Incidental Mutation 'RF009:Ifi207'
ID 628477
Institutional Source Beutler Lab
Gene Symbol Ifi207
Ensembl Gene ENSMUSG00000073490
Gene Name interferon activated gene 207
Synonyms AI607873, Pyhin-A
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # RF009 (G1)
Quality Score 71.0074
Status Validated
Chromosome 1
Chromosomal Location 173550993-173569313 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 173556558 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 727 (P727S)
Ref Sequence ENSEMBL: ENSMUSP00000119350 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042610] [ENSMUST00000127730]
AlphaFold E9Q3L4
Predicted Effect probably benign
Transcript: ENSMUST00000042610
AA Change: P734S

PolyPhen 2 Score 0.281 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000048129
Gene: ENSMUSG00000073490
AA Change: P734S

DomainStartEndE-ValueType
PYRIN 6 84 3.2e-15 SMART
low complexity region 121 133 N/A INTRINSIC
low complexity region 136 162 N/A INTRINSIC
low complexity region 207 215 N/A INTRINSIC
internal_repeat_1 286 472 4.17e-7 PROSPERO
low complexity region 476 496 N/A INTRINSIC
internal_repeat_1 565 782 4.17e-7 PROSPERO
Pfam:HIN 788 954 4.9e-76 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000127730
AA Change: P727S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000119350
Gene: ENSMUSG00000073490
AA Change: P727S

DomainStartEndE-ValueType
PYRIN 6 84 3.2e-15 SMART
low complexity region 121 133 N/A INTRINSIC
low complexity region 136 155 N/A INTRINSIC
low complexity region 200 208 N/A INTRINSIC
internal_repeat_1 279 465 6.41e-7 PROSPERO
low complexity region 469 489 N/A INTRINSIC
internal_repeat_1 558 775 6.41e-7 PROSPERO
Pfam:HIN 781 948 1.8e-78 PFAM
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.5%
Validation Efficiency 96% (53/55)
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030445D17Rik ACACACACCCGC AC 4: 136,189,661 (GRCm39) probably null Het
AI182371 A G 2: 34,979,209 (GRCm39) V153A possibly damaging Het
AI837181 CGG CGGTGG 19: 5,475,262 (GRCm39) probably benign Het
Ankhd1 GCGGCG GCGGCGTCGGCG 18: 36,693,975 (GRCm39) probably benign Het
Apoc2 C T 7: 19,405,767 (GRCm39) M71I probably benign Het
Arhgap17 CTGTTGTTG CTGTTG 7: 122,886,085 (GRCm39) probably benign Het
Atrn C A 2: 130,748,842 (GRCm39) T121K probably benign Het
Btnl12 T C 16: 37,674,841 (GRCm39) D207G probably benign Het
Ccdc170 C CCAG 10: 4,511,030 (GRCm39) probably benign Het
Cckbr GCA G 7: 105,083,893 (GRCm39) probably null Het
Cdk13 T C 13: 17,978,329 (GRCm39) D303G unknown Het
Cfap65 C A 1: 74,944,806 (GRCm39) R1477L probably damaging Het
Chd2 A G 7: 73,169,410 (GRCm39) S37P possibly damaging Het
Chga AGC AGCCGC 12: 102,527,679 (GRCm39) probably benign Het
Csf2rb2 T C 15: 78,176,127 (GRCm39) I259V probably benign Het
Csnk1d A T 11: 120,862,453 (GRCm39) N275K possibly damaging Het
Dmxl1 A C 18: 50,026,461 (GRCm39) R1856S probably damaging Het
Dnah5 T C 15: 28,204,165 (GRCm39) V14A probably benign Het
Edc4 G A 8: 106,615,812 (GRCm39) S729N probably benign Het
Emilin3 T C 2: 160,751,012 (GRCm39) S246G probably benign Het
Epc2 T G 2: 49,422,249 (GRCm39) probably null Het
Exoc6 T A 19: 37,560,068 (GRCm39) F101I probably benign Het
Fam171b GCAGCA GCAGCACCAGCA 2: 83,643,224 (GRCm39) probably benign Het
Fam81b CTGTT CTGTTGTT 13: 76,419,435 (GRCm39) probably benign Het
Flywch1 CTCACCCACTCCTGGTGT CTCACCCACTCCTGGTGTGGGGAGGCTACGTAGTCACCCACTCCTGGTGT 17: 23,981,135 (GRCm39) probably null Het
Gab3 TTC TTCCTC X: 74,043,598 (GRCm39) probably benign Het
Gab3 CTT CTTATT X: 74,043,630 (GRCm39) probably null Het
Gabpa C A 16: 84,641,224 (GRCm39) Q93K probably benign Het
Gabre GGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCTGGCTCAGGCTC GGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCTGGCTCAGGCTC X: 71,314,318 (GRCm39) probably benign Het
Gabre GGCTCA GGCTCAAGCTCA X: 71,314,319 (GRCm39) probably benign Het
H2-T3 TCCCGAAGAAC TC 17: 36,500,294 (GRCm39) probably benign Het
Htr5a A G 5: 28,047,859 (GRCm39) D138G probably damaging Het
Ifna13 T A 4: 88,562,145 (GRCm39) S160C probably damaging Het
Kcnh8 G A 17: 53,285,267 (GRCm39) R1079H probably benign Het
Klri2 GGAG GG 6: 129,710,737 (GRCm39) probably null Het
Lce1m GTTGCTGCCACTG GTTGCTGCCACTGTTGCTGCCACTG 3: 92,925,438 (GRCm39) probably benign Het
Lrch1 TTGGTGGTGCTGGTGG TTGGTGG 14: 75,185,014 (GRCm39) probably benign Het
Lrch4 A G 5: 137,635,805 (GRCm39) probably null Het
Lrrc2 TTGATTCGGTTCACC T 9: 110,810,744 (GRCm39) probably null Het
Map1a GCTCCAGC GCTCCAGCCCCAGCTCCAGCTCCAGCTCCACCTCCAGC 2: 121,136,782 (GRCm39) probably benign Het
Mettl25 T C 10: 105,669,100 (GRCm39) probably benign Het
Mex3b A G 7: 82,516,968 (GRCm39) D37G probably damaging Het
Mon1a T A 9: 107,778,433 (GRCm39) V219E probably damaging Het
Myh3 TTACG TTACGTACG 11: 66,977,183 (GRCm39) probably null Het
Myh3 GATTA GATTAATTA 11: 66,977,181 (GRCm39) probably null Het
Myh3 ATTAC ATTACTTAC 11: 66,977,182 (GRCm39) probably null Het
Myo5b T A 18: 74,777,070 (GRCm39) C377S probably damaging Het
Nefh ACTTGGCCTCAGCTGGGG ACTTGGCCTCAGCTGGGGCCTTGGCCTCAGCTGGGG 11: 4,890,997 (GRCm39) probably benign Het
Nos1ap T C 1: 170,146,150 (GRCm39) D468G probably damaging Het
Ntn5 T C 7: 45,342,684 (GRCm39) probably null Het
Oog2 T C 4: 143,921,855 (GRCm39) V255A probably benign Het
Or5ac15 T A 16: 58,940,274 (GRCm39) H53L probably damaging Het
Or8b37 A T 9: 37,959,043 (GRCm39) H175L probably damaging Het
Pdgfd C A 9: 6,288,624 (GRCm39) L93M probably damaging Het
Pgls G T 8: 72,045,107 (GRCm39) V83L probably damaging Het
Pigw C A 11: 84,767,987 (GRCm39) Q447H probably damaging Het
Pnma8a TCATGATGCACCTGCTTCAACATC TCATGATGCACCTGCTTCAACATCGCATGATGCACCTGCTTCAACATC 7: 16,695,352 (GRCm39) probably benign Het
Poc1a C A 9: 106,172,417 (GRCm39) L253M possibly damaging Het
Ppl T A 16: 4,915,795 (GRCm39) E589D probably benign Het
Prkar1b A G 5: 139,094,376 (GRCm39) S71P probably benign Het
Prx T C 7: 27,218,385 (GRCm39) F1101S probably damaging Het
Rffl A G 11: 82,736,598 (GRCm39) V26A probably benign Het
Scube3 T A 17: 28,387,371 (GRCm39) L923Q probably damaging Het
Setd2 C T 9: 110,379,779 (GRCm39) P1198L probably damaging Het
Shank2 C A 7: 143,965,308 (GRCm39) A972E possibly damaging Het
Slc10a6 A G 5: 103,756,858 (GRCm39) L302P probably damaging Het
Slc29a3 C T 10: 60,586,340 (GRCm39) G42D probably benign Het
Spart T C 3: 55,035,027 (GRCm39) V471A probably benign Het
Srebf1 T C 11: 60,094,942 (GRCm39) T486A probably benign Het
Sspo T A 6: 48,436,919 (GRCm39) Y1284* probably null Het
Supt20 AGCAGC AGCAGCCGCAGC 3: 54,635,083 (GRCm39) probably benign Het
Tcof1 GCA GCACCA 18: 60,968,815 (GRCm39) probably benign Het
Tff1 CTTCCTG C 17: 31,383,901 (GRCm39) probably benign Het
Tmprss13 ATCTCCAGCAAGGGCACCTCCTCAGGCCTCTCCAGCAAGGACACCTCCTCAGGCCTCTCCAACAAGGACACCTCCTCAGGCCTCTCCAGCAAGGGCACCTCCTC ATCTCCAGCAAGGGCACCTCCTCAGGGCTCTCCAGCAAGGGCACCTCCTCAGGCCTCTCCAGCAAGGACACCTCCTCAGGCCTCTCCAACAAGGACACCTCCTCAGGCCTCTCCAGCAAGGGCACCTCCTC 9: 45,239,762 (GRCm39) probably benign Het
Tnfrsf25 T C 4: 152,204,081 (GRCm39) W341R probably damaging Het
Trappc9 GCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCT GCTGCTGCTGCTGCTTCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCT 15: 72,673,136 (GRCm39) probably benign Het
Trav8d-1 T A 14: 53,016,207 (GRCm39) L31Q probably damaging Het
Ttc23 A T 7: 67,375,777 (GRCm39) I452F possibly damaging Het
Uimc1 T C 13: 55,198,598 (GRCm39) E526G possibly damaging Het
Ulbp1 T A 10: 7,397,405 (GRCm39) K233N unknown Het
Usp17ld A T 7: 102,899,495 (GRCm39) V479E probably damaging Het
Utrn T TGTTACCC 10: 12,509,689 (GRCm39) probably null Het
Vmn1r9 C T 6: 57,048,465 (GRCm39) S180L probably benign Het
Wdr97 GAGGAGGA G 15: 76,247,367 (GRCm39) probably null Het
Zfp598 CACC CACCCCTACC 17: 24,899,761 (GRCm39) probably benign Het
Other mutations in Ifi207
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01776:Ifi207 APN 1 173,552,610 (GRCm39) missense probably damaging 1.00
IGL01864:Ifi207 APN 1 173,564,007 (GRCm39) missense possibly damaging 0.72
IGL02293:Ifi207 APN 1 173,551,314 (GRCm39) missense probably damaging 1.00
IGL02402:Ifi207 APN 1 173,555,159 (GRCm39) missense probably damaging 1.00
IGL03160:Ifi207 APN 1 173,562,670 (GRCm39) splice site probably benign
PIT4458001:Ifi207 UTSW 1 173,562,738 (GRCm39) missense unknown
R0043:Ifi207 UTSW 1 173,556,678 (GRCm39) missense possibly damaging 0.48
R0212:Ifi207 UTSW 1 173,563,964 (GRCm39) missense possibly damaging 0.85
R0395:Ifi207 UTSW 1 173,557,431 (GRCm39) missense possibly damaging 0.85
R0506:Ifi207 UTSW 1 173,563,878 (GRCm39) missense possibly damaging 0.52
R0843:Ifi207 UTSW 1 173,555,143 (GRCm39) missense probably damaging 1.00
R1302:Ifi207 UTSW 1 173,562,861 (GRCm39) missense possibly damaging 0.96
R1373:Ifi207 UTSW 1 173,557,913 (GRCm39) missense unknown
R1462:Ifi207 UTSW 1 173,552,513 (GRCm39) missense probably damaging 1.00
R1462:Ifi207 UTSW 1 173,552,513 (GRCm39) missense probably damaging 1.00
R1471:Ifi207 UTSW 1 173,557,629 (GRCm39) missense unknown
R1502:Ifi207 UTSW 1 173,556,872 (GRCm39) missense possibly damaging 0.56
R1533:Ifi207 UTSW 1 173,555,306 (GRCm39) missense probably benign 0.30
R1831:Ifi207 UTSW 1 173,559,992 (GRCm39) missense unknown
R1928:Ifi207 UTSW 1 173,557,211 (GRCm39) missense possibly damaging 0.68
R1982:Ifi207 UTSW 1 173,562,805 (GRCm39) missense probably benign 0.01
R2132:Ifi207 UTSW 1 173,557,337 (GRCm39) missense possibly damaging 0.84
R2248:Ifi207 UTSW 1 173,564,036 (GRCm39) splice site probably benign
R3703:Ifi207 UTSW 1 173,555,029 (GRCm39) nonsense probably null
R3741:Ifi207 UTSW 1 173,555,128 (GRCm39) missense probably damaging 1.00
R3846:Ifi207 UTSW 1 173,562,869 (GRCm39) missense probably benign 0.33
R4747:Ifi207 UTSW 1 173,556,633 (GRCm39) missense probably benign 0.00
R4772:Ifi207 UTSW 1 173,555,253 (GRCm39) missense probably damaging 1.00
R4776:Ifi207 UTSW 1 173,557,622 (GRCm39) missense unknown
R4855:Ifi207 UTSW 1 173,557,381 (GRCm39) missense probably damaging 0.96
R5170:Ifi207 UTSW 1 173,558,064 (GRCm39) missense unknown
R5244:Ifi207 UTSW 1 173,557,503 (GRCm39) missense probably benign 0.04
R5280:Ifi207 UTSW 1 173,557,870 (GRCm39) missense unknown
R5301:Ifi207 UTSW 1 173,556,977 (GRCm39) missense possibly damaging 0.83
R5334:Ifi207 UTSW 1 173,555,097 (GRCm39) missense probably benign 0.21
R5445:Ifi207 UTSW 1 173,555,363 (GRCm39) missense probably damaging 0.99
R5691:Ifi207 UTSW 1 173,559,992 (GRCm39) missense unknown
R5838:Ifi207 UTSW 1 173,559,953 (GRCm39) missense unknown
R6060:Ifi207 UTSW 1 173,558,093 (GRCm39) missense unknown
R6220:Ifi207 UTSW 1 173,557,112 (GRCm39) missense probably damaging 0.99
R6264:Ifi207 UTSW 1 173,555,111 (GRCm39) missense probably damaging 1.00
R6307:Ifi207 UTSW 1 173,552,619 (GRCm39) missense probably damaging 1.00
R6326:Ifi207 UTSW 1 173,557,532 (GRCm39) missense probably benign 0.01
R6394:Ifi207 UTSW 1 173,556,581 (GRCm39) missense probably benign 0.43
R6532:Ifi207 UTSW 1 173,557,211 (GRCm39) missense possibly damaging 0.68
R6660:Ifi207 UTSW 1 173,556,972 (GRCm39) missense probably benign 0.01
R6893:Ifi207 UTSW 1 173,555,208 (GRCm39) missense possibly damaging 0.95
R7190:Ifi207 UTSW 1 173,557,818 (GRCm39) missense unknown
R7192:Ifi207 UTSW 1 173,556,584 (GRCm39) missense not run
R7194:Ifi207 UTSW 1 173,557,490 (GRCm39) missense possibly damaging 0.84
R7327:Ifi207 UTSW 1 173,556,581 (GRCm39) missense probably benign 0.43
R7348:Ifi207 UTSW 1 173,556,762 (GRCm39) small deletion probably benign
R7404:Ifi207 UTSW 1 173,556,494 (GRCm39) missense possibly damaging 0.92
R7442:Ifi207 UTSW 1 173,554,997 (GRCm39) missense probably benign 0.03
R7784:Ifi207 UTSW 1 173,557,698 (GRCm39) missense unknown
R8041:Ifi207 UTSW 1 173,555,268 (GRCm39) missense possibly damaging 0.78
R8116:Ifi207 UTSW 1 173,557,746 (GRCm39) missense unknown
R8166:Ifi207 UTSW 1 173,557,504 (GRCm39) missense probably benign 0.10
R8166:Ifi207 UTSW 1 173,557,166 (GRCm39) missense possibly damaging 0.95
R8168:Ifi207 UTSW 1 173,557,504 (GRCm39) missense probably benign 0.10
R8383:Ifi207 UTSW 1 173,556,770 (GRCm39) small deletion probably benign
R8388:Ifi207 UTSW 1 173,557,016 (GRCm39) frame shift probably null
R8389:Ifi207 UTSW 1 173,557,016 (GRCm39) frame shift probably null
R8390:Ifi207 UTSW 1 173,557,016 (GRCm39) frame shift probably null
R8399:Ifi207 UTSW 1 173,557,844 (GRCm39) missense unknown
R8431:Ifi207 UTSW 1 173,558,070 (GRCm39) missense unknown
R8474:Ifi207 UTSW 1 173,556,605 (GRCm39) missense possibly damaging 0.63
R8505:Ifi207 UTSW 1 173,557,016 (GRCm39) frame shift probably null
R9009:Ifi207 UTSW 1 173,555,382 (GRCm39) missense probably damaging 0.97
R9061:Ifi207 UTSW 1 173,564,153 (GRCm39) intron probably benign
R9071:Ifi207 UTSW 1 173,557,764 (GRCm39) missense unknown
R9090:Ifi207 UTSW 1 173,556,762 (GRCm39) small deletion probably benign
R9323:Ifi207 UTSW 1 173,555,143 (GRCm39) missense probably damaging 1.00
R9407:Ifi207 UTSW 1 173,555,234 (GRCm39) missense probably damaging 1.00
R9493:Ifi207 UTSW 1 173,556,522 (GRCm39) missense probably benign 0.00
R9629:Ifi207 UTSW 1 173,556,561 (GRCm39) small deletion probably benign
RF011:Ifi207 UTSW 1 173,556,687 (GRCm39) missense not run
RF032:Ifi207 UTSW 1 173,562,723 (GRCm39) small deletion probably benign
X0003:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0004:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0005:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0009:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0010:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0011:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0012:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0013:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0014:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0017:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0018:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0019:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0020:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0021:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0022:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0023:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0024:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0025:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0026:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0027:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0028:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0033:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0034:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0035:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0036:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0037:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0038:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0039:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0040:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0050:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0052:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0053:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0054:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0057:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0058:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0060:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0061:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0062:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0063:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0064:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0065:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0066:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0067:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
Z1177:Ifi207 UTSW 1 173,557,145 (GRCm39) missense probably damaging 1.00
Z1187:Ifi207 UTSW 1 173,558,093 (GRCm39) missense unknown
Z1192:Ifi207 UTSW 1 173,558,093 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CTCAGTGGAGAAGCACGTAC -3'
(R):5'- TGGCTCCACATGCAACTTCATC -3'

Sequencing Primer
(F):5'- GGAGAAGCACGTACAATGTATATTAC -3'
(R):5'- GCATCTAGCAACCTCCTGG -3'
Posted On 2020-04-20