Incidental Mutation 'R7644:Clasp1'
| ID |
628276 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Clasp1
|
| Ensembl Gene |
ENSMUSG00000064302 |
| Gene Name |
CLIP associating protein 1 |
| Synonyms |
CLASP1alpha, 1700030C23Rik, 5730583A19Rik, CLASP1, B130045P17Rik, mCLASP1 |
| MMRRC Submission |
045723-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.948)
|
| Stock # |
R7644 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
118314976-118537192 bp(+) (GRCm39) |
| Type of Mutation |
splice site (2374 bp from exon) |
| DNA Base Change (assembly) |
T to G
at 118440480 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140095
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049404]
[ENSMUST00000070989]
[ENSMUST00000165223]
[ENSMUST00000178710]
[ENSMUST00000185405]
[ENSMUST00000186349]
[ENSMUST00000187713]
[ENSMUST00000188710]
[ENSMUST00000189262]
[ENSMUST00000189570]
[ENSMUST00000189738]
[ENSMUST00000190571]
[ENSMUST00000190733]
[ENSMUST00000191445]
[ENSMUST00000191823]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000049404
|
| SMART Domains |
Protein: ENSMUSP00000042266
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
7.31e-51 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
1.14e-11 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
674 |
707 |
N/A |
INTRINSIC |
|
low complexity region
|
751 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
821 |
831 |
N/A |
INTRINSIC |
|
TOG
|
847 |
1085 |
3.23e-1 |
SMART |
|
low complexity region
|
1096 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1134 |
1147 |
N/A |
INTRINSIC |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
TOG
|
1287 |
1525 |
4.96e-30 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000070989
|
| SMART Domains |
Protein: ENSMUSP00000067858
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
7.31e-51 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
1.14e-11 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
674 |
707 |
N/A |
INTRINSIC |
|
low complexity region
|
751 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
850 |
860 |
N/A |
INTRINSIC |
|
TOG
|
876 |
1114 |
3.23e-1 |
SMART |
|
low complexity region
|
1125 |
1142 |
N/A |
INTRINSIC |
|
low complexity region
|
1215 |
1226 |
N/A |
INTRINSIC |
|
TOG
|
1277 |
1515 |
4.96e-30 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000165223
|
| SMART Domains |
Protein: ENSMUSP00000128089
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
7.31e-51 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
1.14e-11 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
684 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
792 |
802 |
N/A |
INTRINSIC |
|
TOG
|
818 |
1056 |
3.23e-1 |
SMART |
|
low complexity region
|
1067 |
1084 |
N/A |
INTRINSIC |
|
low complexity region
|
1157 |
1168 |
N/A |
INTRINSIC |
|
TOG
|
1219 |
1457 |
4.96e-30 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000178710
|
| SMART Domains |
Protein: ENSMUSP00000137137
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
7.31e-51 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
1.14e-11 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
668 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
752 |
766 |
N/A |
INTRINSIC |
|
low complexity region
|
784 |
794 |
N/A |
INTRINSIC |
|
TOG
|
810 |
1047 |
6.55e-2 |
SMART |
|
low complexity region
|
1058 |
1075 |
N/A |
INTRINSIC |
|
low complexity region
|
1148 |
1159 |
N/A |
INTRINSIC |
|
TOG
|
1210 |
1448 |
4.96e-30 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000185405
|
| SMART Domains |
Protein: ENSMUSP00000139619
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
3.4e-55 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
5.5e-16 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
682 |
715 |
N/A |
INTRINSIC |
|
low complexity region
|
769 |
783 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
811 |
N/A |
INTRINSIC |
|
TOG
|
827 |
1065 |
1.6e-5 |
SMART |
|
low complexity region
|
1076 |
1093 |
N/A |
INTRINSIC |
|
low complexity region
|
1166 |
1177 |
N/A |
INTRINSIC |
|
TOG
|
1228 |
1466 |
2.3e-34 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000186349
|
| SMART Domains |
Protein: ENSMUSP00000141105
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
7.31e-51 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
1.14e-11 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
674 |
707 |
N/A |
INTRINSIC |
|
low complexity region
|
751 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
821 |
831 |
N/A |
INTRINSIC |
|
TOG
|
847 |
1085 |
3.23e-1 |
SMART |
|
low complexity region
|
1096 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1134 |
1147 |
N/A |
INTRINSIC |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
TOG
|
1287 |
1525 |
4.96e-30 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187713
|
| SMART Domains |
Protein: ENSMUSP00000139526
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
3.4e-55 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
5.5e-16 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
684 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
768 |
782 |
N/A |
INTRINSIC |
|
low complexity region
|
800 |
810 |
N/A |
INTRINSIC |
|
TOG
|
826 |
1064 |
1.6e-5 |
SMART |
|
low complexity region
|
1075 |
1092 |
N/A |
INTRINSIC |
|
low complexity region
|
1165 |
1176 |
N/A |
INTRINSIC |
|
TOG
|
1227 |
1465 |
2.3e-34 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000188710
|
| SMART Domains |
Protein: ENSMUSP00000140593
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
3.4e-55 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
5.5e-16 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
674 |
707 |
N/A |
INTRINSIC |
|
low complexity region
|
751 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
818 |
832 |
N/A |
INTRINSIC |
|
low complexity region
|
850 |
860 |
N/A |
INTRINSIC |
|
TOG
|
876 |
1114 |
1.6e-5 |
SMART |
|
low complexity region
|
1125 |
1142 |
N/A |
INTRINSIC |
|
low complexity region
|
1215 |
1226 |
N/A |
INTRINSIC |
|
TOG
|
1277 |
1515 |
2.3e-34 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000189262
|
| SMART Domains |
Protein: ENSMUSP00000140860
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
3.4e-55 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
5.5e-16 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
668 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
776 |
786 |
N/A |
INTRINSIC |
|
TOG
|
802 |
1040 |
1.6e-5 |
SMART |
|
low complexity region
|
1051 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1141 |
1152 |
N/A |
INTRINSIC |
|
TOG
|
1203 |
1441 |
2.3e-34 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189570
|
| SMART Domains |
Protein: ENSMUSP00000140167
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
3.4e-55 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
5.5e-16 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
684 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
792 |
802 |
N/A |
INTRINSIC |
|
TOG
|
818 |
1055 |
3.2e-6 |
SMART |
|
low complexity region
|
1066 |
1083 |
N/A |
INTRINSIC |
|
low complexity region
|
1156 |
1167 |
N/A |
INTRINSIC |
|
TOG
|
1218 |
1456 |
2.3e-34 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189738
|
| SMART Domains |
Protein: ENSMUSP00000140665
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
7.31e-51 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
1.14e-11 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
668 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
752 |
766 |
N/A |
INTRINSIC |
|
low complexity region
|
784 |
794 |
N/A |
INTRINSIC |
|
TOG
|
810 |
1048 |
3.23e-1 |
SMART |
|
low complexity region
|
1059 |
1076 |
N/A |
INTRINSIC |
|
low complexity region
|
1149 |
1160 |
N/A |
INTRINSIC |
|
TOG
|
1211 |
1449 |
4.96e-30 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190571
|
| SMART Domains |
Protein: ENSMUSP00000140019
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
3.4e-55 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
5.5e-16 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
682 |
715 |
N/A |
INTRINSIC |
|
low complexity region
|
759 |
771 |
N/A |
INTRINSIC |
|
low complexity region
|
805 |
819 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
847 |
N/A |
INTRINSIC |
|
TOG
|
863 |
1101 |
1.6e-5 |
SMART |
|
low complexity region
|
1112 |
1129 |
N/A |
INTRINSIC |
|
low complexity region
|
1150 |
1163 |
N/A |
INTRINSIC |
|
low complexity region
|
1241 |
1252 |
N/A |
INTRINSIC |
|
TOG
|
1303 |
1541 |
2.3e-34 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190733
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000191445
|
| SMART Domains |
Protein: ENSMUSP00000140095
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
TOG
|
1 |
232 |
3.4e-55 |
SMART |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
|
TOG
|
319 |
551 |
5.5e-16 |
SMART |
|
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
674 |
707 |
N/A |
INTRINSIC |
|
low complexity region
|
761 |
775 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
803 |
N/A |
INTRINSIC |
|
TOG
|
819 |
1056 |
3.2e-6 |
SMART |
|
low complexity region
|
1067 |
1084 |
N/A |
INTRINSIC |
|
low complexity region
|
1157 |
1168 |
N/A |
INTRINSIC |
|
TOG
|
1219 |
1457 |
2.3e-34 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000191823
|
| SMART Domains |
Protein: ENSMUSP00000142203
Gene: ENSMUSG00000064302
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
20 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
64 |
N/A |
INTRINSIC |
|
TOG
|
87 |
319 |
5.6e-16 |
SMART |
|
low complexity region
|
347 |
362 |
N/A |
INTRINSIC |
|
low complexity region
|
374 |
401 |
N/A |
INTRINSIC |
|
low complexity region
|
450 |
483 |
N/A |
INTRINSIC |
|
low complexity region
|
537 |
551 |
N/A |
INTRINSIC |
|
low complexity region
|
568 |
578 |
N/A |
INTRINSIC |
|
TOG
|
594 |
832 |
1.6e-5 |
SMART |
|
low complexity region
|
843 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
944 |
N/A |
INTRINSIC |
|
TOG
|
995 |
1233 |
2.4e-34 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205176
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
100% (86/86) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001O22Rik |
C |
T |
2: 30,687,966 (GRCm39) |
R209Q |
possibly damaging |
Het |
| Abl2 |
A |
G |
1: 156,443,563 (GRCm39) |
D24G |
probably benign |
Het |
| Adar |
C |
T |
3: 89,652,826 (GRCm39) |
A754V |
probably benign |
Het |
| Adcy8 |
C |
T |
15: 64,571,218 (GRCm39) |
V1172I |
possibly damaging |
Het |
| Adgrl2 |
C |
T |
3: 148,544,789 (GRCm39) |
V769M |
probably damaging |
Het |
| Akna |
T |
A |
4: 63,313,634 (GRCm39) |
Q163L |
possibly damaging |
Het |
| Alox15 |
C |
T |
11: 70,236,368 (GRCm39) |
A511T |
probably null |
Het |
| Ano8 |
C |
T |
8: 71,937,474 (GRCm39) |
G90D |
probably damaging |
Het |
| Aqp5 |
G |
A |
15: 99,492,107 (GRCm39) |
R235H |
probably damaging |
Het |
| B3galt4 |
A |
T |
17: 34,169,419 (GRCm39) |
V273E |
probably damaging |
Het |
| Ccdc125 |
C |
T |
13: 100,814,884 (GRCm39) |
|
probably null |
Het |
| Ccdc90b |
A |
G |
7: 92,216,868 (GRCm39) |
R47G |
possibly damaging |
Het |
| Celsr2 |
G |
T |
3: 108,320,806 (GRCm39) |
L669I |
probably damaging |
Het |
| Clec4a2 |
C |
T |
6: 123,101,974 (GRCm39) |
P43L |
probably benign |
Het |
| Cntn1 |
T |
C |
15: 92,207,890 (GRCm39) |
I827T |
probably benign |
Het |
| Col9a1 |
G |
T |
1: 24,224,243 (GRCm39) |
V142F |
unknown |
Het |
| Cplane1 |
T |
A |
15: 8,252,611 (GRCm39) |
D1944E |
probably benign |
Het |
| Cts7 |
G |
T |
13: 61,504,782 (GRCm39) |
Y23* |
probably null |
Het |
| Dcdc2a |
T |
A |
13: 25,291,674 (GRCm39) |
Y220N |
probably damaging |
Het |
| Dennd2b |
A |
T |
7: 109,156,000 (GRCm39) |
L250* |
probably null |
Het |
| Dmxl1 |
T |
G |
18: 50,026,619 (GRCm39) |
V1909G |
probably benign |
Het |
| Ehd2 |
G |
A |
7: 15,691,474 (GRCm39) |
P286L |
possibly damaging |
Het |
| Elf3 |
G |
T |
1: 135,184,244 (GRCm39) |
A208E |
possibly damaging |
Het |
| Eml5 |
A |
G |
12: 98,822,203 (GRCm39) |
I775T |
probably benign |
Het |
| Ephb1 |
T |
C |
9: 101,813,393 (GRCm39) |
T791A |
probably damaging |
Het |
| Fanci |
C |
A |
7: 79,094,219 (GRCm39) |
S1105* |
probably null |
Het |
| Fastkd1 |
T |
A |
2: 69,527,184 (GRCm39) |
|
probably null |
Het |
| Fat4 |
A |
G |
3: 39,064,390 (GRCm39) |
E4782G |
possibly damaging |
Het |
| Fnta |
T |
C |
8: 26,503,516 (GRCm39) |
I90V |
probably damaging |
Het |
| Fosl1 |
C |
T |
19: 5,500,332 (GRCm39) |
R84* |
probably null |
Het |
| Gdf2 |
T |
C |
14: 33,666,847 (GRCm39) |
F190L |
probably benign |
Het |
| Gzmn |
T |
A |
14: 56,404,776 (GRCm39) |
Q88L |
probably damaging |
Het |
| Hat1 |
T |
A |
2: 71,240,525 (GRCm39) |
L73Q |
probably damaging |
Het |
| Hdhd2 |
G |
A |
18: 77,031,871 (GRCm39) |
G109E |
possibly damaging |
Het |
| Il22ra1 |
A |
G |
4: 135,460,346 (GRCm39) |
N34S |
probably damaging |
Het |
| Ino80d |
T |
C |
1: 63,097,930 (GRCm39) |
T760A |
probably benign |
Het |
| Itga7 |
A |
G |
10: 128,789,370 (GRCm39) |
D971G |
probably benign |
Het |
| Kdm6b |
T |
C |
11: 69,291,032 (GRCm39) |
N1574S |
unknown |
Het |
| Kel |
T |
C |
6: 41,667,742 (GRCm39) |
E400G |
probably benign |
Het |
| Kif22 |
G |
A |
7: 126,632,134 (GRCm39) |
T350I |
probably damaging |
Het |
| Kif26b |
A |
G |
1: 178,506,839 (GRCm39) |
N305S |
probably benign |
Het |
| Klk12 |
A |
C |
7: 43,419,134 (GRCm39) |
Q33P |
probably damaging |
Het |
| Klk1b24 |
G |
A |
7: 43,841,304 (GRCm39) |
|
probably null |
Het |
| Krtap31-1 |
T |
A |
11: 99,799,048 (GRCm39) |
C84S |
possibly damaging |
Het |
| Ky |
T |
A |
9: 102,414,972 (GRCm39) |
S295T |
probably benign |
Het |
| Lpin3 |
T |
A |
2: 160,738,690 (GRCm39) |
M214K |
probably benign |
Het |
| Mak |
T |
A |
13: 41,183,586 (GRCm39) |
N565Y |
probably benign |
Het |
| Mphosph6 |
T |
C |
8: 118,528,623 (GRCm39) |
T7A |
probably benign |
Het |
| Muc6 |
G |
C |
7: 141,217,659 (GRCm39) |
P2338R |
probably damaging |
Het |
| Myh11 |
T |
C |
16: 14,039,688 (GRCm39) |
T814A |
|
Het |
| Nmbr |
T |
C |
10: 14,636,433 (GRCm39) |
L134P |
probably damaging |
Het |
| Nup107 |
C |
T |
10: 117,606,375 (GRCm39) |
V456M |
probably damaging |
Het |
| Or56b1b |
A |
G |
7: 108,164,649 (GRCm39) |
S118P |
possibly damaging |
Het |
| Or8g22 |
C |
A |
9: 38,958,638 (GRCm39) |
D26Y |
probably damaging |
Het |
| Pink1 |
A |
T |
4: 138,044,683 (GRCm39) |
H351Q |
probably damaging |
Het |
| Piwil4 |
A |
T |
9: 14,645,711 (GRCm39) |
|
probably null |
Het |
| Pkd1l1 |
C |
A |
11: 8,825,758 (GRCm39) |
V1498F |
|
Het |
| Polb |
A |
G |
8: 23,130,443 (GRCm39) |
I161T |
probably benign |
Het |
| Polg |
A |
T |
7: 79,101,416 (GRCm39) |
L1097Q |
probably damaging |
Het |
| Prelp |
T |
C |
1: 133,842,356 (GRCm39) |
N263S |
probably benign |
Het |
| Pten |
T |
C |
19: 32,789,234 (GRCm39) |
C211R |
probably damaging |
Het |
| Ptprc |
G |
A |
1: 137,995,645 (GRCm39) |
A1012V |
probably benign |
Het |
| Ptprr |
T |
A |
10: 115,884,133 (GRCm39) |
H63Q |
probably benign |
Het |
| Rapsn |
A |
T |
2: 90,872,299 (GRCm39) |
H211L |
possibly damaging |
Het |
| Reln |
T |
C |
5: 22,183,929 (GRCm39) |
N1690S |
probably benign |
Het |
| Rpap2 |
A |
G |
5: 107,768,167 (GRCm39) |
E335G |
probably benign |
Het |
| Rspry1 |
T |
A |
8: 95,385,396 (GRCm39) |
S567T |
probably benign |
Het |
| Sf3b1 |
G |
A |
1: 55,036,302 (GRCm39) |
R924* |
probably null |
Het |
| Sftpb |
G |
A |
6: 72,286,818 (GRCm39) |
E241K |
probably benign |
Het |
| Smarca4 |
G |
T |
9: 21,566,950 (GRCm39) |
A677S |
probably benign |
Het |
| Srrm2 |
G |
A |
17: 24,038,294 (GRCm39) |
R1646Q |
unknown |
Het |
| Tex15 |
T |
A |
8: 34,064,445 (GRCm39) |
C1292S |
probably benign |
Het |
| Tmem140 |
A |
G |
6: 34,849,708 (GRCm39) |
I75V |
probably benign |
Het |
| Trhr2 |
T |
A |
8: 123,084,061 (GRCm39) |
Q313L |
possibly damaging |
Het |
| Trim35 |
A |
G |
14: 66,534,546 (GRCm39) |
T10A |
unknown |
Het |
| Ttn |
T |
C |
2: 76,750,124 (GRCm39) |
I3642V |
probably benign |
Het |
| Ugt1a2 |
T |
C |
1: 88,128,507 (GRCm39) |
L50P |
probably damaging |
Het |
| Unc13a |
C |
A |
8: 72,087,182 (GRCm39) |
V1522L |
probably benign |
Het |
| Usp33 |
A |
G |
3: 152,063,589 (GRCm39) |
D21G |
possibly damaging |
Het |
| Vmn1r90 |
G |
A |
7: 14,295,616 (GRCm39) |
Q161* |
probably null |
Het |
| Vmn2r117 |
A |
T |
17: 23,696,265 (GRCm39) |
W381R |
probably damaging |
Het |
| Vmn2r16 |
G |
C |
5: 109,487,837 (GRCm39) |
A237P |
probably damaging |
Het |
| Vmn2r74 |
A |
G |
7: 85,606,746 (GRCm39) |
V200A |
probably benign |
Het |
| Yjefn3 |
C |
T |
8: 70,340,544 (GRCm39) |
V227M |
probably damaging |
Het |
| Zfp652 |
T |
C |
11: 95,640,914 (GRCm39) |
F280L |
probably damaging |
Het |
| Zfp748 |
G |
A |
13: 67,689,568 (GRCm39) |
T564I |
probably damaging |
Het |
|
| Other mutations in Clasp1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01785:Clasp1
|
APN |
1 |
118,425,466 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL01786:Clasp1
|
APN |
1 |
118,425,466 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL01871:Clasp1
|
APN |
1 |
118,498,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02066:Clasp1
|
APN |
1 |
118,492,990 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02602:Clasp1
|
APN |
1 |
118,399,515 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02683:Clasp1
|
APN |
1 |
118,466,996 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL02728:Clasp1
|
APN |
1 |
118,530,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02820:Clasp1
|
APN |
1 |
118,478,834 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02874:Clasp1
|
APN |
1 |
118,479,773 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02975:Clasp1
|
APN |
1 |
118,390,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03100:Clasp1
|
APN |
1 |
118,395,626 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03115:Clasp1
|
APN |
1 |
118,429,053 (GRCm39) |
nonsense |
probably null |
|
|
IGL03122:Clasp1
|
APN |
1 |
118,438,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03180:Clasp1
|
APN |
1 |
118,433,255 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL03248:Clasp1
|
APN |
1 |
118,530,206 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03388:Clasp1
|
APN |
1 |
118,433,233 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
F5770:Clasp1
|
UTSW |
1 |
118,509,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
I2288:Clasp1
|
UTSW |
1 |
118,492,959 (GRCm39) |
missense |
probably benign |
0.09 |
|
PIT4585001:Clasp1
|
UTSW |
1 |
118,390,285 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0079:Clasp1
|
UTSW |
1 |
118,471,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0395:Clasp1
|
UTSW |
1 |
118,467,061 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R0960:Clasp1
|
UTSW |
1 |
118,479,756 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1448:Clasp1
|
UTSW |
1 |
118,436,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1497:Clasp1
|
UTSW |
1 |
118,479,788 (GRCm39) |
missense |
probably benign |
0.42 |
|
R1607:Clasp1
|
UTSW |
1 |
118,432,689 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1722:Clasp1
|
UTSW |
1 |
118,518,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Clasp1
|
UTSW |
1 |
118,475,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1765:Clasp1
|
UTSW |
1 |
118,433,261 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1855:Clasp1
|
UTSW |
1 |
118,436,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1861:Clasp1
|
UTSW |
1 |
118,498,661 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1874:Clasp1
|
UTSW |
1 |
118,528,315 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1942:Clasp1
|
UTSW |
1 |
118,429,078 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2025:Clasp1
|
UTSW |
1 |
118,432,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2174:Clasp1
|
UTSW |
1 |
118,487,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2280:Clasp1
|
UTSW |
1 |
118,492,913 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2288:Clasp1
|
UTSW |
1 |
118,506,608 (GRCm39) |
missense |
probably benign |
|
|
R2895:Clasp1
|
UTSW |
1 |
118,387,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3958:Clasp1
|
UTSW |
1 |
118,395,611 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4073:Clasp1
|
UTSW |
1 |
118,431,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4206:Clasp1
|
UTSW |
1 |
118,506,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4465:Clasp1
|
UTSW |
1 |
118,488,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4609:Clasp1
|
UTSW |
1 |
118,430,765 (GRCm39) |
intron |
probably benign |
|
|
R4679:Clasp1
|
UTSW |
1 |
118,471,001 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4707:Clasp1
|
UTSW |
1 |
118,470,927 (GRCm39) |
nonsense |
probably null |
|
|
R4809:Clasp1
|
UTSW |
1 |
118,388,980 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4906:Clasp1
|
UTSW |
1 |
118,436,640 (GRCm39) |
nonsense |
probably null |
|
|
R5048:Clasp1
|
UTSW |
1 |
118,475,340 (GRCm39) |
intron |
probably benign |
|
|
R5298:Clasp1
|
UTSW |
1 |
118,475,650 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5485:Clasp1
|
UTSW |
1 |
118,395,643 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5516:Clasp1
|
UTSW |
1 |
118,425,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5821:Clasp1
|
UTSW |
1 |
118,518,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5911:Clasp1
|
UTSW |
1 |
118,434,638 (GRCm39) |
unclassified |
probably benign |
|
|
R6092:Clasp1
|
UTSW |
1 |
118,438,028 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6181:Clasp1
|
UTSW |
1 |
118,347,547 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6478:Clasp1
|
UTSW |
1 |
118,439,910 (GRCm39) |
nonsense |
probably null |
|
|
R7090:Clasp1
|
UTSW |
1 |
118,409,816 (GRCm39) |
missense |
probably benign |
0.45 |
|
R7216:Clasp1
|
UTSW |
1 |
118,475,648 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7508:Clasp1
|
UTSW |
1 |
118,473,164 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7541:Clasp1
|
UTSW |
1 |
118,470,727 (GRCm39) |
splice site |
probably null |
|
|
R7825:Clasp1
|
UTSW |
1 |
118,473,123 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7910:Clasp1
|
UTSW |
1 |
118,530,144 (GRCm39) |
nonsense |
probably null |
|
|
R7971:Clasp1
|
UTSW |
1 |
118,449,559 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8074:Clasp1
|
UTSW |
1 |
118,390,213 (GRCm39) |
missense |
probably benign |
|
|
R8344:Clasp1
|
UTSW |
1 |
118,431,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8847:Clasp1
|
UTSW |
1 |
118,506,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9035:Clasp1
|
UTSW |
1 |
118,431,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9073:Clasp1
|
UTSW |
1 |
118,390,193 (GRCm39) |
splice site |
probably null |
|
|
R9161:Clasp1
|
UTSW |
1 |
118,474,651 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9184:Clasp1
|
UTSW |
1 |
118,470,908 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9379:Clasp1
|
UTSW |
1 |
118,509,168 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R9379:Clasp1
|
UTSW |
1 |
118,509,157 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R9422:Clasp1
|
UTSW |
1 |
118,390,257 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9516:Clasp1
|
UTSW |
1 |
118,431,560 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9566:Clasp1
|
UTSW |
1 |
118,479,801 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9776:Clasp1
|
UTSW |
1 |
118,509,108 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
V7581:Clasp1
|
UTSW |
1 |
118,509,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0028:Clasp1
|
UTSW |
1 |
118,478,855 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACTGTGTTACTCTGGGCTGAG -3'
(R):5'- AGTGCCCTGATTCACCAGAAC -3'
Sequencing Primer
(F):5'- TCCTGGTGAGGCCCCTTAG -3'
(R):5'- GCCCTGATTCACCAGAACAAAGATC -3'
|
| Posted On |
2020-02-21 |
Incidental Mutation