Incidental Mutation 'R7771:Vmn2r98'
| ID |
628568 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r98
|
| Ensembl Gene |
ENSMUSG00000096717 |
| Gene Name |
vomeronasal 2, receptor 98 |
| Synonyms |
EG224552 |
| MMRRC Submission |
045827-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.141)
|
| Stock # |
R7771 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19053460-19082411 bp(+) (GRCm38) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to A
at 19067198 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131261
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170424]
[ENSMUST00000170424]
|
| AlphaFold |
E9PZ56 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000170424
|
| SMART Domains |
Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
|
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000170424
|
| SMART Domains |
Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
|
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (56/56) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb11 |
C |
T |
2: 69,239,191 (GRCm38) |
A1287T |
probably damaging |
Het |
| Ahnak |
A |
G |
19: 9,015,047 (GRCm38) |
K4565R |
probably damaging |
Het |
| Asb13 |
A |
G |
13: 3,649,463 (GRCm38) |
Y221C |
probably damaging |
Het |
| BB014433 |
C |
T |
8: 15,042,395 (GRCm38) |
V153M |
probably damaging |
Het |
| Brip1 |
T |
C |
11: 86,062,024 (GRCm38) |
E977G |
probably benign |
Het |
| C3 |
T |
A |
17: 57,215,797 (GRCm38) |
D1029V |
probably damaging |
Het |
| Ccdc116 |
T |
C |
16: 17,139,591 (GRCm38) |
E568G |
probably benign |
Het |
| Cdhr2 |
T |
C |
13: 54,718,275 (GRCm38) |
V296A |
probably damaging |
Het |
| Cenpe |
A |
G |
3: 135,240,941 (GRCm38) |
|
probably null |
Het |
| Cnot1 |
A |
G |
8: 95,765,125 (GRCm38) |
V357A |
probably damaging |
Het |
| Coa3 |
A |
T |
11: 101,278,815 (GRCm38) |
M38K |
possibly damaging |
Het |
| Cyp2d26 |
T |
C |
15: 82,791,746 (GRCm38) |
N255S |
probably benign |
Het |
| Cysrt1 |
T |
C |
2: 25,239,225 (GRCm38) |
S92G |
probably benign |
Het |
| D030056L22Rik |
A |
G |
19: 18,713,478 (GRCm38) |
E52G |
possibly damaging |
Het |
| Derl1 |
T |
C |
15: 57,880,040 (GRCm38) |
D97G |
probably damaging |
Het |
| Ebf3 |
A |
G |
7: 137,309,363 (GRCm38) |
Y141H |
probably damaging |
Het |
| Eci1 |
T |
A |
17: 24,433,151 (GRCm38) |
L49* |
probably null |
Het |
| Fam208a |
A |
G |
14: 27,467,559 (GRCm38) |
T923A |
probably damaging |
Het |
| Gm7534 |
A |
T |
4: 134,195,443 (GRCm38) |
N526K |
probably benign |
Het |
| Gzma |
C |
T |
13: 113,098,295 (GRCm38) |
C54Y |
probably damaging |
Het |
| Hydin |
A |
G |
8: 110,565,085 (GRCm38) |
N3403S |
probably damaging |
Het |
| Ide |
T |
C |
19: 37,298,126 (GRCm38) |
N495D |
|
Het |
| Ighv1-23 |
T |
A |
12: 114,764,736 (GRCm38) |
Q22L |
probably benign |
Het |
| Itgb2l |
A |
G |
16: 96,426,972 (GRCm38) |
C444R |
probably damaging |
Het |
| Kcnj3 |
C |
A |
2: 55,446,937 (GRCm38) |
H272N |
probably damaging |
Het |
| Lrp6 |
C |
T |
6: 134,462,616 (GRCm38) |
C1218Y |
probably damaging |
Het |
| Lrrd1 |
T |
C |
5: 3,866,476 (GRCm38) |
M831T |
possibly damaging |
Het |
| Map3k11 |
A |
G |
19: 5,690,608 (GRCm38) |
E121G |
probably damaging |
Het |
| Mzt1 |
A |
T |
14: 99,040,576 (GRCm38) |
I52N |
probably damaging |
Het |
| Olfr339 |
T |
C |
2: 36,422,144 (GRCm38) |
S249P |
possibly damaging |
Het |
| Olfr617 |
A |
G |
7: 103,584,090 (GRCm38) |
I23V |
probably benign |
Het |
| Olfr857 |
T |
A |
9: 19,713,471 (GRCm38) |
F215I |
probably benign |
Het |
| Pcdhb17 |
A |
C |
18: 37,486,909 (GRCm38) |
Y584S |
possibly damaging |
Het |
| Per3 |
A |
T |
4: 151,026,200 (GRCm38) |
D380E |
probably damaging |
Het |
| Per3 |
A |
T |
4: 151,041,445 (GRCm38) |
L139Q |
probably damaging |
Het |
| Pik3cg |
T |
C |
12: 32,204,014 (GRCm38) |
H658R |
probably benign |
Het |
| Pitpnm3 |
G |
A |
11: 72,061,488 (GRCm38) |
Q626* |
probably null |
Het |
| Polr3e |
T |
C |
7: 120,940,578 (GRCm38) |
V542A |
probably benign |
Het |
| Rgs22 |
T |
A |
15: 36,050,078 (GRCm38) |
H866L |
possibly damaging |
Het |
| Rnf150 |
A |
G |
8: 82,864,203 (GRCm38) |
E65G |
probably benign |
Het |
| Sema3f |
C |
A |
9: 107,692,426 (GRCm38) |
R100L |
possibly damaging |
Het |
| Smim18 |
T |
C |
8: 33,742,342 (GRCm38) |
D83G |
possibly damaging |
Het |
| Snx13 |
T |
A |
12: 35,124,528 (GRCm38) |
D685E |
probably benign |
Het |
| Stat5a |
A |
C |
11: 100,863,219 (GRCm38) |
N125T |
probably benign |
Het |
| Stk24 |
T |
C |
14: 121,337,633 (GRCm38) |
E21G |
probably damaging |
Het |
| Tlr3 |
C |
T |
8: 45,403,039 (GRCm38) |
V35I |
probably benign |
Het |
| Tmem8 |
T |
C |
17: 26,122,073 (GRCm38) |
Y717H |
probably damaging |
Het |
| Tmprss11b |
A |
T |
5: 86,661,695 (GRCm38) |
|
probably null |
Het |
| Trpm2 |
T |
C |
10: 77,932,179 (GRCm38) |
I829V |
probably benign |
Het |
| Ttc37 |
A |
G |
13: 76,135,030 (GRCm38) |
H792R |
probably benign |
Het |
| Ttc39a |
T |
C |
4: 109,431,450 (GRCm38) |
Y276H |
probably damaging |
Het |
| Wdr73 |
G |
A |
7: 80,893,227 (GRCm38) |
A211V |
probably benign |
Het |
| Zc3h4 |
T |
C |
7: 16,429,899 (GRCm38) |
V673A |
unknown |
Het |
| Zfp382 |
A |
G |
7: 30,133,335 (GRCm38) |
H137R |
probably damaging |
Het |
| Zp2 |
T |
G |
7: 120,143,642 (GRCm38) |
D89A |
probably damaging |
Het |
| Zranb3 |
A |
C |
1: 128,032,868 (GRCm38) |
Y220D |
probably damaging |
Het |
| Zswim8 |
G |
A |
14: 20,712,980 (GRCm38) |
V316I |
probably damaging |
Het |
|
| Other mutations in Vmn2r98 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r98
|
APN |
17 |
19,065,745 (GRCm38) |
splice site |
probably benign |
|
|
IGL01296:Vmn2r98
|
APN |
17 |
19,065,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01363:Vmn2r98
|
APN |
17 |
19,065,758 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01618:Vmn2r98
|
APN |
17 |
19,065,259 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL01746:Vmn2r98
|
APN |
17 |
19,066,451 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01747:Vmn2r98
|
APN |
17 |
19,066,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01770:Vmn2r98
|
APN |
17 |
19,066,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01868:Vmn2r98
|
APN |
17 |
19,066,286 (GRCm38) |
missense |
probably benign |
|
|
IGL02123:Vmn2r98
|
APN |
17 |
19,080,679 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02323:Vmn2r98
|
APN |
17 |
19,065,851 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02543:Vmn2r98
|
APN |
17 |
19,065,821 (GRCm38) |
missense |
probably benign |
|
|
IGL02650:Vmn2r98
|
APN |
17 |
19,080,961 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02676:Vmn2r98
|
APN |
17 |
19,065,259 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02803:Vmn2r98
|
APN |
17 |
19,066,013 (GRCm38) |
missense |
probably benign |
|
|
IGL02807:Vmn2r98
|
APN |
17 |
19,081,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03307:Vmn2r98
|
APN |
17 |
19,065,980 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
IGL03396:Vmn2r98
|
APN |
17 |
19,069,845 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
PIT4131001:Vmn2r98
|
UTSW |
17 |
19,080,961 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0122:Vmn2r98
|
UTSW |
17 |
19,066,400 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0329:Vmn2r98
|
UTSW |
17 |
19,066,347 (GRCm38) |
missense |
probably benign |
0.21 |
|
R0330:Vmn2r98
|
UTSW |
17 |
19,066,347 (GRCm38) |
missense |
probably benign |
0.21 |
|
R0368:Vmn2r98
|
UTSW |
17 |
19,065,827 (GRCm38) |
nonsense |
probably null |
|
|
R0545:Vmn2r98
|
UTSW |
17 |
19,053,613 (GRCm38) |
missense |
probably benign |
0.15 |
|
R0635:Vmn2r98
|
UTSW |
17 |
19,080,497 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0689:Vmn2r98
|
UTSW |
17 |
19,080,520 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R1035:Vmn2r98
|
UTSW |
17 |
19,080,749 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1243:Vmn2r98
|
UTSW |
17 |
19,065,948 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R1421:Vmn2r98
|
UTSW |
17 |
19,065,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1629:Vmn2r98
|
UTSW |
17 |
19,067,383 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1643:Vmn2r98
|
UTSW |
17 |
19,080,908 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1795:Vmn2r98
|
UTSW |
17 |
19,066,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1958:Vmn2r98
|
UTSW |
17 |
19,066,418 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R1962:Vmn2r98
|
UTSW |
17 |
19,065,333 (GRCm38) |
nonsense |
probably null |
|
|
R2165:Vmn2r98
|
UTSW |
17 |
19,081,291 (GRCm38) |
missense |
unknown |
|
|
R2238:Vmn2r98
|
UTSW |
17 |
19,065,951 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2252:Vmn2r98
|
UTSW |
17 |
19,080,436 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2323:Vmn2r98
|
UTSW |
17 |
19,065,819 (GRCm38) |
missense |
probably benign |
0.18 |
|
R2887:Vmn2r98
|
UTSW |
17 |
19,081,177 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R2909:Vmn2r98
|
UTSW |
17 |
19,067,402 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3001:Vmn2r98
|
UTSW |
17 |
19,065,863 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3002:Vmn2r98
|
UTSW |
17 |
19,065,863 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3003:Vmn2r98
|
UTSW |
17 |
19,065,863 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3788:Vmn2r98
|
UTSW |
17 |
19,080,625 (GRCm38) |
missense |
probably benign |
0.31 |
|
R4570:Vmn2r98
|
UTSW |
17 |
19,066,092 (GRCm38) |
missense |
probably benign |
0.11 |
|
R4706:Vmn2r98
|
UTSW |
17 |
19,069,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4723:Vmn2r98
|
UTSW |
17 |
19,066,340 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5036:Vmn2r98
|
UTSW |
17 |
19,066,157 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5072:Vmn2r98
|
UTSW |
17 |
19,066,044 (GRCm38) |
missense |
probably benign |
0.07 |
|
R5121:Vmn2r98
|
UTSW |
17 |
19,053,553 (GRCm38) |
missense |
probably benign |
0.13 |
|
R5283:Vmn2r98
|
UTSW |
17 |
19,080,719 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5294:Vmn2r98
|
UTSW |
17 |
19,069,754 (GRCm38) |
nonsense |
probably null |
|
|
R5371:Vmn2r98
|
UTSW |
17 |
19,069,753 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5532:Vmn2r98
|
UTSW |
17 |
19,067,383 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5598:Vmn2r98
|
UTSW |
17 |
19,080,899 (GRCm38) |
missense |
probably benign |
0.37 |
|
R5800:Vmn2r98
|
UTSW |
17 |
19,065,998 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6089:Vmn2r98
|
UTSW |
17 |
19,066,074 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6155:Vmn2r98
|
UTSW |
17 |
19,065,881 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R6853:Vmn2r98
|
UTSW |
17 |
19,065,801 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6920:Vmn2r98
|
UTSW |
17 |
19,065,248 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7012:Vmn2r98
|
UTSW |
17 |
19,066,268 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7042:Vmn2r98
|
UTSW |
17 |
19,080,922 (GRCm38) |
missense |
probably benign |
|
|
R7068:Vmn2r98
|
UTSW |
17 |
19,065,313 (GRCm38) |
missense |
probably benign |
|
|
R7607:Vmn2r98
|
UTSW |
17 |
19,067,308 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R7763:Vmn2r98
|
UTSW |
17 |
19,080,535 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7915:Vmn2r98
|
UTSW |
17 |
19,067,231 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8028:Vmn2r98
|
UTSW |
17 |
19,053,650 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8205:Vmn2r98
|
UTSW |
17 |
19,081,163 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8241:Vmn2r98
|
UTSW |
17 |
19,080,769 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8906:Vmn2r98
|
UTSW |
17 |
19,066,270 (GRCm38) |
missense |
probably benign |
|
|
R8952:Vmn2r98
|
UTSW |
17 |
19,065,269 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R9147:Vmn2r98
|
UTSW |
17 |
19,066,121 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9148:Vmn2r98
|
UTSW |
17 |
19,066,121 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9187:Vmn2r98
|
UTSW |
17 |
19,081,219 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9344:Vmn2r98
|
UTSW |
17 |
19,066,515 (GRCm38) |
missense |
probably benign |
0.14 |
|
R9467:Vmn2r98
|
UTSW |
17 |
19,067,255 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9487:Vmn2r98
|
UTSW |
17 |
19,081,234 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R9753:Vmn2r98
|
UTSW |
17 |
19,065,403 (GRCm38) |
missense |
probably benign |
0.27 |
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,067,423 (GRCm38) |
nonsense |
probably null |
|
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,065,136 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CATTTTGGACACTGTTGCTCTG -3'
(R):5'- TTGACCCTGGGGAGCATTTG -3'
Sequencing Primer
(F):5'- GGACACTGTTGCTCTGAACATATTC -3'
(R):5'- AGCATTTGCAGAAAAGGATCC -3'
|
| Posted On |
2020-05-05 |
Incidental Mutation