Mutagenetix > Incidental Mutation

Incidental Mutation 'R7771:Tmprss11b'

628567

Institutional Source

Beutler Lab

Gene Symbol

Tmprss11b

Ensembl Gene

ENSMUSG00000035861

Gene Name

transmembrane protease, serine 11B

Synonyms

Tmprss11bnl, 9930019B18Rik

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7771 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

86657631-86676362 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 86661695 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000042406 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038448]

AlphaFold

Q14C59

Predicted Effect

probably null
Transcript: ENSMUST00000038448

SMART Domains

Protein: ENSMUSP00000042406
Gene: ENSMUSG00000035861

Domain	Start	End	E-Value	Type
transmembrane domain	12	34	N/A	INTRINSIC
Pfam:SEA	46	148	2.3e-26	PFAM
Tryp_SPc	184	410	6.19e-89	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

100% (56/56)

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb11	C	T	2: 69,239,191	A1287T	probably damaging	Het
Ahnak	A	G	19: 9,015,047	K4565R	probably damaging	Het
Asb13	A	G	13: 3,649,463	Y221C	probably damaging	Het
BB014433	C	T	8: 15,042,395	V153M	probably damaging	Het
Brip1	T	C	11: 86,062,024	E977G	probably benign	Het
C3	T	A	17: 57,215,797	D1029V	probably damaging	Het
Ccdc116	T	C	16: 17,139,591	E568G	probably benign	Het
Cdhr2	T	C	13: 54,718,275	V296A	probably damaging	Het
Cenpe	A	G	3: 135,240,941		probably null	Het
Cnot1	A	G	8: 95,765,125	V357A	probably damaging	Het
Coa3	A	T	11: 101,278,815	M38K	possibly damaging	Het
Cyp2d26	T	C	15: 82,791,746	N255S	probably benign	Het
Cysrt1	T	C	2: 25,239,225	S92G	probably benign	Het
D030056L22Rik	A	G	19: 18,713,478	E52G	possibly damaging	Het
Derl1	T	C	15: 57,880,040	D97G	probably damaging	Het
Ebf3	A	G	7: 137,309,363	Y141H	probably damaging	Het
Eci1	T	A	17: 24,433,151	L49*	probably null	Het
Fam208a	A	G	14: 27,467,559	T923A	probably damaging	Het
Gm7534	A	T	4: 134,195,443	N526K	probably benign	Het
Gzma	C	T	13: 113,098,295	C54Y	probably damaging	Het
Hydin	A	G	8: 110,565,085	N3403S	probably damaging	Het
Ide	T	C	19: 37,298,126	N495D		Het
Ighv1-23	T	A	12: 114,764,736	Q22L	probably benign	Het
Itgb2l	A	G	16: 96,426,972	C444R	probably damaging	Het
Kcnj3	C	A	2: 55,446,937	H272N	probably damaging	Het
Lrp6	C	T	6: 134,462,616	C1218Y	probably damaging	Het
Lrrd1	T	C	5: 3,866,476	M831T	possibly damaging	Het
Map3k11	A	G	19: 5,690,608	E121G	probably damaging	Het
Mzt1	A	T	14: 99,040,576	I52N	probably damaging	Het
Olfr339	T	C	2: 36,422,144	S249P	possibly damaging	Het
Olfr617	A	G	7: 103,584,090	I23V	probably benign	Het
Olfr857	T	A	9: 19,713,471	F215I	probably benign	Het
Pcdhb17	A	C	18: 37,486,909	Y584S	possibly damaging	Het
Per3	A	T	4: 151,026,200	D380E	probably damaging	Het
Per3	A	T	4: 151,041,445	L139Q	probably damaging	Het
Pik3cg	T	C	12: 32,204,014	H658R	probably benign	Het
Pitpnm3	G	A	11: 72,061,488	Q626*	probably null	Het
Polr3e	T	C	7: 120,940,578	V542A	probably benign	Het
Rgs22	T	A	15: 36,050,078	H866L	possibly damaging	Het
Rnf150	A	G	8: 82,864,203	E65G	probably benign	Het
Sema3f	C	A	9: 107,692,426	R100L	possibly damaging	Het
Smim18	T	C	8: 33,742,342	D83G	possibly damaging	Het
Snx13	T	A	12: 35,124,528	D685E	probably benign	Het
Stat5a	A	C	11: 100,863,219	N125T	probably benign	Het
Stk24	T	C	14: 121,337,633	E21G	probably damaging	Het
Tlr3	C	T	8: 45,403,039	V35I	probably benign	Het
Tmem8	T	C	17: 26,122,073	Y717H	probably damaging	Het
Trpm2	T	C	10: 77,932,179	I829V	probably benign	Het
Ttc37	A	G	13: 76,135,030	H792R	probably benign	Het
Ttc39a	T	C	4: 109,431,450	Y276H	probably damaging	Het
Vmn2r98	T	A	17: 19,067,198		probably null	Het
Wdr73	G	A	7: 80,893,227	A211V	probably benign	Het
Zc3h4	T	C	7: 16,429,899	V673A	unknown	Het
Zfp382	A	G	7: 30,133,335	H137R	probably damaging	Het
Zp2	T	G	7: 120,143,642	D89A	probably damaging	Het
Zranb3	A	C	1: 128,032,868	Y220D	probably damaging	Het
Zswim8	G	A	14: 20,712,980	V316I	probably damaging	Het

Other mutations in Tmprss11b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01122:Tmprss11b	APN	5	86663517	missense	probably benign
IGL02340:Tmprss11b	APN	5	86662231	missense	probably benign
IGL02500:Tmprss11b	APN	5	86667323	critical splice donor site	probably null
demolished	UTSW	5	86664314	missense	probably damaging	1.00
R0356:Tmprss11b	UTSW	5	86660467	makesense	probably null
R0506:Tmprss11b	UTSW	5	86661640	missense	probably damaging	1.00
R0528:Tmprss11b	UTSW	5	86671894	missense	probably damaging	1.00
R1424:Tmprss11b	UTSW	5	86664973	missense	probably benign	0.09
R1471:Tmprss11b	UTSW	5	86660496	missense	possibly damaging	0.76
R1554:Tmprss11b	UTSW	5	86661631	missense	probably benign	0.01
R3436:Tmprss11b	UTSW	5	86667584	nonsense	probably null
R3829:Tmprss11b	UTSW	5	86661590	missense	probably damaging	0.98
R4409:Tmprss11b	UTSW	5	86664278	missense	probably benign	0.26
R4495:Tmprss11b	UTSW	5	86665063	nonsense	probably null
R4624:Tmprss11b	UTSW	5	86665036	missense	probably benign	0.04
R4834:Tmprss11b	UTSW	5	86663559	missense	probably damaging	1.00
R5436:Tmprss11b	UTSW	5	86662233	missense	probably benign	0.10
R5812:Tmprss11b	UTSW	5	86665098	missense	possibly damaging	0.67
R6262:Tmprss11b	UTSW	5	86662260	missense	probably benign	0.07
R6882:Tmprss11b	UTSW	5	86671671	splice site	probably null
R6893:Tmprss11b	UTSW	5	86663386	critical splice donor site	probably null
R7312:Tmprss11b	UTSW	5	86664314	missense	probably damaging	1.00
R8101:Tmprss11b	UTSW	5	86664962	critical splice donor site	probably null
X0067:Tmprss11b	UTSW	5	86662200	missense	probably damaging	1.00
Z1177:Tmprss11b	UTSW	5	86660541	missense	probably damaging	1.00
Z1177:Tmprss11b	UTSW	5	86661613	missense	probably benign	0.13

Predicted Primers

PCR Primer
(F):5'- GTGAATGGTTTCCAGGCTTACC -3'
(R):5'- GGCAACATTTGAAAGGTGTTTC -3'

Sequencing Primer
(F):5'- TTACCTGGCAAGCATCGATACTG -3'
(R):5'- TTCATTAGTTTGGGGGCAAGAGAAAC -3'

Posted On

2020-05-05