Mutagenetix > Incidental Mutation

Incidental Mutation 'R8079:Or7g17'

629212

Institutional Source

Beutler Lab

Gene Symbol

Or7g17

Ensembl Gene

ENSMUSG00000051414

Gene Name

olfactory receptor family 7 subfamily G member 17

Synonyms

Olfr829, GA_x6K02T2PVTD-12599710-12600648, MOR147-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.231) question?

Stock #

R8079 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

18767923-18768888 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 18768725 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 259 (Y259F)

Ref Sequence

ENSEMBL: ENSMUSP00000148395 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058411] [ENSMUST00000212229]

AlphaFold

Q8VGX1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000058411
AA Change: Y268F

PolyPhen 2 Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000058101
Gene: ENSMUSG00000051414
AA Change: Y268F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	40	317	2e-52	PFAM
Pfam:7TM_GPCR_Srsx	44	174	1e-10	PFAM
Pfam:7tm_1	50	299	1.6e-21	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000212229
AA Change: Y259F

PolyPhen 2 Score 0.544 (Sensitivity: 0.88; Specificity: 0.91)

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 99.0%
20x: 96.5%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 86 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb9	A	G	5: 124,221,186 (GRCm39)	I255T	possibly damaging	Het
Ablim1	A	T	19: 57,170,656 (GRCm39)		probably null	Het
Akap10	G	A	11: 61,820,880 (GRCm39)	P8L	possibly damaging	Het
Ankle2	C	T	5: 110,379,182 (GRCm39)	A27V	probably damaging	Het
Anxa8	A	G	14: 33,816,769 (GRCm39)	T246A	probably benign	Het
Arhgap5	A	G	12: 52,613,988 (GRCm39)	N1460S	probably benign	Het
Arid5b	T	G	10: 67,934,186 (GRCm39)	D572A	possibly damaging	Het
Atrn	T	A	2: 130,855,561 (GRCm39)	L1278Q	probably null	Het
AU040320	G	T	4: 126,725,953 (GRCm39)	K454N	possibly damaging	Het
Baz2b	T	A	2: 59,731,112 (GRCm39)	R2085W	probably damaging	Het
Bbx	A	T	16: 50,030,821 (GRCm39)	N649K	probably damaging	Het
BC034090	G	A	1: 155,101,032 (GRCm39)	P411S	probably damaging	Het
Calcoco2	A	T	11: 95,998,363 (GRCm39)	F20Y	probably damaging	Het
Carmil2	A	G	8: 106,413,393 (GRCm39)	R50G	probably damaging	Het
Catspere2	A	G	1: 177,874,525 (GRCm39)	T131A	probably benign	Het
Cdcp1	C	A	9: 123,002,855 (GRCm39)	V739L	probably damaging	Het
Chit1	A	G	1: 134,071,765 (GRCm39)	T92A	possibly damaging	Het
Clstn3	A	G	6: 124,436,763 (GRCm39)	I185T	probably damaging	Het
Dctpp1	C	A	7: 126,858,561 (GRCm39)	V61L	probably damaging	Het
Dip2a	T	C	10: 76,123,155 (GRCm39)	T760A	probably benign	Het
Dock10	C	T	1: 80,556,421 (GRCm39)	V552I	probably benign	Het
Dpp8	A	G	9: 64,951,017 (GRCm39)	E151G	probably damaging	Het
Dvl2	G	C	11: 69,898,344 (GRCm39)	R367P	possibly damaging	Het
Fem1b	A	T	9: 62,703,643 (GRCm39)	I539N	probably damaging	Het
Frat2	A	T	19: 41,836,277 (GRCm39)	L25H	probably damaging	Het
Garnl3	A	T	2: 32,908,511 (GRCm39)		probably null	Het
Gh	T	C	11: 106,192,253 (GRCm39)	H47R	possibly damaging	Het
Glmp	T	C	3: 88,233,045 (GRCm39)	V61A	probably damaging	Het
Gm9925	T	C	18: 74,198,558 (GRCm39)	V129A	unknown	Het
H2-M9	T	A	17: 36,953,025 (GRCm39)	E94V	probably benign	Het
Hira	A	T	16: 18,744,507 (GRCm39)	Q408L	probably benign	Het
Hook3	A	G	8: 26,578,086 (GRCm39)		probably null	Het
Ifi206	G	A	1: 173,308,724 (GRCm39)	P424L		Het
Impdh2	T	C	9: 108,440,524 (GRCm39)	V270A	probably benign	Het
Klhl14	A	G	18: 21,785,022 (GRCm39)	I135T	probably benign	Het
Klra10	C	A	6: 130,252,738 (GRCm39)	V179L	probably benign	Het
Kmt2c	T	C	5: 25,507,730 (GRCm39)	S3236G	probably damaging	Het
Krt76	G	T	15: 101,796,825 (GRCm39)	A358D	possibly damaging	Het
Lacc1	C	A	14: 77,266,992 (GRCm39)	G424C	probably damaging	Het
Limch1	A	G	5: 67,204,096 (GRCm39)	I878V	possibly damaging	Het
Lipi	C	T	16: 75,362,418 (GRCm39)		probably null	Het
Lrrc17	C	T	5: 21,766,069 (GRCm39)	R184W	probably damaging	Het
Mllt10	A	G	2: 18,128,567 (GRCm39)	N183D	probably damaging	Het
Mterf2	C	T	10: 84,956,027 (GRCm39)	G199D	probably damaging	Het
Mucl3	T	C	17: 35,949,084 (GRCm39)	T172A	unknown	Het
Nat8f4	A	T	6: 85,877,976 (GRCm39)	S182R	probably benign	Het
Ndrg3	C	A	2: 156,779,452 (GRCm39)	E238*	probably null	Het
Nop14	A	T	5: 34,811,805 (GRCm39)	L194H	probably damaging	Het
Obscn	T	C	11: 58,972,731 (GRCm39)	E2105G	possibly damaging	Het
Or5b104	A	C	19: 13,072,648 (GRCm39)	Y121*	probably null	Het
Or5g9	A	T	2: 85,552,387 (GRCm39)	T213S	probably benign	Het
Or8k32	T	A	2: 86,368,725 (GRCm39)	H176L	possibly damaging	Het
Pbx3	C	T	2: 34,068,240 (GRCm39)	A320T	probably benign	Het
Pcdhac2	A	T	18: 37,279,197 (GRCm39)	S726C	probably damaging	Het
Pcdhgb2	A	G	18: 37,823,816 (GRCm39)	D269G	probably damaging	Het
Pcgf6	A	T	19: 47,034,271 (GRCm39)	S257T	probably damaging	Het
Pclo	A	T	5: 14,590,472 (GRCm39)	H924L	unknown	Het
Per3	T	A	4: 151,127,135 (GRCm39)	T129S	possibly damaging	Het
Pi4ka	A	T	16: 17,120,924 (GRCm39)	M1270K		Het
Plec	G	A	15: 76,063,750 (GRCm39)	Q2277*	probably null	Het
Pnma1	T	A	12: 84,194,109 (GRCm39)	K198M	probably damaging	Het
Prc1	T	A	7: 79,954,515 (GRCm39)	F196L	possibly damaging	Het
Prkcz	T	C	4: 155,441,962 (GRCm39)	T57A	probably damaging	Het
Repin1	G	T	6: 48,574,279 (GRCm39)	E403*	probably null	Het
Robo4	A	G	9: 37,313,931 (GRCm39)	M61V	possibly damaging	Het
Rps12	C	T	10: 23,661,575 (GRCm39)	V79I	probably benign	Het
Rsph3a	A	G	17: 8,198,020 (GRCm39)	K466E	probably benign	Het
Scly	A	T	1: 91,236,089 (GRCm39)	I168F	probably damaging	Het
Setd1a	T	A	7: 127,384,225 (GRCm39)	F359I	unknown	Het
Sh3tc1	A	G	5: 35,864,201 (GRCm39)	L662P	possibly damaging	Het
Slc12a5	T	C	2: 164,834,372 (GRCm39)	W798R	probably damaging	Het
Slc16a6	C	T	11: 109,364,281 (GRCm39)	R13Q	unknown	Het
Slco1a8	T	G	6: 141,933,460 (GRCm39)	M462L	probably benign	Het
Smarcad1	A	G	6: 65,029,766 (GRCm39)	D118G	possibly damaging	Het
Sos2	T	C	12: 69,653,989 (GRCm39)	T788A	probably damaging	Het
Syvn1	A	G	19: 6,098,396 (GRCm39)	E75G	probably null	Het
Thpo	T	C	16: 20,545,144 (GRCm39)	E103G	probably benign	Het
Trav7d-3	A	T	14: 52,982,193 (GRCm39)	E78V	possibly damaging	Het
Uap1	A	G	1: 169,986,332 (GRCm39)	S217P	probably damaging	Het
Unc45a	T	G	7: 79,981,310 (GRCm39)	R497S	probably damaging	Het
Upf1	A	G	8: 70,791,534 (GRCm39)		probably null	Het
Usp47	A	T	7: 111,646,177 (GRCm39)	K28M	probably damaging	Het
Wdr72	A	C	9: 74,126,054 (GRCm39)	T1062P	probably damaging	Het
Wnt7b	A	T	15: 85,421,646 (GRCm39)	C339S	probably damaging	Het
Zfp954	G	T	7: 7,118,470 (GRCm39)	T358K	probably benign	Het
Zmynd15	G	T	11: 70,350,278 (GRCm39)		probably benign	Het

Other mutations in Or7g17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01142:Or7g17	APN	9	18,768,830 (GRCm39)	missense	probably damaging	0.97
IGL01696:Or7g17	APN	9	18,768,352 (GRCm39)	missense	probably benign	0.19
IGL02285:Or7g17	APN	9	18,768,286 (GRCm39)	missense	possibly damaging	0.87
R0133:Or7g17	UTSW	9	18,767,925 (GRCm39)	start codon destroyed	probably null
R0173:Or7g17	UTSW	9	18,768,325 (GRCm39)	missense	probably damaging	0.98
R0270:Or7g17	UTSW	9	18,768,127 (GRCm39)	missense	probably damaging	1.00
R0449:Or7g17	UTSW	9	18,767,945 (GRCm39)	missense	probably benign	0.00
R1111:Or7g17	UTSW	9	18,768,888 (GRCm39)	makesense	probably null
R1462:Or7g17	UTSW	9	18,768,407 (GRCm39)	missense	probably benign	0.30
R1462:Or7g17	UTSW	9	18,768,407 (GRCm39)	missense	probably benign	0.30
R1845:Or7g17	UTSW	9	18,768,782 (GRCm39)	missense	possibly damaging	0.95
R4090:Or7g17	UTSW	9	18,768,398 (GRCm39)	missense	probably benign	0.00
R4096:Or7g17	UTSW	9	18,767,933 (GRCm39)	missense	probably benign
R4097:Or7g17	UTSW	9	18,767,933 (GRCm39)	missense	probably benign
R4755:Or7g17	UTSW	9	18,768,476 (GRCm39)	missense	probably benign	0.03
R4867:Or7g17	UTSW	9	18,768,862 (GRCm39)	missense	probably benign	0.00
R5084:Or7g17	UTSW	9	18,768,632 (GRCm39)	missense	probably benign	0.43
R7216:Or7g17	UTSW	9	18,768,632 (GRCm39)	missense	probably benign	0.43
R7252:Or7g17	UTSW	9	18,768,548 (GRCm39)	missense	probably damaging	1.00
R7300:Or7g17	UTSW	9	18,768,530 (GRCm39)	missense	not run
R7412:Or7g17	UTSW	9	18,768,085 (GRCm39)	missense	possibly damaging	0.51
R9083:Or7g17	UTSW	9	18,768,550 (GRCm39)	missense	probably benign	0.00
R9648:Or7g17	UTSW	9	18,768,748 (GRCm39)	missense	possibly damaging	0.84
X0024:Or7g17	UTSW	9	18,768,320 (GRCm39)	missense	probably damaging	1.00
X0057:Or7g17	UTSW	9	18,767,933 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- GTTCCAACACTCTTATTGACAACATAC -3'
(R):5'- CAACTATGTTTCCTTGGCTTACTTAAG -3'

Sequencing Primer
(F):5'- TGCAACCACTGTCTTGA -3'
(R):5'- GTTTCCTTGGCTTACTTAAGAAATTC -3'

Posted On

2020-06-30