Incidental Mutation 'R7782:Mob1b'
ID 628627
Institutional Source Beutler Lab
Gene Symbol Mob1b
Ensembl Gene ENSMUSG00000006262
Gene Name MOB kinase activator 1B
Synonyms 1110003E08Rik, Mobkl1a
MMRRC Submission 045838-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.161) question?
Stock # R7782 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 88868730-88906314 bp(+) (GRCm39)
Type of Mutation splice site (25 bp from exon)
DNA Base Change (assembly) A to G at 88897542 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000108855 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006424] [ENSMUST00000113229]
AlphaFold Q8BPB0
Predicted Effect probably null
Transcript: ENSMUST00000006424
SMART Domains Protein: ENSMUSP00000006424
Gene: ENSMUSG00000006262

DomainStartEndE-ValueType
Pfam:Mob1_phocein 29 205 1.2e-83 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000113229
SMART Domains Protein: ENSMUSP00000108855
Gene: ENSMUSG00000006262

DomainStartEndE-ValueType
Mob1_phocein 31 209 2.18e-113 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (80/80)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit no abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933415A04Rik GTGTGTGTATGTGTGT GTGTGTGT 11: 43,478,239 (GRCm39) probably null Het
Adamts16 A G 13: 70,984,265 (GRCm39) S133P probably damaging Het
Adamts17 T C 7: 66,774,802 (GRCm39) W1001R probably damaging Het
Aox4 T A 1: 58,270,251 (GRCm39) probably null Het
B4galnt4 C T 7: 140,644,988 (GRCm39) P221S probably damaging Het
BC005537 C T 13: 24,987,382 (GRCm39) R7W possibly damaging Het
BC034090 T C 1: 155,108,410 (GRCm39) probably benign Het
Best2 T A 8: 85,736,143 (GRCm39) D312V probably damaging Het
Bod1l A T 5: 41,975,286 (GRCm39) D2009E probably benign Het
Ccdc158 A C 5: 92,793,373 (GRCm39) S672A probably benign Het
Ccdc43 A T 11: 102,588,443 (GRCm39) L31Q probably damaging Het
Cdcp3 G A 7: 130,904,466 (GRCm39) probably null Het
Chaf1a T G 17: 56,369,291 (GRCm39) H507Q probably benign Het
Clptm1l A G 13: 73,752,439 (GRCm39) Y28C probably damaging Het
Cp G A 3: 20,029,223 (GRCm39) probably null Het
Crocc C T 4: 140,752,597 (GRCm39) A1432T probably benign Het
Crybg2 A G 4: 133,801,137 (GRCm39) T457A probably benign Het
Csnk2a1-ps3 C T 1: 156,352,552 (GRCm39) T251I probably damaging Het
Dennd4a A G 9: 64,814,202 (GRCm39) D1473G probably damaging Het
Diaph3 A G 14: 87,274,940 (GRCm39) F172S probably benign Het
Dnajc5b A G 3: 19,629,006 (GRCm39) N100S probably benign Het
Dusp13b G A 14: 21,791,404 (GRCm39) T16I possibly damaging Het
Epb42 T G 2: 120,864,916 (GRCm39) K58N probably benign Het
Fat1 A G 8: 45,403,948 (GRCm39) Y233C probably damaging Het
Fcgbp T A 7: 27,784,460 (GRCm39) Y173* probably null Het
Fign T A 2: 63,809,506 (GRCm39) D588V probably damaging Het
Fignl2 C T 15: 100,951,188 (GRCm39) V365M unknown Het
Fnip2 A C 3: 79,415,430 (GRCm39) Y203D probably benign Het
Ftsj3 CCTTCTTCTTCTTCTTCT CCTTCTTCTTCTTCT 11: 106,143,377 (GRCm39) probably benign Het
Gfral C A 9: 76,100,572 (GRCm39) V289L probably benign Het
H2bc21 T A 3: 96,128,487 (GRCm39) probably null Het
Heatr5b G T 17: 79,103,370 (GRCm39) T1161K probably damaging Het
Hectd4 A T 5: 121,443,784 (GRCm39) I1335F possibly damaging Het
Htt T A 5: 35,040,336 (GRCm39) V2166D probably benign Het
Ipo5 G C 14: 121,170,537 (GRCm39) K436N possibly damaging Het
Iqca1l A G 5: 24,749,224 (GRCm39) L758P probably damaging Het
Itga6 A G 2: 71,671,879 (GRCm39) E794G probably damaging Het
Itga9 G A 9: 118,672,712 (GRCm39) C148Y Het
Kcnip2 A C 19: 45,785,524 (GRCm39) probably null Het
Kcnk6 T C 7: 28,925,269 (GRCm39) T116A possibly damaging Het
Kctd21 A G 7: 96,997,297 (GRCm39) I257V probably benign Het
Kif19a G A 11: 114,672,748 (GRCm39) R299Q probably damaging Het
Kifc2 G A 15: 76,548,328 (GRCm39) G391R probably benign Het
Klrg2 A G 6: 38,604,562 (GRCm39) V381A possibly damaging Het
Or13p8 T C 4: 118,584,106 (GRCm39) Y221H probably damaging Het
Or6c69 T G 10: 129,747,392 (GRCm39) S252R probably damaging Het
Or6c75 T C 10: 129,337,020 (GRCm39) V81A probably benign Het
Or7c70 T C 10: 78,683,447 (GRCm39) I101V probably benign Het
Oxsm C A 14: 16,240,925 (GRCm38) A375S possibly damaging Het
Pcdha3 T C 18: 37,081,193 (GRCm39) V645A probably damaging Het
Pcdhb15 T A 18: 37,607,788 (GRCm39) V340E possibly damaging Het
Pced1a G A 2: 130,264,435 (GRCm39) P132S probably damaging Het
Pla2r1 C T 2: 60,334,531 (GRCm39) V414M probably benign Het
Plekhg4 A C 8: 106,104,399 (GRCm39) I493L probably benign Het
Plekhj1 T A 10: 80,634,179 (GRCm39) probably benign Het
Pmfbp1 G T 8: 110,254,412 (GRCm39) K482N probably damaging Het
Ppil3 T C 1: 58,473,574 (GRCm39) N92S probably benign Het
Ppt2 A G 17: 34,844,686 (GRCm39) S156P probably benign Het
Prss41 A T 17: 24,056,087 (GRCm39) D255E probably benign Het
Psg25 T A 7: 18,255,227 (GRCm39) M430L probably benign Het
Rffl A T 11: 82,703,595 (GRCm39) C109* probably null Het
Rock2 A G 12: 17,021,111 (GRCm39) E991G probably benign Het
Rpap2 A G 5: 107,768,058 (GRCm39) I299V probably benign Het
Rras T C 7: 44,670,529 (GRCm39) S158P probably benign Het
Serpinb10 G A 1: 107,463,196 (GRCm39) probably benign Het
Smyd3 A T 1: 178,799,859 (GRCm39) I360N possibly damaging Het
Synm A G 7: 67,384,714 (GRCm39) S541P probably damaging Het
Tasor A G 14: 27,193,901 (GRCm39) T1034A probably benign Het
Tbc1d31 C A 15: 57,821,764 (GRCm39) T813K possibly damaging Het
Trav7n-4 A G 14: 53,329,103 (GRCm39) M38V probably benign Het
Tulp3 A C 6: 128,301,943 (GRCm39) N359K possibly damaging Het
Twf1 T C 15: 94,480,654 (GRCm39) K196E probably benign Het
Usp24 A T 4: 106,173,771 (GRCm39) N35Y probably damaging Het
Usp46 T A 5: 74,162,772 (GRCm39) E342D probably benign Het
Vps50 T A 6: 3,532,202 (GRCm39) probably null Het
Vps8 T A 16: 21,330,308 (GRCm39) I727N possibly damaging Het
Wdr90 C T 17: 26,065,300 (GRCm39) R1652Q probably damaging Het
Zfp11 A T 5: 129,734,027 (GRCm39) V478E possibly damaging Het
Zfp493 A G 13: 67,935,123 (GRCm39) K359E probably benign Het
Zfp536 T C 7: 37,268,126 (GRCm39) Y430C probably damaging Het
Zfpm1 A G 8: 123,063,689 (GRCm39) D916G unknown Het
Other mutations in Mob1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Mob1b APN 5 88,904,014 (GRCm39) missense probably benign 0.00
IGL01475:Mob1b APN 5 88,897,502 (GRCm39) missense probably damaging 1.00
IGL02478:Mob1b APN 5 88,903,947 (GRCm39) splice site probably benign
R0012:Mob1b UTSW 5 88,903,943 (GRCm39) splice site probably benign
R0012:Mob1b UTSW 5 88,903,943 (GRCm39) splice site probably benign
R0938:Mob1b UTSW 5 88,897,452 (GRCm39) missense probably damaging 1.00
R1081:Mob1b UTSW 5 88,901,021 (GRCm39) missense probably benign 0.00
R3500:Mob1b UTSW 5 88,897,479 (GRCm39) missense probably benign 0.00
R3890:Mob1b UTSW 5 88,901,061 (GRCm39) missense probably damaging 0.97
R3891:Mob1b UTSW 5 88,901,061 (GRCm39) missense probably damaging 0.97
R3892:Mob1b UTSW 5 88,901,061 (GRCm39) missense probably damaging 0.97
R7243:Mob1b UTSW 5 88,891,304 (GRCm39) missense probably damaging 0.96
R7302:Mob1b UTSW 5 88,901,036 (GRCm39) missense probably benign
R8101:Mob1b UTSW 5 88,901,093 (GRCm39) missense probably benign 0.10
R9160:Mob1b UTSW 5 88,904,017 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- ACATGTGCATACCTCTCTTCTGATG -3'
(R):5'- CCTTTCAGTTAAAACACTAGGTGC -3'

Sequencing Primer
(F):5'- CTTCTGATGTCATTTTTCTATTGCAG -3'
(R):5'- TTCAGTTAAAACACTAGGTGCAAAGG -3'
Posted On 2020-05-27