Incidental Mutation 'R7643:Lrp2bp'
ID628225
Institutional Source Beutler Lab
Gene Symbol Lrp2bp
Ensembl Gene ENSMUSG00000031637
Gene NameLrp2 binding protein
SynonymsMegBP, 4930479L12Rik, 1700113N17Rik
MMRRC Submission
Accession Numbers

Ncbi RefSeq: NM_026278.3; MGI:1914870

Is this an essential gene? Probably non essential (E-score: 0.140) question?
Stock #R7643 (G1)
Quality Score225.009
Status Validated
Chromosome8
Chromosomal Location45999303-46029477 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 46020527 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000106010 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066451] [ENSMUST00000110380] [ENSMUST00000110381] [ENSMUST00000145597]
Predicted Effect probably null
Transcript: ENSMUST00000066451
SMART Domains Protein: ENSMUSP00000067177
Gene: ENSMUSG00000031637

DomainStartEndE-ValueType
low complexity region 42 53 N/A INTRINSIC
SEL1 110 145 4.45e-3 SMART
SEL1 153 188 5.07e-7 SMART
SEL1 193 226 6.3e-3 SMART
SEL1 227 262 3.9e-8 SMART
Blast:SEL1 263 293 1e-5 BLAST
SEL1 317 352 7.57e-6 SMART
Predicted Effect probably null
Transcript: ENSMUST00000110380
SMART Domains Protein: ENSMUSP00000106009
Gene: ENSMUSG00000031637

DomainStartEndE-ValueType
low complexity region 21 32 N/A INTRINSIC
SEL1 89 124 4.45e-3 SMART
SEL1 132 167 5.07e-7 SMART
SEL1 172 205 6.3e-3 SMART
SEL1 206 241 3.9e-8 SMART
Blast:SEL1 242 272 1e-5 BLAST
SEL1 296 331 7.57e-6 SMART
Predicted Effect probably null
Transcript: ENSMUST00000110381
SMART Domains Protein: ENSMUSP00000106010
Gene: ENSMUSG00000031637

DomainStartEndE-ValueType
low complexity region 21 32 N/A INTRINSIC
SEL1 89 124 4.45e-3 SMART
SEL1 132 167 5.07e-7 SMART
SEL1 172 205 6.3e-3 SMART
SEL1 206 241 3.9e-8 SMART
Blast:SEL1 242 272 1e-5 BLAST
SEL1 296 331 7.57e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132341
Predicted Effect silent
Transcript: ENSMUST00000145597
SMART Domains Protein: ENSMUSP00000135210
Gene: ENSMUSG00000031637

DomainStartEndE-ValueType
low complexity region 21 32 N/A INTRINSIC
SEL1 89 124 4.45e-3 SMART
SEL1 132 167 5.07e-7 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (64/64)
Allele List at MGI

All alleles(3) : Targeted(3)

Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930435E12Rik A G 16: 38,827,863 Y295H probably benign Het
4931406C07Rik A G 9: 15,297,860 F46S probably damaging Het
Acaca T C 11: 84,338,356 Y1670H probably damaging Het
Acrbp G A 6: 125,053,832 R272Q possibly damaging Het
Adcy6 T A 15: 98,593,568 Q1050L probably benign Het
Amn1 C T 6: 149,185,031 M44I probably benign Het
Ankrd13b A G 11: 77,473,085 V395A probably benign Het
Ap3b2 T C 7: 81,477,072 K310R probably benign Het
Bnc2 T C 4: 84,506,574 D123G probably benign Het
Bst1 G A 5: 43,840,449 M263I probably benign Het
Ccdc7a C T 8: 128,889,811 G937E probably damaging Het
Cep290 A G 10: 100,537,553 M1232V probably benign Het
Cfhr1 A G 1: 139,553,585 Y186H possibly damaging Het
Dnah7c A T 1: 46,602,813 H1203L probably benign Het
Emc7 A G 2: 112,455,279 E71G probably benign Het
Exoc3l4 G A 12: 111,421,935 probably benign Het
Fam83c A G 2: 155,831,004 F278L possibly damaging Het
Gabpb2 C A 3: 95,200,225 V180L probably benign Het
Gbp2b G T 3: 142,603,609 Q160H probably benign Het
Gm19965 C G 1: 116,822,229 Q547E unknown Het
Gm40460 ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 142,240,713 probably benign Het
Gon4l T A 3: 88,902,807 D1774E probably damaging Het
Gpr15 A C 16: 58,717,816 Y303* probably null Het
Greb1 T C 12: 16,711,996 D461G probably damaging Het
Gria4 T C 9: 4,793,950 N36S probably benign Het
Hacd1 T C 2: 14,044,791 I119V probably damaging Het
Ing5 T A 1: 93,812,433 D101E probably damaging Het
Irak4 T A 15: 94,558,828 N297K probably benign Het
Itga7 A G 10: 128,953,501 D971G probably benign Het
Klf5 A G 14: 99,313,178 E397G possibly damaging Het
Krtap29-1 C T 11: 99,978,198 G286S probably damaging Het
March4 T G 1: 72,447,220 Q266H probably damaging Het
Med23 A G 10: 24,905,965 T1056A probably benign Het
Megf11 T C 9: 64,706,632 L1079P probably damaging Het
Mycbp2 G T 14: 103,346,265 L85I probably benign Het
Nlgn2 G T 11: 69,827,885 Q290K probably damaging Het
Nox4 A T 7: 87,323,754 E323V probably damaging Het
Nup93 T C 8: 94,286,619 probably null Het
Olfr298 C T 7: 86,489,568 probably null Het
Olfr558 C T 7: 102,709,538 T93I probably benign Het
Olfr977-ps1 T A 9: 39,974,821 M1L unknown Het
Otop3 T C 11: 115,339,648 L117P probably damaging Het
Pde6c C A 19: 38,141,421 Q260K probably damaging Het
Plb1 C T 5: 32,247,557 Q20* probably null Het
Qser1 A T 2: 104,786,977 Y1163* probably null Het
Rbm12 A T 2: 156,098,217 I45N unknown Het
Rictor T A 15: 6,769,269 Y332* probably null Het
Rpp14 C A 14: 8,090,325 S83* probably null Het
Sel1l3 C T 5: 53,123,162 probably null Het
Setd2 T C 9: 110,567,840 probably null Het
Spink5 A G 18: 44,010,252 T759A probably benign Het
Spon2 T A 5: 33,217,456 E2V probably benign Het
Tdrd1 T C 19: 56,837,708 S144P probably damaging Het
Tex15 A C 8: 33,575,120 Y1526S probably damaging Het
Tnfrsf21 T C 17: 43,037,916 S140P probably benign Het
Trav6-2 T A 14: 52,667,442 M11K probably benign Het
Trp53bp1 G T 2: 121,247,814 probably null Het
Ttn T C 2: 76,734,827 N28352S possibly damaging Het
Uckl1 T C 2: 181,573,106 I292V probably benign Het
Unc13b T A 4: 43,216,333 S211T probably benign Het
Zcchc4 T C 5: 52,808,293 I313T possibly damaging Het
Zfp106 C T 2: 120,512,734 R1811K probably benign Het
Zfp599 G T 9: 22,249,892 Q326K probably benign Het
Zscan4e A T 7: 11,309,525 M108K probably damaging Het
Other mutations in Lrp2bp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02152:Lrp2bp APN 8 46023044 missense probably damaging 1.00
PIT4280001:Lrp2bp UTSW 8 46023011 missense probably damaging 0.98
R0016:Lrp2bp UTSW 8 46012031 missense probably damaging 1.00
R0016:Lrp2bp UTSW 8 46012031 missense probably damaging 1.00
R0046:Lrp2bp UTSW 8 46013155 nonsense probably null
R0046:Lrp2bp UTSW 8 46013155 nonsense probably null
R0514:Lrp2bp UTSW 8 46011958 missense probably damaging 1.00
R0838:Lrp2bp UTSW 8 46025124 missense possibly damaging 0.87
R1465:Lrp2bp UTSW 8 46025235 missense possibly damaging 0.93
R1465:Lrp2bp UTSW 8 46025235 missense possibly damaging 0.93
R1735:Lrp2bp UTSW 8 46011988 missense probably benign 0.26
R1842:Lrp2bp UTSW 8 46011115 missense probably benign
R2191:Lrp2bp UTSW 8 46013169 missense probably benign 0.07
R2192:Lrp2bp UTSW 8 46013169 missense probably benign 0.07
R4716:Lrp2bp UTSW 8 46013171 missense probably benign 0.23
R6722:Lrp2bp UTSW 8 46020563 critical splice donor site probably null
R6789:Lrp2bp UTSW 8 46013114 missense possibly damaging 0.56
R8807:Lrp2bp UTSW 8 46020695 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAGCGGTTGGTTATACTCCTAAG -3'
(R):5'- ACTTTGCGCCTTCACACTAG -3'

Sequencing Primer
(F):5'- CGGTTGGTTATACTCCTAAGCATAG -3'
(R):5'- GCCTTCACACTAGCTTTTGGG -3'
Posted On2020-02-11