Incidental Mutation 'R7825:Eif3e'
ID 628560
Institutional Source Beutler Lab
Gene Symbol Eif3e
Ensembl Gene ENSMUSG00000022336
Gene Name eukaryotic translation initiation factor 3, subunit E
Synonyms Eif3s6, Int6, eIF3-p48, eIF3-p46, 48kDa
MMRRC Submission 045879-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.957) question?
Stock # R7825 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 43113454-43146115 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to C at 43129667 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000022960 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022960] [ENSMUST00000022960]
AlphaFold P60229
Predicted Effect probably null
Transcript: ENSMUST00000022960
SMART Domains Protein: ENSMUSP00000022960
Gene: ENSMUSG00000022336

DomainStartEndE-ValueType
eIF3_N 5 138 4.88e-70 SMART
Blast:eIF3_N 157 193 2e-14 BLAST
Blast:PINT 218 251 7e-9 BLAST
Blast:PINT 284 315 3e-13 BLAST
PINT 327 411 8.17e-19 SMART
Predicted Effect probably null
Transcript: ENSMUST00000022960
SMART Domains Protein: ENSMUSP00000022960
Gene: ENSMUSG00000022336

DomainStartEndE-ValueType
eIF3_N 5 138 4.88e-70 SMART
Blast:eIF3_N 157 193 2e-14 BLAST
Blast:PINT 218 251 7e-9 BLAST
Blast:PINT 284 315 3e-13 BLAST
PINT 327 411 8.17e-19 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 98% (55/56)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik C T 4: 137,182,654 (GRCm39) R270C probably damaging Het
Adprs C A 4: 126,215,489 (GRCm39) probably benign Het
Akp3 TCACCACCACCACCACCACCACCACCACCAC TCACCACCACCACCACCACCACCACCAC 1: 87,055,489 (GRCm39) probably benign Het
Ambra1 A G 2: 91,598,106 (GRCm39) H89R probably damaging Het
Atp1a1 T C 3: 101,493,485 (GRCm39) N540D probably benign Het
Cd38 A T 5: 44,058,797 (GRCm39) H137L probably damaging Het
Clasp1 T C 1: 118,473,123 (GRCm39) V3A probably benign Het
Cmya5 G T 13: 93,234,136 (GRCm39) H317Q possibly damaging Het
Cpeb2 A T 5: 43,394,882 (GRCm39) D95V probably damaging Het
Cyp2f2 G A 7: 26,828,678 (GRCm39) V183I probably benign Het
Dcst1 A G 3: 89,260,128 (GRCm39) L572P possibly damaging Het
Ephb4 T C 5: 137,370,699 (GRCm39) S911P probably damaging Het
Fam186b T C 15: 99,181,728 (GRCm39) T157A not run Het
Gnmt T C 17: 47,040,019 (GRCm39) D20G probably damaging Het
Gpatch8 A C 11: 102,372,268 (GRCm39) D423E unknown Het
Gtf3c2 T C 5: 31,315,715 (GRCm39) H790R probably damaging Het
Hepacam T C 9: 37,296,064 (GRCm39) I405T probably benign Het
Hspg2 T A 4: 137,286,160 (GRCm39) V3574E probably damaging Het
Ifi202b A C 1: 173,802,616 (GRCm39) F73V probably damaging Het
Kcnb1 A T 2: 166,947,892 (GRCm39) S319T probably damaging Het
Krt16 T A 11: 100,139,460 (GRCm39) D86V unknown Het
Krt76 T A 15: 101,795,938 (GRCm39) T411S possibly damaging Het
Myh8 A T 11: 67,194,538 (GRCm39) D1583V possibly damaging Het
Nav1 A T 1: 135,377,782 (GRCm39) V1689D probably damaging Het
Ncor2 T C 5: 125,114,141 (GRCm39) T611A possibly damaging Het
Nipbl T A 15: 8,320,971 (GRCm39) Y2712F probably damaging Het
Ntng2 T A 2: 29,094,090 (GRCm39) H427L probably benign Het
Pcdhga4 T A 18: 37,820,374 (GRCm39) L641Q probably damaging Het
Phc1 T C 6: 122,299,340 (GRCm39) K623R probably benign Het
Polr1b C A 2: 128,967,464 (GRCm39) F952L probably damaging Het
Prcc T A 3: 87,777,052 (GRCm39) E307D possibly damaging Het
Prss27 T C 17: 24,261,932 (GRCm39) F80S probably damaging Het
Rsf1 G GACGGCGGCC 7: 97,229,116 (GRCm39) probably benign Het
Serpina11 T C 12: 103,950,836 (GRCm39) Q295R probably benign Het
Sgk2 G T 2: 162,848,801 (GRCm39) V284L possibly damaging Het
Slc15a2 C T 16: 36,573,396 (GRCm39) V603I possibly damaging Het
Smpd3 A C 8: 106,982,254 (GRCm39) C617G probably benign Het
Stat1 A G 1: 52,190,467 (GRCm39) H574R probably damaging Het
Ston1 T C 17: 88,943,881 (GRCm39) V429A possibly damaging Het
Tep1 T C 14: 51,081,344 (GRCm39) probably null Het
Tesk1 A C 4: 43,447,143 (GRCm39) R510S probably damaging Het
Themis A G 10: 28,658,470 (GRCm39) E499G probably benign Het
Thra G A 11: 98,653,774 (GRCm39) V202I probably benign Het
Tiam1 A T 16: 89,694,977 (GRCm39) M160K probably benign Het
Tmc1 T C 19: 20,782,009 (GRCm39) I570V possibly damaging Het
Treml1 C A 17: 48,673,784 (GRCm39) P270Q probably damaging Het
Ttc39d A G 17: 80,523,575 (GRCm39) N78S probably damaging Het
Ttll3 CAAAGTAA CAAAGTAAAGTAA 6: 113,376,118 (GRCm39) probably null Het
Ttll3 AAGTA AAGTAGAGTA 6: 113,376,120 (GRCm39) probably null Het
Ube3b T A 5: 114,539,373 (GRCm39) L388Q probably damaging Het
Ugt2b35 T A 5: 87,149,218 (GRCm39) C156* probably null Het
Vmn1r35 A T 6: 66,656,443 (GRCm39) C76S probably damaging Het
Wwc2 A G 8: 48,443,197 (GRCm39) L12P probably damaging Het
Zfat T C 15: 68,051,769 (GRCm39) E668G probably benign Het
Zfp40 T C 17: 23,395,301 (GRCm39) T429A probably benign Het
Other mutations in Eif3e
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00765:Eif3e APN 15 43,141,745 (GRCm39) missense probably benign 0.17
IGL02333:Eif3e APN 15 43,129,533 (GRCm39) missense probably benign 0.37
IGL02669:Eif3e APN 15 43,146,088 (GRCm39) start codon destroyed probably benign
IGL03119:Eif3e APN 15 43,129,000 (GRCm39) missense probably benign
IGL03200:Eif3e APN 15 43,115,657 (GRCm39) missense probably damaging 1.00
Verdugo UTSW 15 43,135,685 (GRCm39) missense probably benign 0.29
R0152:Eif3e UTSW 15 43,115,632 (GRCm39) missense possibly damaging 0.83
R1439:Eif3e UTSW 15 43,141,824 (GRCm39) splice site probably benign
R1613:Eif3e UTSW 15 43,113,620 (GRCm39) missense possibly damaging 0.81
R1997:Eif3e UTSW 15 43,129,005 (GRCm39) missense probably damaging 1.00
R2221:Eif3e UTSW 15 43,114,943 (GRCm39) missense possibly damaging 0.95
R3761:Eif3e UTSW 15 43,124,480 (GRCm39) missense probably damaging 0.99
R4241:Eif3e UTSW 15 43,126,086 (GRCm39) missense probably damaging 0.97
R4571:Eif3e UTSW 15 43,129,558 (GRCm39) missense possibly damaging 0.74
R5061:Eif3e UTSW 15 43,115,657 (GRCm39) missense probably damaging 1.00
R5227:Eif3e UTSW 15 43,114,917 (GRCm39) missense probably benign 0.01
R5367:Eif3e UTSW 15 43,115,700 (GRCm39) missense probably damaging 1.00
R5417:Eif3e UTSW 15 43,128,917 (GRCm39) missense probably benign 0.00
R5497:Eif3e UTSW 15 43,134,366 (GRCm39) missense probably damaging 0.98
R5928:Eif3e UTSW 15 43,138,728 (GRCm39) splice site probably null
R6083:Eif3e UTSW 15 43,129,540 (GRCm39) missense probably damaging 1.00
R6337:Eif3e UTSW 15 43,115,692 (GRCm39) missense possibly damaging 0.95
R6964:Eif3e UTSW 15 43,135,685 (GRCm39) missense probably benign 0.29
R7692:Eif3e UTSW 15 43,126,642 (GRCm39) missense probably damaging 0.98
R8034:Eif3e UTSW 15 43,135,703 (GRCm39) missense probably benign 0.02
R9463:Eif3e UTSW 15 43,138,709 (GRCm39) missense probably benign
R9583:Eif3e UTSW 15 43,128,957 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GTGCAGTGTTGTTCCATATCAG -3'
(R):5'- CTGCTGTTTGCTAGCTTTAAAATCG -3'

Sequencing Primer
(F):5'- CAAGTGCAAAGAAATTTCAGAGACTC -3'
(R):5'- TGCTAGCTTTAAAATCGCCTTTAC -3'
Posted On 2020-05-04