|Institutional Source||Beutler Lab|
|Gene Name||LIM domain containing preferred translocation partner in lipoma|
|Essential gene?||Probably non essential (E-score: 0.124)|
|Stock #||R7587 (G1)|
|Chromosomal Location||24393507-24992578 bp(+) (GRCm38)|
|Type of Mutation||splice site (3 bp from exon)|
|DNA Base Change (assembly)||A to T at 24762279 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000110969 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000038053] [ENSMUST00000078988] [ENSMUST00000115314]|
|Coding Region Coverage||
|Validation Efficiency||100% (63/63)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
PHENOTYPE: Gene disruption results in fertility problems involving females but not males. Migration and survival of MEFs are also abnormal. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Lpp||
(F):5'- ACTATGCAGCAGGTCCTAGC -3'
(R):5'- GATTCCGCCCTTAGATCAGACTTTC -3'
(F):5'- CTATGCAGCAGGTCCTAGCTATGG -3'
(R):5'- TGCACTGGATGCTGAAGA -3'