Mutagenetix > Incidental Mutation

Incidental Mutation 'R8086:Vmn1r238'

629680

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r238

Ensembl Gene

ENSMUSG00000091539

Gene Name

vomeronasal 1 receptor, 238

Synonyms

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R8086 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

3122492-3123412 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 3123250 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 55 (A55T)

Ref Sequence

ENSEMBL: ENSMUSP00000129804 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165255]

AlphaFold

E9Q373

Predicted Effect

probably damaging
Transcript: ENSMUST00000165255
AA Change: A55T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000129804
Gene: ENSMUSG00000091539
AA Change: A55T

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	302	5.3e-8	PFAM
Pfam:7tm_1	27	292	8.8e-7	PFAM
Pfam:V1R	34	298	1.9e-33	PFAM

Coding Region Coverage

1x: 99.8%
3x: 99.7%
10x: 98.9%
20x: 96.4%

Validation Efficiency

98% (51/52)

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010315B03Rik	T	A	9: 124,293,178	H372L		Het
4931423N10Rik	A	G	2: 23,240,922		probably null	Het
Abcb1a	A	T	5: 8,674,833	T89S	probably benign	Het
Ago1	A	G	4: 126,460,981	V146A	probably benign	Het
App	T	C	16: 85,120,540	Y72C	unknown	Het
Arhgap20	T	C	9: 51,849,263	S805P	probably benign	Het
Bak1	T	A	17: 27,020,937	R208S	probably benign	Het
Btnl4	A	C	17: 34,474,002		probably null	Het
Cacng7	T	C	7: 3,339,002	S134P	probably benign	Het
Capn9	A	T	8: 124,607,953		probably null	Het
Cox4i1	T	A	8: 120,674,040	M148K	probably damaging	Het
Ctnna1	A	G	18: 35,152,660	I20V	possibly damaging	Het
Dennd2c	T	A	3: 103,133,345	Y309N	possibly damaging	Het
Dnah14	C	A	1: 181,766,232	T3380K	probably damaging	Het
Dnajc3	G	T	14: 118,970,780	E276*	probably null	Het
Dock10	C	A	1: 80,503,990	C1772F	probably benign	Het
Fank1	A	T	7: 133,853,230	E26D	possibly damaging	Het
Fcgbp	G	T	7: 28,113,964	C2308F	probably damaging	Het
Fyco1	A	T	9: 123,830,406	M235K	probably damaging	Het
Gm7361	C	T	5: 26,260,448	R148C	probably damaging	Het
Hinfp	C	T	9: 44,298,989	R183Q	probably damaging	Het
Hpd	T	C	5: 123,176,189	Y221C	probably benign	Het
Hrnr	A	T	3: 93,323,421	H322L	unknown	Het
Il6st	T	A	13: 112,494,560		probably null	Het
Impa1	T	C	3: 10,322,928	K145E	probably benign	Het
Itga9	A	T	9: 118,850,801	M847L	probably benign	Het
Itgb6	A	G	2: 60,650,032	V320A	probably damaging	Het
Lrrfip1	T	A	1: 91,115,908	H678Q	probably benign	Het
Mettl16	A	G	11: 74,805,265	T311A	probably benign	Het
Nefl	T	C	14: 68,086,031	Y369H	probably damaging	Het
Olfr412	C	A	11: 74,364,954	P95Q	probably benign	Het
Pkd1	A	G	17: 24,581,214	Y2983C	probably damaging	Het
Prr5l	C	T	2: 101,741,364	E123K	probably benign	Het
Ptprq	A	T	10: 107,646,639	Y1024*	probably null	Het
Ramp2	T	A	11: 101,247,936	L147Q	probably damaging	Het
Rassf1	C	T	9: 107,557,974	R223C	probably benign	Het
Rcbtb2	T	C	14: 73,173,865	F357L	probably damaging	Het
Rnf24	A	G	2: 131,303,548	V114A	probably benign	Het
Slc7a1	T	G	5: 148,352,089	N116T	probably damaging	Het
Sstr2	T	C	11: 113,625,172	C306R	probably damaging	Het
Tatdn2	T	C	6: 113,709,521	S697P	probably damaging	Het
Tmem67	T	A	4: 12,040,738	N935I	probably damaging	Het
Trp73	G	A	4: 154,116,595	P4S	unknown	Het
Vmn1r237	T	G	17: 21,314,247	D77E	possibly damaging	Het
Vsig10l	C	A	7: 43,465,452	A359E	possibly damaging	Het
Wdr24	T	C	17: 25,826,127	Y279H	probably damaging	Het
Zbtb25	A	G	12: 76,349,149	V433A	probably benign	Het
Zfp180	C	A	7: 24,106,110	D651E	probably benign	Het
Zfp979	T	C	4: 147,613,547	D235G	probably damaging	Het

Other mutations in Vmn1r238

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn1r238	APN	18	3123243	missense	probably benign	0.01
IGL01385:Vmn1r238	APN	18	3122770	missense	possibly damaging	0.83
IGL02716:Vmn1r238	APN	18	3123124	missense	probably damaging	1.00
R1219:Vmn1r238	UTSW	18	3123135	missense	possibly damaging	0.81
R1568:Vmn1r238	UTSW	18	3123358	missense	probably benign	0.00
R1864:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R3024:Vmn1r238	UTSW	18	3123305	missense	probably benign	0.13
R4291:Vmn1r238	UTSW	18	3123214	nonsense	probably null
R4304:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R4586:Vmn1r238	UTSW	18	3123294	missense	probably damaging	1.00
R4664:Vmn1r238	UTSW	18	3123300	missense	probably damaging	0.99
R5123:Vmn1r238	UTSW	18	3123243	missense	probably benign
R5430:Vmn1r238	UTSW	18	3122521	missense	possibly damaging	0.63
R5834:Vmn1r238	UTSW	18	3123168	missense	probably benign
R7186:Vmn1r238	UTSW	18	3122661	missense	probably damaging	0.99
R7206:Vmn1r238	UTSW	18	3122623	missense	possibly damaging	0.94
R7308:Vmn1r238	UTSW	18	3122875	missense	probably benign	0.09
R7346:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R7467:Vmn1r238	UTSW	18	3123393	missense	probably benign	0.10
R7571:Vmn1r238	UTSW	18	3122721	missense	probably damaging	1.00
R7808:Vmn1r238	UTSW	18	3123033	missense	probably benign	0.03
R8085:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R8325:Vmn1r238	UTSW	18	3122529	missense	probably benign	0.00
R8423:Vmn1r238	UTSW	18	3123365	nonsense	probably null
R8747:Vmn1r238	UTSW	18	3123232	missense	possibly damaging	0.87
R8930:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R8932:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R9279:Vmn1r238	UTSW	18	3122994	missense	probably damaging	0.99
R9382:Vmn1r238	UTSW	18	3122676	missense	probably damaging	0.99
Z1177:Vmn1r238	UTSW	18	3122505	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TCCACCTGGAGTTATTGGGG -3'
(R):5'- TTCAAGTTCAGGGATTTTGGACC -3'

Sequencing Primer
(F):5'- GCTGATGGTGATTGCTTGGAAAC -3'
(R):5'- TCTGCCAGATTACAGTGG -3'

Posted On

2020-06-30