Incidental Mutation 'R8017:Zfp574'
ID 628810
Institutional Source Beutler Lab
Gene Symbol Zfp574
Ensembl Gene ENSMUSG00000045252
Gene Name zinc finger protein 574
Synonyms A630056B21Rik
MMRRC Submission 067457-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8017 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 24775099-24782917 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 24780095 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 372 (C372*)
Ref Sequence ENSEMBL: ENSMUSP00000057817 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053410] [ENSMUST00000179556]
AlphaFold Q8BY46
Predicted Effect probably null
Transcript: ENSMUST00000053410
AA Change: C372*
SMART Domains Protein: ENSMUSP00000057817
Gene: ENSMUSG00000045252
AA Change: C372*

DomainStartEndE-ValueType
ZnF_C2H2 16 38 4.98e-1 SMART
ZnF_C2H2 76 98 4.05e-1 SMART
low complexity region 107 118 N/A INTRINSIC
ZnF_C2H2 126 148 1.99e0 SMART
low complexity region 156 173 N/A INTRINSIC
ZnF_C2H2 213 235 4.4e-2 SMART
low complexity region 237 254 N/A INTRINSIC
low complexity region 289 298 N/A INTRINSIC
ZnF_C2H2 312 334 7.15e-2 SMART
ZnF_C2H2 339 361 1.04e-3 SMART
ZnF_C2H2 367 389 4.12e0 SMART
ZnF_C2H2 395 416 2.12e1 SMART
low complexity region 418 434 N/A INTRINSIC
ZnF_C2H2 469 492 1.03e-2 SMART
ZnF_C2H2 498 520 2.75e-3 SMART
ZnF_C2H2 526 548 3.39e-3 SMART
ZnF_C2H2 554 576 2.75e-3 SMART
ZnF_C2H2 582 604 2.86e-1 SMART
ZnF_C2H2 610 633 1.25e-1 SMART
ZnF_C2H2 639 659 4.5e1 SMART
low complexity region 660 666 N/A INTRINSIC
ZnF_C2H2 670 692 2.29e0 SMART
ZnF_C2H2 742 764 2.91e-2 SMART
ZnF_C2H2 770 792 5.59e-4 SMART
ZnF_C2H2 798 820 3.34e-2 SMART
ZnF_C2H2 826 848 4.24e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000179556
AA Change: C372*
SMART Domains Protein: ENSMUSP00000136547
Gene: ENSMUSG00000045252
AA Change: C372*

DomainStartEndE-ValueType
ZnF_C2H2 16 38 4.98e-1 SMART
ZnF_C2H2 76 98 4.05e-1 SMART
low complexity region 107 118 N/A INTRINSIC
ZnF_C2H2 126 148 1.99e0 SMART
low complexity region 156 173 N/A INTRINSIC
ZnF_C2H2 213 235 4.4e-2 SMART
low complexity region 237 254 N/A INTRINSIC
low complexity region 289 298 N/A INTRINSIC
ZnF_C2H2 312 334 7.15e-2 SMART
ZnF_C2H2 339 361 1.04e-3 SMART
ZnF_C2H2 367 389 4.12e0 SMART
ZnF_C2H2 395 416 2.12e1 SMART
low complexity region 418 434 N/A INTRINSIC
ZnF_C2H2 469 492 1.03e-2 SMART
ZnF_C2H2 498 520 2.75e-3 SMART
ZnF_C2H2 526 548 3.39e-3 SMART
ZnF_C2H2 554 576 2.75e-3 SMART
ZnF_C2H2 582 604 2.86e-1 SMART
ZnF_C2H2 610 633 1.25e-1 SMART
ZnF_C2H2 639 659 4.5e1 SMART
low complexity region 660 666 N/A INTRINSIC
ZnF_C2H2 670 692 2.29e0 SMART
ZnF_C2H2 742 764 2.91e-2 SMART
ZnF_C2H2 770 792 5.59e-4 SMART
ZnF_C2H2 798 820 3.34e-2 SMART
ZnF_C2H2 826 848 4.24e-4 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 98.9%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110065P20Rik G T 4: 124,744,469 (GRCm39) A51E unknown Het
A2ml1 C T 6: 128,558,410 (GRCm39) probably null Het
Amotl2 C T 9: 102,600,968 (GRCm39) T345I probably benign Het
Bnc2 A G 4: 84,329,662 (GRCm39) L118P Het
Ccdc18 T A 5: 108,376,511 (GRCm39) Y1317* probably null Het
Ccdc93 C T 1: 121,375,993 (GRCm39) T168M probably damaging Het
Cd109 G T 9: 78,614,828 (GRCm39) D1292Y possibly damaging Het
Cdh24 G T 14: 54,876,089 (GRCm39) N184K probably damaging Het
Clpsl2 G A 17: 28,769,702 (GRCm39) G55R probably damaging Het
Cspg4b T A 13: 113,456,157 (GRCm39) S734R Het
Efemp2 T A 19: 5,527,708 (GRCm39) C181* probably null Het
Eftud2 A G 11: 102,734,174 (GRCm39) probably null Het
Elp2 G A 18: 24,739,920 (GRCm39) V49M possibly damaging Het
Evl C T 12: 108,647,783 (GRCm39) R295* probably null Het
Exph5 G A 9: 53,284,752 (GRCm39) C611Y probably benign Het
Gm9376 T G 14: 118,504,951 (GRCm39) Y128D probably damaging Het
Gsdmc2 T A 15: 63,698,762 (GRCm39) N278I probably benign Het
Hace1 C T 10: 45,514,478 (GRCm39) T199M probably damaging Het
Hivep1 T C 13: 42,321,098 (GRCm39) V44A Het
Homez A C 14: 55,095,689 (GRCm39) D6E probably benign Het
Ighv5-12 A T 12: 113,665,792 (GRCm39) M102K probably damaging Het
Jup T C 11: 100,265,023 (GRCm39) T643A probably benign Het
Krt4 T A 15: 101,828,722 (GRCm39) I381F probably damaging Het
Krt6a A G 15: 101,602,304 (GRCm39) V127A probably damaging Het
Ldlrad4 G T 18: 68,368,740 (GRCm39) A66S possibly damaging Het
Mtfr2 A T 10: 20,229,900 (GRCm39) N153Y probably damaging Het
Npas3 G A 12: 54,091,462 (GRCm39) V339I probably damaging Het
Nsun2 C T 13: 69,775,764 (GRCm39) R438C probably damaging Het
Oga A T 19: 45,762,107 (GRCm39) W249R probably damaging Het
Or4c1 T A 2: 89,133,595 (GRCm39) I114F possibly damaging Het
Or4k47 A C 2: 111,452,412 (GRCm39) D2E probably benign Het
Or5w16 T A 2: 87,577,392 (GRCm39) M284K probably damaging Het
Pdzd2 T C 15: 12,373,122 (GRCm39) R2338G probably damaging Het
Pgm1 A G 4: 99,843,875 (GRCm39) M553V probably benign Het
Pira2 A T 7: 3,844,696 (GRCm39) F445Y probably benign Het
Ppp2r5e A G 12: 75,511,703 (GRCm39) I340T probably damaging Het
Qprt C A 7: 126,707,996 (GRCm39) R145L probably damaging Het
Sertad4 T C 1: 192,528,829 (GRCm39) D329G probably benign Het
Setd2 C T 9: 110,431,255 (GRCm39) T583M Het
Slc12a7 T C 13: 73,947,839 (GRCm39) I652T probably damaging Het
Slc27a5 T C 7: 12,723,329 (GRCm39) D539G probably damaging Het
Slc36a2 A G 11: 55,055,095 (GRCm39) I320T probably benign Het
Slc6a20a A G 9: 123,466,917 (GRCm39) Y524H probably damaging Het
Slc6a20a T A 9: 123,493,639 (GRCm39) S81C probably damaging Het
St6gal1 G A 16: 23,176,585 (GRCm39) A393T probably benign Het
Stag3 T C 5: 138,299,465 (GRCm39) M828T possibly damaging Het
Stk36 T C 1: 74,651,925 (GRCm39) V406A probably benign Het
Svep1 G T 4: 58,146,637 (GRCm39) P335Q probably damaging Het
Svs5 T A 2: 164,175,341 (GRCm39) S64R possibly damaging Het
Taf2 A G 15: 54,928,013 (GRCm39) V130A possibly damaging Het
Tbrg4 C T 11: 6,568,517 (GRCm39) V421M probably damaging Het
Tbx4 G T 11: 85,804,986 (GRCm39) K358N probably damaging Het
Tenm4 A T 7: 96,353,248 (GRCm39) T384S probably damaging Het
Tubg1 G T 11: 101,014,854 (GRCm39) A199S probably benign Het
Other mutations in Zfp574
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00228:Zfp574 APN 7 24,781,015 (GRCm39) missense probably benign 0.00
IGL02370:Zfp574 APN 7 24,779,014 (GRCm39) missense possibly damaging 0.95
IGL02706:Zfp574 APN 7 24,780,790 (GRCm39) missense probably damaging 0.98
IGL03119:Zfp574 APN 7 24,779,898 (GRCm39) missense probably benign
glue UTSW 7 24,780,515 (GRCm39) missense
BB004:Zfp574 UTSW 7 24,779,572 (GRCm39) missense probably benign
BB014:Zfp574 UTSW 7 24,779,572 (GRCm39) missense probably benign
R0866:Zfp574 UTSW 7 24,779,323 (GRCm39) missense probably damaging 1.00
R2429:Zfp574 UTSW 7 24,779,482 (GRCm39) nonsense probably null
R3123:Zfp574 UTSW 7 24,781,026 (GRCm39) missense possibly damaging 0.88
R3124:Zfp574 UTSW 7 24,781,026 (GRCm39) missense possibly damaging 0.88
R3125:Zfp574 UTSW 7 24,781,026 (GRCm39) missense possibly damaging 0.88
R4581:Zfp574 UTSW 7 24,780,738 (GRCm39) missense probably damaging 0.98
R4591:Zfp574 UTSW 7 24,778,969 (GRCm39) start gained probably benign
R4915:Zfp574 UTSW 7 24,780,151 (GRCm39) missense probably damaging 0.98
R4953:Zfp574 UTSW 7 24,780,388 (GRCm39) missense probably damaging 0.97
R5305:Zfp574 UTSW 7 24,780,515 (GRCm39) missense
R5541:Zfp574 UTSW 7 24,781,375 (GRCm39) missense probably damaging 0.99
R5934:Zfp574 UTSW 7 24,779,757 (GRCm39) missense probably benign
R6088:Zfp574 UTSW 7 24,779,764 (GRCm39) missense probably benign 0.01
R7061:Zfp574 UTSW 7 24,779,622 (GRCm39) missense possibly damaging 0.95
R7563:Zfp574 UTSW 7 24,780,777 (GRCm39) missense possibly damaging 0.94
R7615:Zfp574 UTSW 7 24,780,001 (GRCm39) missense possibly damaging 0.95
R7927:Zfp574 UTSW 7 24,779,572 (GRCm39) missense probably benign
R8019:Zfp574 UTSW 7 24,780,095 (GRCm39) nonsense probably null
R8788:Zfp574 UTSW 7 24,779,816 (GRCm39) missense unknown
R8871:Zfp574 UTSW 7 24,780,562 (GRCm39) missense probably damaging 0.99
R8915:Zfp574 UTSW 7 24,780,769 (GRCm39) missense probably damaging 1.00
R9484:Zfp574 UTSW 7 24,781,404 (GRCm39) missense possibly damaging 0.77
R9533:Zfp574 UTSW 7 24,780,379 (GRCm39) missense probably damaging 1.00
R9606:Zfp574 UTSW 7 24,780,640 (GRCm39) missense probably damaging 1.00
R9623:Zfp574 UTSW 7 24,780,515 (GRCm39) missense
X0026:Zfp574 UTSW 7 24,780,477 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGCCACCCAGGAACTATTTTG -3'
(R):5'- TGGCTCAGGAAAGCTAATAGC -3'

Sequencing Primer
(F):5'- ACCCAGGAACTATTTTGCTCTG -3'
(R):5'- CTAATAGCAGGCTCCTCTGGTG -3'
Posted On 2020-06-30