Incidental Mutation 'IGL00426:Ceacam18'
ID6286
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ceacam18
Ensembl Gene ENSMUSG00000030472
Gene Namecarcinoembryonic antigen-related cell adhesion molecule 18
Synonyms2010110O04Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #IGL00426
Quality Score
Status
Chromosome7
Chromosomal Location43634707-43649295 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 43639356 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 177 (T177I)
Ref Sequence ENSEMBL: ENSMUSP00000032663 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032663]
Predicted Effect probably benign
Transcript: ENSMUST00000032663
AA Change: T177I

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000032663
Gene: ENSMUSG00000030472
AA Change: T177I

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG_like 36 135 1.03e2 SMART
IG_like 148 226 5.56e0 SMART
IGc2 248 305 5.24e-7 SMART
transmembrane domain 334 356 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik G A 1: 11,748,054 E313K probably damaging Het
Adgrl2 A G 3: 148,865,608 V130A probably damaging Het
Arhgef28 G A 13: 97,988,277 A499V probably benign Het
Cspp1 G A 1: 10,112,551 probably benign Het
Cyp2j7 A T 4: 96,227,512 probably benign Het
Cyp2j7 C T 4: 96,227,513 probably null Het
Dip2c T C 13: 9,606,515 F821L probably damaging Het
Gm5538 T A 3: 59,752,121 L332I possibly damaging Het
Lrig3 A T 10: 125,972,137 R85* probably null Het
Mcf2l A G 8: 12,984,910 D106G probably damaging Het
Mdn1 T C 4: 32,719,214 V2259A possibly damaging Het
Mmp16 C T 4: 18,011,784 P233L probably benign Het
Mrpl27 A G 11: 94,659,697 N110S probably benign Het
Myom2 T C 8: 15,069,502 M131T probably benign Het
Myzap T C 9: 71,555,671 T198A probably benign Het
Nek8 T C 11: 78,167,827 Q549R probably damaging Het
Nr1d2 A G 14: 18,215,502 probably benign Het
Nup155 T C 15: 8,156,794 *1347Q probably null Het
Pkd2l1 C T 19: 44,155,605 R343H probably benign Het
Ppfibp2 T A 7: 107,708,805 L215H probably damaging Het
Ralgds T C 2: 28,552,218 L137P probably damaging Het
Rasa2 C T 9: 96,544,860 D752N probably damaging Het
Spg11 T C 2: 122,065,560 K1726E probably damaging Het
St6gal1 G A 16: 23,356,392 probably benign Het
Tmem183a A G 1: 134,350,144 L294P probably damaging Het
Trav19 T C 14: 53,845,684 L72P probably damaging Het
Vapa T C 17: 65,593,481 T99A possibly damaging Het
Other mutations in Ceacam18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00585:Ceacam18 APN 7 43637011 missense possibly damaging 0.90
IGL01669:Ceacam18 APN 7 43645515 missense probably damaging 1.00
R0001:Ceacam18 UTSW 7 43636876 missense possibly damaging 0.58
R0227:Ceacam18 UTSW 7 43639391 missense probably damaging 1.00
R1524:Ceacam18 UTSW 7 43639355 missense possibly damaging 0.95
R1647:Ceacam18 UTSW 7 43639265 missense possibly damaging 0.78
R1768:Ceacam18 UTSW 7 43648494 missense probably benign 0.00
R1828:Ceacam18 UTSW 7 43639456 missense probably benign 0.19
R3751:Ceacam18 UTSW 7 43641948 missense probably damaging 1.00
R4870:Ceacam18 UTSW 7 43641904 missense probably damaging 1.00
R5259:Ceacam18 UTSW 7 43637112 critical splice donor site probably null
R5358:Ceacam18 UTSW 7 43637073 missense possibly damaging 0.57
R5368:Ceacam18 UTSW 7 43642034 missense probably benign 0.08
R5810:Ceacam18 UTSW 7 43636958 missense probably benign 0.00
R5817:Ceacam18 UTSW 7 43641841 missense probably benign 0.07
R5835:Ceacam18 UTSW 7 43636958 missense probably benign 0.00
R7113:Ceacam18 UTSW 7 43641976 missense probably benign
R7138:Ceacam18 UTSW 7 43639282 missense possibly damaging 0.80
R7275:Ceacam18 UTSW 7 43641884 missense probably damaging 1.00
R7502:Ceacam18 UTSW 7 43636874 missense probably damaging 0.99
Posted On2012-04-20