Incidental Mutation 'R8075:Cyp2c65'
ID 628995
Institutional Source Beutler Lab
Gene Symbol Cyp2c65
Ensembl Gene ENSMUSG00000067231
Gene Name cytochrome P450, family 2, subfamily c, polypeptide 65
Synonyms 2210009K14Rik
MMRRC Submission 067509-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R8075 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 39049459-39082388 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39060682 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 181 (I181V)
Ref Sequence ENSEMBL: ENSMUSP00000084489 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087236]
AlphaFold Q148B1
Predicted Effect probably benign
Transcript: ENSMUST00000087236
AA Change: I181V

PolyPhen 2 Score 0.097 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000084489
Gene: ENSMUSG00000067231
AA Change: I181V

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:p450 30 487 2.1e-160 PFAM
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 98.8%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad10 A T 5: 121,790,148 (GRCm39) H69Q probably benign Het
Aif1 T A 17: 35,390,811 (GRCm39) N87Y unknown Het
Caprin2 A T 6: 148,770,590 (GRCm39) V468E probably benign Het
Cep68 A T 11: 20,189,335 (GRCm39) V559D probably benign Het
Chrna4 A C 2: 180,680,859 (GRCm39) I3S unknown Het
Cog3 T C 14: 75,968,142 (GRCm39) Y407C probably damaging Het
Col15a1 A G 4: 47,208,359 (GRCm39) H3R probably benign Het
Ctxn1 A G 8: 4,308,553 (GRCm39) V26A probably benign Het
Cyp27b1 A C 10: 126,887,382 (GRCm39) T405P probably damaging Het
Dusp6 T A 10: 99,100,810 (GRCm39) S269T possibly damaging Het
Efcab6 A T 15: 83,851,824 (GRCm39) D351E probably damaging Het
Fam181a A T 12: 103,282,296 (GRCm39) H67L possibly damaging Het
Fbxl18 A G 5: 142,871,861 (GRCm39) L458P probably damaging Het
Flnb T C 14: 7,913,048 (GRCm38) I1439T probably benign Het
Foxj2 C T 6: 122,815,055 (GRCm39) Q364* probably null Het
Gm3138 A T 14: 4,250,532 (GRCm38) N55Y probably damaging Het
Hmcn2 A G 2: 31,279,403 (GRCm39) T1802A possibly damaging Het
Hoxc6 T C 15: 102,919,325 (GRCm39) I187T probably damaging Het
Ighg3 T A 12: 113,321,097 (GRCm39) I387F Het
Insr A T 8: 3,205,862 (GRCm39) M1309K probably benign Het
Itsn1 A T 16: 91,686,097 (GRCm39) N1290I unknown Het
Jag2 C A 12: 112,878,894 (GRCm39) R509L probably benign Het
Kctd11 T A 11: 69,771,095 (GRCm39) probably benign Het
Med13 C A 11: 86,163,296 (GRCm39) V2126F probably damaging Het
Mknk2 G A 10: 80,507,982 (GRCm39) probably benign Het
Oga A T 19: 45,749,621 (GRCm39) N699K probably damaging Het
Or52l1 T G 7: 104,830,343 (GRCm39) H74P probably damaging Het
Or5m13b A G 2: 85,754,470 (GRCm39) N286S probably benign Het
Pdzrn4 T C 15: 92,575,605 (GRCm39) V337A probably damaging Het
Pik3c3 A G 18: 30,438,082 (GRCm39) N491D probably damaging Het
Pla2g12b T A 10: 59,257,274 (GRCm39) S96T unknown Het
Rab37 G T 11: 114,982,759 (GRCm39) probably null Het
Rp9 G A 9: 22,368,788 (GRCm39) T57M probably damaging Het
Rrp12 A G 19: 41,851,713 (GRCm39) V1274A probably damaging Het
Serpinb11 G A 1: 107,298,519 (GRCm39) V57M probably damaging Het
Slc1a7 G A 4: 107,869,473 (GRCm39) V513M probably benign Het
Slc39a14 A T 14: 70,546,247 (GRCm39) I392N possibly damaging Het
Sowahb G A 5: 93,192,276 (GRCm39) Q148* probably null Het
Spon1 T C 7: 113,616,026 (GRCm39) probably null Het
Susd4 C A 1: 182,592,748 (GRCm39) T48K possibly damaging Het
Taf4b T C 18: 14,916,749 (GRCm39) V33A possibly damaging Het
Tas2r139 T A 6: 42,118,154 (GRCm39) N95K probably benign Het
Tle3 T C 9: 61,281,841 (GRCm39) M57T probably benign Het
Usp13 T A 3: 32,985,852 (GRCm39) M815K probably damaging Het
Vps8 A G 16: 21,340,644 (GRCm39) D796G probably damaging Het
Wnk1 C T 6: 119,909,675 (GRCm39) G41S probably damaging Het
Zfp867 A G 11: 59,355,066 (GRCm39) S88P probably benign Het
Other mutations in Cyp2c65
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01122:Cyp2c65 APN 19 39,060,621 (GRCm39) critical splice acceptor site probably null
IGL01124:Cyp2c65 APN 19 39,081,954 (GRCm39) utr 3 prime probably benign
IGL01895:Cyp2c65 APN 19 39,060,676 (GRCm39) missense possibly damaging 0.90
IGL02544:Cyp2c65 APN 19 39,079,082 (GRCm39) missense probably damaging 1.00
R0172:Cyp2c65 UTSW 19 39,076,100 (GRCm39) missense possibly damaging 0.86
R0378:Cyp2c65 UTSW 19 39,061,662 (GRCm39) missense probably benign 0.19
R0517:Cyp2c65 UTSW 19 39,070,792 (GRCm39) splice site probably benign
R0585:Cyp2c65 UTSW 19 39,057,686 (GRCm39) missense probably benign 0.00
R1770:Cyp2c65 UTSW 19 39,070,642 (GRCm39) missense probably benign 0.07
R2051:Cyp2c65 UTSW 19 39,070,675 (GRCm39) missense probably benign 0.12
R2310:Cyp2c65 UTSW 19 39,081,826 (GRCm39) missense probably benign 0.02
R2911:Cyp2c65 UTSW 19 39,076,126 (GRCm39) missense probably damaging 0.96
R4208:Cyp2c65 UTSW 19 39,079,099 (GRCm39) missense probably damaging 1.00
R4258:Cyp2c65 UTSW 19 39,081,872 (GRCm39) missense probably benign 0.41
R4734:Cyp2c65 UTSW 19 39,060,778 (GRCm39) missense probably benign 0.00
R4821:Cyp2c65 UTSW 19 39,060,635 (GRCm39) missense probably damaging 1.00
R4926:Cyp2c65 UTSW 19 39,049,597 (GRCm39) missense probably benign 0.00
R5060:Cyp2c65 UTSW 19 39,049,514 (GRCm39) missense unknown
R5091:Cyp2c65 UTSW 19 39,076,009 (GRCm39) critical splice acceptor site probably null
R5433:Cyp2c65 UTSW 19 39,081,928 (GRCm39) missense probably benign 0.00
R6051:Cyp2c65 UTSW 19 39,049,610 (GRCm39) missense probably benign 0.29
R6182:Cyp2c65 UTSW 19 39,049,606 (GRCm39) missense probably benign 0.18
R6400:Cyp2c65 UTSW 19 39,049,558 (GRCm39) missense possibly damaging 0.80
R6586:Cyp2c65 UTSW 19 39,070,662 (GRCm39) missense possibly damaging 0.89
R6672:Cyp2c65 UTSW 19 39,076,118 (GRCm39) missense probably damaging 1.00
R6850:Cyp2c65 UTSW 19 39,057,535 (GRCm39) missense probably benign 0.15
R8756:Cyp2c65 UTSW 19 39,049,552 (GRCm39) nonsense probably null
R9006:Cyp2c65 UTSW 19 39,070,714 (GRCm39) missense probably damaging 1.00
R9031:Cyp2c65 UTSW 19 39,061,663 (GRCm39) nonsense probably null
R9231:Cyp2c65 UTSW 19 39,060,661 (GRCm39) missense possibly damaging 0.92
R9663:Cyp2c65 UTSW 19 39,079,070 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- ACTGTTATGTCTCTCAGGCTG -3'
(R):5'- CAGCACACAGTTAAGCCTTC -3'

Sequencing Primer
(F):5'- CTCAGGCTGTGTGTGTGTATAAGAC -3'
(R):5'- CATGGAGCCTATATCTCTAAGTGG -3'
Posted On 2020-06-30