Incidental Mutation 'R7888:Meaf6'
ID 628562
Institutional Source Beutler Lab
Gene Symbol Meaf6
Ensembl Gene ENSMUSG00000028863
Gene Name MYST/Esa1-associated factor 6
Synonyms 2810036M01Rik, 2310005N01Rik
MMRRC Submission 045940-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.774) question?
Stock # R7888 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 124978927-125007031 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to G at 125003213 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000101777 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055213] [ENSMUST00000106171] [ENSMUST00000154689] [ENSMUST00000184205]
AlphaFold Q2VPQ9
Predicted Effect probably benign
Transcript: ENSMUST00000055213
SMART Domains Protein: ENSMUSP00000053543
Gene: ENSMUSG00000028863

DomainStartEndE-ValueType
Pfam:NuA4 17 96 1.1e-29 PFAM
low complexity region 157 180 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106171
SMART Domains Protein: ENSMUSP00000101777
Gene: ENSMUSG00000028863

DomainStartEndE-ValueType
Pfam:NuA4 1 45 9e-14 PFAM
low complexity region 105 128 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000154689
SMART Domains Protein: ENSMUSP00000122288
Gene: ENSMUSG00000028863

DomainStartEndE-ValueType
Pfam:NuA4 16 97 3e-33 PFAM
low complexity region 157 178 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000184118
Predicted Effect probably benign
Transcript: ENSMUST00000184205
SMART Domains Protein: ENSMUSP00000138973
Gene: ENSMUSG00000028863

DomainStartEndE-ValueType
Pfam:NuA4 16 97 2.6e-33 PFAM
low complexity region 157 178 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (45/45)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox2 G T 14: 8,246,415 (GRCm38) Q459K probably benign Het
Ano3 T A 2: 110,496,773 (GRCm39) Y792F probably damaging Het
Aoc3 C T 11: 101,223,323 (GRCm39) H520Y probably damaging Het
Atp4b A G 8: 13,439,811 (GRCm39) F137S probably damaging Het
Blvrb A G 7: 27,165,159 (GRCm39) T160A probably damaging Het
Brd2 G A 17: 34,335,995 (GRCm39) R73W probably damaging Het
Btaf1 A G 19: 36,943,036 (GRCm39) T306A probably benign Het
Ccdc154 G A 17: 25,383,578 (GRCm39) V212M possibly damaging Het
Ccdc40 A G 11: 119,119,967 (GRCm39) E3G unknown Het
Cenpb T A 2: 131,021,762 (GRCm39) E12V probably damaging Het
Cnot8 T C 11: 58,002,137 (GRCm39) S57P probably benign Het
Cryba4 T C 5: 112,398,918 (GRCm39) E42G probably benign Het
Fam72a T A 1: 131,456,578 (GRCm39) I47N probably damaging Het
Gm27027 A C 2: 93,787,880 (GRCm39) probably null Het
Itgb2 T C 10: 77,400,478 (GRCm39) V697A probably benign Het
Jakmip1 A G 5: 37,262,208 (GRCm39) N336D probably damaging Het
Kansl1 T C 11: 104,233,248 (GRCm39) T760A probably benign Het
Lrrc37a T A 11: 103,392,307 (GRCm39) E1039D probably benign Het
Mpz T C 1: 170,987,204 (GRCm39) probably null Het
Mtss1 A T 15: 58,844,373 (GRCm39) M82K probably damaging Het
Myo6 T C 9: 80,203,947 (GRCm39) S1063P probably damaging Het
Niban2 T A 2: 32,812,137 (GRCm39) Y406* probably null Het
Nsun6 T A 2: 15,001,355 (GRCm39) E400D probably benign Het
Or10al5 A T 17: 38,062,888 (GRCm39) N48Y probably damaging Het
Or1e26 T C 11: 73,480,354 (GRCm39) D70G probably damaging Het
Or1l4b A T 2: 37,036,334 (GRCm39) M37L probably benign Het
Or2t26 T C 11: 49,039,266 (GRCm39) Y61H probably damaging Het
Or52ae7 T A 7: 103,120,006 (GRCm39) Y253* probably null Het
Or5au1 A G 14: 52,273,347 (GRCm39) S74P probably damaging Het
Or8j3b C A 2: 86,205,270 (GRCm39) C162F probably benign Het
Pfdn5 T A 15: 102,237,024 (GRCm39) V92E probably damaging Het
Pik3c2g T C 6: 139,842,470 (GRCm39) V801A Het
Psme2b T A 11: 48,836,402 (GRCm39) T182S possibly damaging Het
Ptcd3 G A 6: 71,860,431 (GRCm39) A592V probably damaging Het
Rabgap1 T A 2: 37,427,319 (GRCm39) Y633* probably null Het
Rnf39 A T 17: 37,258,133 (GRCm39) T222S probably damaging Het
Scnn1g A G 7: 121,342,878 (GRCm39) N277S probably damaging Het
Slc16a13 T G 11: 70,109,806 (GRCm39) I232L possibly damaging Het
Slco2b1 T G 7: 99,338,050 (GRCm39) R111S unknown Het
Sltm C G 9: 70,493,955 (GRCm39) P802R possibly damaging Het
Tmc3 T C 7: 83,249,217 (GRCm39) W269R probably damaging Het
Vmn2r4 T C 3: 64,313,943 (GRCm39) E346G probably damaging Het
Vps52 A G 17: 34,184,725 (GRCm39) N666S probably damaging Het
Wdfy4 C T 14: 32,812,920 (GRCm39) D1618N Het
Zfp773 C A 7: 7,135,978 (GRCm39) C206F probably benign Het
Other mutations in Meaf6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1573:Meaf6 UTSW 4 124,983,931 (GRCm39) missense probably benign 0.29
R4827:Meaf6 UTSW 4 124,996,713 (GRCm39) missense probably damaging 0.98
R6513:Meaf6 UTSW 4 124,983,697 (GRCm39) missense probably damaging 1.00
R8032:Meaf6 UTSW 4 124,996,795 (GRCm39) missense unknown
R8852:Meaf6 UTSW 4 124,979,990 (GRCm39) missense probably damaging 1.00
R8860:Meaf6 UTSW 4 124,979,990 (GRCm39) missense probably damaging 1.00
R9007:Meaf6 UTSW 4 125,001,450 (GRCm39) intron probably benign
R9306:Meaf6 UTSW 4 124,996,766 (GRCm39) missense unknown
R9678:Meaf6 UTSW 4 124,996,689 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- TCATTTGATCAAACCGAGGTGG -3'
(R):5'- AGAATCAGAGGTGTGTGCAC -3'

Sequencing Primer
(F):5'- CCGAGGTGGTAAGTCGTGGC -3'
(R):5'- TCACAGATGGAGCTGGTGC -3'
Posted On 2020-05-04