Incidental Mutation 'R0652:Or5b109'
ID 62349
Institutional Source Beutler Lab
Gene Symbol Or5b109
Ensembl Gene ENSMUSG00000096365
Gene Name olfactory receptor family 5 subfamily B member 109
Synonyms Olfr1463, GA_x6K02T2RE5P-3560863-3561795, MOR202-29P
MMRRC Submission 038837-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R0652 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 13211616-13212548 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 13211899 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 95 (Y95F)
Ref Sequence ENSEMBL: ENSMUSP00000146566 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064102] [ENSMUST00000207246]
AlphaFold Q7TQR3
Predicted Effect possibly damaging
Transcript: ENSMUST00000064102
AA Change: Y95F

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000070872
Gene: ENSMUSG00000096365
AA Change: Y95F

DomainStartEndE-ValueType
Pfam:7tm_4 32 310 1e-51 PFAM
Pfam:7TM_GPCR_Srsx 36 306 3.2e-6 PFAM
Pfam:7tm_1 42 291 1.4e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000207246
AA Change: Y95F

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.3%
  • 20x: 90.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T C 11: 110,042,889 (GRCm39) N387D probably benign Het
Adgrg5 T A 8: 95,660,785 (GRCm39) probably null Het
Ahi1 C A 10: 20,855,360 (GRCm39) H556Q probably damaging Het
Amph A G 13: 19,270,791 (GRCm39) probably null Het
Apol7a T C 15: 77,274,055 (GRCm39) probably benign Het
Apoo-ps A T 13: 107,550,910 (GRCm39) noncoding transcript Het
Arpc1b A G 5: 145,063,670 (GRCm39) D306G probably damaging Het
Astn2 T C 4: 65,712,795 (GRCm39) D615G probably damaging Het
Atm A G 9: 53,397,314 (GRCm39) V1673A probably damaging Het
B3gnt3 A T 8: 72,146,466 (GRCm39) V21E probably benign Het
Bco1 A G 8: 117,832,435 (GRCm39) D77G probably damaging Het
Brinp2 A T 1: 158,074,191 (GRCm39) H643Q probably damaging Het
Bsn A G 9: 107,982,941 (GRCm39) F3604S unknown Het
Cacna1c A G 6: 118,579,190 (GRCm39) F1753L probably damaging Het
Cd74 T C 18: 60,944,957 (GRCm39) S201P probably damaging Het
Cep192 T A 18: 67,940,336 (GRCm39) L101Q probably benign Het
Cfap161 T C 7: 83,442,484 (GRCm39) I110V probably null Het
Cnksr3 T C 10: 7,070,463 (GRCm39) D257G probably damaging Het
Col14a1 A C 15: 55,208,278 (GRCm39) E121A unknown Het
Cpne3 T C 4: 19,532,486 (GRCm39) D309G probably benign Het
Ctnnd1 A G 2: 84,433,240 (GRCm39) I609T probably benign Het
Cyp2s1 A G 7: 25,508,683 (GRCm39) V253A probably damaging Het
Dock7 T C 4: 98,943,586 (GRCm39) D552G possibly damaging Het
Dpyd A G 3: 119,220,924 (GRCm39) D965G probably damaging Het
Efcab2 T A 1: 178,308,911 (GRCm39) M138K probably damaging Het
Eml3 T C 19: 8,910,649 (GRCm39) S204P probably damaging Het
Fbxw16 T A 9: 109,265,236 (GRCm39) S432C possibly damaging Het
Fbxw20 T G 9: 109,061,400 (GRCm39) Q116H probably damaging Het
Fech A G 18: 64,591,240 (GRCm39) S395P probably damaging Het
Fgf7 A G 2: 125,877,875 (GRCm39) K81E probably benign Het
Fras1 T A 5: 96,929,199 (GRCm39) Y3868N possibly damaging Het
Ganab A T 19: 8,892,766 (GRCm39) probably null Het
Gfra1 T C 19: 58,288,986 (GRCm39) N153S possibly damaging Het
Gja4 T A 4: 127,205,920 (GRCm39) Y281F probably benign Het
Gm5141 T C 13: 62,921,946 (GRCm39) T407A probably damaging Het
Gm5422 T C 10: 31,125,277 (GRCm39) noncoding transcript Het
Greb1 T C 12: 16,746,457 (GRCm39) Y1271C probably damaging Het
Hp1bp3 C A 4: 137,956,080 (GRCm39) N50K possibly damaging Het
Hspg2 T C 4: 137,242,033 (GRCm39) F589S probably damaging Het
Ido1 A G 8: 25,075,260 (GRCm39) F183S probably damaging Het
Iqgap1 T A 7: 80,386,143 (GRCm39) K936I probably damaging Het
Kdm4a T C 4: 118,032,886 (GRCm39) D60G probably benign Het
L3mbtl4 G A 17: 69,081,286 (GRCm39) C558Y probably damaging Het
Lrrc28 T C 7: 67,267,833 (GRCm39) N98S probably damaging Het
Lypd11 T A 7: 24,423,622 (GRCm39) N14I possibly damaging Het
Map1a A G 2: 121,133,264 (GRCm39) D1360G probably benign Het
Megf10 C T 18: 57,410,796 (GRCm39) P702S probably benign Het
Met A G 6: 17,491,709 (GRCm39) E157G probably benign Het
Mff A G 1: 82,728,285 (GRCm39) D187G possibly damaging Het
Mlph A T 1: 90,870,630 (GRCm39) I514F possibly damaging Het
Mroh2a C T 1: 88,158,402 (GRCm39) R150* probably null Het
Myo15b T C 11: 115,755,468 (GRCm39) V976A probably benign Het
Myo9a A G 9: 59,779,209 (GRCm39) D1655G probably benign Het
Ncoa6 C T 2: 155,233,131 (GRCm39) G2059D probably benign Het
Ndst4 A T 3: 125,405,188 (GRCm39) H481L possibly damaging Het
Nipbl A G 15: 8,332,964 (GRCm39) S2220P probably benign Het
Nom1 C A 5: 29,640,309 (GRCm39) P212T probably damaging Het
Nsd1 A G 13: 55,395,399 (GRCm39) D1000G possibly damaging Het
Nudt9 T C 5: 104,198,467 (GRCm39) F44S possibly damaging Het
Numb C T 12: 83,842,566 (GRCm39) V537I probably damaging Het
Or10j3b T A 1: 173,043,524 (GRCm39) I102N possibly damaging Het
Or13a27 A T 7: 139,925,545 (GRCm39) M119K probably damaging Het
Or51q1c A G 7: 103,652,446 (GRCm39) probably null Het
Or5h17 A G 16: 58,820,063 (GRCm39) N5S probably damaging Het
Or6c211 T A 10: 129,506,248 (GRCm39) T47S probably benign Het
Osgin1 A T 8: 120,172,211 (GRCm39) Y335F probably damaging Het
Pcdh10 T A 3: 45,334,199 (GRCm39) V171E probably damaging Het
Pira13 T A 7: 3,825,762 (GRCm39) Y369F probably benign Het
Plxna4 T C 6: 32,162,436 (GRCm39) N1359S probably damaging Het
Ppp1r16a C T 15: 76,574,999 (GRCm39) probably benign Het
Prr5l T C 2: 101,602,635 (GRCm39) T2A possibly damaging Het
Rbp3 T A 14: 33,680,605 (GRCm39) I1069N possibly damaging Het
Rnf144b A G 13: 47,373,983 (GRCm39) Y60C probably damaging Het
Sbno2 A T 10: 79,903,128 (GRCm39) V396E probably damaging Het
Sdk1 A G 5: 141,940,713 (GRCm39) T494A probably benign Het
Serac1 G T 17: 6,102,031 (GRCm39) D384E probably damaging Het
Sgk1 A G 10: 21,758,556 (GRCm39) N7D probably damaging Het
Sigirr A T 7: 140,672,980 (GRCm39) V69D possibly damaging Het
Slc17a3 C T 13: 24,039,841 (GRCm39) S293F probably damaging Het
St6gal2 T C 17: 55,805,290 (GRCm39) Y396H probably benign Het
Ttn A T 2: 76,598,956 (GRCm39) F19319Y probably damaging Het
Ubr4 T A 4: 139,128,637 (GRCm39) I599N probably damaging Het
Vmn1r213 A G 13: 23,195,564 (GRCm39) probably benign Het
Vmn2r96 T A 17: 18,817,830 (GRCm39) M469K probably benign Het
Wasf1 T A 10: 40,807,902 (GRCm39) probably null Het
Wdr20rt T C 12: 65,272,689 (GRCm39) S51P probably damaging Het
Other mutations in Or5b109
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01131:Or5b109 APN 19 13,212,103 (GRCm39) missense probably benign 0.01
IGL02596:Or5b109 APN 19 13,211,763 (GRCm39) missense probably damaging 1.00
IGL03030:Or5b109 APN 19 13,212,418 (GRCm39) missense probably damaging 0.98
IGL03232:Or5b109 APN 19 13,212,341 (GRCm39) nonsense probably null
IGL03380:Or5b109 APN 19 13,212,365 (GRCm39) missense probably benign 0.00
PIT4382001:Or5b109 UTSW 19 13,212,259 (GRCm39) missense probably damaging 1.00
PIT4519001:Or5b109 UTSW 19 13,212,216 (GRCm39) missense probably benign 0.00
R0658:Or5b109 UTSW 19 13,212,424 (GRCm39) missense possibly damaging 0.94
R1181:Or5b109 UTSW 19 13,212,195 (GRCm39) missense probably benign 0.07
R1239:Or5b109 UTSW 19 13,212,040 (GRCm39) missense possibly damaging 0.80
R1316:Or5b109 UTSW 19 13,211,803 (GRCm39) missense probably damaging 1.00
R1465:Or5b109 UTSW 19 13,212,265 (GRCm39) missense possibly damaging 0.61
R1465:Or5b109 UTSW 19 13,212,265 (GRCm39) missense possibly damaging 0.61
R1900:Or5b109 UTSW 19 13,212,277 (GRCm39) missense possibly damaging 0.54
R1927:Or5b109 UTSW 19 13,212,393 (GRCm39) missense probably damaging 1.00
R2239:Or5b109 UTSW 19 13,212,085 (GRCm39) missense probably benign 0.00
R2380:Or5b109 UTSW 19 13,212,085 (GRCm39) missense probably benign 0.00
R3760:Or5b109 UTSW 19 13,212,250 (GRCm39) missense probably damaging 1.00
R3765:Or5b109 UTSW 19 13,211,795 (GRCm39) missense probably damaging 1.00
R3835:Or5b109 UTSW 19 13,212,103 (GRCm39) missense probably benign 0.18
R4690:Or5b109 UTSW 19 13,212,132 (GRCm39) missense possibly damaging 0.91
R4907:Or5b109 UTSW 19 13,212,157 (GRCm39) missense probably damaging 1.00
R5444:Or5b109 UTSW 19 13,212,322 (GRCm39) missense probably benign 0.28
R5465:Or5b109 UTSW 19 13,212,052 (GRCm39) missense probably benign 0.00
R6083:Or5b109 UTSW 19 13,211,889 (GRCm39) missense probably benign 0.01
R6259:Or5b109 UTSW 19 13,211,785 (GRCm39) missense probably damaging 0.98
R6324:Or5b109 UTSW 19 13,212,468 (GRCm39) missense possibly damaging 0.95
R6561:Or5b109 UTSW 19 13,212,394 (GRCm39) missense probably damaging 1.00
R6845:Or5b109 UTSW 19 13,211,997 (GRCm39) missense probably damaging 1.00
R7260:Or5b109 UTSW 19 13,212,388 (GRCm39) missense probably damaging 0.98
R7843:Or5b109 UTSW 19 13,211,901 (GRCm39) missense possibly damaging 0.48
R8560:Or5b109 UTSW 19 13,211,656 (GRCm39) missense possibly damaging 0.91
R8719:Or5b109 UTSW 19 13,211,836 (GRCm39) missense probably damaging 0.97
R9207:Or5b109 UTSW 19 13,212,400 (GRCm39) missense possibly damaging 0.60
R9273:Or5b109 UTSW 19 13,212,268 (GRCm39) missense probably damaging 1.00
R9607:Or5b109 UTSW 19 13,211,953 (GRCm39) missense
X0063:Or5b109 UTSW 19 13,211,999 (GRCm39) missense probably damaging 1.00
X0067:Or5b109 UTSW 19 13,212,061 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- GCTGGGACTTACTGATGATCCAGGAC -3'
(R):5'- GCTCATTGATATGCCTATCCGAGCAAG -3'

Sequencing Primer
(F):5'- CCTCATCTACATTTTCACCCTGG -3'
(R):5'- TGTATCTCCAAGGTAAACTGAGACAC -3'
Posted On 2013-07-30