Incidental Mutation 'R8079:Robo4'
| ID |
629213 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo4
|
| Ensembl Gene |
ENSMUSG00000032125 |
| Gene Name |
roundabout guidance receptor 4 |
| Synonyms |
Magic roundabout, 1200012D01Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.224)
|
| Stock # |
R8079 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
37313198-37325319 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 37313931 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 61
(M61V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150722
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102895]
[ENSMUST00000115046]
[ENSMUST00000115048]
[ENSMUST00000156972]
[ENSMUST00000214185]
|
| AlphaFold |
Q8C310 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000102895
AA Change: M61V
PolyPhen 2
Score 0.851 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000099959
Gene: ENSMUSG00000032125
AA Change: M61V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
748 |
762 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
799 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
866 |
N/A |
INTRINSIC |
|
low complexity region
|
871 |
880 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000115046
AA Change: M61V
PolyPhen 2
Score 0.851 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000110698
Gene: ENSMUSG00000032125
AA Change: M61V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
484 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
540 |
546 |
N/A |
INTRINSIC |
|
low complexity region
|
596 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
756 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
821 |
N/A |
INTRINSIC |
|
low complexity region
|
834 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
914 |
925 |
N/A |
INTRINSIC |
|
low complexity region
|
930 |
939 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000115048
|
| SMART Domains |
Protein: ENSMUSP00000110700
Gene: ENSMUSG00000032125
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
695 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
727 |
740 |
N/A |
INTRINSIC |
|
low complexity region
|
755 |
769 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
806 |
N/A |
INTRINSIC |
|
low complexity region
|
862 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
887 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000156972
AA Change: M61V
PolyPhen 2
Score 0.756 (Sensitivity: 0.85; Specificity: 0.92)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000214185
AA Change: M61V
PolyPhen 2
Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 99.0%
- 20x: 96.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a reporter/null allele display enhanced VEGF-induced endothelial migration, tube formation and vascular permeability, and show increased pathologic angiogenesis and vascular leak in models of oxygen-induced retinopathy and choroidal neovascularization. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb9 |
A |
G |
5: 124,221,186 (GRCm39) |
I255T |
possibly damaging |
Het |
| Ablim1 |
A |
T |
19: 57,170,656 (GRCm39) |
|
probably null |
Het |
| Akap10 |
G |
A |
11: 61,820,880 (GRCm39) |
P8L |
possibly damaging |
Het |
| Ankle2 |
C |
T |
5: 110,379,182 (GRCm39) |
A27V |
probably damaging |
Het |
| Anxa8 |
A |
G |
14: 33,816,769 (GRCm39) |
T246A |
probably benign |
Het |
| Arhgap5 |
A |
G |
12: 52,613,988 (GRCm39) |
N1460S |
probably benign |
Het |
| Arid5b |
T |
G |
10: 67,934,186 (GRCm39) |
D572A |
possibly damaging |
Het |
| Atrn |
T |
A |
2: 130,855,561 (GRCm39) |
L1278Q |
probably null |
Het |
| AU040320 |
G |
T |
4: 126,725,953 (GRCm39) |
K454N |
possibly damaging |
Het |
| Baz2b |
T |
A |
2: 59,731,112 (GRCm39) |
R2085W |
probably damaging |
Het |
| Bbx |
A |
T |
16: 50,030,821 (GRCm39) |
N649K |
probably damaging |
Het |
| BC034090 |
G |
A |
1: 155,101,032 (GRCm39) |
P411S |
probably damaging |
Het |
| Calcoco2 |
A |
T |
11: 95,998,363 (GRCm39) |
F20Y |
probably damaging |
Het |
| Carmil2 |
A |
G |
8: 106,413,393 (GRCm39) |
R50G |
probably damaging |
Het |
| Catspere2 |
A |
G |
1: 177,874,525 (GRCm39) |
T131A |
probably benign |
Het |
| Cdcp1 |
C |
A |
9: 123,002,855 (GRCm39) |
V739L |
probably damaging |
Het |
| Chit1 |
A |
G |
1: 134,071,765 (GRCm39) |
T92A |
possibly damaging |
Het |
| Clstn3 |
A |
G |
6: 124,436,763 (GRCm39) |
I185T |
probably damaging |
Het |
| Dctpp1 |
C |
A |
7: 126,858,561 (GRCm39) |
V61L |
probably damaging |
Het |
| Dip2a |
T |
C |
10: 76,123,155 (GRCm39) |
T760A |
probably benign |
Het |
| Dock10 |
C |
T |
1: 80,556,421 (GRCm39) |
V552I |
probably benign |
Het |
| Dpp8 |
A |
G |
9: 64,951,017 (GRCm39) |
E151G |
probably damaging |
Het |
| Dvl2 |
G |
C |
11: 69,898,344 (GRCm39) |
R367P |
possibly damaging |
Het |
| Fem1b |
A |
T |
9: 62,703,643 (GRCm39) |
I539N |
probably damaging |
Het |
| Frat2 |
A |
T |
19: 41,836,277 (GRCm39) |
L25H |
probably damaging |
Het |
| Garnl3 |
A |
T |
2: 32,908,511 (GRCm39) |
|
probably null |
Het |
| Gh |
T |
C |
11: 106,192,253 (GRCm39) |
H47R |
possibly damaging |
Het |
| Glmp |
T |
C |
3: 88,233,045 (GRCm39) |
V61A |
probably damaging |
Het |
| Gm9925 |
T |
C |
18: 74,198,558 (GRCm39) |
V129A |
unknown |
Het |
| H2-M9 |
T |
A |
17: 36,953,025 (GRCm39) |
E94V |
probably benign |
Het |
| Hira |
A |
T |
16: 18,744,507 (GRCm39) |
Q408L |
probably benign |
Het |
| Hook3 |
A |
G |
8: 26,578,086 (GRCm39) |
|
probably null |
Het |
| Ifi206 |
G |
A |
1: 173,308,724 (GRCm39) |
P424L |
|
Het |
| Impdh2 |
T |
C |
9: 108,440,524 (GRCm39) |
V270A |
probably benign |
Het |
| Klhl14 |
A |
G |
18: 21,785,022 (GRCm39) |
I135T |
probably benign |
Het |
| Klra10 |
C |
A |
6: 130,252,738 (GRCm39) |
V179L |
probably benign |
Het |
| Kmt2c |
T |
C |
5: 25,507,730 (GRCm39) |
S3236G |
probably damaging |
Het |
| Krt76 |
G |
T |
15: 101,796,825 (GRCm39) |
A358D |
possibly damaging |
Het |
| Lacc1 |
C |
A |
14: 77,266,992 (GRCm39) |
G424C |
probably damaging |
Het |
| Limch1 |
A |
G |
5: 67,204,096 (GRCm39) |
I878V |
possibly damaging |
Het |
| Lipi |
C |
T |
16: 75,362,418 (GRCm39) |
|
probably null |
Het |
| Lrrc17 |
C |
T |
5: 21,766,069 (GRCm39) |
R184W |
probably damaging |
Het |
| Mllt10 |
A |
G |
2: 18,128,567 (GRCm39) |
N183D |
probably damaging |
Het |
| Mterf2 |
C |
T |
10: 84,956,027 (GRCm39) |
G199D |
probably damaging |
Het |
| Mucl3 |
T |
C |
17: 35,949,084 (GRCm39) |
T172A |
unknown |
Het |
| Nat8f4 |
A |
T |
6: 85,877,976 (GRCm39) |
S182R |
probably benign |
Het |
| Ndrg3 |
C |
A |
2: 156,779,452 (GRCm39) |
E238* |
probably null |
Het |
| Nop14 |
A |
T |
5: 34,811,805 (GRCm39) |
L194H |
probably damaging |
Het |
| Obscn |
T |
C |
11: 58,972,731 (GRCm39) |
E2105G |
possibly damaging |
Het |
| Or5b104 |
A |
C |
19: 13,072,648 (GRCm39) |
Y121* |
probably null |
Het |
| Or5g9 |
A |
T |
2: 85,552,387 (GRCm39) |
T213S |
probably benign |
Het |
| Or7g17 |
A |
T |
9: 18,768,725 (GRCm39) |
Y259F |
possibly damaging |
Het |
| Or8k32 |
T |
A |
2: 86,368,725 (GRCm39) |
H176L |
possibly damaging |
Het |
| Pbx3 |
C |
T |
2: 34,068,240 (GRCm39) |
A320T |
probably benign |
Het |
| Pcdhac2 |
A |
T |
18: 37,279,197 (GRCm39) |
S726C |
probably damaging |
Het |
| Pcdhgb2 |
A |
G |
18: 37,823,816 (GRCm39) |
D269G |
probably damaging |
Het |
| Pcgf6 |
A |
T |
19: 47,034,271 (GRCm39) |
S257T |
probably damaging |
Het |
| Pclo |
A |
T |
5: 14,590,472 (GRCm39) |
H924L |
unknown |
Het |
| Per3 |
T |
A |
4: 151,127,135 (GRCm39) |
T129S |
possibly damaging |
Het |
| Pi4ka |
A |
T |
16: 17,120,924 (GRCm39) |
M1270K |
|
Het |
| Plec |
G |
A |
15: 76,063,750 (GRCm39) |
Q2277* |
probably null |
Het |
| Pnma1 |
T |
A |
12: 84,194,109 (GRCm39) |
K198M |
probably damaging |
Het |
| Prc1 |
T |
A |
7: 79,954,515 (GRCm39) |
F196L |
possibly damaging |
Het |
| Prkcz |
T |
C |
4: 155,441,962 (GRCm39) |
T57A |
probably damaging |
Het |
| Repin1 |
G |
T |
6: 48,574,279 (GRCm39) |
E403* |
probably null |
Het |
| Rps12 |
C |
T |
10: 23,661,575 (GRCm39) |
V79I |
probably benign |
Het |
| Rsph3a |
A |
G |
17: 8,198,020 (GRCm39) |
K466E |
probably benign |
Het |
| Scly |
A |
T |
1: 91,236,089 (GRCm39) |
I168F |
probably damaging |
Het |
| Setd1a |
T |
A |
7: 127,384,225 (GRCm39) |
F359I |
unknown |
Het |
| Sh3tc1 |
A |
G |
5: 35,864,201 (GRCm39) |
L662P |
possibly damaging |
Het |
| Slc12a5 |
T |
C |
2: 164,834,372 (GRCm39) |
W798R |
probably damaging |
Het |
| Slc16a6 |
C |
T |
11: 109,364,281 (GRCm39) |
R13Q |
unknown |
Het |
| Slco1a8 |
T |
G |
6: 141,933,460 (GRCm39) |
M462L |
probably benign |
Het |
| Smarcad1 |
A |
G |
6: 65,029,766 (GRCm39) |
D118G |
possibly damaging |
Het |
| Sos2 |
T |
C |
12: 69,653,989 (GRCm39) |
T788A |
probably damaging |
Het |
| Syvn1 |
A |
G |
19: 6,098,396 (GRCm39) |
E75G |
probably null |
Het |
| Thpo |
T |
C |
16: 20,545,144 (GRCm39) |
E103G |
probably benign |
Het |
| Trav7d-3 |
A |
T |
14: 52,982,193 (GRCm39) |
E78V |
possibly damaging |
Het |
| Uap1 |
A |
G |
1: 169,986,332 (GRCm39) |
S217P |
probably damaging |
Het |
| Unc45a |
T |
G |
7: 79,981,310 (GRCm39) |
R497S |
probably damaging |
Het |
| Upf1 |
A |
G |
8: 70,791,534 (GRCm39) |
|
probably null |
Het |
| Usp47 |
A |
T |
7: 111,646,177 (GRCm39) |
K28M |
probably damaging |
Het |
| Wdr72 |
A |
C |
9: 74,126,054 (GRCm39) |
T1062P |
probably damaging |
Het |
| Wnt7b |
A |
T |
15: 85,421,646 (GRCm39) |
C339S |
probably damaging |
Het |
| Zfp954 |
G |
T |
7: 7,118,470 (GRCm39) |
T358K |
probably benign |
Het |
| Zmynd15 |
G |
T |
11: 70,350,278 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Robo4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Robo4
|
APN |
9 |
37,322,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00392:Robo4
|
APN |
9 |
37,319,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00491:Robo4
|
APN |
9 |
37,317,231 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL00792:Robo4
|
APN |
9 |
37,319,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01062:Robo4
|
APN |
9 |
37,317,296 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01287:Robo4
|
APN |
9 |
37,324,336 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02289:Robo4
|
APN |
9 |
37,319,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02486:Robo4
|
APN |
9 |
37,319,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02851:Robo4
|
APN |
9 |
37,324,678 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02898:Robo4
|
APN |
9 |
37,319,472 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02965:Robo4
|
APN |
9 |
37,321,765 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03071:Robo4
|
APN |
9 |
37,315,580 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Robo4
|
APN |
9 |
37,315,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8562:Robo4
|
UTSW |
9 |
37,317,106 (GRCm39) |
intron |
probably benign |
|
|
PIT4305001:Robo4
|
UTSW |
9 |
37,322,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0068:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0416:Robo4
|
UTSW |
9 |
37,316,062 (GRCm39) |
splice site |
probably benign |
|
|
R1005:Robo4
|
UTSW |
9 |
37,319,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1174:Robo4
|
UTSW |
9 |
37,324,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1183:Robo4
|
UTSW |
9 |
37,319,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1254:Robo4
|
UTSW |
9 |
37,322,136 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1398:Robo4
|
UTSW |
9 |
37,319,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1505:Robo4
|
UTSW |
9 |
37,314,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Robo4
|
UTSW |
9 |
37,314,739 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1834:Robo4
|
UTSW |
9 |
37,324,355 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1899:Robo4
|
UTSW |
9 |
37,315,366 (GRCm39) |
splice site |
probably benign |
|
|
R2203:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2204:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2351:Robo4
|
UTSW |
9 |
37,322,956 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2448:Robo4
|
UTSW |
9 |
37,313,958 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2847:Robo4
|
UTSW |
9 |
37,315,772 (GRCm39) |
nonsense |
probably null |
|
|
R2851:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2852:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2877:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3123:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3124:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3125:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3805:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3806:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3892:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3905:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R3938:Robo4
|
UTSW |
9 |
37,313,313 (GRCm39) |
start gained |
probably benign |
|
|
R4261:Robo4
|
UTSW |
9 |
37,316,877 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4434:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4435:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4561:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4562:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4568:Robo4
|
UTSW |
9 |
37,316,118 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4695:Robo4
|
UTSW |
9 |
37,314,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4921:Robo4
|
UTSW |
9 |
37,313,856 (GRCm39) |
missense |
probably benign |
|
|
R5000:Robo4
|
UTSW |
9 |
37,319,664 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5056:Robo4
|
UTSW |
9 |
37,316,102 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5125:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5178:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5279:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5285:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5347:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5348:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5361:Robo4
|
UTSW |
9 |
37,324,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5403:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5404:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5488:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5489:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5490:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5494:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5629:Robo4
|
UTSW |
9 |
37,319,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5736:Robo4
|
UTSW |
9 |
37,316,093 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5796:Robo4
|
UTSW |
9 |
37,322,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5987:Robo4
|
UTSW |
9 |
37,322,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6178:Robo4
|
UTSW |
9 |
37,316,926 (GRCm39) |
nonsense |
probably null |
|
|
R6189:Robo4
|
UTSW |
9 |
37,314,829 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6365:Robo4
|
UTSW |
9 |
37,322,008 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6528:Robo4
|
UTSW |
9 |
37,315,664 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6887:Robo4
|
UTSW |
9 |
37,313,363 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7196:Robo4
|
UTSW |
9 |
37,314,001 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7408:Robo4
|
UTSW |
9 |
37,322,277 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7419:Robo4
|
UTSW |
9 |
37,314,105 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7486:Robo4
|
UTSW |
9 |
37,316,870 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7707:Robo4
|
UTSW |
9 |
37,324,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7839:Robo4
|
UTSW |
9 |
37,322,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8081:Robo4
|
UTSW |
9 |
37,316,936 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8280:Robo4
|
UTSW |
9 |
37,315,372 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8526:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R8547:Robo4
|
UTSW |
9 |
37,315,674 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8735:Robo4
|
UTSW |
9 |
37,319,577 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8836:Robo4
|
UTSW |
9 |
37,317,130 (GRCm39) |
missense |
unknown |
|
|
R8889:Robo4
|
UTSW |
9 |
37,314,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9018:Robo4
|
UTSW |
9 |
37,315,520 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Robo4
|
UTSW |
9 |
37,313,206 (GRCm39) |
start gained |
probably benign |
|
|
R9375:Robo4
|
UTSW |
9 |
37,316,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9621:Robo4
|
UTSW |
9 |
37,317,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGGACTCAGACCTTCTCCC -3'
(R):5'- CCAGGATTGCTGAGAGGATG -3'
Sequencing Primer
(F):5'- AGACCTTCTCCCCTCCTAGTTAG -3'
(R):5'- CTGAGAGGATGTTCTGGTCATC -3'
|
| Posted On |
2020-06-30 |
Incidental Mutation