Incidental Mutation 'R8080:Zfp600'
ID 629271
Institutional Source Beutler Lab
Gene Symbol Zfp600
Ensembl Gene ENSMUSG00000066007
Gene Name zinc finger protein 600
Synonyms Gm13164
MMRRC Submission 067513-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.271) question?
Stock # R8080 (G1)
Quality Score 181.009
Status Not validated
Chromosome 4
Chromosomal Location 146093397-146135326 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 146133182 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 617 (C617S)
Ref Sequence ENSEMBL: ENSMUSP00000090425 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092750] [ENSMUST00000131932] [ENSMUST00000168483]
AlphaFold A2A7V0
Predicted Effect unknown
Transcript: ENSMUST00000092750
AA Change: C617S
SMART Domains Protein: ENSMUSP00000090425
Gene: ENSMUSG00000066007
AA Change: C617S

DomainStartEndE-ValueType
KRAB 28 90 1.29e-17 SMART
ZnF_C2H2 251 273 7.9e-4 SMART
ZnF_C2H2 279 301 7.9e-4 SMART
ZnF_C2H2 307 329 3.49e-5 SMART
ZnF_C2H2 335 357 1.95e-3 SMART
ZnF_C2H2 363 385 7.9e-4 SMART
ZnF_C2H2 391 413 7.9e-4 SMART
ZnF_C2H2 419 441 3.49e-5 SMART
ZnF_C2H2 447 469 3.89e-3 SMART
ZnF_C2H2 475 497 2.75e-3 SMART
ZnF_C2H2 503 525 3.04e-5 SMART
ZnF_C2H2 531 553 8.34e-3 SMART
ZnF_C2H2 559 581 5.67e-5 SMART
ZnF_C2H2 587 609 1.98e-4 SMART
ZnF_C2H2 615 637 5.29e-5 SMART
ZnF_C2H2 643 665 1.58e-3 SMART
ZnF_C2H2 671 693 1.28e-3 SMART
ZnF_C2H2 699 721 1.6e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131932
SMART Domains Protein: ENSMUSP00000117892
Gene: ENSMUSG00000066007

DomainStartEndE-ValueType
KRAB 28 90 1.29e-17 SMART
Predicted Effect unknown
Transcript: ENSMUST00000168483
AA Change: C617S
SMART Domains Protein: ENSMUSP00000126879
Gene: ENSMUSG00000066007
AA Change: C617S

DomainStartEndE-ValueType
KRAB 28 90 1.29e-17 SMART
ZnF_C2H2 251 273 7.9e-4 SMART
ZnF_C2H2 279 301 7.9e-4 SMART
ZnF_C2H2 307 329 3.49e-5 SMART
ZnF_C2H2 335 357 1.95e-3 SMART
ZnF_C2H2 363 385 7.9e-4 SMART
ZnF_C2H2 391 413 7.9e-4 SMART
ZnF_C2H2 419 441 3.49e-5 SMART
ZnF_C2H2 447 469 3.89e-3 SMART
ZnF_C2H2 475 497 2.75e-3 SMART
ZnF_C2H2 503 525 3.04e-5 SMART
ZnF_C2H2 531 553 8.34e-3 SMART
ZnF_C2H2 559 581 5.67e-5 SMART
ZnF_C2H2 587 609 1.98e-4 SMART
ZnF_C2H2 615 637 5.29e-5 SMART
ZnF_C2H2 643 665 1.58e-3 SMART
ZnF_C2H2 671 693 1.28e-3 SMART
ZnF_C2H2 699 721 1.6e-4 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 94.9%
Validation Efficiency 100% (64/64)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aloxe3 A G 11: 69,023,900 (GRCm39) Q277R probably damaging Het
Anapc5 T C 5: 122,945,401 (GRCm39) N226D probably damaging Het
Arb2a T A 13: 78,154,565 (GRCm39) L316Q probably damaging Het
Bcl2l11 T C 2: 127,970,586 (GRCm39) C12R probably damaging Het
Bpnt1 A G 1: 185,084,406 (GRCm39) T168A probably damaging Het
Brca2 A T 5: 150,463,357 (GRCm39) E1040D probably benign Het
Cdca2 G A 14: 67,915,004 (GRCm39) Q752* probably null Het
Cntn2 T C 1: 132,449,536 (GRCm39) D635G probably damaging Het
Cntnap5b A T 1: 99,999,928 (GRCm39) I229F probably benign Het
Ctr9 G A 7: 110,650,774 (GRCm39) E900K possibly damaging Het
Dmbt1 A G 7: 130,690,500 (GRCm39) Y911C unknown Het
Egflam T A 15: 7,427,561 (GRCm39) D2V probably benign Het
Enpep A T 3: 129,092,783 (GRCm39) N505K probably damaging Het
Fam13a A G 6: 58,933,790 (GRCm39) S267P probably damaging Het
Fancc G T 13: 63,550,837 (GRCm39) T12K Het
Fbxo3 A G 2: 103,864,012 (GRCm39) Y89C probably damaging Het
Garem2 A G 5: 30,313,385 (GRCm39) Y83C probably damaging Het
Gm17079 T C 14: 51,930,480 (GRCm39) T122A Het
Gm3696 A T 14: 18,435,071 (GRCm39) L71* probably null Het
Gm4559 C T 7: 141,827,553 (GRCm39) R183K unknown Het
Gmip A T 8: 70,268,736 (GRCm39) T454S possibly damaging Het
Helz2 T A 2: 180,880,055 (GRCm39) T554S probably damaging Het
Hoxc9 C T 15: 102,890,551 (GRCm39) T156M probably benign Het
Hrc A G 7: 44,986,262 (GRCm39) E471G probably damaging Het
Hydin A G 8: 111,261,863 (GRCm39) I2655V probably benign Het
Ighv1-64 T C 12: 115,471,463 (GRCm39) H18R probably benign Het
Jcad A G 18: 4,649,270 (GRCm39) Y47C probably benign Het
Jmjd4 A G 11: 59,341,179 (GRCm39) T37A probably benign Het
Kalrn C T 16: 33,796,038 (GRCm39) G2915S possibly damaging Het
Kdm5d T C Y: 910,742 (GRCm39) F285L probably benign Het
Lmna A G 3: 88,393,868 (GRCm39) F237L probably damaging Het
Med12l A G 3: 59,172,607 (GRCm39) K1788E probably damaging Het
Mrgprb1 T C 7: 48,096,658 (GRCm39) probably null Het
Myh1 T A 11: 67,102,228 (GRCm39) Y840N probably benign Het
Negr1 C A 3: 156,866,357 (GRCm39) A302E probably damaging Het
Nup188 T C 2: 30,227,045 (GRCm39) V1206A possibly damaging Het
Nup205 T C 6: 35,204,311 (GRCm39) L1399P probably damaging Het
Or13a20 T C 7: 140,232,387 (GRCm39) M165T probably benign Het
Or4a81 T A 2: 89,618,971 (GRCm39) I242F possibly damaging Het
Or5v1b G A 17: 37,841,555 (GRCm39) R229H probably benign Het
Or6c69b T C 10: 129,626,997 (GRCm39) I154V probably benign Het
Or8c14-ps1 T C 9: 38,101,885 (GRCm39) L288S unknown Het
Pcdhb4 A G 18: 37,442,349 (GRCm39) D553G probably benign Het
Phip A G 9: 82,769,662 (GRCm39) L1147P probably damaging Het
Phlpp1 A G 1: 106,320,706 (GRCm39) D1567G probably benign Het
Pigz T C 16: 31,760,858 (GRCm39) C20R probably damaging Het
Plpp1 A G 13: 113,004,002 (GRCm39) K252R probably benign Het
Polr2a A T 11: 69,625,874 (GRCm39) S1759T unknown Het
Rbm42 G T 7: 30,345,136 (GRCm39) P212T unknown Het
Repin1 G T 6: 48,574,279 (GRCm39) E403* probably null Het
Slc35e1 G A 8: 73,246,030 (GRCm39) P134L Het
Slc9a3 A C 13: 74,314,146 (GRCm39) Q818P probably benign Het
St3gal4 T C 9: 35,017,617 (GRCm39) probably null Het
Stard3nl G T 13: 19,554,521 (GRCm39) A151E probably damaging Het
Syt9 T A 7: 107,035,997 (GRCm39) I338N probably benign Het
Ticrr A T 7: 79,334,012 (GRCm39) probably null Het
Tlr4 T A 4: 66,757,713 (GRCm39) Y169N probably damaging Het
Tnc A C 4: 63,894,706 (GRCm39) I1560S possibly damaging Het
Usp7 C A 16: 8,515,771 (GRCm39) D644Y probably benign Het
Utp20 A G 10: 88,618,577 (GRCm39) I1141T possibly damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Vmn2r60 A G 7: 41,790,521 (GRCm39) M503V probably benign Het
Zfp384 T C 6: 125,013,521 (GRCm39) S530P unknown Het
Zfp819 A G 7: 43,267,148 (GRCm39) R544G probably damaging Het
Other mutations in Zfp600
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4131001:Zfp600 UTSW 4 146,131,802 (GRCm39) frame shift probably null
R1004:Zfp600 UTSW 4 146,133,103 (GRCm39) unclassified probably benign
R1323:Zfp600 UTSW 4 146,133,261 (GRCm39) missense probably damaging 1.00
R1323:Zfp600 UTSW 4 146,133,261 (GRCm39) missense probably damaging 1.00
R1702:Zfp600 UTSW 4 146,133,497 (GRCm39) missense probably benign 0.04
R2165:Zfp600 UTSW 4 146,133,488 (GRCm39) nonsense probably null
R5238:Zfp600 UTSW 4 146,131,741 (GRCm39) splice site probably null
R5548:Zfp600 UTSW 4 146,133,019 (GRCm39) missense possibly damaging 0.86
R5646:Zfp600 UTSW 4 146,131,670 (GRCm39) missense probably damaging 1.00
R5948:Zfp600 UTSW 4 146,131,645 (GRCm39) missense probably damaging 0.96
R6112:Zfp600 UTSW 4 146,131,701 (GRCm39) missense probably benign 0.41
R7044:Zfp600 UTSW 4 146,131,892 (GRCm39) nonsense probably null
R7836:Zfp600 UTSW 4 146,133,523 (GRCm39) missense probably benign
R8749:Zfp600 UTSW 4 146,133,151 (GRCm39) missense unknown
R9255:Zfp600 UTSW 4 146,131,673 (GRCm39) missense possibly damaging 0.70
Z1176:Zfp600 UTSW 4 146,133,209 (GRCm39) missense unknown
Z1177:Zfp600 UTSW 4 146,133,333 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACAAAGGCAGTCTCAGAGTTC -3'
(R):5'- GACTGTGTTTGTCACTAAAGCAT -3'

Sequencing Primer
(F):5'- GGCAGTCTCAGAGTTCATCAG -3'
(R):5'- CGGGTAAAGCATTTGTCACATTCAC -3'
Posted On 2020-06-30