Incidental Mutation 'R8081:Senp5'
ID 629379
Institutional Source Beutler Lab
Gene Symbol Senp5
Ensembl Gene ENSMUSG00000022772
Gene Name SUMO/sentrin specific peptidase 5
Synonyms A730063F07Rik, 6230429P13Rik
MMRRC Submission 067514-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8081 (G1)
Quality Score 178.009
Status Not validated
Chromosome 16
Chromosomal Location 31778490-31822105 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 31784577 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 692 (T692A)
Ref Sequence ENSEMBL: ENSMUSP00000023457 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023457] [ENSMUST00000126215] [ENSMUST00000155515] [ENSMUST00000231360]
AlphaFold Q6NXL6
Predicted Effect probably damaging
Transcript: ENSMUST00000023457
AA Change: T692A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000023457
Gene: ENSMUSG00000022772
AA Change: T692A

DomainStartEndE-ValueType
low complexity region 2 11 N/A INTRINSIC
low complexity region 441 452 N/A INTRINSIC
Pfam:Peptidase_C48 575 747 3.9e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000126215
Predicted Effect probably benign
Transcript: ENSMUST00000155515
SMART Domains Protein: ENSMUSP00000117481
Gene: ENSMUSG00000022772

DomainStartEndE-ValueType
low complexity region 22 33 N/A INTRINSIC
Pfam:Peptidase_C48 156 208 2.7e-9 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000231360
AA Change: T692A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.9%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003E16Rik A T 6: 83,138,313 (GRCm39) E119V probably damaging Het
Adamts2 A T 11: 50,668,004 (GRCm39) D522V probably damaging Het
Agtpbp1 A T 13: 59,676,221 (GRCm39) L183* probably null Het
Arhgap10 T C 8: 78,109,375 (GRCm39) I403V possibly damaging Het
Arhgef11 T C 3: 87,632,949 (GRCm39) S687P probably damaging Het
Cdhr1 C T 14: 36,815,967 (GRCm39) V144I probably benign Het
Cdk20 A G 13: 64,586,766 (GRCm39) I339V probably benign Het
Ceacam13 A G 7: 17,747,113 (GRCm39) K189E probably damaging Het
Cep290 C T 10: 100,394,038 (GRCm39) Q2082* probably null Het
Cgrrf1 A G 14: 47,091,468 (GRCm39) T331A probably benign Het
Cntn4 G A 6: 106,651,568 (GRCm39) V706I possibly damaging Het
Csrnp2 T C 15: 100,387,462 (GRCm39) D2G probably damaging Het
Cux2 A G 5: 122,007,519 (GRCm39) I714T probably benign Het
Cx3cr1 C T 9: 119,880,878 (GRCm39) E175K possibly damaging Het
Dennd1c G A 17: 57,381,139 (GRCm39) P163L possibly damaging Het
Dhtkd1 C T 2: 5,928,919 (GRCm39) E251K probably damaging Het
Epas1 C T 17: 87,136,797 (GRCm39) P787S probably benign Het
Epha2 T C 4: 141,049,605 (GRCm39) V737A probably damaging Het
Fam50b G A 13: 34,931,084 (GRCm39) E187K possibly damaging Het
Fcsk T A 8: 111,615,783 (GRCm39) R515S probably benign Het
Fscb A T 12: 64,518,802 (GRCm39) M888K unknown Het
Gldc ACGACC AC 19: 30,135,987 (GRCm39) probably null Het
Gm14443 A T 2: 175,012,238 (GRCm39) C69* probably null Het
Gm19668 G A 10: 77,634,420 (GRCm39) A183V unknown Het
Gm49368 A G 7: 127,726,280 (GRCm39) R1231G unknown Het
Grin2c T C 11: 115,140,719 (GRCm39) Y1133C probably damaging Het
H3c13 C A 3: 96,176,309 (GRCm39) Y100* probably null Het
Hydin T C 8: 111,092,101 (GRCm39) S425P possibly damaging Het
Ifnl3 T C 7: 28,223,682 (GRCm39) S173P probably damaging Het
Igkv4-63 A T 6: 69,355,018 (GRCm39) S88T possibly damaging Het
Klhl5 C A 5: 65,320,268 (GRCm39) N607K possibly damaging Het
Lag3 A T 6: 124,882,410 (GRCm39) L362* probably null Het
Lats2 C A 14: 57,937,968 (GRCm39) G174C probably damaging Het
Mcm6 T C 1: 128,265,905 (GRCm39) E622G probably damaging Het
Med13l C A 5: 118,866,333 (GRCm39) H462Q probably damaging Het
Mrpl53 T A 6: 83,086,159 (GRCm39) F23I probably damaging Het
Muc5b T G 7: 141,417,743 (GRCm39) I3563S possibly damaging Het
Myo16 A C 8: 10,372,743 (GRCm39) L147F unknown Het
Npc1l1 G C 11: 6,167,768 (GRCm39) Q1008E probably benign Het
Npy4r A G 14: 33,868,524 (GRCm39) S255P probably damaging Het
Nup210 T C 6: 91,053,657 (GRCm39) N287D probably benign Het
Opn3 T A 1: 175,493,135 (GRCm39) H143L probably damaging Het
Or12e7 G T 2: 87,287,513 (GRCm39) M1I probably null Het
Or12j3 A T 7: 139,952,972 (GRCm39) L184M probably damaging Het
Or12j5 A T 7: 140,084,369 (GRCm39) M1K probably null Het
Or4k2 T A 14: 50,423,825 (GRCm39) N284I probably damaging Het
Or5ap2b-ps1 C T 2: 85,693,839 (GRCm39) P28L probably damaging Het
Pdcd7 C T 9: 65,253,967 (GRCm39) R182C probably damaging Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Picalm T A 7: 89,840,451 (GRCm39) L540* probably null Het
Ppp1r21 T A 17: 88,866,272 (GRCm39) I356N probably damaging Het
Rgs6 C T 12: 83,094,347 (GRCm39) Q67* probably null Het
Ripor2 C A 13: 24,897,683 (GRCm39) Q794K probably benign Het
Rnf216 A T 5: 143,013,719 (GRCm39) I702N probably damaging Het
Robo4 T C 9: 37,316,936 (GRCm39) L417P probably damaging Het
Samhd1 A T 2: 156,943,358 (GRCm39) C605* probably null Het
Scaper C T 9: 55,823,330 (GRCm39) G22D unknown Het
Six6 G T 12: 72,986,875 (GRCm39) G16W probably damaging Het
Slc38a8 A T 8: 120,212,269 (GRCm39) M358K possibly damaging Het
Snx2 T C 18: 53,349,459 (GRCm39) F407L probably benign Het
Srrm2 T A 17: 24,039,219 (GRCm39) N1954K probably damaging Het
Syk A T 13: 52,792,195 (GRCm39) M429L probably benign Het
Tln2 T A 9: 67,264,029 (GRCm39) N537Y probably damaging Het
Usp29 T A 7: 6,966,629 (GRCm39) M824K probably benign Het
Utrn A G 10: 12,423,803 (GRCm39) probably benign Het
Wdr37 C T 13: 8,885,406 (GRCm39) D346N probably damaging Het
Zfpm2 T A 15: 40,965,644 (GRCm39) C710S probably damaging Het
Other mutations in Senp5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00838:Senp5 APN 16 31,807,991 (GRCm39) missense probably damaging 1.00
IGL00990:Senp5 APN 16 31,809,092 (GRCm39) missense probably benign 0.00
IGL01707:Senp5 APN 16 31,808,588 (GRCm39) missense probably damaging 0.99
IGL01923:Senp5 APN 16 31,784,634 (GRCm39) missense probably damaging 1.00
IGL01997:Senp5 APN 16 31,782,288 (GRCm39) missense probably damaging 0.97
IGL02273:Senp5 APN 16 31,808,690 (GRCm39) missense probably benign 0.14
IGL02560:Senp5 APN 16 31,808,210 (GRCm39) missense probably benign
IGL02651:Senp5 APN 16 31,808,897 (GRCm39) missense probably benign 0.04
IGL02830:Senp5 APN 16 31,802,303 (GRCm39) splice site probably benign
R0578:Senp5 UTSW 16 31,808,163 (GRCm39) missense possibly damaging 0.75
R1879:Senp5 UTSW 16 31,802,642 (GRCm39) missense probably damaging 1.00
R2153:Senp5 UTSW 16 31,787,692 (GRCm39) missense probably damaging 1.00
R4903:Senp5 UTSW 16 31,802,117 (GRCm39) missense probably damaging 1.00
R5092:Senp5 UTSW 16 31,807,960 (GRCm39) missense probably benign 0.00
R5590:Senp5 UTSW 16 31,808,331 (GRCm39) missense probably damaging 0.99
R6346:Senp5 UTSW 16 31,802,665 (GRCm39) missense probably damaging 1.00
R6362:Senp5 UTSW 16 31,808,702 (GRCm39) missense probably damaging 0.99
R6762:Senp5 UTSW 16 31,808,702 (GRCm39) missense probably damaging 0.99
R7002:Senp5 UTSW 16 31,802,593 (GRCm39) missense probably damaging 1.00
R7027:Senp5 UTSW 16 31,808,113 (GRCm39) missense probably benign
R7436:Senp5 UTSW 16 31,794,847 (GRCm39) missense unknown
R7721:Senp5 UTSW 16 31,809,252 (GRCm39) start codon destroyed unknown
R7847:Senp5 UTSW 16 31,808,991 (GRCm39) missense probably benign 0.25
R7992:Senp5 UTSW 16 31,796,514 (GRCm39) missense probably damaging 1.00
R8147:Senp5 UTSW 16 31,808,128 (GRCm39) missense probably benign 0.00
R8313:Senp5 UTSW 16 31,808,117 (GRCm39) missense probably benign 0.10
R8353:Senp5 UTSW 16 31,808,166 (GRCm39) missense probably benign 0.00
R8453:Senp5 UTSW 16 31,808,166 (GRCm39) missense probably benign 0.00
R8506:Senp5 UTSW 16 31,787,719 (GRCm39) missense probably damaging 1.00
R9079:Senp5 UTSW 16 31,787,718 (GRCm39) missense probably damaging 1.00
R9317:Senp5 UTSW 16 31,802,390 (GRCm39) missense probably damaging 1.00
R9776:Senp5 UTSW 16 31,782,279 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTACAAGGTAAGGTGCCACCC -3'
(R):5'- GCTTGCACAGACCTCCTAAC -3'

Sequencing Primer
(F):5'- TTAACGCTACCAAGTTACATGCAG -3'
(R):5'- TGCACAGACCTCCTAACTGGTG -3'
Posted On 2020-06-30