Mutagenetix > Incidental Mutation

Incidental Mutation 'R0655:Vmn2r72'

62484

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

MMRRC Submission

038840-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R0655 (G1)

Quality Score

136

Status

Not validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 85738111 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 748 (C748*)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably null
Transcript: ENSMUST00000063425
AA Change: C748*

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: C748*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Coding Region Coverage

1x: 99.4%
3x: 99.0%
10x: 97.7%
20x: 95.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcf1	G	C	17: 35,957,845 (GRCm38)	I757M	probably benign	Het
Atg16l1	T	A	1: 87,766,829 (GRCm38)	I76N	probably damaging	Het
Baz1b	T	A	5: 135,242,430 (GRCm38)	I1289N	probably benign	Het
Bcl2l15	T	A	3: 103,832,969 (GRCm38)		probably null	Het
Btbd11	A	G	10: 85,645,526 (GRCm38)	T931A	probably damaging	Het
Cbl	G	T	9: 44,158,752 (GRCm38)	T566K	probably damaging	Het
Cbwd1	T	C	19: 24,953,320 (GRCm38)	M122V	possibly damaging	Het
Cd96	T	C	16: 46,099,119 (GRCm38)	K180E	probably benign	Het
Cpxm2	G	A	7: 132,054,820 (GRCm38)	T571I	possibly damaging	Het
Cyp2a12	A	T	7: 27,036,621 (GRCm38)	Y485F	probably benign	Het
Cyp4f17	T	A	17: 32,524,897 (GRCm38)	Y350N	possibly damaging	Het
Dstn	T	A	2: 143,938,422 (GRCm38)	I14N	probably damaging	Het
Eea1	A	G	10: 95,995,598 (GRCm38)	S184G	probably benign	Het
Eif1a	G	T	18: 46,608,063 (GRCm38)	G122C	probably damaging	Het
Esf1	T	A	2: 140,148,879 (GRCm38)	T562S	probably benign	Het
Fem1c	G	A	18: 46,505,160 (GRCm38)	R592C	probably benign	Het
Fig4	T	C	10: 41,285,677 (GRCm38)	N30S	probably damaging	Het
Gria2	C	A	3: 80,732,070 (GRCm38)	E212*	probably null	Het
Gsdmc2	C	T	15: 63,827,773 (GRCm38)	A269T	probably benign	Het
Herc4	T	C	10: 63,273,571 (GRCm38)	V195A	probably benign	Het
Hivep1	T	C	13: 42,167,585 (GRCm38)	S2123P	probably damaging	Het
Hspa4	T	C	11: 53,269,692 (GRCm38)	E519G	probably benign	Het
Htr2b	A	G	1: 86,110,843 (GRCm38)	S14P	probably benign	Het
Ifit1	T	C	19: 34,647,647 (GRCm38)	V61A	probably damaging	Het
Ifitm1	C	A	7: 140,969,536 (GRCm38)	F77L	probably benign	Het
Matn2	T	C	15: 34,345,200 (GRCm38)	S118P	probably benign	Het
Mtmr3	C	A	11: 4,488,610 (GRCm38)	D615Y	probably damaging	Het
Mtss1	C	A	15: 59,081,502 (GRCm38)	C9F	probably damaging	Het
Muc5b	A	T	7: 141,863,942 (GRCm38)	I3542F	probably benign	Het
Nwd2	T	C	5: 63,791,585 (GRCm38)	S167P	possibly damaging	Het
Olfr394	T	C	11: 73,887,805 (GRCm38)	D189G	possibly damaging	Het
Olfr694	A	T	7: 106,689,425 (GRCm38)	F102Y	probably damaging	Het
Olfr921	C	T	9: 38,775,554 (GRCm38)	Q100*	probably null	Het
Oscp1	T	C	4: 126,058,733 (GRCm38)	L18P	probably damaging	Het
Pax5	A	G	4: 44,537,462 (GRCm38)	S297P	probably damaging	Het
Phldb3	A	T	7: 24,624,372 (GRCm38)	D476V	probably benign	Het
Phlpp2	A	T	8: 109,895,587 (GRCm38)	I154L	probably benign	Het
Prx	T	A	7: 27,517,421 (GRCm38)	V449E	probably damaging	Het
Psd3	A	G	8: 67,963,689 (GRCm38)	S519P	probably benign	Het
Rnf138	T	G	18: 21,010,783 (GRCm38)	V128G	probably benign	Het
Safb	T	A	17: 56,597,803 (GRCm38)	S209T	probably benign	Het
Sbno1	C	A	5: 124,376,149 (GRCm38)	V1327L	possibly damaging	Het
Scarb1	A	G	5: 125,300,440 (GRCm38)	V176A	probably damaging	Het
Scd4	A	G	19: 44,338,968 (GRCm38)	H161R	possibly damaging	Het
Selenoo	T	A	15: 89,095,655 (GRCm38)	H335Q	probably damaging	Het
Slfn8	A	G	11: 83,003,821 (GRCm38)	F664S	probably benign	Het
Spef2	T	C	15: 9,626,131 (GRCm38)	I1116M	possibly damaging	Het
Taf2	G	A	15: 55,038,294 (GRCm38)	R835W	probably damaging	Het
Tdrd9	A	G	12: 112,040,465 (GRCm38)	E921G	probably damaging	Het
Tectb	G	A	19: 55,189,870 (GRCm38)	G234S	possibly damaging	Het
Tmc1	C	T	19: 20,799,176 (GRCm38)	M606I	probably damaging	Het
Tmed10	T	A	12: 85,343,517 (GRCm38)	I88F	probably damaging	Het
Tnfrsf11a	G	A	1: 105,808,155 (GRCm38)	V31I	unknown	Het
Trp53inp2	G	T	2: 155,386,168 (GRCm38)	G98*	probably null	Het
Tssc4	A	G	7: 143,070,045 (GRCm38)	D30G	probably damaging	Het
Uaca	T	C	9: 60,872,029 (GRCm38)	Y1233H	probably benign	Het
Unc13c	G	A	9: 73,930,953 (GRCm38)	T872I	probably damaging	Het
Unc80	A	G	1: 66,503,781 (GRCm38)	H398R	probably damaging	Het
Vmn1r64	G	A	7: 5,884,208 (GRCm38)	T112I	probably benign	Het
Vmn1r85	A	G	7: 13,084,723 (GRCm38)	Y165H	probably damaging	Het
Wdr17	A	G	8: 54,649,198 (GRCm38)	W929R	probably damaging	Het
Yeats2	A	T	16: 20,193,824 (GRCm38)	K591*	probably null	Het
Zbtb9	T	A	17: 26,974,100 (GRCm38)	S160T	probably damaging	Het
Znfx1	T	A	2: 167,056,907 (GRCm38)	R32S	probably damaging	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85,749,646 (GRCm38)	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85,738,334 (GRCm38)	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85,749,646 (GRCm38)	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85,738,367 (GRCm38)	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85,738,166 (GRCm38)	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85,738,166 (GRCm38)	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85,738,166 (GRCm38)	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85,750,711 (GRCm38)	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85,737,962 (GRCm38)	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85,750,693 (GRCm38)	missense	probably benign
IGL02514:Vmn2r72	APN	7	85,738,699 (GRCm38)	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85,738,183 (GRCm38)	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85,738,671 (GRCm38)	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85,751,813 (GRCm38)	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85,752,041 (GRCm38)	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85,751,176 (GRCm38)	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85,754,954 (GRCm38)	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85,750,867 (GRCm38)	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85,751,836 (GRCm38)	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85,754,876 (GRCm38)	missense	probably benign
R0778:Vmn2r72	UTSW	7	85,749,739 (GRCm38)	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85,751,309 (GRCm38)	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85,751,944 (GRCm38)	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85,751,944 (GRCm38)	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85,751,944 (GRCm38)	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85,749,188 (GRCm38)	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85,738,257 (GRCm38)	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85,749,211 (GRCm38)	missense	probably benign
R1632:Vmn2r72	UTSW	7	85,751,792 (GRCm38)	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85,738,170 (GRCm38)	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85,749,161 (GRCm38)	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85,738,236 (GRCm38)	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85,738,341 (GRCm38)	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85,738,256 (GRCm38)	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85,750,953 (GRCm38)	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85,751,269 (GRCm38)	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85,750,836 (GRCm38)	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85,750,836 (GRCm38)	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85,750,836 (GRCm38)	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85,749,642 (GRCm38)	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85,738,077 (GRCm38)	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85,738,077 (GRCm38)	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85,749,735 (GRCm38)	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85,751,131 (GRCm38)	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85,749,809 (GRCm38)	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85,738,500 (GRCm38)	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85,738,500 (GRCm38)	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85,737,828 (GRCm38)	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85,751,926 (GRCm38)	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85,751,926 (GRCm38)	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85,751,926 (GRCm38)	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85,737,911 (GRCm38)	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85,737,861 (GRCm38)	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85,750,598 (GRCm38)	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85,751,109 (GRCm38)	missense	probably benign
R4991:Vmn2r72	UTSW	7	85,751,130 (GRCm38)	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85,738,485 (GRCm38)	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85,737,853 (GRCm38)	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85,737,840 (GRCm38)	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85,738,254 (GRCm38)	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85,750,897 (GRCm38)	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85,751,942 (GRCm38)	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85,737,850 (GRCm38)	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85,737,929 (GRCm38)	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85,737,929 (GRCm38)	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85,750,539 (GRCm38)	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85,751,174 (GRCm38)	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85,749,684 (GRCm38)	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85,737,996 (GRCm38)	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85,749,803 (GRCm38)	splice site	probably null
R7189:Vmn2r72	UTSW	7	85,754,917 (GRCm38)	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85,738,274 (GRCm38)	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85,750,563 (GRCm38)	missense	probably benign
R7426:Vmn2r72	UTSW	7	85,751,140 (GRCm38)	missense	probably benign
R7606:Vmn2r72	UTSW	7	85,751,154 (GRCm38)	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85,751,938 (GRCm38)	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85,754,890 (GRCm38)	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85,750,626 (GRCm38)	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85,749,630 (GRCm38)	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85,751,233 (GRCm38)	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85,751,019 (GRCm38)	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85,751,960 (GRCm38)	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85,738,175 (GRCm38)	missense	probably benign
R8989:Vmn2r72	UTSW	7	85,754,926 (GRCm38)	missense	probably benign	0.10
R9015:Vmn2r72	UTSW	7	85,749,180 (GRCm38)	missense	probably benign	0.01
R9080:Vmn2r72	UTSW	7	85,738,256 (GRCm38)	missense	probably damaging	1.00
R9269:Vmn2r72	UTSW	7	85,751,203 (GRCm38)	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85,754,814 (GRCm38)	missense	probably benign	0.04
R9509:Vmn2r72	UTSW	7	85,754,867 (GRCm38)	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85,749,191 (GRCm38)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GCCCTGCACTTGATGCCAAGATAC -3'
(R):5'- TGGTCATCCCACTACGGTCATCTG -3'

Sequencing Primer
(F):5'- TTCCACAGCAACCATAGTCTTG -3'
(R):5'- AGCAGACCACTTTTGCCATTG -3'

Posted On

2013-07-30