Incidental Mutation 'R8074:Cd300lg'
ID 620433
Institutional Source Beutler Lab
Gene Symbol Cd300lg
Ensembl Gene ENSMUSG00000017309
Gene Name CD300 molecule like family member G
Synonyms nepmucin, D11Ertd736e, Clm9, 2310016B05Rik
MMRRC Submission 067508-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8074 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 101932337-101946443 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 101932427 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Arginine at position 4 (L4R)
Ref Sequence ENSEMBL: ENSMUSP00000102782 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017453] [ENSMUST00000107163] [ENSMUST00000107164] [ENSMUST00000123895]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000017453
AA Change: L4R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000017453
Gene: ENSMUSG00000017309
AA Change: L4R

DomainStartEndE-ValueType
IG 22 124 1.82e-6 SMART
low complexity region 142 155 N/A INTRINSIC
transmembrane domain 163 185 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000107163
AA Change: L4R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000102781
Gene: ENSMUSG00000017309
AA Change: L4R

DomainStartEndE-ValueType
IG 22 124 1.82e-6 SMART
internal_repeat_1 154 188 2.12e-12 PROSPERO
internal_repeat_1 180 213 2.12e-12 PROSPERO
low complexity region 226 239 N/A INTRINSIC
transmembrane domain 247 269 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000107164
AA Change: L4R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000102782
Gene: ENSMUSG00000017309
AA Change: L4R

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
IG 22 124 1.82e-6 SMART
low complexity region 270 283 N/A INTRINSIC
transmembrane domain 291 313 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000123895
AA Change: L4R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000120921
Gene: ENSMUSG00000017309
AA Change: L4R

DomainStartEndE-ValueType
IG 22 124 1.82e-6 SMART
low complexity region 186 199 N/A INTRINSIC
transmembrane domain 207 229 N/A INTRINSIC
Meta Mutation Damage Score 0.7486 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Phenotypic analysis of mice homozygous for a targeted allele indicates that this mutation shows no notable phenotype in any parameter tested. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b T A 11: 109,829,320 (GRCm39) I1380L probably benign Het
Adcy3 T C 12: 4,184,420 (GRCm39) V32A probably benign Het
Ano3 T A 2: 110,780,577 (GRCm39) probably benign Het
Arhgef12 G A 9: 42,882,399 (GRCm39) R1482* probably null Het
Cfap57 T A 4: 118,426,822 (GRCm39) K1072M possibly damaging Het
Clasp1 G T 1: 118,390,213 (GRCm39) M132I probably benign Het
Clec18a T G 8: 111,798,230 (GRCm39) D489A probably damaging Het
Cngb1 A G 8: 95,978,801 (GRCm39) S551P Het
Efna4 G A 3: 89,242,633 (GRCm39) T87M probably benign Het
Fam229b T C 10: 38,996,255 (GRCm39) R42G probably null Het
Gm17175 C T 14: 51,809,080 (GRCm39) M95I probably damaging Het
Grk4 A G 5: 34,833,482 (GRCm39) E96G probably benign Het
Helb A C 10: 119,925,321 (GRCm39) F1019V probably benign Het
Hsd17b2 T C 8: 118,485,440 (GRCm39) V301A possibly damaging Het
Htr1b A G 9: 81,513,582 (GRCm39) F342L probably benign Het
Idua C A 5: 108,828,441 (GRCm39) A265E possibly damaging Het
Jup T G 11: 100,277,113 (GRCm39) T32P probably damaging Het
Kidins220 A G 12: 25,107,715 (GRCm39) K1632E probably benign Het
Lef1 G A 3: 130,997,954 (GRCm39) probably null Het
Lypla2 A G 4: 135,697,112 (GRCm39) probably null Het
Mall A G 2: 127,571,785 (GRCm39) M1T probably null Het
Mettl25 G T 10: 105,661,941 (GRCm39) A343E probably benign Het
Mpdz T C 4: 81,267,324 (GRCm39) N940S probably benign Het
Nsun4 A T 4: 115,908,631 (GRCm39) V643D possibly damaging Het
Nupr1 A T 7: 126,224,109 (GRCm39) F70Y possibly damaging Het
Or1e17 T A 11: 73,831,213 (GRCm39) V47D possibly damaging Het
Or52b4i A G 7: 102,191,830 (GRCm39) H229R probably benign Het
Or52e8 A T 7: 104,624,934 (GRCm39) I90N probably damaging Het
Or5ac20 A G 16: 59,104,549 (GRCm39) F104L probably benign Het
Or8g32 A T 9: 39,305,242 (GRCm39) I49F probably damaging Het
Or8k3 C G 2: 86,058,473 (GRCm39) V281L possibly damaging Het
Pabpc4 A T 4: 123,180,508 (GRCm39) M77L probably benign Het
Phactr3 A G 2: 177,944,589 (GRCm39) E429G probably damaging Het
Polr3b A G 10: 84,549,523 (GRCm39) D915G probably damaging Het
Pramel14 A T 4: 143,718,424 (GRCm39) F340I probably benign Het
Prkcg T A 7: 3,372,037 (GRCm39) M501K probably damaging Het
Prkch G A 12: 73,747,041 (GRCm39) A307T possibly damaging Het
Ptprt A G 2: 161,769,581 (GRCm39) V428A possibly damaging Het
Rnf145 C A 11: 44,448,263 (GRCm39) D373E probably damaging Het
Scfd2 G T 5: 74,680,257 (GRCm39) Q299K probably benign Het
Septin2 A G 1: 93,433,283 (GRCm39) D315G probably benign Het
Sf3a1 T A 11: 4,125,435 (GRCm39) Y408* probably null Het
Siglecf A T 7: 43,001,214 (GRCm39) N61Y possibly damaging Het
Sis A T 3: 72,824,531 (GRCm39) I1334K probably damaging Het
Slc38a6 A T 12: 73,391,658 (GRCm39) T307S possibly damaging Het
Spag9 T A 11: 94,002,877 (GRCm39) F1129Y probably damaging Het
Sra1 G A 18: 36,808,064 (GRCm39) A388V possibly damaging Het
Srpk1 T G 17: 28,840,990 (GRCm39) K12T probably damaging Het
Stam2 A T 2: 52,596,438 (GRCm39) I333K probably damaging Het
Tle1 GAA GA 4: 72,057,216 (GRCm39) probably null Het
Tmem121b T C 6: 120,469,869 (GRCm39) K283E possibly damaging Het
Tmem200a T C 10: 25,868,850 (GRCm39) E473G probably damaging Het
Tnxb T A 17: 34,922,955 (GRCm39) S2513T probably benign Het
Ttc16 A T 2: 32,664,135 (GRCm39) probably benign Het
Ttll8 C T 15: 88,799,578 (GRCm39) C621Y probably damaging Het
Ubn2 T A 6: 38,417,475 (GRCm39) M171K probably benign Het
Vmn2r19 T A 6: 123,312,904 (GRCm39) V658D probably damaging Het
Vmn2r6 A T 3: 64,455,064 (GRCm39) probably benign Het
Vwa3a A T 7: 120,398,321 (GRCm39) I941L probably benign Het
Zbtb24 A G 10: 41,327,228 (GRCm39) D38G probably damaging Het
Zfp628 T C 7: 4,923,205 (GRCm39) C476R probably damaging Het
Zfp831 A C 2: 174,486,528 (GRCm39) N401T possibly damaging Het
Other mutations in Cd300lg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01125:Cd300lg APN 11 101,945,047 (GRCm39) unclassified probably benign
IGL01655:Cd300lg APN 11 101,937,901 (GRCm39) missense probably benign 0.41
R0129:Cd300lg UTSW 11 101,944,918 (GRCm39) critical splice acceptor site probably null
R0427:Cd300lg UTSW 11 101,933,852 (GRCm39) missense probably damaging 0.98
R1401:Cd300lg UTSW 11 101,944,981 (GRCm39) missense possibly damaging 0.88
R1533:Cd300lg UTSW 11 101,934,047 (GRCm39) missense probably damaging 0.98
R1809:Cd300lg UTSW 11 101,933,938 (GRCm39) missense probably benign 0.00
R1848:Cd300lg UTSW 11 101,937,032 (GRCm39) splice site probably benign
R1863:Cd300lg UTSW 11 101,932,430 (GRCm39) missense probably damaging 0.99
R1918:Cd300lg UTSW 11 101,944,936 (GRCm39) missense probably damaging 1.00
R4018:Cd300lg UTSW 11 101,932,420 (GRCm39) missense probably damaging 0.98
R4591:Cd300lg UTSW 11 101,937,006 (GRCm39) missense probably benign 0.01
R4758:Cd300lg UTSW 11 101,944,417 (GRCm39) critical splice donor site probably null
R6211:Cd300lg UTSW 11 101,944,995 (GRCm39) missense possibly damaging 0.50
R6425:Cd300lg UTSW 11 101,937,749 (GRCm39) missense probably benign 0.15
R6470:Cd300lg UTSW 11 101,941,331 (GRCm39) missense possibly damaging 0.61
R7025:Cd300lg UTSW 11 101,933,900 (GRCm39) missense probably damaging 1.00
R7312:Cd300lg UTSW 11 101,937,767 (GRCm39) missense probably benign 0.37
R7522:Cd300lg UTSW 11 101,945,028 (GRCm39) missense probably benign 0.25
R8176:Cd300lg UTSW 11 101,932,390 (GRCm39) start gained probably benign
R8922:Cd300lg UTSW 11 101,945,028 (GRCm39) missense probably damaging 0.99
R9026:Cd300lg UTSW 11 101,944,998 (GRCm39) missense probably damaging 0.98
R9273:Cd300lg UTSW 11 101,939,590 (GRCm39) missense probably damaging 0.99
R9471:Cd300lg UTSW 11 101,944,920 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AACCTGTGGTAACTGGCACTG -3'
(R):5'- AGAAAGACCCTGGGCTCAAG -3'

Sequencing Primer
(F):5'- GGTAACTGGCACTGGGTAG -3'
(R):5'- AAGTGCTGAGCTCAGGGC -3'
Posted On 2020-01-23