|List |< first << previous [record 43 of 58] next >> last >||
|Institutional Source||Beutler Lab|
|Gene Name||R-spondin 4|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||RF006 (G1)|
|Chromosomal Location||151842927-151874668 bp(+) (GRCm38)|
|Type of Mutation||synonymous|
|DNA Base Change (assembly)||C to T at 151867877 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000041578 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000042217]|
|Predicted Effect||probably null
|Coding Region Coverage||
|Validation Efficiency||97% (36/37)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Rspo4||
(F):5'- GCCCAATGAGGAGTCCATCTAAG -3'
(R):5'- ATCTAGAACGAGCAAGCTTGGG -3'
(F):5'- GGAGTCCATCTAAGTAGCTCACATG -3'
(R):5'- CAAGCTTGGGGTTGGGCATG -3'