Incidental Mutation 'R0715:Arhgef37'
ID 62844
Institutional Source Beutler Lab
Gene Symbol Arhgef37
Ensembl Gene ENSMUSG00000045094
Gene Name Rho guanine nucleotide exchange factor 37
Synonyms 4933429F08Rik
MMRRC Submission 038898-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R0715 (G1)
Quality Score 170
Status Validated
Chromosome 18
Chromosomal Location 61624728-61669665 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 61641860 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 170 (Q170K)
Ref Sequence ENSEMBL: ENSMUSP00000130560 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171629]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000171629
AA Change: Q170K

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000130560
Gene: ENSMUSG00000045094
AA Change: Q170K

DomainStartEndE-ValueType
RhoGEF 34 212 2.62e-35 SMART
Pfam:BAR 311 444 5.6e-10 PFAM
SH3 509 568 8.06e-1 SMART
SH3 606 665 2.56e-14 SMART
Meta Mutation Damage Score 0.4664 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 95.8%
Validation Efficiency 98% (61/62)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930438A08Rik A G 11: 58,179,176 (GRCm39) Y170C probably damaging Het
Adcy2 C T 13: 69,036,161 (GRCm39) V167I probably benign Het
Agl A G 3: 116,545,825 (GRCm39) Y1324H probably damaging Het
Asah2 A G 19: 31,994,176 (GRCm39) S390P probably damaging Het
Atp8a1 A T 5: 67,932,068 (GRCm39) H240Q probably benign Het
Btbd16 T A 7: 130,390,557 (GRCm39) N151K probably damaging Het
Ccdc73 T A 2: 104,803,499 (GRCm39) probably benign Het
Cecr2 G T 6: 120,735,159 (GRCm39) M21I probably benign Het
Ckap2l T C 2: 129,127,636 (GRCm39) T181A probably benign Het
Col4a3 T C 1: 82,629,879 (GRCm39) probably benign Het
Cplane1 T A 15: 8,252,576 (GRCm39) C1933S probably benign Het
Dnah9 A G 11: 65,972,074 (GRCm39) probably benign Het
Efcab3 T C 11: 104,611,706 (GRCm39) L516P possibly damaging Het
Fat3 T C 9: 16,286,419 (GRCm39) T1035A probably benign Het
Fzd8 A G 18: 9,212,947 (GRCm39) T10A unknown Het
Gm9631 C A 11: 121,833,328 (GRCm39) C636F probably damaging Het
Gp1ba A G 11: 70,531,614 (GRCm39) probably benign Het
Gsk3a A G 7: 24,931,134 (GRCm39) V277A probably damaging Het
H2-M1 T A 17: 36,981,120 (GRCm39) probably benign Het
Hesx1 T A 14: 26,722,809 (GRCm39) W45R probably damaging Het
Il23r T A 6: 67,463,317 (GRCm39) M59L possibly damaging Het
Insc T A 7: 114,444,312 (GRCm39) V433E probably benign Het
Itga8 T C 2: 12,196,053 (GRCm39) probably benign Het
Kif13a T A 13: 46,966,299 (GRCm39) E436V probably damaging Het
Liph A G 16: 21,814,100 (GRCm39) F7S probably benign Het
Lpar2 T C 8: 70,276,823 (GRCm39) V204A probably damaging Het
Lrfn4 T A 19: 4,662,668 (GRCm39) probably null Het
Man2b2 A T 5: 36,983,402 (GRCm39) D182E probably benign Het
Mmp27 T C 9: 7,581,156 (GRCm39) probably benign Het
Mrm1 A G 11: 84,705,639 (GRCm39) probably benign Het
Mtx3 T C 13: 92,986,869 (GRCm39) S271P probably damaging Het
Myh11 A T 16: 14,044,480 (GRCm39) M641K possibly damaging Het
Necab2 A G 8: 120,197,670 (GRCm39) D332G probably damaging Het
Ngfr A G 11: 95,465,065 (GRCm39) I261T possibly damaging Het
Nrap T C 19: 56,345,757 (GRCm39) E617G probably damaging Het
Obscn G T 11: 58,941,306 (GRCm39) T4505K probably benign Het
Or8b37 G T 9: 37,959,123 (GRCm39) V202L probably benign Het
Or8b57 A G 9: 40,003,807 (GRCm39) Y148H probably damaging Het
Osbpl11 T A 16: 33,062,100 (GRCm39) probably benign Het
Otof A G 5: 30,552,041 (GRCm39) V301A probably damaging Het
Phf3 A T 1: 30,850,919 (GRCm39) L1145Q probably damaging Het
Phospho2 T A 2: 69,626,540 (GRCm39) I232N possibly damaging Het
Pomgnt2 T A 9: 121,811,127 (GRCm39) K551N probably damaging Het
Ptchd3 A G 11: 121,721,984 (GRCm39) T286A possibly damaging Het
Rnf213 A G 11: 119,331,976 (GRCm39) D2396G probably damaging Het
Sh3pxd2b A G 11: 32,373,341 (GRCm39) E836G possibly damaging Het
Simc1 G T 13: 54,673,468 (GRCm39) M605I possibly damaging Het
Slc12a3 G A 8: 95,056,061 (GRCm39) E66K possibly damaging Het
Spg11 T C 2: 121,915,464 (GRCm39) N1060S probably benign Het
Supt5 A T 7: 28,028,462 (GRCm39) W178R probably damaging Het
Tmem41a G T 16: 21,756,740 (GRCm39) F126L probably benign Het
Ube2m T A 7: 12,771,553 (GRCm39) Q35L probably benign Het
Usp33 A G 3: 152,086,211 (GRCm39) D658G probably damaging Het
Vmn2r12 A T 5: 109,238,373 (GRCm39) C456S probably benign Het
Vmn2r81 T A 10: 79,104,434 (GRCm39) D352E probably damaging Het
Zfp516 A G 18: 83,005,388 (GRCm39) Y764C probably damaging Het
Zswim7 A G 11: 62,167,473 (GRCm39) probably benign Het
Other mutations in Arhgef37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00485:Arhgef37 APN 18 61,656,942 (GRCm39) missense probably damaging 1.00
IGL00801:Arhgef37 APN 18 61,632,905 (GRCm39) missense probably damaging 1.00
IGL01146:Arhgef37 APN 18 61,651,081 (GRCm39) missense possibly damaging 0.93
IGL02052:Arhgef37 APN 18 61,632,839 (GRCm39) missense probably damaging 1.00
IGL02489:Arhgef37 APN 18 61,639,540 (GRCm39) missense possibly damaging 0.91
IGL03236:Arhgef37 APN 18 61,656,897 (GRCm39) missense probably damaging 1.00
R0746:Arhgef37 UTSW 18 61,651,064 (GRCm39) critical splice donor site probably null
R1843:Arhgef37 UTSW 18 61,651,121 (GRCm39) missense probably damaging 0.99
R1934:Arhgef37 UTSW 18 61,657,014 (GRCm39) missense probably benign 0.00
R1980:Arhgef37 UTSW 18 61,641,767 (GRCm39) missense probably damaging 0.98
R2012:Arhgef37 UTSW 18 61,637,427 (GRCm39) missense possibly damaging 0.56
R2237:Arhgef37 UTSW 18 61,637,477 (GRCm39) missense probably damaging 1.00
R3024:Arhgef37 UTSW 18 61,634,959 (GRCm39) missense probably damaging 0.96
R4864:Arhgef37 UTSW 18 61,627,996 (GRCm39) missense probably benign
R4876:Arhgef37 UTSW 18 61,631,310 (GRCm39) nonsense probably null
R5024:Arhgef37 UTSW 18 61,639,511 (GRCm39) missense probably damaging 0.99
R5050:Arhgef37 UTSW 18 61,637,402 (GRCm39) missense probably benign 0.43
R5512:Arhgef37 UTSW 18 61,632,845 (GRCm39) nonsense probably null
R5611:Arhgef37 UTSW 18 61,640,334 (GRCm39) missense probably benign 0.03
R6051:Arhgef37 UTSW 18 61,640,345 (GRCm39) missense probably damaging 0.97
R6488:Arhgef37 UTSW 18 61,651,123 (GRCm39) missense probably benign 0.43
R6612:Arhgef37 UTSW 18 61,627,952 (GRCm39) missense probably benign
R7117:Arhgef37 UTSW 18 61,637,481 (GRCm39) missense probably benign 0.00
R7351:Arhgef37 UTSW 18 61,631,286 (GRCm39) missense possibly damaging 0.93
R7426:Arhgef37 UTSW 18 61,637,456 (GRCm39) missense probably damaging 1.00
R7571:Arhgef37 UTSW 18 61,637,403 (GRCm39) missense probably damaging 0.97
R7992:Arhgef37 UTSW 18 61,638,827 (GRCm39) missense probably benign 0.03
R8493:Arhgef37 UTSW 18 61,640,277 (GRCm39) missense probably benign 0.03
R8936:Arhgef37 UTSW 18 61,656,948 (GRCm39) missense probably damaging 0.98
R9000:Arhgef37 UTSW 18 61,637,333 (GRCm39) missense possibly damaging 0.81
R9053:Arhgef37 UTSW 18 61,641,760 (GRCm39) missense probably damaging 1.00
R9298:Arhgef37 UTSW 18 61,651,072 (GRCm39) missense probably damaging 0.98
R9490:Arhgef37 UTSW 18 61,641,907 (GRCm39) missense probably damaging 1.00
R9559:Arhgef37 UTSW 18 61,640,267 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CTTCCGACTACAAGCAACCTGAGAG -3'
(R):5'- ACACCGAGCTAAGTGACAGAGCTG -3'

Sequencing Primer
(F):5'- aactccttcccagcccc -3'
(R):5'- tgacagagctgggccac -3'
Posted On 2013-07-30