Incidental Mutation 'R7742:Hcfc2'
ID 628406
Institutional Source Beutler Lab
Gene Symbol Hcfc2
Ensembl Gene ENSMUSG00000020246
Gene Name host cell factor C2
Synonyms 1700129L13Rik, fkls
MMRRC Submission 045798-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.194) question?
Stock # R7742 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 82531994-82578262 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 82547659 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000020478 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020478]
AlphaFold Q9D968
Predicted Effect probably null
Transcript: ENSMUST00000020478
SMART Domains Protein: ENSMUSP00000020478
Gene: ENSMUSG00000020246

DomainStartEndE-ValueType
Pfam:Kelch_1 22 60 2.1e-6 PFAM
Pfam:Kelch_5 68 106 1.1e-6 PFAM
Pfam:Kelch_3 81 135 8.8e-7 PFAM
Pfam:Kelch_5 186 230 8.4e-7 PFAM
Pfam:Kelch_3 206 253 1.6e-11 PFAM
Pfam:Kelch_1 244 302 7.5e-9 PFAM
Pfam:Kelch_3 254 323 3.4e-7 PFAM
Pfam:Kelch_5 312 356 1.4e-6 PFAM
FN3 357 591 8.43e-9 SMART
FN3 607 703 6.06e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162422
SMART Domains Protein: ENSMUSP00000124472
Gene: ENSMUSG00000020246

DomainStartEndE-ValueType
Pfam:Kelch_1 1 38 8.5e-7 PFAM
Pfam:Kelch_5 46 84 3.7e-8 PFAM
Pfam:Kelch_3 59 113 2.6e-8 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for null or severely hypomorphic allele exhibit reduced poly(I:C)-mediated TLR3 signaling and increased mortality following viral infection. [provided by MGI curators]
Allele List at MGI

none known

Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T C 14: 32,384,714 (GRCm39) K417R possibly damaging Het
Adgrl2 A T 3: 148,542,064 (GRCm39) I886N probably damaging Het
Angptl2 A G 2: 33,133,928 (GRCm39) T417A probably damaging Het
Ankrd33b T C 15: 31,367,538 (GRCm39) M1V probably null Het
Col3a1 A G 1: 45,384,161 (GRCm39) H1155R unknown Het
Csad A G 15: 102,095,599 (GRCm39) S153P probably damaging Het
Dennd1b G A 1: 138,990,611 (GRCm39) E192K probably damaging Het
Dmtf1 C T 5: 9,172,457 (GRCm39) probably benign Het
Dna2 T C 10: 62,809,073 (GRCm39) I1055T probably benign Het
Dnai4 C T 4: 102,947,630 (GRCm39) M215I probably benign Het
Dync2h1 T C 9: 7,076,232 (GRCm39) D2975G probably benign Het
Eif1ad7 A T 12: 88,238,476 (GRCm39) Y95N probably damaging Het
F5 G T 1: 164,035,453 (GRCm39) V1876F possibly damaging Het
Fam81b T A 13: 76,399,809 (GRCm39) I150F probably damaging Het
Fbl T A 7: 27,877,684 (GRCm39) V252E probably damaging Het
Fbln1 A G 15: 85,124,917 (GRCm39) D475G probably damaging Het
Fshr T A 17: 89,293,590 (GRCm39) I363F probably benign Het
Gapvd1 A G 2: 34,568,635 (GRCm39) L1328P probably damaging Het
Ifi209 C A 1: 173,470,198 (GRCm39) T262K probably damaging Het
Kif2b T A 11: 91,467,411 (GRCm39) I291F possibly damaging Het
Lrp1b T A 2: 40,712,641 (GRCm39) D3231V Het
Mcidas G A 13: 113,135,521 (GRCm39) G315S probably damaging Het
Naip5 T A 13: 100,356,338 (GRCm39) E1092D probably benign Het
Nudcd1 T C 15: 44,268,754 (GRCm39) K209E probably benign Het
Nup98 C T 7: 101,802,464 (GRCm39) probably null Het
Odad3 T C 9: 21,904,193 (GRCm39) D361G possibly damaging Het
Or2ag2 T C 7: 106,485,829 (GRCm39) Q65R probably damaging Het
Or2j6 T A 7: 139,980,234 (GRCm39) I242F probably benign Het
Pign T C 1: 105,480,122 (GRCm39) I851V probably benign Het
Pkd1l3 T A 8: 110,341,204 (GRCm39) L19Q unknown Het
Plat G T 8: 23,262,248 (GRCm39) G91W probably damaging Het
Plekhm2 A G 4: 141,355,150 (GRCm39) L959P probably benign Het
Prkcg T C 7: 3,378,459 (GRCm39) I627T possibly damaging Het
Prl7b1 A T 13: 27,791,031 (GRCm39) M18K probably benign Het
Ptpn3 T A 4: 57,265,092 (GRCm39) probably null Het
Rp1 A T 1: 4,240,457 (GRCm39) F899I unknown Het
Sis T A 3: 72,832,431 (GRCm39) Y1026F probably benign Het
Slc4a10 T G 2: 62,127,194 (GRCm39) V879G probably damaging Het
Specc1l T C 10: 75,082,251 (GRCm39) I549T probably benign Het
Spmip11 T A 15: 98,483,250 (GRCm39) V60E probably damaging Het
Sprr2a3 G A 3: 92,196,066 (GRCm39) V58M unknown Het
Sptbn2 C G 19: 4,799,040 (GRCm39) R2037G probably benign Het
Syne2 C T 12: 76,106,209 (GRCm39) H785Y probably benign Het
Tat T A 8: 110,718,242 (GRCm39) N42K probably benign Het
Tmem184a C T 5: 139,792,744 (GRCm39) A271T probably benign Het
Tmprss11d T C 5: 86,451,493 (GRCm39) I411V probably damaging Het
Ttn T C 2: 76,733,872 (GRCm39) I4468V unknown Het
Vcam1 T C 3: 115,909,734 (GRCm39) N531S possibly damaging Het
Vmn1r257 C T 7: 22,391,343 (GRCm39) V134I probably benign Het
Xcl1 T C 1: 164,763,041 (GRCm39) T7A unknown Het
Zc3h11a A G 1: 133,565,173 (GRCm39) V242A probably benign Het
Zc3h7a A T 16: 10,971,025 (GRCm39) Y335N probably benign Het
Zp2 T C 7: 119,731,731 (GRCm39) I675V unknown Het
Other mutations in Hcfc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00847:Hcfc2 APN 10 82,577,112 (GRCm39) splice site probably null
IGL01799:Hcfc2 APN 10 82,536,825 (GRCm39) missense probably damaging 1.00
IGL01916:Hcfc2 APN 10 82,570,217 (GRCm39) missense possibly damaging 0.94
IGL02150:Hcfc2 APN 10 82,545,852 (GRCm39) missense probably damaging 1.00
IGL02378:Hcfc2 APN 10 82,544,905 (GRCm39) missense possibly damaging 0.64
IGL02580:Hcfc2 APN 10 82,564,256 (GRCm39) missense probably benign 0.00
IGL02641:Hcfc2 APN 10 82,538,383 (GRCm39) missense probably damaging 1.00
Backstabbing UTSW 10 82,547,659 (GRCm39) splice site probably null
feckless UTSW 10 82,547,895 (GRCm39) missense probably damaging 1.00
Minions UTSW 10 82,575,079 (GRCm39) missense probably damaging 1.00
scaffold UTSW 10 82,574,242 (GRCm39) missense probably damaging 1.00
R0380:Hcfc2 UTSW 10 82,564,272 (GRCm39) splice site probably benign
R0528:Hcfc2 UTSW 10 82,575,079 (GRCm39) missense probably damaging 1.00
R0534:Hcfc2 UTSW 10 82,574,242 (GRCm39) missense probably damaging 1.00
R1646:Hcfc2 UTSW 10 82,536,861 (GRCm39) missense probably damaging 1.00
R1903:Hcfc2 UTSW 10 82,538,392 (GRCm39) missense probably damaging 0.98
R1939:Hcfc2 UTSW 10 82,538,284 (GRCm39) missense probably damaging 0.99
R2014:Hcfc2 UTSW 10 82,574,814 (GRCm39) missense probably benign 0.23
R2015:Hcfc2 UTSW 10 82,574,814 (GRCm39) missense probably benign 0.23
R2571:Hcfc2 UTSW 10 82,544,857 (GRCm39) missense probably damaging 1.00
R4540:Hcfc2 UTSW 10 82,568,481 (GRCm39) missense probably benign 0.10
R4694:Hcfc2 UTSW 10 82,559,534 (GRCm39) missense probably damaging 1.00
R4735:Hcfc2 UTSW 10 82,547,914 (GRCm39) missense probably damaging 1.00
R4833:Hcfc2 UTSW 10 82,544,980 (GRCm39) missense probably null 0.01
R6837:Hcfc2 UTSW 10 82,575,030 (GRCm39) missense probably damaging 0.96
R7268:Hcfc2 UTSW 10 82,544,846 (GRCm39) nonsense probably null
R7683:Hcfc2 UTSW 10 82,535,063 (GRCm39) missense probably benign 0.00
R7733:Hcfc2 UTSW 10 82,575,013 (GRCm39) missense probably benign 0.00
R8319:Hcfc2 UTSW 10 82,574,201 (GRCm39) missense probably damaging 0.98
R8829:Hcfc2 UTSW 10 82,574,179 (GRCm39) missense probably damaging 1.00
R8989:Hcfc2 UTSW 10 82,536,822 (GRCm39) missense probably damaging 1.00
R9189:Hcfc2 UTSW 10 82,535,041 (GRCm39) missense probably benign 0.06
R9241:Hcfc2 UTSW 10 82,568,485 (GRCm39) missense probably benign
R9362:Hcfc2 UTSW 10 82,574,258 (GRCm39) missense probably damaging 1.00
R9363:Hcfc2 UTSW 10 82,574,258 (GRCm39) missense probably damaging 1.00
R9386:Hcfc2 UTSW 10 82,574,937 (GRCm39) missense probably damaging 1.00
R9701:Hcfc2 UTSW 10 82,574,269 (GRCm39) nonsense probably null
R9802:Hcfc2 UTSW 10 82,574,269 (GRCm39) nonsense probably null
V3553:Hcfc2 UTSW 10 82,547,895 (GRCm39) missense probably damaging 1.00
X0022:Hcfc2 UTSW 10 82,545,801 (GRCm39) missense probably damaging 0.99
Z1176:Hcfc2 UTSW 10 82,535,006 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- CCCATGACTTGAGATGTGTAAATTC -3'
(R):5'- GGAACTTCCATGACTCAGGTAC -3'

Sequencing Primer
(F):5'- TAGGGCCTGCGTATTTCT -3'
(R):5'- AGACTCACCGAGGTTTAG -3'
Posted On 2020-03-19