Incidental Mutation 'R8077:Muc21'
| ID |
629112 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Muc21
|
| Ensembl Gene |
ENSMUSG00000090588 |
| Gene Name |
mucin 21 |
| Synonyms |
epiglycanin, Gm9573 |
| MMRRC Submission |
067511-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.087)
|
| Stock # |
R8077 (G1)
|
| Quality Score |
115.467 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
35928815-35937529 bp(-) (GRCm39) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
TCAGTGGTGGTCAGGATGGGGGTAGAGCCTGAGCCACTCCTGGATGCAGTGGTGGTCAGG to TCAGTGGTGGTCAGG
at 35930628 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134221
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164502]
[ENSMUST00000174521]
|
| AlphaFold |
F7C950 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164502
|
| SMART Domains |
Protein: ENSMUSP00000130987
Gene: ENSMUSG00000090588
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
59 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
144 |
N/A |
INTRINSIC |
|
low complexity region
|
149 |
578 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
653 |
N/A |
INTRINSIC |
|
low complexity region
|
655 |
1179 |
N/A |
INTRINSIC |
|
low complexity region
|
1183 |
1373 |
N/A |
INTRINSIC |
|
low complexity region
|
1383 |
1436 |
N/A |
INTRINSIC |
|
low complexity region
|
1438 |
1479 |
N/A |
INTRINSIC |
|
Pfam:Epiglycanin_C
|
1518 |
1605 |
3.8e-22 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174521
|
| SMART Domains |
Protein: ENSMUSP00000134221
Gene: ENSMUSG00000090509
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:SFTA2
|
80 |
117 |
9.2e-18 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.8%
- 20x: 95.4%
|
| Validation Efficiency |
100% (60/60) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 61 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700093K21Rik |
A |
T |
11: 23,467,237 (GRCm39) |
V132E |
probably benign |
Het |
| 4930563M21Rik |
C |
T |
9: 55,895,250 (GRCm39) |
V315M |
probably damaging |
Het |
| Aadacl4fm1 |
T |
C |
4: 144,255,126 (GRCm39) |
I182T |
probably benign |
Het |
| Alb |
G |
C |
5: 90,615,214 (GRCm39) |
R242P |
probably damaging |
Het |
| Amotl1 |
A |
T |
9: 14,461,798 (GRCm39) |
V805D |
probably damaging |
Het |
| Arhgef3 |
T |
C |
14: 27,107,881 (GRCm39) |
L179P |
probably damaging |
Het |
| Atp8b3 |
G |
A |
10: 80,366,858 (GRCm39) |
L247F |
possibly damaging |
Het |
| Ccdc191 |
T |
C |
16: 43,735,968 (GRCm39) |
|
probably null |
Het |
| Celsr3 |
A |
G |
9: 108,705,530 (GRCm39) |
H671R |
probably benign |
Het |
| Cemip |
C |
A |
7: 83,652,616 (GRCm39) |
|
probably benign |
Het |
| Cfap97 |
G |
T |
8: 46,623,482 (GRCm39) |
V291F |
possibly damaging |
Het |
| Clca3a2 |
A |
G |
3: 144,777,288 (GRCm39) |
V861A |
possibly damaging |
Het |
| Cln8 |
A |
T |
8: 14,944,950 (GRCm39) |
D88V |
probably damaging |
Het |
| Col18a1 |
C |
A |
10: 76,916,685 (GRCm39) |
G330V |
unknown |
Het |
| Dis3 |
C |
T |
14: 99,327,471 (GRCm39) |
R344Q |
probably benign |
Het |
| Esyt2 |
T |
A |
12: 116,305,848 (GRCm39) |
S359R |
possibly damaging |
Het |
| Fbxo41 |
A |
T |
6: 85,450,211 (GRCm39) |
L844Q |
probably damaging |
Het |
| Fn1 |
G |
A |
1: 71,651,761 (GRCm39) |
T1372M |
probably damaging |
Het |
| Gbp5 |
G |
A |
3: 142,213,500 (GRCm39) |
R472H |
probably benign |
Het |
| Gm4559 |
C |
T |
7: 141,827,553 (GRCm39) |
R183K |
unknown |
Het |
| Gm9507 |
T |
A |
10: 77,647,604 (GRCm39) |
E25V |
unknown |
Het |
| Golgb1 |
A |
G |
16: 36,738,995 (GRCm39) |
I2486V |
probably damaging |
Het |
| Ifitm10 |
A |
T |
7: 141,924,704 (GRCm39) |
V45D |
probably damaging |
Het |
| Ift80 |
A |
G |
3: 68,823,478 (GRCm39) |
Y595H |
probably benign |
Het |
| Itga8 |
C |
T |
2: 12,247,244 (GRCm39) |
V326I |
probably benign |
Het |
| Kif14 |
A |
T |
1: 136,399,186 (GRCm39) |
H449L |
possibly damaging |
Het |
| Klrh1 |
A |
G |
6: 129,743,658 (GRCm39) |
Y209H |
probably benign |
Het |
| Ldlrad1 |
G |
A |
4: 107,066,688 (GRCm39) |
A8T |
probably benign |
Het |
| Lrrc8b |
C |
A |
5: 105,627,883 (GRCm39) |
S76R |
possibly damaging |
Het |
| Lrrn1 |
T |
C |
6: 107,545,783 (GRCm39) |
L527P |
probably damaging |
Het |
| Luc7l |
T |
C |
17: 26,474,047 (GRCm39) |
V35A |
probably damaging |
Het |
| Luzp1 |
T |
G |
4: 136,270,402 (GRCm39) |
V875G |
probably damaging |
Het |
| Mcf2l |
G |
T |
8: 13,048,494 (GRCm39) |
|
probably null |
Het |
| Mcoln2 |
T |
C |
3: 145,896,169 (GRCm39) |
M497T |
probably damaging |
Het |
| Mrgprb4 |
A |
T |
7: 47,848,203 (GRCm39) |
S242T |
probably benign |
Het |
| Nipbl |
T |
A |
15: 8,340,734 (GRCm39) |
R1995S |
possibly damaging |
Het |
| Nup35 |
A |
G |
2: 80,469,280 (GRCm39) |
|
probably null |
Het |
| Or13a17 |
C |
T |
7: 140,271,046 (GRCm39) |
S76F |
probably benign |
Het |
| Or2o1 |
A |
G |
11: 49,051,312 (GRCm39) |
D157G |
probably damaging |
Het |
| Or6k2 |
A |
G |
1: 173,979,411 (GRCm39) |
|
probably benign |
Het |
| Prdm12 |
A |
G |
2: 31,532,316 (GRCm39) |
K109E |
probably damaging |
Het |
| Ptch1 |
A |
T |
13: 63,688,626 (GRCm39) |
L444Q |
probably damaging |
Het |
| Qtrt1 |
C |
T |
9: 21,331,392 (GRCm39) |
R374* |
probably null |
Het |
| Rnase11 |
T |
C |
14: 51,287,398 (GRCm39) |
D52G |
probably damaging |
Het |
| Rps6 |
A |
G |
4: 86,774,158 (GRCm39) |
S148P |
probably benign |
Het |
| Rrm2b |
T |
C |
15: 37,947,044 (GRCm39) |
K86E |
possibly damaging |
Het |
| Sh2d1b2 |
A |
G |
1: 170,075,742 (GRCm39) |
K59E |
possibly damaging |
Het |
| Six6 |
T |
A |
12: 72,987,100 (GRCm39) |
W91R |
probably damaging |
Het |
| Slc23a2 |
C |
A |
2: 131,931,092 (GRCm39) |
A136S |
possibly damaging |
Het |
| Slc9a5 |
G |
A |
8: 106,086,012 (GRCm39) |
R593H |
probably damaging |
Het |
| Smbd1 |
T |
C |
16: 32,630,804 (GRCm39) |
M1V |
probably null |
Het |
| Ssbp4 |
T |
C |
8: 71,051,647 (GRCm39) |
Y239C |
probably damaging |
Het |
| Stox1 |
T |
C |
10: 62,501,345 (GRCm39) |
E405G |
probably damaging |
Het |
| Tle7 |
C |
T |
8: 110,836,735 (GRCm39) |
T207M |
probably damaging |
Het |
| Tmem192 |
A |
G |
8: 65,418,196 (GRCm39) |
I194V |
probably benign |
Het |
| Tns3 |
A |
T |
11: 8,395,667 (GRCm39) |
C1246S |
probably damaging |
Het |
| Ugt1a6a |
A |
T |
1: 88,066,575 (GRCm39) |
Q127L |
probably benign |
Het |
| Ush2a |
A |
G |
1: 188,275,025 (GRCm39) |
I1833V |
probably benign |
Het |
| Vmn2r66 |
A |
T |
7: 84,656,093 (GRCm39) |
Y308N |
probably benign |
Het |
| Vti1a |
T |
G |
19: 55,564,917 (GRCm39) |
L191R |
probably benign |
Het |
| Zbtb38 |
A |
T |
9: 96,570,153 (GRCm39) |
N310K |
probably benign |
Het |
|
| Other mutations in Muc21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
BB009:Muc21
|
UTSW |
17 |
35,933,525 (GRCm39) |
intron |
probably benign |
|
|
FR4304:Muc21
|
UTSW |
17 |
35,933,013 (GRCm39) |
intron |
probably benign |
|
|
R0334:Muc21
|
UTSW |
17 |
35,933,614 (GRCm39) |
intron |
probably benign |
|
|
R0946:Muc21
|
UTSW |
17 |
35,929,105 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1117:Muc21
|
UTSW |
17 |
35,930,920 (GRCm39) |
intron |
probably benign |
|
|
R1345:Muc21
|
UTSW |
17 |
35,932,489 (GRCm39) |
intron |
probably benign |
|
|
R1697:Muc21
|
UTSW |
17 |
35,931,540 (GRCm39) |
intron |
probably benign |
|
|
R1750:Muc21
|
UTSW |
17 |
35,931,940 (GRCm39) |
intron |
probably benign |
|
|
R1756:Muc21
|
UTSW |
17 |
35,930,131 (GRCm39) |
intron |
probably benign |
|
|
R1946:Muc21
|
UTSW |
17 |
35,933,416 (GRCm39) |
intron |
probably benign |
|
|
R1978:Muc21
|
UTSW |
17 |
35,933,857 (GRCm39) |
intron |
probably benign |
|
|
R1991:Muc21
|
UTSW |
17 |
35,929,600 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1992:Muc21
|
UTSW |
17 |
35,929,600 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2063:Muc21
|
UTSW |
17 |
35,932,297 (GRCm39) |
intron |
probably benign |
|
|
R2356:Muc21
|
UTSW |
17 |
35,932,563 (GRCm39) |
intron |
probably benign |
|
|
R2866:Muc21
|
UTSW |
17 |
35,930,599 (GRCm39) |
intron |
probably benign |
|
|
R3826:Muc21
|
UTSW |
17 |
35,932,504 (GRCm39) |
intron |
probably benign |
|
|
R4020:Muc21
|
UTSW |
17 |
35,930,953 (GRCm39) |
intron |
probably benign |
|
|
R4474:Muc21
|
UTSW |
17 |
35,931,496 (GRCm39) |
intron |
probably benign |
|
|
R4677:Muc21
|
UTSW |
17 |
35,930,599 (GRCm39) |
intron |
probably benign |
|
|
R4786:Muc21
|
UTSW |
17 |
35,930,221 (GRCm39) |
intron |
probably benign |
|
|
R5071:Muc21
|
UTSW |
17 |
35,931,444 (GRCm39) |
intron |
probably benign |
|
|
R5173:Muc21
|
UTSW |
17 |
35,931,633 (GRCm39) |
intron |
probably benign |
|
|
R5283:Muc21
|
UTSW |
17 |
35,932,224 (GRCm39) |
intron |
probably benign |
|
|
R5446:Muc21
|
UTSW |
17 |
35,933,395 (GRCm39) |
intron |
probably benign |
|
|
R5542:Muc21
|
UTSW |
17 |
35,933,395 (GRCm39) |
intron |
probably benign |
|
|
R5716:Muc21
|
UTSW |
17 |
35,931,675 (GRCm39) |
intron |
probably benign |
|
|
R5913:Muc21
|
UTSW |
17 |
35,934,123 (GRCm39) |
intron |
probably benign |
|
|
R6011:Muc21
|
UTSW |
17 |
35,933,074 (GRCm39) |
intron |
probably benign |
|
|
R6198:Muc21
|
UTSW |
17 |
35,931,808 (GRCm39) |
intron |
probably benign |
|
|
R6394:Muc21
|
UTSW |
17 |
35,931,058 (GRCm39) |
intron |
probably benign |
|
|
R6786:Muc21
|
UTSW |
17 |
35,934,057 (GRCm39) |
intron |
probably benign |
|
|
R6940:Muc21
|
UTSW |
17 |
35,934,118 (GRCm39) |
intron |
probably benign |
|
|
R7082:Muc21
|
UTSW |
17 |
35,932,093 (GRCm39) |
missense |
unknown |
|
|
R7103:Muc21
|
UTSW |
17 |
35,932,432 (GRCm39) |
missense |
unknown |
|
|
R7110:Muc21
|
UTSW |
17 |
35,933,510 (GRCm39) |
intron |
probably benign |
|
|
R7139:Muc21
|
UTSW |
17 |
35,933,525 (GRCm39) |
intron |
probably benign |
|
|
R7165:Muc21
|
UTSW |
17 |
35,932,870 (GRCm39) |
missense |
unknown |
|
|
R7200:Muc21
|
UTSW |
17 |
35,933,525 (GRCm39) |
intron |
probably benign |
|
|
R7204:Muc21
|
UTSW |
17 |
35,932,105 (GRCm39) |
intron |
probably benign |
|
|
R7289:Muc21
|
UTSW |
17 |
35,929,761 (GRCm39) |
missense |
unknown |
|
|
R7290:Muc21
|
UTSW |
17 |
35,929,761 (GRCm39) |
missense |
unknown |
|
|
R7295:Muc21
|
UTSW |
17 |
35,929,761 (GRCm39) |
missense |
unknown |
|
|
R7319:Muc21
|
UTSW |
17 |
35,932,935 (GRCm39) |
intron |
probably benign |
|
|
R7462:Muc21
|
UTSW |
17 |
35,931,568 (GRCm39) |
missense |
unknown |
|
|
R7529:Muc21
|
UTSW |
17 |
35,930,123 (GRCm39) |
missense |
unknown |
|
|
R7718:Muc21
|
UTSW |
17 |
35,933,728 (GRCm39) |
missense |
unknown |
|
|
R7762:Muc21
|
UTSW |
17 |
35,932,977 (GRCm39) |
missense |
unknown |
|
|
R7788:Muc21
|
UTSW |
17 |
35,929,798 (GRCm39) |
missense |
unknown |
|
|
R7798:Muc21
|
UTSW |
17 |
35,932,146 (GRCm39) |
missense |
unknown |
|
|
R7831:Muc21
|
UTSW |
17 |
35,929,651 (GRCm39) |
missense |
unknown |
|
|
R7896:Muc21
|
UTSW |
17 |
35,930,917 (GRCm39) |
missense |
unknown |
|
|
R7899:Muc21
|
UTSW |
17 |
35,931,493 (GRCm39) |
intron |
probably benign |
|
|
R7932:Muc21
|
UTSW |
17 |
35,933,525 (GRCm39) |
intron |
probably benign |
|
|
R8025:Muc21
|
UTSW |
17 |
35,931,879 (GRCm39) |
intron |
probably benign |
|
|
R8090:Muc21
|
UTSW |
17 |
35,932,617 (GRCm39) |
missense |
unknown |
|
|
R8169:Muc21
|
UTSW |
17 |
35,932,072 (GRCm39) |
missense |
unknown |
|
|
R8184:Muc21
|
UTSW |
17 |
35,933,722 (GRCm39) |
missense |
unknown |
|
|
R8209:Muc21
|
UTSW |
17 |
35,930,599 (GRCm39) |
intron |
probably benign |
|
|
R8226:Muc21
|
UTSW |
17 |
35,930,599 (GRCm39) |
intron |
probably benign |
|
|
R8464:Muc21
|
UTSW |
17 |
35,933,098 (GRCm39) |
intron |
probably benign |
|
|
R8670:Muc21
|
UTSW |
17 |
35,932,540 (GRCm39) |
missense |
unknown |
|
|
R8783:Muc21
|
UTSW |
17 |
35,930,875 (GRCm39) |
missense |
unknown |
|
|
R8856:Muc21
|
UTSW |
17 |
35,931,865 (GRCm39) |
missense |
unknown |
|
|
R9155:Muc21
|
UTSW |
17 |
35,932,131 (GRCm39) |
missense |
unknown |
|
|
R9214:Muc21
|
UTSW |
17 |
35,931,838 (GRCm39) |
missense |
unknown |
|
|
R9353:Muc21
|
UTSW |
17 |
35,930,545 (GRCm39) |
missense |
unknown |
|
|
R9618:Muc21
|
UTSW |
17 |
35,932,935 (GRCm39) |
intron |
probably benign |
|
|
R9621:Muc21
|
UTSW |
17 |
35,932,720 (GRCm39) |
missense |
unknown |
|
|
R9679:Muc21
|
UTSW |
17 |
35,930,491 (GRCm39) |
missense |
unknown |
|
|
RF025:Muc21
|
UTSW |
17 |
35,933,771 (GRCm39) |
intron |
probably benign |
|
|
Z1176:Muc21
|
UTSW |
17 |
35,932,137 (GRCm39) |
missense |
unknown |
|
|
Z1177:Muc21
|
UTSW |
17 |
35,931,951 (GRCm39) |
missense |
unknown |
|
|
Z1177:Muc21
|
UTSW |
17 |
35,931,817 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGCAGTGCTAGATTCAGTGG -3'
(R):5'- TGAATCCAGCACTGCCTCAG -3'
Sequencing Primer
(F):5'- CAGTGCTAGATTCAGTGGTGGTC -3'
(R):5'- TCAGGCTCTACACCTACCCGG -3'
|
| Posted On |
2020-06-30 |
Incidental Mutation