Incidental Mutation 'R0711:Zfp850'
ID 62735
Institutional Source Beutler Lab
Gene Symbol Zfp850
Ensembl Gene ENSMUSG00000096916
Gene Name zinc finger protein 850
Synonyms C130069I09Rik, Gm4636
MMRRC Submission 038894-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R0711 (G1)
Quality Score 120
Status Validated
Chromosome 7
Chromosomal Location 27984854-28014115 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 27990273 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 170 (N170S)
Ref Sequence ENSEMBL: ENSMUSP00000141063 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099111] [ENSMUST00000180024] [ENSMUST00000180502]
AlphaFold J3QPC5
Predicted Effect probably benign
Transcript: ENSMUST00000099111
Predicted Effect probably benign
Transcript: ENSMUST00000180024
AA Change: N170S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000137192
Gene: ENSMUSG00000096916
AA Change: N170S

DomainStartEndE-ValueType
KRAB 14 75 1.56e-34 SMART
ZnF_C2H2 172 194 7.18e1 SMART
ZnF_C2H2 200 222 3.63e-3 SMART
ZnF_C2H2 228 250 8.94e-3 SMART
ZnF_C2H2 256 278 7.49e-5 SMART
ZnF_C2H2 313 335 1.01e-1 SMART
ZnF_C2H2 341 363 4.4e-2 SMART
ZnF_C2H2 369 391 7.37e-4 SMART
ZnF_C2H2 397 419 8.47e-4 SMART
ZnF_C2H2 425 447 1.92e-2 SMART
ZnF_C2H2 453 475 2.99e-4 SMART
ZnF_C2H2 481 503 7.78e-3 SMART
ZnF_C2H2 509 531 1.95e-3 SMART
ZnF_C2H2 537 559 1.92e-2 SMART
ZnF_C2H2 565 587 2.99e-4 SMART
ZnF_C2H2 593 615 1.79e-2 SMART
ZnF_C2H2 621 643 7.37e-4 SMART
ZnF_C2H2 649 671 4.4e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000180502
AA Change: N170S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000141063
Gene: ENSMUSG00000096916
AA Change: N170S

DomainStartEndE-ValueType
KRAB 14 75 6.5e-37 SMART
ZnF_C2H2 172 194 3e-1 SMART
ZnF_C2H2 200 222 1.5e-5 SMART
ZnF_C2H2 228 250 3.8e-5 SMART
ZnF_C2H2 256 274 2.5e-1 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 91.4%
Validation Efficiency 100% (91/91)
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T A 3: 138,068,225 (GRCm38) D1058E probably damaging Het
4933405L10Rik A T 8: 105,708,931 (GRCm38) probably null Het
Adamtsl3 T A 7: 82,465,699 (GRCm38) probably benign Het
Afdn C T 17: 13,852,436 (GRCm38) P874S probably damaging Het
Ankrd6 G A 4: 32,815,326 (GRCm38) A391V probably damaging Het
Arhgef28 T G 13: 97,931,254 (GRCm38) T1388P probably damaging Het
Asxl3 G T 18: 22,524,451 (GRCm38) M1839I probably benign Het
BC005537 T C 13: 24,805,940 (GRCm38) F129L probably damaging Het
Celf2 A G 2: 6,721,415 (GRCm38) probably null Het
Chid1 C T 7: 141,496,677 (GRCm38) V325I probably benign Het
Cnn3 T A 3: 121,449,984 (GRCm38) D31E probably benign Het
Col12a1 G A 9: 79,652,035 (GRCm38) P1857L probably damaging Het
Cpeb1 T A 7: 81,351,870 (GRCm38) R430W probably benign Het
Daw1 T C 1: 83,191,338 (GRCm38) probably benign Het
Dcaf13 A G 15: 39,138,089 (GRCm38) Y264C probably damaging Het
Dnah6 T C 6: 73,087,602 (GRCm38) I2666V probably damaging Het
Dnai2 A C 11: 114,754,332 (GRCm38) D531A probably benign Het
Dock10 A T 1: 80,523,975 (GRCm38) F1833I probably damaging Het
Efhd2 C T 4: 141,859,872 (GRCm38) A200T probably damaging Het
Epb41l5 T A 1: 119,623,911 (GRCm38) probably benign Het
Ermp1 A G 19: 29,631,388 (GRCm38) Y164H possibly damaging Het
Gkn2 T C 6: 87,373,419 (GRCm38) probably benign Het
Golgb1 A T 16: 36,918,790 (GRCm38) Q2497L probably damaging Het
Gzme A T 14: 56,117,739 (GRCm38) M245K probably damaging Het
Iars2 A T 1: 185,322,388 (GRCm38) probably benign Het
Icosl T A 10: 78,073,941 (GRCm38) V240D probably damaging Het
Igsf3 T C 3: 101,427,393 (GRCm38) M262T probably benign Het
Ing3 G T 6: 21,971,237 (GRCm38) E336* probably null Het
Kat2a A T 11: 100,706,471 (GRCm38) V625E probably damaging Het
Ksr1 A G 11: 79,038,247 (GRCm38) probably benign Het
Lypd8 A T 11: 58,386,757 (GRCm38) M122L probably benign Het
Mdfi A T 17: 47,832,930 (GRCm38) probably benign Het
Med13 A G 11: 86,301,353 (GRCm38) probably benign Het
Msh6 C T 17: 87,986,684 (GRCm38) R956C probably damaging Het
Myo15b A G 11: 115,883,838 (GRCm38) E670G probably damaging Het
Myo1d A G 11: 80,484,332 (GRCm38) L972P probably damaging Het
Or4s2b A G 2: 88,678,674 (GRCm38) D266G probably damaging Het
Or51ai2 G A 7: 103,937,817 (GRCm38) A146T probably benign Het
Or7g12 T A 9: 18,988,151 (GRCm38) N54K probably benign Het
Pde8b C G 13: 95,107,817 (GRCm38) S143T possibly damaging Het
Pias4 G T 10: 81,157,530 (GRCm38) probably benign Het
Prkca A G 11: 107,981,654 (GRCm38) Y427H probably benign Het
Psg25 G A 7: 18,529,560 (GRCm38) Q113* probably null Het
Rab3gap2 T A 1: 185,249,926 (GRCm38) S392T probably damaging Het
Scrib A G 15: 76,066,907 (GRCm38) probably benign Het
Sdk2 A G 11: 113,903,144 (GRCm38) probably benign Het
Serpinb1c T A 13: 32,886,283 (GRCm38) probably benign Het
Serpinb9f T A 13: 33,327,921 (GRCm38) W136R probably damaging Het
Skic3 C T 13: 76,182,891 (GRCm38) P1480L probably damaging Het
Skint10 C A 4: 112,715,905 (GRCm38) probably benign Het
Slc25a13 T C 6: 6,117,128 (GRCm38) T196A probably damaging Het
Slc26a5 T C 5: 21,847,232 (GRCm38) H33R probably damaging Het
Slc27a6 T C 18: 58,598,757 (GRCm38) probably benign Het
Slitrk6 A T 14: 110,749,819 (GRCm38) Y819N probably damaging Het
Spata46 C T 1: 170,312,034 (GRCm38) Q201* probably null Het
Sptbn1 A T 11: 30,114,739 (GRCm38) V1920E probably damaging Het
Taf6l A G 19: 8,778,517 (GRCm38) F256L probably benign Het
Tmco3 T A 8: 13,292,039 (GRCm38) N104K probably damaging Het
Tmem200c A G 17: 68,842,254 (GRCm38) T611A probably damaging Het
Tmem202 T G 9: 59,525,372 (GRCm38) Y24S probably damaging Het
Tpp1 A G 7: 105,749,419 (GRCm38) L230P probably damaging Het
Trim56 C T 5: 137,112,992 (GRCm38) E557K probably benign Het
Trrap C T 5: 144,853,499 (GRCm38) L3590F probably damaging Het
Tulp4 A G 17: 6,139,112 (GRCm38) T70A possibly damaging Het
Vcp G C 4: 42,986,201 (GRCm38) A297G probably benign Het
Vwf T A 6: 125,626,271 (GRCm38) H861Q probably benign Het
Wdr64 T C 1: 175,772,185 (GRCm38) I536T probably benign Het
Zfp72 G A 13: 74,376,425 (GRCm38) probably benign Het
Other mutations in Zfp850
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02278:Zfp850 APN 7 28,008,397 (GRCm38) missense probably damaging 0.96
R0610:Zfp850 UTSW 7 27,989,394 (GRCm38) missense probably damaging 0.99
R0690:Zfp850 UTSW 7 27,985,217 (GRCm38) missense possibly damaging 0.67
R1310:Zfp850 UTSW 7 27,989,459 (GRCm38) missense probably benign 0.40
R1594:Zfp850 UTSW 7 27,989,391 (GRCm38) missense probably benign 0.00
R1771:Zfp850 UTSW 7 27,985,275 (GRCm38) nonsense probably null
R2189:Zfp850 UTSW 7 27,989,055 (GRCm38) missense probably benign 0.02
R2192:Zfp850 UTSW 7 27,985,195 (GRCm38) missense probably damaging 1.00
R2417:Zfp850 UTSW 7 27,989,183 (GRCm38) missense possibly damaging 0.54
R4321:Zfp850 UTSW 7 27,989,400 (GRCm38) missense probably damaging 0.99
R4770:Zfp850 UTSW 7 27,984,986 (GRCm38) splice site probably null
R4970:Zfp850 UTSW 7 27,990,233 (GRCm38) nonsense probably null
R5112:Zfp850 UTSW 7 27,990,233 (GRCm38) nonsense probably null
R5166:Zfp850 UTSW 7 27,990,356 (GRCm38) nonsense probably null
R5303:Zfp850 UTSW 7 28,008,413 (GRCm38) missense probably damaging 1.00
R5315:Zfp850 UTSW 7 27,990,318 (GRCm38) missense probably benign 0.02
R5496:Zfp850 UTSW 7 28,007,346 (GRCm38) missense probably damaging 0.98
R5547:Zfp850 UTSW 7 27,989,419 (GRCm38) missense probably damaging 1.00
R5677:Zfp850 UTSW 7 27,989,088 (GRCm38) missense probably damaging 1.00
R5927:Zfp850 UTSW 7 27,990,195 (GRCm38) missense probably benign 0.17
R6654:Zfp850 UTSW 7 27,985,215 (GRCm38) nonsense probably null
R6950:Zfp850 UTSW 7 27,990,514 (GRCm38) missense possibly damaging 0.86
R6987:Zfp850 UTSW 7 27,990,001 (GRCm38) missense probably damaging 1.00
R6990:Zfp850 UTSW 7 27,990,376 (GRCm38) missense probably benign 0.09
R7640:Zfp850 UTSW 7 27,989,209 (GRCm38) missense probably benign 0.05
R7856:Zfp850 UTSW 7 27,990,474 (GRCm38) missense probably benign 0.02
R9498:Zfp850 UTSW 7 27,989,850 (GRCm38) missense possibly damaging 0.88
R9506:Zfp850 UTSW 7 27,989,562 (GRCm38) missense possibly damaging 0.82
Z1186:Zfp850 UTSW 7 27,990,279 (GRCm38) missense probably benign 0.00
Z1186:Zfp850 UTSW 7 27,989,124 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCTGAGTGATGAGCTGTGCTAGAAC -3'
(R):5'- AGTGAAACTTTTGAACTCAAGGGCTCC -3'

Sequencing Primer
(F):5'- ggctttcccacattcattacattc -3'
(R):5'- GAACTCAAGGGCTCCAGTTTTAG -3'
Posted On 2013-07-30