|Institutional Source||Beutler Lab|
|Gene Name||glutathione S-transferase, mu 1|
|Essential gene?||Probably non essential (E-score: 0.136)|
|Stock #||R7638 (G1)|
|Chromosomal Location||108012255-108017973 bp(-) (GRCm38)|
|Type of Mutation||splice site (203 bp from exon)|
|DNA Base Change (assembly)||C to T at 108014550 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000123481 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000004140] [ENSMUST00000126593] [ENSMUST00000153314]|
|Meta Mutation Damage Score||0.9756|
|Coding Region Coverage||
|Validation Efficiency||100% (71/71)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for the deletion of this gene display a reduced ability to metabolize 1,2-dichloro-4-nitrobenzene. Mice homozygous for a different knock-out allele exhibit abnormal behavior, altered response to valproic acid, and increased serotonin and dopamine levels in the cerebellum. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gstm1||
(F):5'- CTCTCAGCACTCAAGTCTGG -3'
(R):5'- TTTCTCGGGTCCATGATGC -3'
(F):5'- GGCTATGTTACATTAGCTCTGC -3'
(R):5'- ATGATGCTTTCTAGTCCCAAGAC -3'