18	49,878,631 (GRCm38)	missense	probably damaging	0.99
R4683:Dmxl1	UTSW	18	49,878,021 (GRCm38)	missense	probably damaging	1.00
R4782:Dmxl1	UTSW	18	49,862,992 (GRCm38)	missense	probably damaging	1.00
R4878:Dmxl1	UTSW	18	49,851,476 (GRCm38)	missense	probably damaging	1.00
R4879:Dmxl1	UTSW	18	49,889,467 (GRCm38)	missense	probably damaging	1.00
R4881:Dmxl1	UTSW	18	49,957,281 (GRCm38)	intron	probably benign
R4885:Dmxl1	UTSW	18	49,878,795 (GRCm38)	missense	probably damaging	0.99
R4916:Dmxl1	UTSW	18	49,877,697 (GRCm38)	missense	probably damaging	1.00
R5022:Dmxl1	UTSW	18	49,895,127 (GRCm38)	missense	probably damaging	0.99
R5056:Dmxl1	UTSW	18	49,870,923 (GRCm38)	missense	probably benign	0.00
R5177:Dmxl1	UTSW	18	49,893,584 (GRCm38)	missense	probably damaging	0.99
R5342:Dmxl1	UTSW	18	49,951,235 (GRCm38)	missense	probably damaging	0.96
R5421:Dmxl1	UTSW	18	49,863,119 (GRCm38)	critical splice donor site	probably null
R5433:Dmxl1	UTSW	18	49,867,899 (GRCm38)	splice site	probably null
R5484:Dmxl1	UTSW	18	49,889,464 (GRCm38)	missense	probably damaging	1.00
R5598:Dmxl1	UTSW	18	49,864,478 (GRCm38)	missense	probably benign	0.04
R5633:Dmxl1	UTSW	18	49,877,697 (GRCm38)	missense	probably damaging	1.00
R5638:Dmxl1	UTSW	18	49,891,626 (GRCm38)	missense	possibly damaging	0.95
R5694:Dmxl1	UTSW	18	49,894,257 (GRCm38)	missense	probably damaging	1.00
R5696:Dmxl1	UTSW	18	49,931,941 (GRCm38)	nonsense	probably null
R5706:Dmxl1	UTSW	18	49,957,395 (GRCm38)	critical splice donor site	probably null
R5745:Dmxl1	UTSW	18	49,846,586 (GRCm38)	missense	probably benign
R5876:Dmxl1	UTSW	18	49,870,984 (GRCm38)	missense	possibly damaging	0.70
R6054:Dmxl1	UTSW	18	49,857,386 (GRCm38)	missense	probably benign	0.00
R6145:Dmxl1	UTSW	18	49,912,766 (GRCm38)	missense	possibly damaging	0.90
R6189:Dmxl1	UTSW	18	49,893,335 (GRCm38)	missense	probably benign	0.33
R6213:Dmxl1	UTSW	18	49,863,015 (GRCm38)	missense	possibly damaging	0.93
R6219:Dmxl1	UTSW	18	49,902,367 (GRCm38)	missense	probably damaging	0.99
R6221:Dmxl1	UTSW	18	49,871,732 (GRCm38)	missense	probably damaging	0.96
R6276:Dmxl1	UTSW	18	49,846,586 (GRCm38)	missense	probably benign
R6319:Dmxl1	UTSW	18	49,852,300 (GRCm38)	missense	probably benign	0.00
R6426:Dmxl1	UTSW	18	49,864,578 (GRCm38)	missense	probably damaging	0.99
R6567:Dmxl1	UTSW	18	49,859,179 (GRCm38)	missense	probably damaging	0.99
R6739:Dmxl1	UTSW	18	49,878,246 (GRCm38)	missense	probably benign	0.03
R6743:Dmxl1	UTSW	18	49,880,780 (GRCm38)	missense	possibly damaging	0.95
R6776:Dmxl1	UTSW	18	49,893,974 (GRCm38)	missense	probably damaging	1.00
R6827:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6828:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6829:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6830:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6833:Dmxl1	UTSW	18	49,955,823 (GRCm38)	missense	probably damaging	0.99
R6834:Dmxl1	UTSW	18	49,955,823 (GRCm38)	missense	probably damaging	0.99
R6856:Dmxl1	UTSW	18	49,852,288 (GRCm38)	nonsense	probably null
R6857:Dmxl1	UTSW	18	49,864,835 (GRCm38)	missense	probably damaging	0.99
R6881:Dmxl1	UTSW	18	49,935,305 (GRCm38)	missense	probably benign	0.00
R6882:Dmxl1	UTSW	18	49,843,784 (GRCm38)	critical splice acceptor site	probably null
R6892:Dmxl1	UTSW	18	49,920,902 (GRCm38)	missense	probably damaging	0.98
R6897:Dmxl1	UTSW	18	49,863,057 (GRCm38)	missense	possibly damaging	0.51
R6897:Dmxl1	UTSW	18	49,851,495 (GRCm38)	missense	probably null	0.99
R6917:Dmxl1	UTSW	18	49,864,148 (GRCm38)	missense	probably damaging	1.00
R7192:Dmxl1	UTSW	18	49,955,853 (GRCm38)	missense	probably damaging	0.99
R7447:Dmxl1	UTSW	18	49,864,614 (GRCm38)	missense	probably damaging	0.99
R7460:Dmxl1	UTSW	18	49,878,612 (GRCm38)	missense	probably benign	0.00
R7570:Dmxl1	UTSW	18	49,893,957 (GRCm38)	missense	possibly damaging	0.82
R7626:Dmxl1	UTSW	18	49,902,794 (GRCm38)	missense	probably benign
R7629:Dmxl1	UTSW	18	49,859,270 (GRCm38)	missense	probably damaging	1.00
R7644:Dmxl1	UTSW	18	49,893,552 (GRCm38)	missense	probably benign
R7688:Dmxl1	UTSW	18	49,955,871 (GRCm38)	missense	probably benign	0.03
R7689:Dmxl1	UTSW	18	49,846,618 (GRCm38)	missense	probably benign	0.00
R7712:Dmxl1	UTSW	18	49,893,461 (GRCm38)	missense	probably damaging	0.99
R7808:Dmxl1	UTSW	18	49,878,315 (GRCm38)	missense	probably benign	0.00
R7834:Dmxl1	UTSW	18	49,920,977 (GRCm38)	missense	probably damaging	1.00
R7848:Dmxl1	UTSW	18	49,840,490 (GRCm38)	missense	possibly damaging	0.88
R7849:Dmxl1	UTSW	18	49,961,147 (GRCm38)	missense	probably benign	0.00
R7881:Dmxl1	UTSW	18	49,864,383 (GRCm38)	missense	probably damaging	0.99
R7884:Dmxl1	UTSW	18	49,893,407 (GRCm38)	missense	possibly damaging	0.65
R8089:Dmxl1	UTSW	18	49,888,830 (GRCm38)	missense	probably damaging	0.99
R8266:Dmxl1	UTSW	18	49,843,811 (GRCm38)	missense	probably benign	0.17
R8371:Dmxl1	UTSW	18	49,898,714 (GRCm38)	missense	probably benign	0.08
R8402:Dmxl1	UTSW	18	49,878,342 (GRCm38)	missense	probably benign
R8402:Dmxl1	UTSW	18	49,878,326 (GRCm38)	nonsense	probably null
R8402:Dmxl1	UTSW	18	49,878,327 (GRCm38)	missense	probably benign	0.09
R8423:Dmxl1	UTSW	18	49,865,116 (GRCm38)	missense	probably damaging	1.00
R8678:Dmxl1	UTSW	18	49,871,692 (GRCm38)	nonsense	probably null
R8702:Dmxl1	UTSW	18	49,859,135 (GRCm38)	missense	probably benign	0.09
R8749:Dmxl1	UTSW	18	49,955,870 (GRCm38)	missense	probably damaging	1.00
R8813:Dmxl1	UTSW	18	49,957,339 (GRCm38)	missense	probably damaging	0.99
R8877:Dmxl1	UTSW	18	49,878,225 (GRCm38)	missense	possibly damaging	0.55
R8945:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,893,674 (GRCm38)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,864,508 (GRCm38)	missense	possibly damaging	0.96
R8978:Dmxl1	UTSW	18	49,922,612 (GRCm38)	missense	probably benign	0.37
R8987:Dmxl1	UTSW	18	49,893,852 (GRCm38)	missense
R9011:Dmxl1	UTSW	18	49,864,173 (GRCm38)	missense	probably damaging	1.00
R9124:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9131:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9132:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9156:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9165:Dmxl1	UTSW	18	49,878,925 (GRCm38)	missense	probably damaging	1.00
R9244:Dmxl1	UTSW	18	49,893,249 (GRCm38)	missense	probably benign
R9254:Dmxl1	UTSW	18	49,891,500 (GRCm38)	missense	possibly damaging	0.67
R9262:Dmxl1	UTSW	18	49,843,852 (GRCm38)	missense	probably benign	0.03
R9335:Dmxl1	UTSW	18	49,859,120 (GRCm38)	missense	probably damaging	0.96
R9375:Dmxl1	UTSW	18	49,958,410 (GRCm38)	missense	probably damaging	1.00
R9379:Dmxl1	UTSW	18	49,891,500 (GRCm38)	missense	possibly damaging	0.67
R9434:Dmxl1	UTSW	18	49,877,721 (GRCm38)	missense	probably damaging	0.98
R9470:Dmxl1	UTSW	18	49,893,710 (GRCm38)	missense	possibly damaging	0.69
R9500:Dmxl1	UTSW	18	49,878,204 (GRCm38)	missense	probably damaging	1.00
R9507:Dmxl1	UTSW	18	49,891,500 (GRCm38)	missense	possibly damaging	0.94
R9617:Dmxl1	UTSW	18	49,865,161 (GRCm38)	missense	probably damaging	1.00
R9642:Dmxl1	UTSW	18	49,880,758 (GRCm38)	missense	probably damaging	1.00
RF009:Dmxl1	UTSW	18	49,893,394 (GRCm38)	missense	probably damaging	0.96
X0025:Dmxl1	UTSW	18	49,864,368 (GRCm38)	missense	probably damaging	0.98
X0066:Dmxl1	UTSW	18	49,919,899 (GRCm38)	missense	probably damaging	1.00
Z1088:Dmxl1	UTSW	18	49,920,965 (GRCm38)	missense	probably benign
Z1188:Dmxl1	UTSW	18	49,868,003 (GRCm38)	missense	probably damaging	0.96
Z1189:Dmxl1	UTSW	18	49,868,003 (GRCm38)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- AACTGTAGGGATTGGCTCAAAAC -3'
(R):5'- CATGGATCGAGTCAGAGTCTTC -3'

Sequencing Primer
(F):5'- GGCTCAAAACTTTTTATGTATGGACC -3'
(R):5'- TCTTTGGAGGATGTAGCCCAGAAC -3'

Posted On

2020-01-23