Incidental Mutation 'R7670:Otud4'
ID 628373
Institutional Source Beutler Lab
Gene Symbol Otud4
Ensembl Gene ENSMUSG00000036990
Gene Name OTU domain containing 4
Synonyms 4930431L18Rik, D8Ertd69e
MMRRC Submission 045742-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.168) question?
Stock # R7670 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 80366305-80404384 bp(+) (GRCm39)
Type of Mutation splice site (72 bp from exon)
DNA Base Change (assembly) T to A at 80382493 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134097 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000173078] [ENSMUST00000173286]
AlphaFold B2RRE7
Predicted Effect probably null
Transcript: ENSMUST00000173078
SMART Domains Protein: ENSMUSP00000133939
Gene: ENSMUSG00000036990

DomainStartEndE-ValueType
Pfam:OTU 40 154 3.4e-17 PFAM
low complexity region 189 213 N/A INTRINSIC
Blast:TUDOR 280 335 2e-7 BLAST
low complexity region 392 405 N/A INTRINSIC
low complexity region 473 486 N/A INTRINSIC
low complexity region 543 555 N/A INTRINSIC
low complexity region 1014 1025 N/A INTRINSIC
low complexity region 1082 1104 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000173286
SMART Domains Protein: ENSMUSP00000134097
Gene: ENSMUSG00000036990

DomainStartEndE-ValueType
Pfam:OTU 40 149 5.3e-21 PFAM
low complexity region 189 213 N/A INTRINSIC
Blast:TUDOR 280 334 9e-9 BLAST
low complexity region 391 404 N/A INTRINSIC
low complexity region 472 485 N/A INTRINSIC
low complexity region 542 554 N/A INTRINSIC
low complexity region 1013 1024 N/A INTRINSIC
low complexity region 1081 1103 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26a T A 8: 44,023,190 (GRCm39) H100L probably benign Het
Adgrf2 T C 17: 43,022,263 (GRCm39) N187S probably damaging Het
Adipoq T A 16: 22,976,332 (GRCm39) H244Q probably damaging Het
Arhgap40 T A 2: 158,373,845 (GRCm39) S209T probably benign Het
Arrdc3 C T 13: 81,037,212 (GRCm39) L123F probably damaging Het
Aspscr1 A G 11: 120,579,865 (GRCm39) N212D probably benign Het
Ccr9 A T 9: 123,608,371 (GRCm39) S18C probably damaging Het
Cdc42bpa T A 1: 179,892,646 (GRCm39) V270D probably damaging Het
Clic4 A G 4: 134,944,516 (GRCm39) Y220H probably damaging Het
Cntln A C 4: 84,897,577 (GRCm39) H388P possibly damaging Het
Col12a1 A G 9: 79,538,925 (GRCm39) V2457A probably damaging Het
Ctsk A G 3: 95,408,925 (GRCm39) N103D probably benign Het
Ddx60 T C 8: 62,428,826 (GRCm39) S779P probably damaging Het
Dnah5 T A 15: 28,246,378 (GRCm39) probably null Het
Dnah7b T A 1: 46,148,462 (GRCm39) D279E probably benign Het
Eif1ad10 T C 12: 88,216,524 (GRCm39) N116S probably benign Het
Fam117a A G 11: 95,269,660 (GRCm39) N308S probably benign Het
Fasn A G 11: 120,704,245 (GRCm39) V1419A probably damaging Het
Fhad1 A G 4: 141,678,802 (GRCm39) S625P probably benign Het
Gemin5 A G 11: 58,038,754 (GRCm39) V585A probably benign Het
Gm5145 C A 17: 20,790,646 (GRCm39) P8Q probably benign Het
Herc1 C A 9: 66,323,629 (GRCm39) T1381K probably damaging Het
Herc6 T C 6: 57,637,107 (GRCm39) I824T probably damaging Het
Klrb1 C T 6: 128,687,050 (GRCm39) V161I probably benign Het
Krtap31-1 A G 11: 99,799,258 (GRCm39) N154D not run Het
Lcp1 A T 14: 75,437,871 (GRCm39) I94F probably benign Het
Lin7a A T 10: 107,218,552 (GRCm39) Q154L possibly damaging Het
Lnx1 T C 5: 74,846,351 (GRCm39) Y33C probably damaging Het
Myo5b T C 18: 74,834,517 (GRCm39) V859A probably benign Het
Ncbp1 A G 4: 46,170,015 (GRCm39) Q696R probably damaging Het
Neurl1b C G 17: 26,657,720 (GRCm39) H219Q probably benign Het
Nme8 T C 13: 19,842,999 (GRCm39) E392G probably benign Het
Nufip1 CAAAACAGAAAACAGAAAAC CAAAACAGAAAACAGAAAACAGAAAAC 14: 76,349,414 (GRCm39) probably null Het
Nuggc A G 14: 65,850,975 (GRCm39) I298V probably damaging Het
Nup155 A C 15: 8,183,180 (GRCm39) K1247Q probably damaging Het
Or1a1 A G 11: 74,087,033 (GRCm39) K235E probably damaging Het
Or5c1 A T 2: 37,221,771 (GRCm39) E4V probably benign Het
Pacc1 A G 1: 191,073,065 (GRCm39) N162S probably benign Het
Pcdhb18 T C 18: 37,624,749 (GRCm39) V693A probably damaging Het
Pcnx3 A G 19: 5,727,210 (GRCm39) F1108L probably benign Het
Prkca A T 11: 107,905,170 (GRCm39) N189K probably damaging Het
Rbm24 A G 13: 46,582,683 (GRCm39) I201V probably benign Het
Reep6 T C 10: 80,169,627 (GRCm39) L105P probably damaging Het
Retreg1 T C 15: 25,941,126 (GRCm39) probably benign Het
Rev3l C T 10: 39,712,718 (GRCm39) T2382I probably benign Het
Rnf31 A G 14: 55,831,818 (GRCm39) N230S probably benign Het
Rreb1 T C 13: 38,115,548 (GRCm39) L969P probably benign Het
Rsph4a T A 10: 33,785,029 (GRCm39) N313K probably damaging Het
Serpina3f T A 12: 104,183,525 (GRCm39) L129Q probably damaging Het
Slc9a2 T A 1: 40,758,157 (GRCm39) V232D probably damaging Het
Stmn2 T C 3: 8,619,925 (GRCm39) L121P probably damaging Het
Svep1 C T 4: 58,097,424 (GRCm39) G1373D probably damaging Het
Tex55 C T 16: 38,648,453 (GRCm39) D219N possibly damaging Het
Tns1 C A 1: 73,991,636 (GRCm39) R1014L possibly damaging Het
Top2b T C 14: 16,416,620 (GRCm38) S1127P possibly damaging Het
Txndc16 A T 14: 45,373,324 (GRCm39) C768* probably null Het
Ubl7 A T 9: 57,837,052 (GRCm39) E354D probably benign Het
Ush2a T C 1: 188,516,905 (GRCm39) L3205P possibly damaging Het
Xirp2 A G 2: 67,340,917 (GRCm39) T1053A possibly damaging Het
Zbtb21 A G 16: 97,753,077 (GRCm39) L402P probably damaging Het
Zfp27 T A 7: 29,594,221 (GRCm39) K581N possibly damaging Het
Zfp62 A T 11: 49,105,903 (GRCm39) probably benign Het
Other mutations in Otud4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Otud4 APN 8 80,399,510 (GRCm39) missense probably damaging 0.99
IGL01353:Otud4 APN 8 80,391,650 (GRCm39) missense probably benign
IGL01371:Otud4 APN 8 80,400,390 (GRCm39) missense probably damaging 1.00
IGL01782:Otud4 APN 8 80,399,640 (GRCm39) missense possibly damaging 0.95
IGL01912:Otud4 APN 8 80,400,466 (GRCm39) missense probably benign
IGL02294:Otud4 APN 8 80,391,606 (GRCm39) splice site probably benign
IGL02830:Otud4 APN 8 80,399,930 (GRCm39) missense probably benign 0.00
IGL03063:Otud4 APN 8 80,390,419 (GRCm39) missense probably benign 0.01
IGL03077:Otud4 APN 8 80,400,087 (GRCm39) missense probably damaging 0.97
R0437:Otud4 UTSW 8 80,396,626 (GRCm39) missense probably benign 0.02
R1024:Otud4 UTSW 8 80,390,722 (GRCm39) missense probably benign 0.01
R1118:Otud4 UTSW 8 80,379,980 (GRCm39) splice site probably benign
R1296:Otud4 UTSW 8 80,400,603 (GRCm39) missense unknown
R1321:Otud4 UTSW 8 80,396,579 (GRCm39) missense probably benign 0.03
R1674:Otud4 UTSW 8 80,399,776 (GRCm39) missense probably benign 0.12
R1736:Otud4 UTSW 8 80,378,294 (GRCm39) splice site probably benign
R1815:Otud4 UTSW 8 80,366,618 (GRCm39) nonsense probably null
R1950:Otud4 UTSW 8 80,372,961 (GRCm39) missense probably damaging 0.99
R1985:Otud4 UTSW 8 80,366,641 (GRCm39) missense probably damaging 1.00
R2173:Otud4 UTSW 8 80,395,093 (GRCm39) missense probably damaging 1.00
R2869:Otud4 UTSW 8 80,387,702 (GRCm39) missense possibly damaging 0.82
R2869:Otud4 UTSW 8 80,387,702 (GRCm39) missense possibly damaging 0.82
R2870:Otud4 UTSW 8 80,387,702 (GRCm39) missense possibly damaging 0.82
R2870:Otud4 UTSW 8 80,387,702 (GRCm39) missense possibly damaging 0.82
R2872:Otud4 UTSW 8 80,387,702 (GRCm39) missense possibly damaging 0.82
R2872:Otud4 UTSW 8 80,387,702 (GRCm39) missense possibly damaging 0.82
R2907:Otud4 UTSW 8 80,399,697 (GRCm39) missense probably benign 0.02
R3545:Otud4 UTSW 8 80,391,684 (GRCm39) missense probably damaging 1.00
R4628:Otud4 UTSW 8 80,366,597 (GRCm39) missense possibly damaging 0.73
R4790:Otud4 UTSW 8 80,393,402 (GRCm39) missense possibly damaging 0.82
R4989:Otud4 UTSW 8 80,382,318 (GRCm39) missense probably damaging 1.00
R5133:Otud4 UTSW 8 80,382,318 (GRCm39) missense probably damaging 1.00
R5134:Otud4 UTSW 8 80,382,318 (GRCm39) missense probably damaging 1.00
R5294:Otud4 UTSW 8 80,399,521 (GRCm39) missense possibly damaging 0.54
R5410:Otud4 UTSW 8 80,399,626 (GRCm39) missense probably benign 0.04
R5454:Otud4 UTSW 8 80,377,671 (GRCm39) missense possibly damaging 0.94
R5579:Otud4 UTSW 8 80,390,737 (GRCm39) missense probably benign
R5738:Otud4 UTSW 8 80,400,090 (GRCm39) missense probably benign 0.02
R5886:Otud4 UTSW 8 80,399,436 (GRCm39) missense probably damaging 1.00
R6062:Otud4 UTSW 8 80,400,525 (GRCm39) missense probably damaging 1.00
R6364:Otud4 UTSW 8 80,372,970 (GRCm39) missense probably damaging 0.99
R6427:Otud4 UTSW 8 80,395,126 (GRCm39) missense probably benign 0.00
R6450:Otud4 UTSW 8 80,399,626 (GRCm39) missense probably benign 0.04
R6744:Otud4 UTSW 8 80,400,407 (GRCm39) nonsense probably null
R6773:Otud4 UTSW 8 80,370,435 (GRCm39) missense possibly damaging 0.95
R7046:Otud4 UTSW 8 80,377,671 (GRCm39) missense possibly damaging 0.94
R7142:Otud4 UTSW 8 80,399,391 (GRCm39) splice site probably null
R7420:Otud4 UTSW 8 80,390,737 (GRCm39) missense probably benign 0.11
R7470:Otud4 UTSW 8 80,399,989 (GRCm39) missense probably benign 0.00
R7736:Otud4 UTSW 8 80,382,394 (GRCm39) missense possibly damaging 0.53
R8229:Otud4 UTSW 8 80,400,604 (GRCm39) missense unknown
R8397:Otud4 UTSW 8 80,395,927 (GRCm39) missense probably benign 0.06
R8520:Otud4 UTSW 8 80,385,896 (GRCm39) missense probably damaging 1.00
R9041:Otud4 UTSW 8 80,400,441 (GRCm39) missense probably damaging 0.98
R9291:Otud4 UTSW 8 80,372,952 (GRCm39) missense probably damaging 1.00
R9495:Otud4 UTSW 8 80,400,087 (GRCm39) missense probably damaging 1.00
R9502:Otud4 UTSW 8 80,400,480 (GRCm39) missense probably benign 0.01
X0024:Otud4 UTSW 8 80,372,939 (GRCm39) missense probably benign 0.01
Z1176:Otud4 UTSW 8 80,385,558 (GRCm39) missense probably benign
Z1177:Otud4 UTSW 8 80,370,441 (GRCm39) missense probably damaging 0.99
Z1177:Otud4 UTSW 8 80,370,440 (GRCm39) nonsense probably null
Z1177:Otud4 UTSW 8 80,391,656 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- ACAGCTCTCCTTTATGAGTTGC -3'
(R):5'- AACCGCACTTCATCACTGG -3'

Sequencing Primer
(F):5'- GCTGTATGAGAAGGTATTCAAAACTG -3'
(R):5'- ACTGGATGTGAAAACAAGGTAAC -3'
Posted On 2020-03-13