Incidental Mutation 'R0711:Pias4'
ID 62747
Institutional Source Beutler Lab
Gene Symbol Pias4
Ensembl Gene ENSMUSG00000004934
Gene Name protein inhibitor of activated STAT 4
Synonyms PIASy
MMRRC Submission 038894-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.903) question?
Stock # R0711 (G1)
Quality Score 184
Status Validated
Chromosome 10
Chromosomal Location 80989795-81003554 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to T at 80993364 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000121361 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005064] [ENSMUST00000121840] [ENSMUST00000135765]
AlphaFold Q9JM05
Predicted Effect probably benign
Transcript: ENSMUST00000005064
SMART Domains Protein: ENSMUSP00000005064
Gene: ENSMUSG00000004934

DomainStartEndE-ValueType
SAP 12 46 4.44e-7 SMART
Pfam:PINIT 123 270 9.6e-35 PFAM
Pfam:zf-MIZ 315 364 2.4e-24 PFAM
low complexity region 429 454 N/A INTRINSIC
low complexity region 469 489 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000121840
SMART Domains Protein: ENSMUSP00000113787
Gene: ENSMUSG00000035011

DomainStartEndE-ValueType
BTB 34 131 5.01e-30 SMART
low complexity region 195 205 N/A INTRINSIC
low complexity region 215 232 N/A INTRINSIC
low complexity region 245 261 N/A INTRINSIC
low complexity region 267 289 N/A INTRINSIC
low complexity region 297 314 N/A INTRINSIC
ZnF_C2H2 376 398 7.55e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134017
Predicted Effect probably benign
Transcript: ENSMUST00000135765
SMART Domains Protein: ENSMUSP00000121361
Gene: ENSMUSG00000004934

DomainStartEndE-ValueType
PDB:4FO9|A 1 70 9e-15 PDB
Predicted Effect
SMART Domains Protein: ENSMUSP00000122183
Gene: ENSMUSG00000004934

DomainStartEndE-ValueType
SAP 12 46 4.44e-7 SMART
Pfam:PINIT 119 270 1.8e-43 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147436
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 91.4%
Validation Efficiency 100% (91/91)
MGI Phenotype PHENOTYPE: Homozygous null mutants display mild postnatal lethality or a normal phenotype depending on strain background. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T A 3: 137,773,986 (GRCm39) D1058E probably damaging Het
4933405L10Rik A T 8: 106,435,563 (GRCm39) probably null Het
Adamtsl3 T A 7: 82,114,907 (GRCm39) probably benign Het
Afdn C T 17: 14,072,698 (GRCm39) P874S probably damaging Het
Ankrd6 G A 4: 32,815,326 (GRCm39) A391V probably damaging Het
Arhgef28 T G 13: 98,067,762 (GRCm39) T1388P probably damaging Het
Asxl3 G T 18: 22,657,508 (GRCm39) M1839I probably benign Het
BC005537 T C 13: 24,989,923 (GRCm39) F129L probably damaging Het
Celf2 A G 2: 6,726,226 (GRCm39) probably null Het
Chid1 C T 7: 141,076,590 (GRCm39) V325I probably benign Het
Cnn3 T A 3: 121,243,633 (GRCm39) D31E probably benign Het
Col12a1 G A 9: 79,559,317 (GRCm39) P1857L probably damaging Het
Cpeb1 T A 7: 81,001,618 (GRCm39) R430W probably benign Het
Daw1 T C 1: 83,169,059 (GRCm39) probably benign Het
Dcaf13 A G 15: 39,001,484 (GRCm39) Y264C probably damaging Het
Dnah6 T C 6: 73,064,585 (GRCm39) I2666V probably damaging Het
Dnai2 A C 11: 114,645,158 (GRCm39) D531A probably benign Het
Dock10 A T 1: 80,501,692 (GRCm39) F1833I probably damaging Het
Efhd2 C T 4: 141,587,183 (GRCm39) A200T probably damaging Het
Epb41l5 T A 1: 119,551,641 (GRCm39) probably benign Het
Ermp1 A G 19: 29,608,788 (GRCm39) Y164H possibly damaging Het
Gkn2 T C 6: 87,350,401 (GRCm39) probably benign Het
Golgb1 A T 16: 36,739,152 (GRCm39) Q2497L probably damaging Het
Gzme A T 14: 56,355,196 (GRCm39) M245K probably damaging Het
Iars2 A T 1: 185,054,585 (GRCm39) probably benign Het
Icosl T A 10: 77,909,775 (GRCm39) V240D probably damaging Het
Igsf3 T C 3: 101,334,709 (GRCm39) M262T probably benign Het
Ing3 G T 6: 21,971,236 (GRCm39) E336* probably null Het
Kat2a A T 11: 100,597,297 (GRCm39) V625E probably damaging Het
Ksr1 A G 11: 78,929,073 (GRCm39) probably benign Het
Lypd8 A T 11: 58,277,583 (GRCm39) M122L probably benign Het
Mdfi A T 17: 48,143,855 (GRCm39) probably benign Het
Med13 A G 11: 86,192,179 (GRCm39) probably benign Het
Msh6 C T 17: 88,294,112 (GRCm39) R956C probably damaging Het
Myo15b A G 11: 115,774,664 (GRCm39) E670G probably damaging Het
Myo1d A G 11: 80,375,158 (GRCm39) L972P probably damaging Het
Or4s2b A G 2: 88,509,018 (GRCm39) D266G probably damaging Het
Or51ai2 G A 7: 103,587,024 (GRCm39) A146T probably benign Het
Or7g12 T A 9: 18,899,447 (GRCm39) N54K probably benign Het
Pde8b C G 13: 95,244,325 (GRCm39) S143T possibly damaging Het
Prkca A G 11: 107,872,480 (GRCm39) Y427H probably benign Het
Psg25 G A 7: 18,263,485 (GRCm39) Q113* probably null Het
Rab3gap2 T A 1: 184,982,123 (GRCm39) S392T probably damaging Het
Scrib A G 15: 75,938,756 (GRCm39) probably benign Het
Sdk2 A G 11: 113,793,970 (GRCm39) probably benign Het
Serpinb1c T A 13: 33,070,266 (GRCm39) probably benign Het
Serpinb9f T A 13: 33,511,904 (GRCm39) W136R probably damaging Het
Skic3 C T 13: 76,331,010 (GRCm39) P1480L probably damaging Het
Skint10 C A 4: 112,573,102 (GRCm39) probably benign Het
Slc25a13 T C 6: 6,117,128 (GRCm39) T196A probably damaging Het
Slc26a5 T C 5: 22,052,230 (GRCm39) H33R probably damaging Het
Slc27a6 T C 18: 58,731,829 (GRCm39) probably benign Het
Slitrk6 A T 14: 110,987,251 (GRCm39) Y819N probably damaging Het
Spata46 C T 1: 170,139,603 (GRCm39) Q201* probably null Het
Sptbn1 A T 11: 30,064,739 (GRCm39) V1920E probably damaging Het
Taf6l A G 19: 8,755,881 (GRCm39) F256L probably benign Het
Tmco3 T A 8: 13,342,039 (GRCm39) N104K probably damaging Het
Tmem200c A G 17: 69,149,249 (GRCm39) T611A probably damaging Het
Tmem202 T G 9: 59,432,655 (GRCm39) Y24S probably damaging Het
Tpp1 A G 7: 105,398,626 (GRCm39) L230P probably damaging Het
Trim56 C T 5: 137,141,846 (GRCm39) E557K probably benign Het
Trrap C T 5: 144,790,309 (GRCm39) L3590F probably damaging Het
Tulp4 A G 17: 6,189,387 (GRCm39) T70A possibly damaging Het
Vcp G C 4: 42,986,201 (GRCm39) A297G probably benign Het
Vwf T A 6: 125,603,234 (GRCm39) H861Q probably benign Het
Wdr64 T C 1: 175,599,751 (GRCm39) I536T probably benign Het
Zfp850 T C 7: 27,689,698 (GRCm39) N170S probably benign Het
Zfp87 G A 13: 74,524,544 (GRCm39) probably benign Het
Other mutations in Pias4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01655:Pias4 APN 10 80,991,492 (GRCm39) missense probably benign 0.07
IGL01790:Pias4 APN 10 80,993,332 (GRCm39) missense probably damaging 0.98
IGL02553:Pias4 APN 10 80,999,621 (GRCm39) missense probably damaging 1.00
IGL02670:Pias4 APN 10 80,999,904 (GRCm39) missense probably damaging 0.99
R0083:Pias4 UTSW 10 81,000,000 (GRCm39) missense probably damaging 1.00
R0122:Pias4 UTSW 10 80,992,921 (GRCm39) missense probably damaging 0.96
R1399:Pias4 UTSW 10 80,991,509 (GRCm39) missense probably damaging 1.00
R1726:Pias4 UTSW 10 80,991,689 (GRCm39) missense probably damaging 1.00
R1907:Pias4 UTSW 10 80,990,197 (GRCm39) missense possibly damaging 0.46
R3730:Pias4 UTSW 10 80,999,888 (GRCm39) missense probably damaging 0.98
R4764:Pias4 UTSW 10 80,999,868 (GRCm39) missense possibly damaging 0.88
R4790:Pias4 UTSW 10 80,993,326 (GRCm39) missense probably damaging 0.98
R4808:Pias4 UTSW 10 80,991,674 (GRCm39) splice site probably null
R6351:Pias4 UTSW 10 80,993,098 (GRCm39) missense probably damaging 1.00
R6786:Pias4 UTSW 10 80,993,080 (GRCm39) missense probably damaging 1.00
R7113:Pias4 UTSW 10 80,990,287 (GRCm39) missense possibly damaging 0.94
R7260:Pias4 UTSW 10 80,993,302 (GRCm39) missense possibly damaging 0.95
R7487:Pias4 UTSW 10 80,999,806 (GRCm39) missense probably benign
R7609:Pias4 UTSW 10 80,993,860 (GRCm39) splice site probably null
R8224:Pias4 UTSW 10 81,003,565 (GRCm39) start gained probably benign
R8387:Pias4 UTSW 10 80,990,342 (GRCm39) missense probably benign
R8443:Pias4 UTSW 10 80,992,844 (GRCm39) critical splice donor site probably null
R8794:Pias4 UTSW 10 80,999,846 (GRCm39) missense probably damaging 1.00
R9319:Pias4 UTSW 10 80,991,750 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TTGCCCCAGGTGACAGTAATGC -3'
(R):5'- TGGTCTGTGCTGCAACTGACTC -3'

Sequencing Primer
(F):5'- AGGGCCTCTTAGGTTCCAC -3'
(R):5'- GCAACTGACTCCTGCTCTTG -3'
Posted On 2013-07-30